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31. 发明申请

WO2004002983A2 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2004002983A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/020509
申请日：2003-06-27
申请人： EURO-CELTIQUE, S.A. , KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , ZHANG, Chongwu , ZHOU, Xiaoming
发明人： KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea , ZHANG, Chongwu , ZHOU, Xiaoming
IPC分类号： C07D401/00
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula (I): wherein A, Ar, R 3 , R 6 , and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a "Cyanoiminopiperazine Compound"), cornposition, comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndi - oine, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke. a sc z , are, a prurifc condition, psychosis, a cognitive disorder;`a memory deficit, restricted brain function. R rnfington's chorea., arsiyotrophic lateral sclerosis, dementia, retinopathy, a muscie ,spasm„ a migraine, vomiting, dyskinesia or depression in an animal comprising administek - irgT . b ati animal in need thereof an effective amount of a Cyanoi:irinopiperazine Compound are disclosed.
摘要翻译：式（I）化合物：其中A，Ar，R 3，R 6和m在本文中公开，或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量氰酰亚哌嗪化合物，以及治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风的方法。是一种瘙痒症状，精神病，认知障碍，记忆障碍，脑功能受限。 Rnfington的舞蹈病，arsiyotrophial侧索硬化症，痴呆症，视网膜病变，肌肉，痉挛“偏头痛，呕吐，运动障碍或抑郁症包括有需要的有效量的Cyanoi 公开了伊立哌嗪化合物。

32. 发明申请

WO2003066595A3 2 - PIPERAZINE - PYRIDINES USEFUL FOR TREATING PAIN 审中-公开
公开(公告)号：WO2003066595A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/002983
申请日：2003-01-31
申请人： EURO-CELTIQUE S.A. , KYLE, Donald, J. , SUN, Qun
发明人： KYLE, Donald, J. , SUN, Qun
IPC分类号： C07D213/74
摘要： A compound of formula (I) (wherein X is O or S and R 1 -R 5 are disclosed herein) or a pharmaceutically acceptable salt thereof (each being a "Piperazine Compound"), pharmaceutical compositions comprising a Piperazine Compound and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.

33. 发明申请

WO1996036612A1 TRIBENZIMIDAZOLES USEFUL AS TOPOISOMERASE I INHIBITORS 审中-公开
标题翻译：三苯并咪唑作为TOPOISOMERASE I抑制剂有用
公开(公告)号：WO1996036612A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006853
申请日：1996-05-14
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , LAVOIE, Edmond, J. , LIU, Leroy, Fong , SUN, Qun
发明人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
IPC分类号： C07D235/18
CPC分类号： C07D401/14 , C07D235/18
摘要： The present invention provides anti-neoplastic topoisomerase I inhibitors of formula (I) wherein Ar is (C6-C12)aryl or (5- to 12-membered) heteroaryl comprising 1-3 N, S or non peroxyde O, wherein N is unsubstituted or is substituted with (C1-C4)alkyl; X is H, CN, CHO, OH, acetyl, CF3, O(C1-C4)alkyl, NO2, NH2, halogen or halo-(C1-C4)alkyl; each Y is individually H, (C1-C4)alkyl or aralkyl; Y' is H or (C1-C4)alkyl; n is 0 or 1; and each Z is individually H, (C1-C4)alkyl, halogen or halo(C1-C4)alkyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式（I）的抗肿瘤拓扑异构酶I抑制剂，其中Ar是（C 6 -C 12）芳基或包含1-3个N，S或非过氧化物O的（5-至12-元）杂芳基，其中N是未取代的或被（C 1 -C 4）烷基取代; X是H，CN，CHO，OH，乙酰基，CF 3，O（C 1 -C 4）烷基，NO 2，NH 2，卤素或卤代（C 1 -C 4）每个Y各自为H，（C 1 -C 4）烷基或芳烷基; Y'是H或（C 1 -C 4）烷基; n为0或1; 并且每个Z独立地为H，（C 1 -C 4）烷基，卤素或卤素（C 1 -C 4）烷基; 或其药学上可接受的盐。

