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31. 发明申请

US20170218463A1 METHOD OF IDENTIFYING IMPORTANT METHYLOME FEATURES AND USE THEREOF 审中-公开
公开(公告)号：US20170218463A1
公开(公告)日：2017-08-03
申请号：US15422409
申请日：2017-02-01
申请人： The Board of Regents of the University of Nebraska
发明人： Sally A. Mackenzie , Robersy Sanchez
IPC分类号： C12Q1/68 , G06F19/00 , G06F19/24 , G06F19/22 , G06F19/18
CPC分类号： C12Q1/6895 , C12Q2600/13 , C12Q2600/154 , G16B20/00 , G16B20/20 , G16B30/00 , G16B40/00 , G16H50/20 , Y02A90/26
摘要： A computer-implemented method of preparing a set of differentially informative methylated positions (DIMPs) or differentially informative methylated regions (DIMRs) from a sample methylome of an animal or plant having a phenotypic characteristic different from a wild-type of the same species of animal or plant, and the characteristic is associate with differences in methylation of the genome, comprises: providing a computer with the sample methylome, and a reference methylome of the wild-type of the same species of animal or plant; calculating with the computer a divergence between a plurality of cytosine positions of the sample methylome and the reference methylome; and selecting with the computer a set of DIMPs or DIMRs. Each DIMP or DIMR is selected based on an approximation of the energy required to produce the divergence between methylation levels of the plurality of cytosine positions of the sample methylome as compared to the wild-type methylome.

32. 发明授权

US09577555B2 Methods of estimating a position of a rotor in a motor under transient and systems thereof 有权
标题翻译：在瞬态及其系统下估计电机中转子的位置的方法
公开(公告)号：US09577555B2
公开(公告)日：2017-02-21
申请号：US14243252
申请日：2014-04-02
申请人： DEERE & COMPANY , The Board of Regents of the University of Nebraska
发明人： Long Wu , Yue Zhao , Wei Qiao
IPC分类号： H02P6/00 , H02P6/18 , H02P21/00 , H02P23/12
CPC分类号： H02P6/183 , H02P6/18 , H02P21/0007 , H02P21/18 , H02P23/12
摘要： At least one example embodiment discloses a method of estimating a position of a rotor in a motor. The method includes obtaining a current regulation quality index based on a current command and a measured current, determining an estimated position of the rotor based on the current regulation quality index and position estimation data and controlling the motor based on the estimated position of the rotor.
摘要翻译：至少一个示例性实施例公开了一种估计电动机中的转子的位置的方法。该方法包括基于电流指令和测量电流获得电流调节质量指标，基于当前调节质量指标和位置估计数据确定转子的估计位置，并基于转子的估计位置来控制电动机。

33. 发明申请

US20160346222A1 Compositions and Methods for the Delivery of Therapeutics 有权
公开(公告)号：US20160346222A1
公开(公告)日：2016-12-01
申请号：US15111046
申请日：2015-01-14
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： Howard E. Gendelman , Xin-Ming Liu
IPC分类号： A61K9/51 , A61K45/06 , A61K31/46
CPC分类号： A61K9/5153 , A61K9/5123 , A61K31/46 , A61K45/06 , A61K47/24
摘要： The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.

34. 发明申请

US20160222407A1 PARENTAL RNAI SUPPRESSION OF HUNCHBACK GENE TO CONTROL COLEOPTERAN PESTS 审中-公开
标题翻译：双歧杆菌RNAi抑制反转录病毒基因控制
公开(公告)号：US20160222407A1
公开(公告)日：2016-08-04
申请号：US14971366
申请日：2015-12-16
申请人： Dow AgroSciences LLC , The Board of Regents of the University of Nebraska
发明人： Blair D. Siegfried , Kenneth E. Narva , Kanika Arora , Sarah E. Worden , Chitvan Khajuria , Elane Fishilevich , Nicholas P. Storer , Meghan Frey , Ronda L. Hamm , Ana M. Velez
IPC分类号： C12N15/82 , A01N57/16 , C12N15/113
CPC分类号： C12N15/8286 , A01N57/16 , C12N15/113 , C12N15/8218 , C12N2310/14 , Y02A40/162
摘要： This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.
摘要翻译：本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。

