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31. 发明申请

US20150306249A1 REVERSIBLE IMMOBILIZATION AND/OR CONTROLLED RELEASE OF NUCLEIC ACID CONTAINING NANOPARTICLES BY (BIODEGRADABLE) POLYMER COATINGS 审中-公开
标题翻译：（可生物降解）聚合物涂层可逆稳定和/或控制含有纳米粒子的核酸的释放
公开(公告)号：US20150306249A1
公开(公告)日：2015-10-29
申请号：US14402053
申请日：2012-05-25
申请人： CureVac GmbH
发明人： Patrick BAUMHOF , Hans-Peter WENDEL , Andrea NOLTE , Tobias WALKER
IPC分类号： A61K48/00 , A61K47/48 , C12N9/02 , A61L31/16 , A61L31/14 , A61K9/51 , A61L31/10
CPC分类号： A61K48/0041 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K47/34 , A61K47/645 , A61K47/6937 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2300/62 , A61L2300/802 , A61L2400/12 , C12N9/0069 , C12N15/88 , C12Y113/12005 , C08L67/04
摘要： The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation. Additionally, the present invention is directed to a method of preparing these nucleic acid comprising nanoparticles coated with a (biodegradable) polymer and to a method for coating nucleic acid comprising nanoparticles by a (biodegradable) polymer on medical or diagnostic devices.
摘要翻译：本发明涉及包含用可生物降解的聚合物涂覆的核酸的纳米颗粒，用于可逆地固定和/或控制释放包含纳米颗粒的核酸。此外，本发明涉及医疗或诊断装置，特别是由可生物降解的聚合物涂覆的支架和植入物，其中核酸包含用于可逆固定和/或控制释放的纳米颗粒。此外，本发明涉及涂覆有（可生物降解的）聚合物的这些纳米颗粒的用途，以及使用包含（可生物降解的）聚合物的医疗装置和植入物，其中包含纳米颗粒的这些核酸在预防或治疗疾病中特别是在预防或治疗再狭窄，加压，异物反应或炎症中。另外，本发明涉及一种制备这些核酸的方法，所述核酸包含涂覆有（可生物降解的）聚合物的纳米颗粒，以及通过医学或诊断装置上的（可生物降解的）聚合物涂覆包含纳米颗粒的核酸的方法。

32. 发明申请

US20150030633A1 APPLICATION OF MRNA FOR USE AS A THERAPEUTIC AGAINST TUMOUR DISEASES 有权
标题翻译：应用MRNA作为抗肿瘤疾病的治疗方法
公开(公告)号：US20150030633A1
公开(公告)日：2015-01-29
申请号：US14325850
申请日：2014-07-08
申请人： CUREVAC GMBH
发明人： Ingmar HOERR , Florian VON DER MULBE , Steve PASCOLO
IPC分类号： A61K39/00 , A61K38/19
CPC分类号： A61K39/0011 , A61K9/0021 , A61K38/193 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/55522 , A61K2039/572 , A61K2039/70 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a tumour, in combination with an aqueous solvent and preferably a cytokine, e.g. GM-CSF, and a process for the preparation of the pharmaceutical composition. The pharmaceutical composition according to the invention is used in particular for therapy and/or prophylaxis against cancer.
摘要翻译：本发明涉及药物组合物，其包含至少一种mRNA，其包含至少一个来自肿瘤的至少一种抗原的编码区，与水性溶剂，优选细胞因子（例如细胞因子）组合。 GM-CSF，以及制备药物组合物的方法。本发明的药物组合物特别用于治疗和/或预防癌症。

