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31. 发明申请

WO2008016847A3 SYSTEM AND METHOD FOR DETERMINING PHSYIOLOGIC EVENTS DURING PACING MODE OPERATION 审中-公开
标题翻译：在启动模式操作期间确定疾病事件的系统和方法
公开(公告)号：WO2008016847A3
公开(公告)日：2008-05-22
申请号：PCT/US2007074589
申请日：2007-07-27
申请人： MEDTRONIC INC , SHELDON TODD J , STANSLASKI SCOTT R , SWEENEY MICHAEL O , BETZHOLD ROBERT A , HETTRICK DOUGLAS A , BELK PAUL A
发明人： SHELDON TODD J , STANSLASKI SCOTT R , SWEENEY MICHAEL O , BETZHOLD ROBERT A , HETTRICK DOUGLAS A , BELK PAUL A
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3702 , A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：可植入医疗设备根据心室起搏协议（VPP）进行操作，该协议阻止在前一周期中感测到的心室事件已经发生的任何心动周期中的心室起搏。提供改进的心室感测，检测和分类。

32. 发明申请

WO2008006119A3 SYSTEM AND METHOD FOR PROMOTING INSTRINSIC CONDUCTION THROUGH ATRIAL MODIFICATION AND CALCULATION OF TIMING PARAMETERS 审中-公开
标题翻译：通过ATRIAL修改和时序参数的计算来促进晶体管的系统和方法
公开(公告)号：WO2008006119A3
公开(公告)日：2008-02-21
申请号：PCT/US2007074306
申请日：2007-07-25
申请人： MEDTRONIC INC , SHELDON TODD J , BELK PAUL A , SWEENEY MICHAEL D
发明人： SHELDON TODD J , BELK PAUL A , SWEENEY MICHAEL D
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

33. 发明申请

WO2007124238A1 IMPLANTABLE MEDICAL DEVICE WITH AUTOMATIC ISCHEMIA THRESHOLD DETERMINATION 审中-公开
标题翻译：具有自动ISCHEMIA阈值确定的可植入医疗设备
公开(公告)号：WO2007124238A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/065733
申请日：2007-03-31
申请人： MEDTRONIC, INC. , STYLOS, Lee , SHELDON, Todd J. , LU, Steven Ning , COMBS, William J. , NEHLS, Robert J.
发明人： STYLOS, Lee , SHELDON, Todd J. , LU, Steven Ning , COMBS, William J. , NEHLS, Robert J.
IPC分类号： A61N1/365 , A61N1/37 , A61N1/372
CPC分类号： A61N1/3702 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/37252
摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.
摘要翻译：可植入医疗装置（IMD）执行患者的周期性测试以确定缺血阈值信息。在患者静止时的选定时间，IMD随着时间的推移增加起搏速率，直到其从患者或缺血传感器接收到反馈。 IMD根据接收到反馈时的起搏速率来确定阈值。阈值信息可以用于调整速率自适应起搏期间可以使用的上起搏速率，以确定药物治疗的效果，并提供患者冠状动脉疾病状态的一般指示。对缺血区的起搏速率的周期性增加也提供心肌的预处理，以允许患者在没有心绞痛的情况下更大的运动益处。

34. 发明申请

WO2007073514A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 审中-公开
标题翻译： LV阈值测量和捕获管理
公开(公告)号：WO2007073514A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/060813
申请日：2006-11-13
申请人： MEDTRONIC, INC. , PAIRKH, Purvee, P. , STROEBEL, John, C. , SHELDON, Todd, J. , KLECKNER, Karen, J.
发明人： PAIRKH, Purvee, P. , STROEBEL, John, C. , SHELDON, Todd, J. , KLECKNER, Karen, J.
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT").
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面的一些或全部。例如，将心室起搏速率增加到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是亚阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

