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31. 发明申请

US20160038541A1 INDUCED DENDRITIC CELLS AND USES THEREOF 审中-公开
标题翻译：诱导的细胞及其用途
公开(公告)号：US20160038541A1
公开(公告)日：2016-02-11
申请号：US14820645
申请日：2015-08-07
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Renata Stripecke , Gustavo Salguero-Lopez , Anusara Daenthanasanmak , Arnold Ganser
IPC分类号： A61K35/15 , A61K49/00 , C12N5/0784
CPC分类号： A61K35/15 , A61K49/0008 , A61K2035/122 , A61K2035/124 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/24 , C12N2502/1121 , C12N2510/00
摘要： The present invention relates to cells engineered to express at least one cytokine and at least one antigen which induces the self differentiation of dendritic cell (DC) progenitor cells into functional antigen-presenting induced DC (iDC). Moreover, therapeutic uses of said iDC for regenerating the immune system after transplantation of hematopoietic stem cells are disclosed. Said iDC are also useful for generating mice with a functional endogenously regenerated humanized immune system producing antigen-specific T and B cell responses which can be used as animal models for the study of the human adaptive immune responses.
摘要翻译：本发明涉及工程化以表达至少一种细胞因子和至少一种诱导树突状细胞（DC）祖细胞自身分化为功能性抗原呈递诱导DC（iDC）的抗原的细胞。此外，公开了所述iDC在移植造血干细胞后再生免疫系统的治疗用途。所述iDC还可用于产生具有产生抗原特异性T和B细胞应答的功能性内源性再生的人源化免疫系统的小鼠，其可以用作用于人适应性免疫应答的研究的动物模型。

32. 发明申请

US20150024206A1 COATED DEVICES AND METHODS FOR COATING 有权
标题翻译：涂层装置和涂层方法
公开(公告)号：US20150024206A1
公开(公告)日：2015-01-22
申请号：US14376884
申请日：2013-02-06
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Philip Dannhuser , Ernst Ungewickell
IPC分类号： A61K9/127 , A61K47/48 , C07K14/705
CPC分类号： A61K9/1277 , A61K9/1271 , A61K47/6425 , A61K47/65 , A61K47/6911 , C07K14/705 , Y10T428/2982
摘要： The present invention relates in a first aspect to a method of coating surfaces of substrates with a lattice-like structure. In particular, the present invention relates to an in vitro method of coating surfaces by binding of epsin or a fragment thereof on the surface and, thereafter, binding of a compound forming the lattice like structure, in particular, binding of the clathrin heavy chain, to the epsin bound on the surface, thus, obtaining a coated substrate having a lattice like structure on the surface. In another aspect, the present invention relates to an in vitro method of producing nanometer-sized liposomes having a clathrin structure on its surface. In addition, substrates, like elements or devices, with coated surfaces having a lattice-like structure on the surface are provided obtainable by a method according to the present invention.
摘要翻译：本发明在第一方面涉及涂覆具有格子状结构的基材表面的方法。特别地，本发明涉及通过在表面上结合epsin或其片段，然后结合形成格子状结构的化合物，特别是网格蛋白重链的结合来结合表面的体外方法，到表面上结合的epsin，从而获得表面上具有格子状结构的涂布基材。另一方面，本发明涉及制备其表面具有网格蛋白结构的纳米尺寸脂质体的体外方法。此外，通过根据本发明的方法可以提供具有表面上具有格子状结构的涂覆表面的基底（如元件或器件）。