33. 发明申请

US20140037660A1 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION 审中-公开
标题翻译： RNA和阳离子肽的复制用于转移和免疫
公开(公告)号：US20140037660A1
公开(公告)日：2014-02-06
申请号：US13904868
申请日：2013-05-29
申请人： CureVac GmbH
发明人： Mariola FOTIN-MLECZEK , Patrick BAUMHOF
IPC分类号： C07K19/00
CPC分类号： A61K48/005 , A61K9/0019 , A61K38/45 , A61K38/4846 , A61K39/00 , A61K47/61 , A61K47/6455 , A61K48/0033 , A61K48/0041 , A61K48/0066 , A61K48/0075 , A61K2039/53 , C07K19/00 , C12N9/0069 , C12N15/87 , C12Y113/12007 , C12Y204/01007 , C12Y304/21022
摘要： The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the function of cell-penetrating peptide (CPP), has a length of 8 to 15 amino acids and has the empirical formula (Arg)l;(Lys)m;(His)n;(Om)o;(Xaa)x with the majority of residues being selected from Arg, Lys, His, Om. The invention further relates to a method for transfecting a cell or an organism, thereby applying the inventive complexed RNA. Additionally, pharmaceutical compositions and kits comprising the inventive complexed RNA, as well as the use of the inventive complexed RNA for transfecting a cell, tissue or an organism and/or for modulating, preferably inducing or enhancing, an immune response are disclosed herein.
摘要翻译：本发明涉及复合RNA，其包含与一种或多种寡肽复合的至少一种RNA，其中具有细胞穿透肽（CPP）功能的寡肽具有8至15个氨基酸的长度，并且具有经验式（Arg）l;（Lys）m;（His）n;（Om）o;（Xaa）x，大部分残基选自Arg，Lys，His，Om。本发明还涉及用于转染细胞或生物体的方法，从而应用本发明的复合RNA。此外，本文公开了包含本发明复合RNA的药物组合物和试剂盒，以及本发明的复合RNA用于转染细胞，组织或生物体和/或用于调节，优选诱导或增强免疫应答的用途。

34. 发明授权

US09616084B2 Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids 有权
公开(公告)号：US09616084B2
公开(公告)日：2017-04-11
申请号：US14492334
申请日：2014-09-22
申请人： CureVac GmbH
发明人： Thorsten Mutzke
IPC分类号： A61K31/7004 , A61K31/7105 , A61K47/26 , A61K31/7088 , C12N15/87 , A61K39/00 , A61K47/12 , A61K48/00
CPC分类号： A61K31/7088 , A61K39/0011 , A61K47/12 , A61K47/26 , A61K48/00 , A61K2039/53 , C12N15/87
摘要： The present invention is directed to (the use of) a solution containing at least one nucleic acid (sequence) and free mannose for lyophilization, transfection and/or injection, particularly of RNA and mRNA. The inventive solution exhibits a positive effect on stabilization of the nucleic acid (sequence) during lyophilization and storage but also leads to a considerable increase of the transfection efficiency of a nucleic acid. It thus also increases in vivo expression of a protein encoded by such a nucleic acid upon increased transfection rate. The present invention is furthermore directed to a method of lyophilization using the mannose-containing solution, to pharmaceutical compositions, vaccines, kits, first and second medical uses applying such a mannose-containing solution and/or a nucleic acid (sequence) lyophilized or resuspended with such a solution.

35. 发明申请

US20150258214A1 COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION 审中-公开
标题翻译：用转移和免疫接种的交联中和组分的核酸复合物
公开(公告)号：US20150258214A1
公开(公告)日：2015-09-17
申请号：US14600628
申请日：2015-01-20
申请人： CUREVAC GMBH
发明人： Patrick BAUMHOF , Söhnke VOSS , Thomas KRAMPS , Karl-Josef KALLEN
IPC分类号： A61K48/00 , A61K39/385 , A61K39/39
CPC分类号： A61K48/0041 , A61K39/00 , A61K39/385 , A61K39/39 , A61K47/645 , A61K2039/51 , A61K2039/55516 , A61K2039/55561 , C12N15/87 , Y02A50/412 , Y02A50/487
摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.
摘要翻译：本发明涉及一种聚合物载体货物复合物，其包含至少一种核酸（分子）和作为（优选无毒的和非免疫原性的）聚合物载体的二硫键交联的阳离子组分。本发明的聚合物载体货物复合物允许在体内和体外有效地将核酸转染到细胞中和/或诱导（先天和/或自适应）免疫应答，优选依赖于作为货物运输的核酸。本发明还提供药物组合物，特别是疫苗和佐剂，其包含本发明的聚合物载体货物复合物和任选的抗原，以及使用本发明的本发明的聚合物载体货物复合物和任选的抗原用于转染细胞，组织或用于本文公开的（基因 - ）治疗目的的生物体，和/或作为免疫刺激剂或佐剂，例如，用于引发用于治疗或预防上述疾病的免疫应答。最后，本发明涉及在试剂盒的一个或多个部分中含有本发明的聚合物载体货物复合物和/或本发明的药物组合物，佐剂或疫苗的试剂盒。

