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31. 发明申请

WO2014008381A3 ASSAY CARTRIDGE VALVE SYSTEM 审中-公开
公开(公告)号：WO2014008381A3
公开(公告)日：2014-01-09
申请号：PCT/US2013/049296
申请日：2013-07-03
申请人： MESO SCALE TECHNOLOGIES, LLC. , GLEZER, Eli, N. , JEFFREY-COKER, Bandele , PAGE, Kenneth , KOVACS, Sandor , KUMAR, Sudeep , ROTH, Kristian
发明人： GLEZER, Eli, N. , JEFFREY-COKER, Bandele , PAGE, Kenneth , KOVACS, Sandor , KUMAR, Sudeep , ROTH, Kristian
IPC分类号： F16K11/06
摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed. The multi-port valve has a cap, a stator comprising a rotor engagement member, and a rotor biased toward the stator and comprising a sealing member disposed between the rotor and the stator. A stator engagement member is configured to disengage the rotor when the stator engagement member is in communication with the rotor engagement member.

32. 发明申请

WO2012094459A2 ASSAY CARTRIDGES AND METHODS OF USING THE SAME 审中-公开
标题翻译：测定盒及其使用方法
公开(公告)号：WO2012094459A2
公开(公告)日：2012-07-12
申请号：PCT/US2012/020278
申请日：2012-01-05
申请人： GLEZER, Eli N. , HIGGINS, Stephen , KOVACS, Sandor , KUMAR, Sudeep , PAGE, Kenneth , ROTH, Kristian , SIGAL, George
发明人： GLEZER, Eli N. , HIGGINS, Stephen , KOVACS, Sandor , KUMAR, Sudeep , PAGE, Kenneth , ROTH, Kristian , SIGAL, George
IPC分类号： C12M1/34 , C12M1/38 , C12Q1/68
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
摘要翻译：描述了具有净化，反应和检测区域以及可以包括样品室，废物室，导管，通风口，试剂室，重构室等的流体组分的测定盒。测定盒用于进行多重核酸测量。还描述了包括这种盒的试剂盒，使用它们的方法，以及配置成分析使用测定盒进行的分析的读取器。

33. 发明申请

WO2011071772A2 ASSAY CARTRIDGES AND METHODS OF USING THE SAME 审中-公开
标题翻译：测定盒及其使用方法
公开(公告)号：WO2011071772A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/058913
申请日：2010-12-03
申请人： MESO SCALE TECHNOLOGIES, LLC. , ANDERSON, Nicholas , DEBAD, Jeffrey , GLEZER, Eli, N. , KUMAR, Sudeep , LAWRENCE, Noel , PAGE, Kenneth , SIGAL, George , WEST, Sharon
发明人： ANDERSON, Nicholas , DEBAD, Jeffrey , GLEZER, Eli, N. , KUMAR, Sudeep , LAWRENCE, Noel , PAGE, Kenneth , SIGAL, George , WEST, Sharon
IPC分类号： G01N21/03
CPC分类号： G01N21/05 , B01L3/5027 , B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2200/147 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/027 , B01L2300/044 , B01L2300/0645 , B01L2300/0654 , B01L2300/0809 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/0487 , B01L2400/0672 , B01L2400/0683 , B01L2400/0688 , G01F23/02 , G01F23/292 , G01N21/03 , G01N21/0303 , G01N21/69 , G01N21/76 , G01N2021/0346 , Y10T137/0396 , Y10T137/8593
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
摘要翻译：描述了具有检测室，优选具有集成电极的测定盒，以及可包括样品室，废物室，导管，通气口，气泡阱，试剂室，干试剂药片区等的其它流体组分。在某些实施例中，这些盒适于接收和分析在施用器棒上收集的样品。还描述了包括这种盒的试剂盒和盒读取器，其被配置为分析使用分析盒进行的分析。

34. 发明申请

WO2011017082A3 ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES 审中-公开
标题翻译：测量信息管理方法和设备
公开(公告)号：WO2011017082A3
公开(公告)日：2011-05-19
申请号：PCT/US2010043335
申请日：2010-07-27
申请人： CLINTON CHARLES M , CONG XINRI , GLEZER ELI N , KUMAR SUDEEP , STEVENS CARL , VOCK MICHAEL , WILLOUGHBY JON S
发明人： CLINTON CHARLES M , CONG XINRI , GLEZER ELI N , KUMAR SUDEEP , STEVENS CARL , VOCK MICHAEL , WILLOUGHBY JON S
IPC分类号： G01N27/00 , G01N37/00 , G06K17/00 , G11C11/00
CPC分类号： G06F19/703 , B01L3/54 , B01L2300/02 , G01N33/54306 , G01N35/00663 , G01N2035/00633 , G01N2035/00851
摘要： The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.
摘要翻译：本发明涉及用于将测定信息与生物测定中使用的测定消耗品相关联的方法，装置和系统。提供了测定系统和相关的消耗品，其中测定系统包括读取器，其适于从与测定消耗品相关联的测定消耗品标识符读取/写入/写入信息。描述了各种类型的测定信息，以及在通过测定系统进行测定中使用这些信息的方法。