33. 发明申请

US20140350566A1 Device Combination for Connecting Hollow Organs (Anastomosis) 审中-公开
标题翻译：连接空心器官的装置组合（吻合）
公开(公告)号：US20140350566A1
公开(公告)日：2014-11-27
申请号：US14353669
申请日：2012-10-26
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Nikos Emmanouilidis
IPC分类号： A61B17/11 , A61B17/00 , A61B17/115
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/0485 , A61B17/07207 , A61B17/1155 , A61B17/12013 , A61B2017/00278 , A61B2017/00358 , A61B2017/0046 , A61B2017/00477 , A61B2017/1135 , A61B2018/141
摘要： The invention relates to a surgical device (100) designed to be inserted into a stump or a hollow organ (40) of a person or animal in order to prepare a circular anastomosis, wherein the device (100) is designed without a stapling unit for producing a surgical stapled scam, wherein the device (100) has an instrument shaft (120) having a handle section (121, 300) and, at the end of time instrument shaft (120) away from the handle section (121, 300), a head section (130) that is or can be coupled to the instrument shaft (120) by means of a detachable coupling (113), wherein the handle section (121, 300) is designed for a user to hold the device (100), wherein the head section (130) has at least one first molded body (109) and a counter-pressure plate (111) of a surgical circular stapling device (160) connected to the first molded body (109), wherein the surgical device has fu least one first molded body (109) and one second molded body (108) between the handle section and the counter-pressure plate, the second molded body being arranged immediately adjacent to the first molded body (109), wherein a third cross-section reduction (122), which is used as a cutting aid for severing a part of the hollow organ (40) and which rotates about the longitudinal axis of the device (100), is present between the first molded body (109) and the second molded body (108), at which third cross-section reduction the cross-section of the device (100) is reduced relative to the cross-section of the first and second molded bodies (108, 109), wherein the first and second molded body (108, 109) have rounded transitions without edges at the transitions to the third cross-section reduction (122).
摘要翻译：本发明涉及一种被设计成插入到人或动物的残端或空心器官（40）中以便制备圆形吻合的外科装置（100），其中所述装置（100）被设计成没有装订单元产生外科缝合的垃圾，其中所述装置（100）具有具有手柄部分（121,300）的器具轴（120），并且在仪器轴（120）的结束时远离手柄部分（121,300），通过可拆卸联轴器（113）可以或可以联接到仪器轴（120）的头部（130），其中手柄部分（121,300）被设计用于使用者握住装置（100）），其中所述头部（130）具有连接到所述第一模制体（109）的手术圆形缝合装置（160）的至少一个第一模制体（109）和反压板（111），其中所述手术装置在手柄部分和反向前部之间具有至少一个第一模制体（109）和一个第二模制体（108）所述第二成型体紧邻所述第一成形体（109）配置，其特征在于，所述第三截面缩小（122）被用作切断所述中空器官（40）的一部分的切削辅助件存在于第一成型体（109）和第二成型体（108）之间，其围绕装置（100）的纵向轴线旋转，第二横截面减小装置（100）的横截面为相对于第一和第二成型体（108,109）的横截面减小，其中第一和第二成型体（108,109）在没有边缘的情况下具有在到第三横截面减小（122）的过渡处的圆形过渡部，。

34. 发明公开

US20240287542A1 AAV VECTOR VARIANTS FOR OCULAR GENE DELIVERY 审中-公开
公开(公告)号：US20240287542A1
公开(公告)日：2024-08-29
申请号：US17755434
申请日：2020-11-02
申请人： UNIVERSITÄT BERN , MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Sonja KLEINLOGEL , Anand DAVID , Hildegard BÜNING
IPC分类号： C12N15/86 , A61K9/00 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/005
CPC分类号： C12N15/86 , A61K9/0019 , A61K9/0048 , A61K48/0075 , A61P27/02 , C07K14/005 , A61K38/00 , C07K2319/33 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145 , C12N2810/40
摘要： The present invention relates to adeno-associated virus capsid polypeptide sequences and their use in therapeutic transgene delivery to the eye and potentially other tissues.

35. 发明授权

US12044682B2 Method and means for diagnosing autoimmune hepatitis using autoantibody markers 有权
公开(公告)号：US12044682B2
公开(公告)日：2024-07-23
申请号：US16754006
申请日：2018-10-26
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Richard Taubert , Elmar Jaeckel , Niklas T. Baerlecken
IPC分类号： G01N33/543 , A61B5/00 , G01N33/564 , G01N33/576 , A61K31/52 , A61K31/573
CPC分类号： G01N33/5767 , A61B5/41 , G01N33/564 , A61K31/52 , A61K31/573 , G01N2800/52
摘要： A method for determining or diagnosing the presence or absence, or the risk of development, or the therapy control of autoimmune hepatitis in a subject is provided. In a method, the presence or absence of antibodies against the huntingtin interacting protein 1 related protein (HIP1R) or against immunoreactive peptides derived therefrom are analyzed, the presence of said antibodies is indicative for the presence, or the risk of development or for therapy control of autoimmune hepatitis of the subject. The use of the HIP1R or an immunoreactive peptide derived therefrom in the diagnosis, the risk assessment or therapy control of hepatitis diseases by determining the presence of antibodies against said HIP1R or immunoreactive peptide derived therefrom, may be helpful for differential diagnosis of autoimmune hepatitis.

