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31. 外观设计

USD853873S1 Housing for biochemical analysis apparatus 有权
公开(公告)号：USD853873S1
公开(公告)日：2019-07-16
申请号：US29650002
申请日：2018-06-04
申请人： IntegenX Inc.
设计人： Robert A. Schueren , Alexander Kindwall , David King , Chungsoo Charles Park , James Klevenberg
摘要： FIG. 1 is an isometric view of a housing for a biochemical analysis apparatus with a fingerprint reader and cartridge slot on the sloped front surface, the “IntegenX” logo and a pentagonal raised panel encircling the logo, most of the back face and underside of the housing, and a seam that runs along the front face of the housing and down the sides of the housing rendered in broken lines to indicate unclaimed environmental structure.
FIG. 2 is a rear isometric view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 3 is a front view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 4 is a back view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 5 is a bottom view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 6 is a top view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 7 is a left side view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 8 is a right side view of the housing for a biochemical analysis apparatus of FIG. 1.
FIG. 9 is an isometric view of a housing for a biochemical analysis apparatus with the cartridge slot, “IntegenX” logo and surrounding pentagonal area, and most of the underside and back face of the housing rendered in broken lines to indicate unclaimed environmental structure.
FIG. 10 is a rear isometric view of the housing for a biochemical analysis apparatus of FIG. 33.
FIG. 11 is a front view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 12 is a back view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 13 is a bottom view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 14 is a top view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 15 is a left side view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 16 is a right side view of the housing for a biochemical analysis apparatus of FIG. 9.
FIG. 17 is an isometric view of a housing for a biochemical analysis apparatus with the fingerprint reader, “IntegenX” logo and surrounding pentagonal area, and most of the underside and back face of the housing rendered in broken lines to indicate unclaimed environmental structure.
FIG. 18 is a rear isometric view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 19 is a front view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 20 is a back view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 21 is a bottom view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 22 is a top view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 23 is a left side view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 24 is a right side view of the housing for a biochemical analysis apparatus of FIG. 17.
FIG. 25 is an isometric view of a housing for a biochemical analysis apparatus with the fingerprint reader, cartridge slot, “IntegenX” logo and surrounding pentagonal area, and most of the underside and back face of the housing rendered in broken lines to indicate unclaimed environmental structure.
FIG. 26 is a rear isometric view of the housing for a biochemical analysis apparatus of FIG. 25.
FIG. 27 is a front view of the housing for a biochemical analysis apparatus of FIG. 25.
FIG. 28 is a back view of the housing for a biochemical analysis apparatus of FIG. 25.
FIG. 29 is a bottom view of the housing for a biochemical analysis apparatus of FIG. 25.
FIG. 30 is a top view of the housing for a biochemical analysis apparatus of FIG. 25.
FIG. 31 is a left side view of the housing for a biochemical analysis apparatus of FIG. 25; and,
FIG. 32 is a right side view of the housing for a biochemical analysis apparatus of FIG. 25.
FIGS. 1 through 32 are drawn to scale.
A housing for a biochemical analysis apparatus is shown in FIGS. 1-32.
Stipple shading is used throughout to show surface contouring and as an aid to determining boundaries between claimed subject matter and unclaimed environmental structure; unclaimed environmental structure is not shaded or hatched, whereas claimed subject matter is shaded or hatched. It is to be understood that the use of stipple shading does not convey any particular surface finish or surface texture, but is merely used as an aid to show surface contouring and the extent of claimed subject matter. In views where no natural boundary exists between claimed subject matter and unclaimed environmental structure, dashed-dotted-dashed lines are used to indicate such boundaries. For further clarity, tangent lines indicating smooth transitions between surfaces are depicted in grey dashed lines (short-short-long dashes). Broken lines, such as dashed and dotted lines, are used to indicate unclaimed environmental structure. In cases where broken lines are used to represent features on a shaded surface, such as is the case with the IntegenX logo, it is to be understood that the surface itself is still claimed but that the particular structures on that surface are unclaimed environmental structure.

32. 发明授权

US10208332B2 Fluidic cartridge with valve mechanism 有权
公开(公告)号：US10208332B2
公开(公告)日：2019-02-19
申请号：US15117053
申请日：2015-04-30
申请人： IntegenX Inc.
发明人： David Eberhart , William D. Nielsen , Helen Franklin , Stevan B. Jovanovich , Dennis Lehto , Kaiwan Chear , James Klevenberg , Chungsoo Charles Park , Corey Smith , Philip Justus Wunderle , David King
IPC分类号： A61J1/06 , B01L3/00 , G01N21/00 , G01N15/06 , C12Q1/6806 , C12Q1/686 , G01N27/447
摘要： Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

33. 发明申请

US20190026132A1 SYSTEMS AND METHODS FOR LIVE HELP 审中-公开
公开(公告)号：US20190026132A1
公开(公告)日：2019-01-24
申请号：US15761066
申请日：2016-09-21
申请人： INTEGENX INC.
发明人： David KING , Chungsoo Charles PARK
IPC分类号： G06F9/451 , G06Q30/00 , G06F3/0487
摘要： A live help system provides an intuitive display of help information on a user's graphical user interface. A request is received from a client device for help, and a live help provider interface is initiated at a live help location. Data is acquired regarding a user's location, including data on external devices in the user's location. Indicators are provided to allow the live help provider to point to or otherwise indicate items on the user interface or outside of the user interface. Live help input is captured at the live help provider interface. Instructions are then transmitted to the display of the client device to display live help input, as though the agent were present and interacting with or indicating items on the screen or off the screen.