35. 发明申请

WO2006069032A9 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 审中-公开
标题翻译： LV阈值测量和捕获管理
公开(公告)号：WO2006069032A9
公开(公告)日：2006-08-31
申请号：PCT/US2005046054
申请日：2005-12-20
申请人： MEDTRONIC INC , SHELDON TODD J , STROEBEL JOHN C , PARIKH PURVEE PRADUMAN , KLECKNER KAREN J
发明人： SHELDON TODD J , STROEBEL JOHN C , PARIKH PURVEE PRADUMAN , KLECKNER KAREN J
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate o ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT").
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否正在俘获起搏心室的方法和设备，包括以下方面中的一些或全部。例如，将心室起搏频率增加一个名义量至高于最近心率的超速起搏频率，并评估从第一起搏心室至第二心室的传导时间间隔，然后继续监测基础频率o确保阈值测试起搏速率将不超过预定的最小时间间隔，并向第一心室提供起搏刺激并感测第二心室以确定对第一心室的起搏刺激是否是亚阈值和超阈值之一。该方法和装置在确保心室起搏方案（例如心脏再同步治疗或“CRT”）的实际输送方面特别有用。

36. 发明申请

WO2013019505A1 APPARATUS FOR SETTING CARDIAC PACING PARAMETERS IN RELATIVELY HIGH EFFICIENCY PACING SYSTEMS 审中-公开
标题翻译：在相对高效的PACING系统中设置心脏参数的设备
公开(公告)号：WO2013019505A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/048123
申请日：2012-07-25
申请人： MEDTRONIC, INC. , SHELDON, Todd J. , DEMMER, Wade M.
发明人： SHELDON, Todd J. , DEMMER, Wade M.
IPC分类号： A61N1/37 , A61N1/372 , A61N1/375
CPC分类号： A61N1/3712 , A61N1/3708 , A61N1/37205 , A61N1/3756
摘要： According to some methods, for example, preprogrammed in a microprocessor element of an implantable cardiac pacing system, at least one of a number of periodic pacing threshold searches includes steps to reduce an evoked response amplitude threshold for evoked response signal detection. The reduction may be to a minimum value measurable above zero, for example, as determined by establishing a 'noise floor'. Alternately, amplitudes of test pacing pulses and corresponding post pulse signals are collected and reviewed to search for a break, to determine a lower value to which the evoked response threshold may be adjusted without detecting noise. Subsequent to reducing the threshold, if no evoked response signal is detected for a test pulse applied at or above a predetermined maximum desirable pulse energy, an operational pacing pulse energy is set to greater than or equal to the maximum desirable in conjunction with a reduction in pacing rate.
摘要翻译：根据一些方法，例如，在可植入心脏起搏系统的微处理器元件中预编程，多个周期性起搏阈值搜索中的至少一个包括减少诱发响应信号检测的诱发响应振幅阈值的步骤。该减小可以是在零以上可测量的最小值，例如通过建立“本底噪声”确定的最小值。或者，收集和检查测试起搏脉冲和对应的后脉冲信号的振幅以搜索中断，以确定可以在不检测噪声的情况下调整诱发响应阈值的较低值。在降低阈值之后，如果对于在预定的最大期望脉冲能量之上或之上施加的测试脉冲没有检测到诱发响应信号，则可以将运行起搏脉冲能量设置为大于或等于期望的最大值，起搏率

37. 发明申请

WO2011019488A3 IMPROVED METHOD FOR SCHEDULING ATRIAL-VENTRICULAR CONDUCTION CHECKS IN MINIMUM VENTRICULAR PACING 审中-公开
公开(公告)号：WO2011019488A3
公开(公告)日：2011-02-17
申请号：PCT/US2010/042674
申请日：2010-07-21
申请人： MEDTRONIC, INC. , SHELDON, Todd, J.
发明人： SHELDON, Todd, J.
IPC分类号： A61N1/368
摘要： A medical device and associated method deliver cardiac pacing in a dual chamber pacing mode and schedule an atrial-ventricular (AV) conduction check during the dual chamber pacing mode to detect the presence of AV conduction. If AV conduction is detected during the scheduled AV conduction check, the medical device switches to an atrial pacing mode and switches back to the dual chamber pacing mode in response to an absence of AV conduction during the atrial pacing mode. The detected AV conduction is identified as a false positive detection in response to the pacing mode switch to the dual chamber pacing mode occurring within a predetermined interval of time from detecting the AV conduction.