34. 发明申请

WO2019200084A1 FORMULATIONS AND COMPOSITIONS OF DOCETAXEL 审中-公开
公开(公告)号：WO2019200084A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026965
申请日：2019-04-11
申请人： ZHUHAI BEIHAI BIOTECH CO., LTD. , SUN, Qun
发明人： SUN, Qun
IPC分类号： A61K31/337 , A61K38/17 , A61K38/38
摘要： This document relates to a composition comprising Docetaxel, human serum albumin, and one or more amino acids selected from aspartic acid, glutamic acid, and cysteine, wherein the human serum albumin and the Docetaxel in the composition have a ratio by weight of no less than 60:1. This document also relates to a composition comprising Docetaxel, human serum albumin, one or more amino acids selected from aspartic acid, glutamic acid, and cysteine, and a sugar alcohol or a sugar, wherein the human serum albumin and the Docetaxel in the composition have a ratio by weight of no less than 60:1.

35. 发明申请

WO2017123760A1 COMPOSITIONS AND FORMULATIONS INCLUDING CABAZITAXEL AND HUMAN SERUM ALBUMIN 审中-公开
标题翻译：包含卡巴他赛和人血清白蛋白的组合物和制剂
公开(公告)号：WO2017123760A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013194
申请日：2017-01-12
申请人： SUN, Qun
发明人： SUN, Qun
IPC分类号： A61K38/38 , A61K9/08 , A61K9/51 , A61K47/42 , C07D305/14
CPC分类号： C07D305/14 , A61K9/0019 , A61K9/19 , A61K38/38 , A61K47/42
摘要： This document relates to non-covalently bound complexes comprising cabazitaxel and human serum albumin. This document also relates to compositions comprising non-covalently bound complexes comprising cabazitaxel and human serum albumin. This document also relates to compositions comprising cabazitaxel and human serum albumin. This document also relates to compositions consisting essentially of cabazitaxel and human serum albumin.
摘要翻译：本文涉及包含卡巴他赛和人血清白蛋白的非共价结合的复合物。该文献还涉及包含非共价结合的复合物的组合物，所述复合物包含卡巴他赛和人血清白蛋白。该文件还涉及包含卡巴他赛和人血清白蛋白的组合物。该文件还涉及基本上由卡巴他赛和人血清白蛋白组成的组合物。

36. 发明申请

WO2010120289A1 IMPROVED COPOLYETHER GLYCOL MANUFACTURING PROCESS 审中-公开
标题翻译：改进的聚乙二醇制造工艺
公开(公告)号：WO2010120289A1
公开(公告)日：2010-10-21
申请号：PCT/US2009/040642
申请日：2009-04-15
申请人： INVISTA TECHNOLOGIES S.A R.L. , SUN, Qun , KISER, Gary, L. , ORLANDI, Robert, D.
发明人： SUN, Qun , KISER, Gary, L. , ORLANDI, Robert, D.
IPC分类号： C08G65/32 , C08G65/20 , C08G65/00 , C08G65/10 , C08G65/30
CPC分类号： C08G65/20 , C08G65/2609 , C08G65/2696
摘要： The present invention provides a process for manufacturing copolyether glycol having a mean molecular weight of from about 650 to about 5000 dalton by polymerization of tetrahydrofuran and at least one alkylene oxide in the presence of an acid catalyst and at least one compound containing reactive hydrogen atoms. More particularly, the invention relates to a process for manufacturing copolyether glycol which comprises recycle to the polymerization reaction step of at least a portion of the oligomeric cyclic ether which is co-produced with the copolyether glycol.
摘要翻译：本发明提供了在酸催化剂和至少一种含有反应性氢原子的化合物的存在下，通过四氢呋喃和至少一种烯化氧的聚合制备平均分子量为约650至约5000道尔顿的共聚醚二醇的方法。更具体地说，本发明涉及一种制备共聚醚二醇的方法，该方法包括向聚合反应步骤循环至少部分与共聚醚二醇共同生产的低聚环醚的一部分。

