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31. 发明专利

FR2677981A1 未知
公开(公告)号：FR2677981A1
公开(公告)日：1992-12-24
申请号：FR9107518
申请日：1991-06-19
申请人： PANMEDICA
发明人： CLAUDE LARUELLE , MARCEL LEPANT
IPC分类号： C07C35/08 , C07C45/59 , C07C49/403 , C07C227/32 , C07D207/28
摘要： Process for the preparation of pure isomeric forms of 3,3,5-trimethyl cyclohexanol amino acid esters and process for the preparation of different pure isomeric forms of 3,3,5-trimethyl cyclohexanone, an intermediate product for the preparation of said esters. The process for the preparation of pure isomeric forms of 3,3,5-trimethyl cyclohexanol amino acid esters is characterized in that: (1) a 3,3,5-trimethyl cyclohexanol alcohol having a previously selected asymmetric carbon configuration (C1 and C5), is prepared by reduction from a pure isomeric trimethyl cyclohexanone, and (2) a suitable isomeric form of an amino acid is reacted with 3,3,5-trimethyl cyclohexanol alcohol of preselected configuration, obtained in (1), in a new stoichiometric ratio by weight and at a temperature sufficient to eliminate the water formed, without causing the ester obtained to be racemized. For use in the correction of dislipidemias.

32. 发明专利

CA2111309A1 METHODE DE PREPARATION DES FORMES ISOMERES PURES D'ESTERS D'AMINOACIDES DU 3,3,5-TRIMETHYLCYCLOHEXANOL ET DE LA 3,3,5-TRIMETHYLCYCLOHEXANONE 未知
公开(公告)号：CA2111309A1
公开(公告)日：1992-12-23
申请号：CA2111309
申请日：1992-06-17
申请人： PANMEDICA
发明人： LARUELLE CLAUDE , LEPANT MARCEL
IPC分类号： C07C35/08 , C07C45/59 , C07C49/403 , C07C227/32 , C07D207/28 , C07C229/02 , C07D207/16 , C07D209/20 , A61K31/22 , A61K31/40 , C07C323/60
摘要： 2111309 9222529 Procédé de préparation des formes isomères pures d'esters d'aminoacides du triméthyl-3,3,5 cyclohexanol ainsi que procédé de préparation des différentes formes isomères pures de la triméthyl-3,3,5 cyclohexanone, produit intermédiaire pour la préparation desdits esters. Le procédé de préparation des formes isomères pures d'esters d'aminoacides du triméthyl-3,3,5 cyclohexanol est caractérisé en ce que: (1) l'on prépare un alcool triméthyl-3,3,5 cyclohexanol de configuration présélectionnée au niveau de ses carbones asymétriques (C1 et C5), par réduction à partir d'une triméthylcyclohexanone isomère pure, et (2) l'on fait réagir une forme isomère appropriée d'un acide aminé avec l'alcool triméthyl-3,3,5 cyclohexanol de configuration présélectionnée, obtenu en (1), dans un rapport pondéral proche de la stoechiométrie et à une température suffisante pour éliminer l'eau formée, tout en n'entraînant pas une racémisation de l'ester obtenu. Utilisation desdites formes d'isomères pures d'esters dans la correction des dislipidémies.

33. 发明专利

AU606611B2 CYCLOALIPHATIC ESTERS OF ALPHA AMINO ACIDS 未知
公开(公告)号：AU606611B2
公开(公告)日：1991-02-14
申请号：AU7776387
申请日：1987-09-01
申请人： PANMEDICA SA
发明人： LARUELLE CLAUDE , LEPANT MARCEL , RAYNIER BERNARD
IPC分类号： A61K31/215 , A61K31/22 , A61K31/40 , A61K31/4015 , A61P3/06 , A61P43/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/28 , C07C229/02 , C07C229/06 , C07C229/30 , C07C233/45 , C07C233/47 , C07C233/83 , C07D207/28 , C12N9/99 , C07C101/22 , C07C103/84 , C07C103/46 , C07C103/48
摘要： Cycloaliphatic alcohol derivatives of formula: in which: R denotes a natural amino acid residue, Y denotes hydrogen or an acetyl, propionyl or benzoyl radical or forms with R a 2-pyrrolidinone ring A denotes a cycloaliphatic radical, and processes for obtaining them. These compounds can be employed as medications, especially in the disorders of lipidaemia, cholesterolaemia and in the treatment of the ailments resulting therefrom.

34. 发明专利

AU575054B2 DIPEPTIDES OF L-5-HYDROXYTRYPTOPHAN 未知
公开(公告)号：AU575054B2
公开(公告)日：1988-07-21
申请号：AU2841284
申请日：1984-05-18
申请人： PANMEDICA SA
发明人： LARUELLE CLAUDE , LEPANT MARCEL , RAYNIER BERNARD
IPC分类号： C07K1/113 , A61K38/00 , A61P25/00 , A61P25/04 , A61P43/00 , C07D209/20 , C07K5/06 , C07K5/078 , C07K5/097 , A61K37/02
摘要： The present invention relates to new dipeptides of L-5-hydroxytryptophan. They correspond to the general formula below: (I) in which: X represents hydrogen or a lower acyl radical and Q represents a free or esterified aminoacid radical. Application: drugs for combating disorder of the serotoninergic system.