38. 发明申请

WO2010099424A1 A SYSTEM AND METHOD FOR CONDITIONAL BIVENTRICULAR PACING 审中-公开
标题翻译：一种有条件的双心跳动的系统和方法
公开(公告)号：WO2010099424A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/025557
申请日：2010-02-26
申请人： MEDTRONIC, INC. , SWEENEY, Michael O. , SHELDON, Todd J.
发明人： SWEENEY, Michael O. , SHELDON, Todd J.
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/3682 , A61N1/3688
摘要： An implantable pacing system with single, double and triple chamber pacing capabilities, provided individually or in concert on a conditional or continuous basis depending upon ongoing analyses of atrial rhythm status, atrioventricular conduction status and ventricular rate. A mode is selected to reduce the occurrence of any ventricular pacing in favor of intrinsic atrioventricular and ventricular conduction. If excessively long PR intervals are occurring too frequently or atrioventricular conduction is unreliable or absent, the implantable pulse generator is operated in a conditional triple chamber pacing mode that provides atrial-synchronous biventricular pacing in every cardiac cycle for a period of time as necessary to restore and maintain AV synchrony, while minimizing ventricular asynchrony otherwise associated with monochamber RV pacing as in conventional dual chamber pacing systems. Similarly, biventricular pacing is provided in every cardiac cycle when ventricular rates are undesirably slow during atrial fibrillation, where AV synchronization is excluded.
摘要翻译：根据对心房心律状态，房室传导状态和心室率的持续分析，有条件或连续地单独或一起提供具有单室，双室和三室起搏能力的可植入起搏系统。选择一种模式以减少任何心室起搏的发生，有利于固有的房室传导和心室传导。如果过长的PR间期过于频繁地发生或者房室传导不可靠或不存在，则植入式脉冲发生器以有条件的三腔起搏模式运行，该模式在每个心动周期中提供心房同步双心室起搏一段时间以恢复所需的时间并保持AV同步，同时最大限度地减少与单室RV起搏相关的心室不同步，正如常规双腔起搏系统一样。类似地，当心室颤动期间心室率不合需要地缓慢时，在每个心动周期中提供双心室起搏，其中AV同步被排除。

39. 发明申请

WO2007146661A3 SYSTEM AND METHOD FOR VENTRICULAR INTERVAL SMOOTHING FOLLOWING A PREMATURE VENTRICULAR CONTRACTION 审中-公开
标题翻译：普通静脉压缩后的心室间隔平滑的系统和方法
公开(公告)号：WO2007146661A3
公开(公告)日：2008-03-27
申请号：PCT/US2007070386
申请日：2007-06-05
申请人： MEDTRONIC INC , SHELDON TODD J , BELK PAUL A , SWEENEY DR MICHAEL O
发明人： SHELDON TODD J , BELK PAUL A , SWEENEY DR MICHAEL O
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3621
摘要： An implantable medical device includes cardiac pacing functions. In order to reduce ventricular pacing, various modes are employed that tolerate missed ventricular beats, provide backup pacing and maintain overall AV synchrony. Upon the occurrence of a PVC, A-A timing is modified so that resultant V-V intervals are appropriate and ventricular pacing is avoided.
摘要翻译：可植入医疗装置包括心脏起搏功能。为了减少心室起搏，采用各种模式，允许心跳失败，提供后备起搏和维持整体AV同步。发生PVC时，修改A-A定时，以便得到合适的V-V间隔，避免心室起搏。

40. 发明申请

WO2008016847A2 SYSTEM AND METHOD FOR DETERMINING PHSYIOLOGIC EVENTS DURING PACING MODE OPERATION 审中-公开
标题翻译：用于确定PAC模式运行期间的PHSYIOLOGIC事件的系统和方法
公开(公告)号：WO2008016847A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/074589
申请日：2007-07-27
申请人： MEDTRONIC, INC. , SHELDON, Todd J. , STANSLASKI, Scott R. , SWEENEY, Michael O. , BETZHOLD, Robert A. , HETTRICK, Douglas A. , BELK, Paul A.
发明人： SHELDON, Todd J. , STANSLASKI, Scott R. , SWEENEY, Michael O. , BETZHOLD, Robert A. , HETTRICK, Douglas A. , BELK, Paul A.
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

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