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31. 发明授权

US3998966A Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof 失效
标题翻译：抗炎，止痛，抗裂解和抗瘙痒性6-取代的含2-萘基乙酸衍生物的组合物及其使用方法
公开(公告)号：US3998966A
公开(公告)日：1976-12-21
申请号：US558988
申请日：1975-03-17
申请人： John H. Fried , Ian T. Harrison
发明人： John H. Fried , Ian T. Harrison
IPC分类号： A61K31/16 , A61K31/19 , A61K31/235 , C07C45/46 , C07C49/697 , C07C49/755 , C07C57/58 , C07C59/64 , C07C59/72
CPC分类号： C07C323/00 , C07C45/28 , C07C45/46 , C07C57/58 , C07C59/64 , C07C59/72 , Y10S514/886
摘要： 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
摘要翻译： 2-萘基乙酸衍生物和相应的酰胺，酯，异羟肟酸及其加成盐，任选在乙酸部分和/或第6位和/或第1,4,7或8位的α-位上被取代在萘环上并且任选地在3和4位饱和是抗炎，止痛，抗裂解和抗瘙痒剂。通过给予萘基乙酸衍生物来治疗炎症，疼痛，发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，其包含萘基乙酸衍生物。

32. 发明授权

US3993769A 1,5(6)-Disubstituted benzimidazole-2-carbamate derivatives having anthelmintic activity 失效
标题翻译： 1,5（6）具有驱虫活性的二取代苯并咪唑-2-氨基甲酸酯衍生物
公开(公告)号：US3993769A
公开(公告)日：1976-11-23
申请号：US605704
申请日：1975-08-18
申请人： Colin C. Beard , John A. Edwards , John H. Fried
发明人： Colin C. Beard , John A. Edwards , John H. Fried
IPC分类号： C07D235/32
摘要： This application relates to 1,5(6)-disubstituted benzimidazole-2-carbamate derivatives represented by the following formula: ##SPC1##Where R is lower alkyl having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 ; R.sup.2 is lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, or aralkyl or aryl; R.sup.5 is lower alkenyl, lower alkynyl or aralkyl; R.sup.7 is lower alkyl having 1 to 4 carbon atoms or aryl;M and M' are independently ##EQU1## n is 1-4; AND R.sup.8 is lower alkyl having 1 to 12 carbon atoms optionally substituted with a --COOR group where R is lower alkyl having 1 to 4 carbon atoms, aryl or aralkyl. The R.sup.1 substitution is at the 5(6)-position.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.
摘要翻译：本申请涉及由下式表示的1,5（6） - 二取代苯并咪唑-2-氨基甲酸酯衍生物：+ q，10，其中R是具有1至4个碳原子的低级烷基; R 1是-SOR 2，-SR 5，-OR 5或M'（CH 2）nMR 7; R2是具有1至6个碳原子的低级烷基，具有3至7个碳原子的环烷基，具有3至6个碳原子的低级链烯基或低级炔基，或芳烷基或芳基; R5是低级烯基，低级炔基或芳烷基; R7是具有1-4个碳原子的低级烷基或芳基; M和M'独立地为O＆amp; O，S，S或S; ＆darr＆＆darr＆OO n为1-4; 且R 8为任选被-COOR基团取代的具有1至12个碳原子的低级烷基，其中R是具有1至4个碳原子的低级烷基，芳基或芳烷基。 R1取代为5（6）位。

33. 发明授权

US3989720A Disubstituted xanthone carboxylic acid compounds 失效
公开(公告)号：US3989720A
公开(公告)日：1976-11-02
申请号：US637559
申请日：1975-12-04
申请人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
发明人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
IPC分类号： C07D311/86
CPC分类号： Y10S514/826
摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

34. 发明授权

US3988352A Disubstituted xanthone carboxylic acid compounds 失效
公开(公告)号：US3988352A
公开(公告)日：1976-10-26
申请号：US637561
申请日：1975-12-04
申请人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
发明人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
IPC分类号： C07D311/86
摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

35. 发明授权

US3978116A 2-Naphthyl acetic acid derivatives and compositions and methods thereof 失效
标题翻译： 2-萘基乙酸衍生物及其组合物及其方法
公开(公告)号：US3978116A
公开(公告)日：1976-08-31
申请号：US559357
申请日：1975-03-17
申请人： John H. Fried , Ian T. Harrison
发明人： John H. Fried , Ian T. Harrison
IPC分类号： C07C45/46 , C07C49/697 , C07C49/755 , C07C57/58 , C07C59/52 , C07C59/72 , C07C59/74 , C07C59/84 , C07C59/90 , C07C63/33 , C07C69/14 , C07C119/00 , C07C83/00
CPC分类号： C07C255/00 , C07C45/28 , C07C45/46 , C07C57/58 , C07C59/52 , C07C59/72 , C07C59/74 , C07C59/84 , C07C59/90 , C07C63/33 , Y10S514/916
摘要： 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

36. 发明授权

US3965115A Disubstituted xanthone carboxylic acid compounds 失效
公开(公告)号：US3965115A
公开(公告)日：1976-06-22
申请号：US558025
申请日：1975-03-13
申请人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
发明人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
IPC分类号： C07D311/86
摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methyl-sulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.