37. 发明申请

WO2005030753A3 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2005030753A3
公开(公告)日：2005-05-06
申请号：PCT/US2004030825
申请日：2004-09-21
申请人： EURO CELTIQUE SA , SUN QUN
发明人： SUN QUN
IPC分类号： A61K31/41 , A61K31/44 , A61K31/495 , C07D213/81 , C07D401/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D213/80 , C07D213/81
摘要： The present invention discloses a compound of formula: where Ar1, Ar2, X, Z1, Z2, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a "Pyridylene Compound"); compositions comprising an effective amount of a Pyridylene Compound; and methods for treating or preventing pain or other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Pyridylene Compound.
摘要翻译：本发明公开了下式的化合物：其中Ar1，Ar2，X，Z1，Z2，R3和m如本文所公开或其药学上可接受的盐（“吡咯啉化合物”）; 包含有效量的吡啶化合物的组合物; 以及用于治疗或预防动物中的疼痛或其他病症的方法，其包括向有需要的动物施用有效量的吡啶并吡啶化合物。

38. 发明申请

WO2005012287A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2005012287A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/024753
申请日：2004-07-30
申请人： EURO-CELTIQUE S.A. , KYLE, Donald, J. , SUN, Qun
发明人： KYLE, Donald, J. , SUN, Qun
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D213/74 , C07D213/85
摘要： Compounds of formulae (I) and (II) where X is S or O and Ar 2 , R 1 , R 2 , R 3 , R 8 , n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a "3-substituted Pyridyl Compound"), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.
摘要翻译：本文公开了X为S或O的式（I）和（II）的化合物，以及Ar2，R1，R2，R3，R8，n，m和t，或其药学上可接受的盐（“3-取代的吡啶基化合物“），包含有效量的3-取代的吡啶基化合物的组合物，以及用于治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁包括向有需要的动物施用有效量的3-取代的吡啶基化合物。

39. 发明申请

WO2004013111A1 2-SUBSTITUTED BICYCLIC BENZOHETEROCYCLIC COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译： 2-取代的双环苯并二唑类化合物及其作为钠通道阻断剂的用途
公开(公告)号：WO2004013111A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/023791
申请日：2003-07-30
申请人： EURO-CELTIQUE S.A. , SUN, Qun , KYLE, Donald, J. , VICTORY, Samuel, F.
发明人： SUN, Qun , KYLE, Donald, J. , VICTORY, Samuel, F.
IPC分类号： C07D239/91
CPC分类号： C07D239/91 , C07D279/08
摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel 2-substituted bicyclic benzoheterocyclic compounds of Formula I, or a pharmaceutically-acceptable salt or solvate thereof, wherein X is -NH-, -N= or -S-, Y is oxygen or sulfur, and n, p, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及使用新的式I的2-取代双环苯并杂环化合物或其药学上可接受的盐或溶剂合物来治疗对钠离子通道阻断有反应的病症的方法，其中X是-NH-，-N =或 -S-，Y是氧或硫，n，p，R1，R2，R3和R4在说明书中定义。本发明还涉及式I化合物用于治疗全身或局部缺血后神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途急性或慢性疼痛，神经性疼痛或外科手术疼痛，作为抗惊厥药，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

40. 发明申请

WO2004010950A2 ARYL SUBSTITUTED HYDANTOIN COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译： ARYL取代的HYDANTOIN化合物及其作为钠通道阻断剂使用
公开(公告)号：WO2004010950A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023827
申请日：2003-07-31
申请人： EURO-CELTIQUE S.A. , SUN, Qun , KYLE, Donald, J.
发明人： SUN, Qun , KYLE, Donald, J.
IPC分类号： A61K
CPC分类号： C07D233/86 , C07D233/74 , C07D233/84
摘要： This invention relates to aryl substituted hydantoins of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein n, A, A', R, R 1 and R 2 , are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及式（I）的芳基取代的乙内酰脲或其药学上可接受的盐，前药或溶剂合物，其中n，A，A'，R，R 1和R 2在本说明书中定义。本发明还涉及式（I）化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善急性或慢性疼痛，作为抗惊厥剂，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药，以及用于治疗或预防糖尿病性神经病变。

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