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31. 发明专利

AU2020201856A1 METHODS MODULATING IMMUNOREGULATORY EFFECT OF STEM CELLS 未知
公开(公告)号：AU2020201856A1
公开(公告)日：2020-04-02
申请号：AU2020201856
申请日：2020-03-13
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： SHI YUFANG , REN GUANGWEN , ZHANG LIYING
IPC分类号： C12N5/0775
摘要： The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs). See Fig. 3.

32. 发明专利

AU2018272848A1 Target mediated 未知
公开(公告)号：AU2018272848A1
公开(公告)日：2019-11-28
申请号：AU2018272848
申请日：2018-05-23
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： TYAGI SANJAY , MARRAS SALVATORE A E
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6813 , C12Q1/682 , C12Q1/6827 , C12Q1/6841
摘要： The present invention relates to the detection of nucleic acids sequences

33. 发明专利

SG11201908351TA INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS 未知
公开(公告)号：SG11201908351TA
公开(公告)日：2019-10-30
申请号：SG11201908351T
申请日：2018-03-09
申请人： LAVOIE EDMOND J , PARHI AJIT , YUAN YI , ZHANG YONGZHENG , SUN YANGSHENG , RUTGERS THE STATE UNIVERSITY OF NEW JERSEY , TAXIS PHARMACEUTICALS INC
发明人： LAVOIE EDMOND J , PARHI AJIT , YUAN YI , ZHANG YONGZHENG , SUN YANGSHENG
IPC分类号： C07D403/12 , A61K31/404 , A61P31/04 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIPO I PCT 0111111010 0111 °nolo mu IIIII Em OH oinio oimIE (10) International Publication Number WO 2018/165611 Al (51) International Patent Classification: CO7D 403/12 (2006.01) CO7D 401/12 (2006.01) CO7D 401/14 (2006.01) CO7D 405/04 (2006.01) A61K 31/404 (2006.01) C07D 209/42 (2006.01) C07D 401/04 (2006.01) A61P 31/04 (2006.01) (21) International Application Number: PCT/US2018/021848 (22) International Filing Date: 09 March 2018 (09.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469,987 10 March 2017 (10.03.2017) US 62/523,154 21 June 2017 (21.06.2017) US (71) Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; Old Queens Building, Som- erset and George Streets, New Brunswick, New Jer- sey 08903 (US). TAXIS PHARMACEUTICALS, INC. [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junc- tion, New Jersey 08852 (US). (72) Inventors; and (71) Applicants: LAVOIE, Edmond J. [US/US]; Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). PARHI, Ajit [US/US]; Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). YUAN, Yi [CN/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). ZHANG, Yongzheng [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). SUN, Yangsheng [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). (74) Agent: MICKELSON, John W. et al.; 7851 Metro Park- way, Suite 325, Bloomington, Minnesota 55425 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) = (54) Title: INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS (57) : Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of for- mula I for use in treating or preventing bacterial infections. (I) W O 20 18/ 165 6 11 Al

35. 发明专利

AU2015202526B2 Biocompatible polymers for medical devices 未知
公开(公告)号：AU2015202526B2
公开(公告)日：2017-03-02
申请号：AU2015202526
申请日：2015-05-11
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： KOHN JOACHIM , BOLIKAL DURGADAS
IPC分类号： C08G69/08
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and 5 copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.

36. 发明专利

AU2014225619A1 Nutritional supplement/feed formula and methods of use thereof to reduce development of Osteochondrosis Dissecans (OCD) lesions 未知
公开(公告)号：AU2014225619A1
公开(公告)日：2015-10-15
申请号：AU2014225619
申请日：2014-03-06
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY , UNIV PRINCETON
发明人： RALSTON SARAH , PELCZER ISTVAN
IPC分类号： A23K1/16
摘要： A novel dietary supplement and nutritional aid and methods for the manufacture and administration of the same are disclosed for the inhibition of OCD in afflicted animals, particularly horses. The present invention relates generally to a feed composition and methods of use thereof for reducing the development of Osteochondrosis Dissecans (OCD) lesions in predisposed young animals, particularly horses. More specifically the invention provides a nutritional formula that targets the metabolic deficiencies identified as being correlated with development of OCD.

37. 发明专利

AU2010303170B2 Biocompatible polymers for medial devices 未知
公开(公告)号：AU2010303170B2
公开(公告)日：2015-02-26
申请号：AU2010303170
申请日：2010-10-11
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： KOHN JOACHIM , BOLIKAL DURGADAS
IPC分类号： C08G69/08
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.

38. 发明专利

AU2013209622A1 Compounds and methods for treating Candidiasis and Aspergillus infections 未知
公开(公告)号：AU2013209622A1
公开(公告)日：2014-09-11
申请号：AU2013209622
申请日：2013-01-18
申请人： CELLCEUTIX CORP , RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： SCOTT RICHARD W , FREEMAN KATIE , TANG HAIZHONG , GILL DIAMOND
IPC分类号： A01N25/00
摘要： The present disclosure provides facially arnphiphilic antimicrobial oligomers, pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, useful for killing or inhibiting the growth of a Candida or Aspergillus species, as well as preventing or treating a mammal having oral or disseminated candidiasis or an aspergillus infection. The method(s) employed comprise(s) contacting the Candida or Aspergillus species with or administering to the mammal in need thereof an effective amount of such an antimicrobial oligomer, pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof.

39. 发明专利

AU2012308555A1 Process for the oxidation of hydrocarbons with the use of iridium metal catalyst complexes 未知
公开(公告)号：AU2012308555A1
公开(公告)日：2014-03-27
申请号：AU2012308555
申请日：2012-09-13
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： GOLDMAN ALAN STUART , STIBRANY ROBERT TIMOTHY
IPC分类号： B01J23/46 , C07D235/20
摘要： Provided is a process for effectively and efficiently oxidizing alkyl-containing molecules with the use of an oxygen-containing gas. An iridium metal catalyst complex with the iridium being coordinated with the nitrogen atoms of a benzimidazolyl-containing ligand is used as the catalyst. The process generates alcohols, ketones and aldehydes directly from alkyl-containing molecules and/or aromatic molecules.

40. 发明专利

AU2010254820B2 Compositions and methods modulating MG29 for the treatment of diabetes 未知
公开(公告)号：AU2010254820B2
公开(公告)日：2014-01-30
申请号：AU2010254820
申请日：2010-06-04
申请人： RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
发明人： LIN PEIHUI , MA JIANJIE , WEISLEDER NOAH , ZHU HUA
IPC分类号： A61K38/16 , A61K31/7105 , A61K38/17 , A61P3/00 , A61P3/10
摘要： Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal musle disorders. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

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