37. 发明授权

US3965113A 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity 失效
标题翻译： 5（6）具有驱虫活性的苯并环取代的苯并咪唑-2-氨基甲酸酯衍生物
公开(公告)号：US3965113A
公开(公告)日：1976-06-22
申请号：US417968
申请日：1973-11-21
申请人： Colin C. Beard , John A. Edwards , John H. Fried
发明人： Colin C. Beard , John A. Edwards , John H. Fried
IPC分类号： C07C335/38 , C07D235/32
CPC分类号： C07D235/32 , C07C335/38
摘要： Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SR.sup.5 or --OR.sup.5 ; and R.sup.5 is aryl. The R.sup.1 substitution is at the 5(6)-position.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.
摘要翻译：由下式表示的苯环取代的苯并咪唑-2-氨基甲酸酯衍生物：

38. 发明授权

US3963752A Disubstituted xanthone carboxylic acid compounds 失效
标题翻译：二取代的呫吨酮羧酸化合物
公开(公告)号：US3963752A
公开(公告)日：1976-06-15
申请号：US558024
申请日：1975-03-13
申请人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
发明人： Jurg R. Pfister , Ian T. Harrison , John H. Fried
IPC分类号： C07D311/86
摘要： Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylsulfinyl-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di(methylsulfinyl)xanthone-2-carboxylic acid are illustrated as representative compounds.
摘要翻译：含有可用于治疗过敏症状的新型二取代呫吨酮羧酸化合物作为必需成分的组合物和方法。还公开了制备这些化合物及其组合物和中间体的方法。 5-甲基亚磺酰基-7-异丙氧基呫吨酮-2-羧酸和5,7-二（甲基亚磺酰基）呫吨酮-2-羧酸作为代表性化合物。

39. 发明授权

US3958012A D 2-(6-Substituted-2-naphthyl)-propanals 失效
标题翻译： D 2-（6-取代-2-萘基） - 丙醛
公开(公告)号：US3958012A
公开(公告)日：1976-05-18
申请号：US562714
申请日：1975-03-27
申请人： John H. Fried , Ian T. Harrison
发明人： John H. Fried , Ian T. Harrison
IPC分类号： A61K31/11
CPC分类号： A61K31/11 , C07C45/292 , C07C45/41
摘要： The d 2-(6-substituted-2-naphthyl)propanals of this invention are prepared by oxidizing the corresponding 2-(6-substituted-2-naphthyl)-1-propanols or by reducing d 2-(6-substituted-2-naphthyl)propionic acids, the 6-substituent being a methyl, ethyl, isopropyl, cyclopropyl, trifluoromethyl, vinyl, ethynyl, fluoro, chloro, methoxy, methoxymethyloxy, difluoromethoxy, methylthio, methoxymethylthio or difluoromethylthio group. The products have anti-inflammatory, analgesic and antipyretic activities.
摘要翻译：本发明的d2-（6-取代-2-萘基）丙醛通过氧化相应的2-（6-取代-2-萘基）-1-丙醇或通过还原d 2-（6-取代-2 乙基，异丙基，环丙基，三氟甲基，乙烯基，乙炔基，氟代，氯代，甲氧基，甲氧基甲氧基，二氟甲氧基，甲硫基，甲氧基甲硫基或二氟甲硫基。该产品具有抗炎，止痛和解热活性。

40. 发明授权

US3935273A Naphthyl acetaldehyde derivatives 失效
标题翻译：萘乙醛衍生物
公开(公告)号：US3935273A
公开(公告)日：1976-01-27
申请号：US464029
申请日：1974-04-25
申请人： John H. Fried , Ian T. Harrison
发明人： John H. Fried , Ian T. Harrison
IPC分类号： C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/84 , C07C47/52
CPC分类号： C07C45/41 , C07C45/673 , C07C57/40 , C07C57/42 , C07C57/46 , C07C57/50 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/84
摘要： 2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
摘要翻译：任选在2位和/或C-1'，4'，5'，7'或8'位置取代的2-（2'-萘基）乙醛衍生物; 和/或位置C-6'或位置C-5'和7'表现出抗炎，镇痛，解热和抗瘙痒活性。

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