36. 发明专利

FR2564832B1 未知
公开(公告)号：FR2564832B1
公开(公告)日：1987-05-15
申请号：FR8408036
申请日：1984-05-23
申请人： PANMEDICA SA
发明人： LARUELLE CLAUDE , LEPANT MARCEL , RAYNIER BERNARD
IPC分类号： A61K31/435 , A61P9/12 , A61P11/08 , A61P37/08 , C07D215/56 , C07D317/00 , C07D471/04 , C07D491/04 , C07D491/056 , C07D221/04 , C07D471/06 , A61K31/47
摘要： The present invention relates to new N-acyl derivatives of amino acids. These derivatives correspond to the general formula I below: I in which A represents a linear or branched, saturated hydrocarbon radical containing from 1 to 6 carbon atoms or a saturated ring containing 6 carbon atoms, X represents a -COOH radical, a -COOAlkyl radical (alkyl from C1 to C4), a hydrogen atom or a -CH3 group when Y is -COOH or -COOAlkyl, Y represents a -COOH radical, a -COOAlkyl radical (alkyl from C1 to C4), an -NH2 group, an -SH group, an -SCH3 group, a -NH-CH(=NH)-NH2 group, a substituted or unsubstituted phenyl group, an indolin-3-yl group or a 5-hydroxyindolin-3-yl group, and Q represents an optionally substituted aromatic ring or an optionally substituted heterocycle containing 1 or 2 nitrogen atoms. Drugs having an antiallergic action.

37. 发明专利

AU6306886A ALKYLCARBOXAMIDES OF PYRIDYLALKYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL PREPARATIONS 未知
公开(公告)号：AU6306886A
公开(公告)日：1987-04-16
申请号：AU6306886
申请日：1986-09-23
申请人： PANMEDICA SA
发明人： NAME NOT GIVEN
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P9/00 , A61P9/02 , A61P9/06 , A61P25/02 , A61P25/04 , C07D213/40 , C07D213/89
摘要： Alkylcarboxamides of pyridylalkylamines, useful in human and verterinary medicine, correspond to the general formula I: (I) wherein n=0 or 1, R3 represents an alkyl group of C1 to C3 or a hydrogen atom, R1 represents a hydrogen atom, R2 represents a group: (II) in which: X and Y are different, X and Y each represent a linear or branched saturated or unsaturated hydrocarbon chain comprising from 1 to 16 carbon atoms; X and Y together determine a saturated or unsaturated cyclic radical substituted or not comprising from 3 to 12 carbon atoms.

38. 发明专利

FR2572399B1 未知
公开(公告)号：FR2572399B1
公开(公告)日：1987-01-16
申请号：FR8416656
申请日：1984-10-31
申请人： PANMEDICA SA
发明人： LARUELLE CLAUDE , LEPANT MARCEL , RAYNIER BERNARD
IPC分类号： A61K31/40 , A61K31/4015 , A61P3/06 , A61P31/12 , A61P31/16 , C07D207/28
摘要： The present invention relates to new adamantanamine derivatives. These derivatives correspond to the general formula I: (I) in which: R represents hydrogen or a substituted or unsubstituted, linear or branched alkyl radical containing from 1 to 7 carbon atoms. Drugs possessing anticonvulsant properties.

39. 发明专利

FR2583751A1 未知
公开(公告)号：FR2583751A1
公开(公告)日：1986-12-26
申请号：FR8509371
申请日：1985-06-20
申请人： PANMEDICA
发明人： LARUELLE CLAUDE , LEPANT MARCEL , RAYNIER BERNARD
IPC分类号： A61K31/47 , A61P7/10 , A61P11/08 , A61P21/02 , A61P25/24 , A61P25/26 , A61P31/04 , C07D215/56 , C07D471/04 , C07D491/04 , C07D491/056

40. 发明专利

FR2571372A1 Process for the separation of the diastereiosomers of zearalanol 未知
公开(公告)号：FR2571372A1
公开(公告)日：1986-04-11
申请号：FR8411937
申请日：1984-07-25
申请人： PANMEDICA SA
发明人： LEPANT MARCEL , LARUELLE CLAUDE , RAYNIER BERNARD
IPC分类号： C07D313/00
摘要： The two isomers of - 7, 14, 16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10,11,12-decahydro-1H-2-benzoxacy clotetradecin-1-one -have [3S-(3R , 7S )] and [3S-(3R , 7R )] configurations. They are separated by a system of reverse phase high performance chromotography coupling a column of high flowrate and average particle size with a second column of high resolution.

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