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    • 40. 发明公开
    • EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR
    • Extrakt aus Fraxinus-Excelsior-Samen undantiischen Anwendungen davon
    • EP2664361A1
    • 2013-11-20
    • EP13180284.5
    • 2008-11-05
    • Naturex S.A.
    • He,, KanIbarra,, AlvinRoller,, MarcDikansky,, JacquesBily,, AntoineBai,, Naisheng
    • A61Q9/00
    • A61K36/63A61K31/7088
    • A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
    • 可以通过阻断脂肪合成,激活PPAR-α,增加降血糖活性,降低体重,控制空腹血浆胰岛素水平以抵抗高胰岛素血症,以及促进胰岛素敏感性以及促进胰岛素敏感性的方法,用于治疗受试者(包括人)的Fraxinus excelsior种子提取物 引起有益的急性促胰岛素效应。 Fraxinus excelsior种子提取物尤其包括分离的化合物(2S,3E,4S)2H-吡喃-4-乙酸-3-亚乙基-2 - [(6-O-2-D-吡喃葡萄糖基-2D - 吡喃葡糖基)氧基] -3,4-二氢-5-(甲氧基羰基)甲酯,通常称为excelside A,分离的化合物(2S,3E,4S)2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-(甲氧基羰基)-2-(4-羟苯基)乙酯(通常称为excelside B)和化合物(6-O-2-D-吡喃葡萄糖基-2-D-吡喃葡萄糖基)氧基] GI5,GI3,nunzhenide和油脂二甲酯。