35. 发明授权

US09391287B1 Photovoltaic perovskite material and method of fabrication 有权
标题翻译：光伏钙钛矿材料及其制造方法
公开(公告)号：US09391287B1
公开(公告)日：2016-07-12
申请号：US14576878
申请日：2014-12-19
申请人： The Board of Regents of the University of Nebraska
发明人： Jinsong Huang , Qingfeng Dong , Rui Dong , Yuchuan Sao , Cheng Bi , Qi Wang , Zhengguo Xiao
IPC分类号： H01L51/42 , H01L51/44 , H01L51/00
CPC分类号： H01L51/4213 , H01L51/0003 , H01L51/0037 , H01L51/0047 , H01L51/0094 , H01L51/424 , H01L2251/308 , Y02E10/549
摘要： A semiconductor device and a method for fabrication of the semiconductor device are described that include a perovskite layer formed using a solution process with lead iodine and methylammonium halide. In an implementation, a semiconductor device that employs example techniques in accordance with the present disclosure includes a cathode layer; an anode layer; and an active layer disposed between the cathode layer and the anode layer, where the active layer includes a perovskite layer including an interdiffused and annealed lead iodine (PbI2) film and methylammonium halide (CH3NH3X) film. In implementations, a process for fabricating a continuous-perovskite semiconductor device that employs example techniques in accordance with the present disclosure includes spinning a PbI2 layer onto an ITO-covered glass; spinning an MAI layer onto the PbI2 layer; annealing the PbI2 layer and the MAI layer; spinning a PCBM layer onto a resulting perovskite layer; and depositing an Al layer.
摘要翻译：描述了半导体器件和半导体器件的制造方法，其包括使用铅碘和甲基卤化铵的溶液法形成的钙钛矿层。在一个实现中，采用根据本公开的示例技术的半导体器件包括阴极层; 阳极层; 以及设置在阴极层和阳极层之间的有源层，其中活性层包括包含相互扩散和退火的铅碘（PbI 2）膜和甲基卤化铵（CH 3 NH 3 X）膜的钙钛矿层。在实现中，根据本公开的采用示例技术的连续钙钛矿半导体器件的制造方法包括将PbI 2层旋转到ITO覆盖的玻璃上; 将MAI层旋转到PbI2层上; 退火PbI2层和MAI层; 将PCBM层旋转到所得的钙钛矿层上; 并沉积Al层。

36. 发明申请

US20040229829A1 Enzyme inhibitors for metabolic redirection 审中-公开
公开(公告)号：US20040229829A1
公开(公告)日：2004-11-18
申请号：US10723354
申请日：2003-11-25
申请人： The Board of Regents of the University of Nebraska
发明人： Patrick L. Iversen
IPC分类号： A61K048/00
CPC分类号： C12N15/1137 , A61K31/337 , A61K38/00 , C12N2310/314 , C12N2310/3233 , A61K2300/00
摘要： A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.

37. 发明申请

US20030165889A1 Method of isolation of regulated determinants from bacterial pathogens 审中-公开
标题翻译：从细菌病原体中分离受控决定簇的方法
公开(公告)号：US20030165889A1
公开(公告)日：2003-09-04
申请号：US10144907
申请日：2002-05-13
申请人： The Board of Regents of the University of Nebraska
发明人： Jeffrey D. Cirillo
IPC分类号： C12Q001/68 , C12Q001/04 , C12N015/74 , C12N001/21
CPC分类号： C12N15/1089 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12N15/1034 , C12Q1/689 , C12Q2600/156 , C12Q2600/158 , G01N2333/265 , Y02A50/451 , Y02A50/478
摘要： The present invention relates to novel methods for isolation and identification of virulence determinants from bacterial pathogens. The present invention also relates to novel genes of the Legionella pneumophila bacteria, and methods of detection of Legionella pneumophila bacteria in samples.
摘要翻译：本发明涉及用于分离和鉴定来自细菌病原体的毒力决定簇的新方法。本发明还涉及嗜肺军团病菌的新型基因，以及样品中肺炎链球菌属细菌的检测方法。