34. 发明授权

US09752185B2 Microfluidic devices 有权
公开(公告)号：US09752185B2
公开(公告)日：2017-09-05
申请号：US14824333
申请日：2015-08-12
申请人： IntegenX Inc.
发明人： Allen Boronkay , Stevan Bogdan Jovanovich , Iuliu Ioan Blaga
IPC分类号： C12M1/00 , C12M1/34 , G01N15/06 , B01J19/08 , B01J19/12 , B01D21/00 , C12Q1/68 , B01F11/00 , B01F13/00 , C12Q1/24 , C12Q1/70 , C12N15/10 , B01L3/00 , B01L7/00 , B01L9/00 , G01N35/00
CPC分类号： C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense. Also disclosed in the present disclosure is a flow through, traveling-wave, bead-beating device which comprises a rotating pole piece, a flow through tube, and a magnetic piece. Rotation of the rotating pole piece may create a magnetic wave down the flow through tube, thereby producing sufficient acceleration of beads through the tube to disrupt or lyse target analytes flowing through the tube.

35. 发明申请

US20140170645A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：US20140170645A1
公开(公告)日：2014-06-19
申请号：US13967957
申请日：2013-08-15
申请人： IntegenX Inc.
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

36. 发明申请

US20140065628A1 Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis 审中-公开
标题翻译：电泳中多色，异相检测的方法和装置
公开(公告)号：US20140065628A1
公开(公告)日：2014-03-06
申请号：US13966252
申请日：2013-08-13
申请人： IntegenX Inc.
发明人： Ezra Van Gelder , Stephen J. Williams
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44726 , G01N27/44791
摘要： The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans.
摘要翻译：本公开提供了用于使用单个光源或多个光源分离和检测用多个可光谱可分辨染料标记的核酸片段的方法和装置。使用更多数量的光源可增加可询问的光谱可分辨染料的数量。具有更多数量的光谱可分辨染料的标记片段允许具有片段分化的片段更多的重叠，因此可以在更小的片段大小/长度范围上进行分离。为了提高使用多个光源的检测系统的检测灵敏度，光源发射的光可以在空间上彼此分离和/或可以调制每个光源的强度。一个或多个光源中的每一个可以是例如激光器或发光二极管。本公开的方法和装置可用于进行遗传分析，例如分析在法医数据库（例如，CODIS）中使用的多个STR标记以鉴定人。

37. 发明申请

US20130074944A1 Methods and Apparatuses for Releasably Fastening Pins 审中-公开
标题翻译：可释放紧固销的方法和装置
公开(公告)号：US20130074944A1
公开(公告)日：2013-03-28
申请号：US13626765
申请日：2012-09-25
申请人： IntegenX Inc.
发明人： Ezra Van Gelder
IPC分类号： F16L55/00
CPC分类号： B01L9/547 , B01L3/0279 , B01L2200/025 , B01L2200/148 , B01L2300/0838 , G01N35/1009 , G01N35/1065 , G01N2035/1037 , G01N2035/1076 , Y10T137/0402 , Y10T137/598
摘要： The present technology relates to pins that are used for moving liquid samples from source wells into target wells. A releasable fastening mechanism simplifies calibration of positions (e.g., vertical positions) of the pins relative to a frame releasably holding the pins.
摘要翻译：本技术涉及用于将液体样品从源阱移动到目标井中的引脚。可释放的紧固机构简化了相对于可释放地保持销的框架的销的位置（例如，垂直位置）的校准。

38. 发明申请

WO2018217816A1 COMPOSITIONS, METHODS, KITS AND DEVICES FOR MOLECULAR ANALYSIS 审中-公开
公开(公告)号：WO2018217816A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033972
申请日：2018-05-22
申请人： INTEGENX INC. , LIFE TECHNOLOGIES CORPORATION
发明人： LIU, Jen-Kuei , SOLANKI, Bharti , WENZ, Hans Michael , MERCER, Frank , AKIN, Cevat , KARGER, Achim , BARRON, Annelise , MACK, Scott
IPC分类号： G01N27/447
摘要： Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C. Also provided herein are sieving compositions, including polymer-based sieving compositions, for molecular sieving as well as related kits, devices and methods of use. Such compositions can be useful for separation of biomolecules such as nucleic acids, proteins, glycoproteins and glycans.

39. 发明申请

WO2018217789A3 COMPOSITIONS, METHODS, KITS AND DEVICES FOR MOLECULAR ANALYSIS 审中-公开
公开(公告)号：WO2018217789A3
公开(公告)日：2018-11-29
申请号：PCT/US2018/033939
申请日：2018-05-22
申请人： INTEGENX INC.
发明人： MACK, Scott , BARRON, Annelise
IPC分类号： G01N27/447 , B01J20/285
摘要： Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C.

40. 发明申请

WO2018217721A1 SERIAL ELECTROPHORESIS 审中-公开
公开(公告)号：WO2018217721A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033853
申请日：2018-05-22
申请人： INTEGENX INC.
发明人： VANGBO, Mattias , KING, David , BARICAN, Arnaldo
IPC分类号： C12Q1/6806 , C12Q1/68 , C12Q1/00
摘要： Disclosed are methods for performing capillary electrophoresis on two or more nucleic acid samples. The methods employ a forward voltage to move a first sample forward from an inlet to an interrogation region in the capillary, then a backward voltage to move the first sample backward, and then a forward voltage again to move the first sample and a second sample forward. Systems and apparatuses for performing capillary electrophoresis are also provided.

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