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    • 37. 发明授权
    • Effervescent ranitidine formulations
    • 泡腾雷尼替丁配方
    • US5728401A
    • 1998-03-17
    • US837488
    • 1997-04-16
    • Farhan AhmedChetan RajsharadHimadri Sen
    • Farhan AhmedChetan RajsharadHimadri Sen
    • A61K9/46A61K31/341
    • A61K31/341A61K9/0007
    • An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.
    • 用于口服用于治疗由组胺H2受体介导的病症的泡腾药物组合物含有治疗有效量的雷尼替丁或其生理上可接受的盐,约25-70重量%柠檬酸二钠,约20-50% 重量的碳酸氢钠。 任选地,泡腾组合物还可以包括约0.5-25重量%的可食用有机酸如富马酸。 优选地,泡腾组合物是片剂的形式。 用于泡腾组合物的附加赋形剂包括约2-10重量%的甘氨酸,调味剂,甜味剂,粘合剂和/或润滑剂。