38. 发明申请

US20030064008A1 Microcolumns for the separation of analytes from a sample in the millisecond time scale 审中-公开
公开(公告)号：US20030064008A1
公开(公告)日：2003-04-03
申请号：US10280922
申请日：2002-10-25
申请人： The Board of Regents of the University of Nebraska
发明人： David S. Hage , William A. Clarke
IPC分类号： G01N030/56
CPC分类号： G01N33/54366 , G01N33/54313 , G01N33/54393 , G01N2030/527 , Y10T436/25375 , Y10T436/255 , G01N30/02 , B01D15/3804
摘要： The present invention generally relates to a microcolumn capable of separating an analyte from a sample in the millisecond time domain. The microcolumn is capable of such rapid separation by employing small column volumes that can tolerate medium to high flow rates. The invention also relates to a method of loading a microcolumn capable of separating an analyte from a sample in the millisecond time domain.

39. 发明申请

US20030032826A1 Transesterification process for production of biodiesel 审中-公开
标题翻译：用于生产生物柴油的酯交换方法
公开(公告)号：US20030032826A1
公开(公告)日：2003-02-13
申请号：US10200061
申请日：2002-07-19
申请人： The Board of Regents of the University of Nebraska
发明人： Milford A. Hanna
IPC分类号： C11B003/00
CPC分类号： C11B13/00 , C10L1/026 , C11C3/003 , C11C3/10 , Y02E50/13 , Y02W30/74
摘要： A process for the production of fatty acid esters from a triglyceride feedstock is provided. The process comprises introducing a catalyst and a triglyceride feed stream comprising the triglyceride feedstock into a reaction zone and introducing an alcohol into the feed stream within the reaction zone to form a product mixture comprising fatty acid esters, glycerol and unreacted alcohol. The feed stream into which the alcohol is introduced is characterized as having a Reynolds number of at least about 2100. The invention further provides for a process and apparatus for introducing the alcohol into the triglyceride feed stream via a distributed feed system.
摘要翻译：提供了从甘油三酯原料生产脂肪酸酯的方法。该方法包括将包含甘油三酯原料的催化剂和甘油三酯进料流引入反应区并将醇引入反应区内的进料流中以形成包含脂肪酸酯，甘油和未反应的醇的产物混合物。引入醇的进料流的特征在于具有至少约2100的雷诺数。本发明还提供了一种通过分配进料系统将醇引入甘油三酯进料流中的方法和装置。

40. 发明申请

US20030017448A1 Method of prophylaxis and treatment of porcine reproductive and respiratory syndrome 审中-公开
标题翻译：预防和治疗猪繁殖与呼吸综合征的方法
公开(公告)号：US20030017448A1
公开(公告)日：2003-01-23
申请号：US10081753
申请日：2002-02-22
申请人： The Board of Regents of the University of Nebraska
发明人： Fernando A. Osorio
IPC分类号： C12Q001/70 , C07H021/04 , C12P019/34 , A61K039/42 , C12N005/06 , C12N005/16
CPC分类号： C07K16/10 , A61K39/42 , A61K2039/505 , A61K2300/00
摘要： A method for the prevention of intra uterine infection of fetuses with porcine reproductive and respiratory syndrome virus (PRRSV) is provided comprising administering to a pregnant female a composition containing an effective dose of anti-PRRSV antibodies. Also provided is a method for the prophylaxis or treatment of porcine reproductive and respiratory syndrome comprising administering to a pig a composition comprising an effective amount of anti-PRRS virus antibodies.
摘要翻译：提供了一种用于预防猪繁殖和呼吸综合征病毒（PRRSV）的胎儿子宫内感染的方法，包括向孕妇施用含有有效剂量的抗PRRSV抗体的组合物。还提供了预防或治疗猪繁殖和呼吸综合征的方法，其包括向猪施用包含有效量的抗PRRS病毒抗体的组合物。

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