35. 发明申请

WO2011017082A2 ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES 审中-公开
标题翻译：分析信息管理方法和设备
公开(公告)号：WO2011017082A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/043335
申请日：2010-07-27
申请人： CLINTON, Charles M. , CONG, Xinri , GLEZER, Eli N. , KUMAR, Sudeep , STEVENS, Carl , VOCK, Michael , WILLOUGHBY, Jon S.
发明人： CLINTON, Charles M. , CONG, Xinri , GLEZER, Eli N. , KUMAR, Sudeep , STEVENS, Carl , VOCK, Michael , WILLOUGHBY, Jon S.
IPC分类号： G01N27/00 , G01N37/00 , G06K17/00 , G11C11/00
CPC分类号： G06F19/703 , B01L3/54 , B01L2300/02 , G01N33/54306 , G01N35/00663 , G01N2035/00633 , G01N2035/00851
摘要： The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.
摘要翻译：本发明涉及用于将测定信息与生物测定中使用的测定消耗品相关联的方法，装置和系统。提供测定系统和相关联的消耗品，其中测定系统包括适合于从与测定消耗品相关联的测定消耗品标识符读取/擦除/写入信息的读取器。描述了各种类型的测定信息，以及在通过测定系统进行测定时使用这些信息的方法。

36. 发明申请

WO2009126303A3 ASSAY APPARATUSES, METHODS AND REAGENTS 审中-公开
标题翻译：测定装置，方法和试剂
公开(公告)号：WO2009126303A3
公开(公告)日：2010-01-28
申请号：PCT/US2009002244
申请日：2009-04-10
申请人： MESO SCALE TECHNOLOGIES LLC , CLINTON CHARLES M , GLEZER ELI N , WEST SHARON , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
发明人： CLINTON CHARLES M , GLEZER ELI N , WEST SHARON , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
IPC分类号： G01N1/28 , G01N21/00 , G01N35/00
CPC分类号： G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N35/1079 , G01N2035/0425 , Y10T436/114165
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
摘要翻译：我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。

37. 发明申请

WO2009126303A2 ASSAY APPARATUSES, METHODS AND REAGENTS 审中-公开
标题翻译：测定装置，方法和试剂
公开(公告)号：WO2009126303A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002244
申请日：2009-04-10
申请人： MESO SCALE TECHNOLOGIES, LLC , CLINTON, Charles, M. , GLEZER, Eli, N. , WEST, Sharon , SIGAL, George , STEVENS, Carl , VOCK, Michael
发明人： CLINTON, Charles, M. , GLEZER, Eli, N. , WEST, Sharon , SIGAL, George , STEVENS, Carl , VOCK, Michael
IPC分类号： G01N1/28 , G01N35/00 , G01N21/00
CPC分类号： G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N35/1079 , G01N2035/0425 , Y10T436/114165
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
摘要翻译：我们描述了用于进行测定的装置，系统，方法，试剂和试剂盒以及它们的制备方法。它们特别适合于以多孔板分析方式进行自动取样，样品制备和分析。例如，它们可以用于自动分析空气中的微粒和/或从环境监测中得到的液体样品。

38. 发明专利

IL223316A Assay apparatuses, methods and reagents 未知
公开(公告)号：IL223316A
公开(公告)日：2015-03-31
申请号：IL22331612
申请日：2012-11-28
申请人： MESO SCALE TECHNOLOGIES LLC , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOVACS SANDOR , KUMAR SUDEEP M , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
发明人： CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOVACS SANDOR , KUMAR SUDEEP M , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
IPC分类号： B01L99/00
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

39. 发明专利

IL192157D0 ASSAY APPARATUSES, METHODS AND REAGENTS 未知
公开(公告)号：IL192157D0
公开(公告)日：2008-12-29
申请号：IL19215708
申请日：2008-06-12
申请人： MESO SCALE TECHNOLOGIES LLC , CLINTON CHARLES M , GLEZER ELI N , JEFFREY COKER BANDELE , KOVACS SANDOR , KUMAR SUDEEP M , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
IPC分类号： B01L99/00 , G01N20100101
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

40. 发明专利

ES2884100T3 Procedimientos de ensayo asistidos por coagente de unión 未知
公开(公告)号：ES2884100T3
公开(公告)日：2021-12-10
申请号：ES18192525
申请日：2012-11-09
申请人： GLEZER ELI N , SIGAL GEORGE
发明人： GLEZER ELI N , SIGAL GEORGE
IPC分类号： G01N33/53 , C12Q1/68 , C12Q1/6813 , G01N33/52 , G01N33/542 , G01N33/543
摘要： Procedimiento para llevar a cabo un ensayo de unión que comprende: (a) poner en contacto una muestra que comprende uno o más analitos con (i) una superficie sólida que incluye uno o más primeros reactivos de unión inmovilizados en la misma, comprendiendo cada uno de entre dicho uno o más primeros reactivos de unión una primera región de unión que se une a dichos analitos, y estando cada uno de entre dicho uno o más primeros reactivos de unión enlazado a un primer agente de enlace que comprende una primera secuencia oligonucleotídica; (ii) uno o más segundos reactivos de unión que comprenden una segunda región de unión que se une a dichos analitos, en el que cada uno de entre dicho uno o más segundos reactivos de unión está enlazado a un segundo agente de enlace que comprende una segunda secuencia oligonucleotídica, en el que dicho uno o más segundos reactivos de unión no están inmovilizados en la superficie sólida, e (iii) una o más secuencias oligonucleotídicas de puente que comprende cada una de ellas una secuencia complementaria de por lo menos una parte de dicha primera secuencia oligonucleotídica y dicha segunda secuencia oligonucleotídica; en el que dicha etapa de contacto se lleva a cabo en condiciones en las que dicha primera y segunda regiones de unión se unen a dichos analitos y dichas secuencias oligonucleotídicas de puente se hibridan con dicha primera secuencia oligonucleotídica y dicha segunda secuencia oligonucleotídica; y (b) medir la cantidad de dichos analitos unidos a dicho soporte sólido.

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