36. 发明申请

US20230074198A1 Viral vector particle based on AA V2 for gene therapy 有权
公开(公告)号：US20230074198A1
公开(公告)日：2023-03-09
申请号：US17800338
申请日：2021-02-22
申请人： Medizinische Hochschule Hannover
发明人： Thomas Thum , Hildegard Büning , Laura Rode , Christian Bär
IPC分类号： C12N15/86
摘要： The invention provides a viral vector particle based on AAV2, which in its capsid protein (CAP) contains an inserted amino acid section which confers tropism for cardiomyocytes.

37. 发明申请

US20220357324A1 TCR-INDEPENDENT MOLECULAR IDENTIFICATION OF MUTATION-RELATED AND TUMOR-SPECIFIC T CELLS 有权
公开(公告)号：US20220357324A1
公开(公告)日：2022-11-10
申请号：US17754452
申请日：2020-10-15
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Norman WOLLER
IPC分类号： G01N33/569 , G01N33/574
摘要： The present invention relates to the field of tumor immunology. It provides a method for identifying mutation-related human CD8+ T cells, in particular, tumor-specific T cells of a human subject, comprising analyzing CD8+ T cells of the subject by analysing the expression of at least one marker selected from a first group consisting of CD82, CD194, CD244, CD28, CD62L and CD55, and preferably, a marker selected from a second group comprising CD11a or CD18 or CD43. A preferred marker for mutation-related CD8+ T cells is CD82, which may be analysed in combination, e.g., with CD11a. Without the need to identify any epitope to which T cells reacts, this method can advantageously be used to isolate the entire individual pool of mutation-related T cells, and, optionally, to identify the sequence of a mutation-related TCR, which allows for generation of transgenic T cells expressing the TCR. Compositions substantially comprising tumor-specific CD82hiCD8+ T cells and/or CD194hi, CD244−, CD28+, CD62L+ and/or CD55+ CD82hi CD8+ T cells can be used for treatment of a cancer patient, e.g., by adoptive T cell transfer. The method of the invention can also be used for diagnostic purposes to identify human mutation-related T cells or diagnosing a tumor disease or for testing responses of a cancer patient to an immune stimulatory therapy, preferably, a therapy with a checkpoint inhibitor.

38. 发明授权

US11471617B2 Nebultzation of immunoglobulin 有权
公开(公告)号：US11471617B2
公开(公告)日：2022-10-18
申请号：US15300820
申请日：2015-04-02
申请人： CSL BEHRING AG , PARI PHARMA GMBH , MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Cédric Pierre Vonarburg , Karin Steinfuehrer , Ulrich Baumann
IPC分类号： A61M11/00 , A61K9/00 , A61K39/395 , C07K16/10 , C07K16/12 , B05B17/00 , A61M15/00 , C07K16/00 , A61K39/00
摘要： The invention relates to methods for generating an aerosol by nebulization of a composition comprising polyclonal immunoglobulin (Ig). The selection of an efficient membrane nebulizer and a composition optimized for nebulization with such membrane nebulizer results in a particularly efficient method of generating an aerosol for administration of Ig to the respiratory tract.

39. 发明申请

US20220315924A1 LNCRNAS FOR THERAPY AND DIAGNOSIS OF CARDIAC HYPERTROPHY 有权
公开(公告)号：US20220315924A1
公开(公告)日：2022-10-06
申请号：US17658957
申请日：2022-04-12
申请人： Medizinische Hochschule Hannover
发明人： Thomas THUM , Kumarswamy REGALLA , Janika VIERECK
IPC分类号： C12N15/113 , A61K48/00 , A61P9/00 , C12Q1/6883
摘要： The present invention relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) a compound inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28. The present invention also relates to a compound (i) promoting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28 for use in treating or preventing cardiac hypertrophy.

40. 发明申请

US20220265799A1 ANALYTICAL METHOD AND IMMUNOLOGICAL TREATMENT FOR BLADDER CANCER 有权
公开(公告)号：US20220265799A1
公开(公告)日：2022-08-25
申请号：US17631598
申请日：2020-07-30
申请人： Medizinische Hochschule Hannover
发明人： Falk Büttner , Charlotte Rossdam , Rita Gerardy-Schahn , Astrid Oberbeck , Hossein Tezval
IPC分类号： A61K39/00 , G01N33/574
摘要： The invention provides an analytical method for detecting bladder cancer by analysing a urine sample for presence of a glycan tumour antigen, the presence of which has been identified to indicate bladder cancer. The analytical method has the advantage that the tumour antigen can be analysed in a urine sample and has a high accuracy for indicating presence of cancer in the urinary tract, especially bladder cancer, e.g. the method has a low rate of false positive results.

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