36. 发明申请

US20150184195A1 ARTIFICIAL NUCLEIC ACID MOLECULES 有权
标题翻译：人工核酸分子
公开(公告)号：US20150184195A1
公开(公告)日：2015-07-02
申请号：US14388220
申请日：2013-03-27
申请人： CureVac GmbH
发明人： Andreas Thess , Karl-Josef Kallen
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K48/00 , C12N15/67 , C12N15/88 , C12N2830/50
摘要： The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3′UTR element.
摘要翻译：本发明涉及包含至少一个开放阅读框和至少一个3'UTR元件的人源核酸分子，其包含衍生自白蛋白基因的3'UTR或3'UTR的变体的核酸序列的白蛋白基因。本发明还涉及这种人工核酸分子在基因治疗和/或基因疫苗接种中的用途。此外，本发明涉及包含衍生自白蛋白基因的3'UTR或白蛋白基因的3'UTR的变体的核酸序列的3'UTR元件用于稳定化和/或从包含这种3'UTR元件的核酸序列延长蛋白质表达。

37. 发明申请

US20150165006A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN 审中-公开
标题翻译：包含或编码HISTONE STEM-LOOP和POLY（A）序列或聚合信号的核酸包含增加编码的过敏原抗原或自身免疫自身抗体的表达
公开(公告)号：US20150165006A1
公开(公告)日：2015-06-18
申请号：US14378591
申请日：2013-02-15
申请人： CureVac GmbH
发明人： Andreas Thess , Thomas Schlake , Jochen Probst
IPC分类号： A61K39/00 , C12N15/67 , A61K39/35 , C12N15/85
CPC分类号： A61K39/0008 , A61K39/35 , A61K48/00 , A61K48/005 , A61K2039/53 , A61K2039/55516 , A61K2039/64 , C12N15/63 , C12N15/67 , C12N15/85 , C12N2830/50 , Y02A50/401
摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of allergies or autoimmune diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.
摘要翻译：本发明涉及包含或编码编码区的核酸序列，其编码至少一种包含过敏原抗原或自身免疫自身抗原或其片段，变体或衍生物的肽或蛋白质，至少一种组蛋白干 - 环和聚（A）序列或聚腺苷酸化信号。此外，本发明提供了用于增加所述编码的肽或蛋白质的表达的核酸的用途。它还公开了其用于制备药物组合物，特别是疫苗的用途。用于治疗过敏或自身免疫性疾病。本发明还描述了使用包含或编码组蛋白茎环的核酸和增加包含变应原性抗原或自身免疫自身抗原或其自身免疫自身抗原或其片段，变体或衍生物的肽或蛋白质的表达的方法，聚（A）序列或聚腺苷酸化信号。

38. 发明申请

US20150093413A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN 有权
标题翻译：用于组蛋白干扰素的核酸包封或编码，以及用于增加编码的病原性抗原表达的聚（A）序列或聚乙烯化信号
公开(公告)号：US20150093413A1
公开(公告)日：2015-04-02
申请号：US14378538
申请日：2013-02-15
申请人： CureVac GmbH
发明人： Andreas Thess , Thomas Schlake , Jochen Probst
IPC分类号： A61K39/145 , C12N7/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/64 , C12N7/00 , C12N15/63 , C12N15/67 , C12N2760/16134 , C12N2830/50 , Y02A50/386 , Y02A50/388 , Y02A50/403 , Y02A50/414 , Y02A50/416 , Y02A50/464 , Y02A50/466 , Y02A50/476 , Y02A50/487 , Y02A50/489 , Y02A50/491 , Y02A50/492
摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of infectious diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.
摘要翻译：本发明涉及包含或编码编码区的核酸序列，其编码至少一种包含病原性抗原或其片段，变体或衍生物的肽或蛋白质，至少一种组蛋白茎环和聚（A ）序列或聚腺苷酸化信号。此外，本发明提供了用于增加所述编码的肽或蛋白质的表达的核酸的用途。它还公开了其用于制备药物组合物，特别是疫苗的用途。用于治疗传染病。本发明还描述了使用包含或编码组蛋白茎环和聚（A）序列的核酸或增加包含病毒抗原或其片段，变体或衍生物的肽或蛋白质的表达的方法，多聚腺苷酸化信号。

39. 发明申请

US20140294877A1 DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES FOR THE TRANSFECTION OF NUCLEIC ACIDS 有权
标题翻译：用于转运核酸的分离的聚乙二醇/肽结合物
公开(公告)号：US20140294877A1
公开(公告)日：2014-10-02
申请号：US14195864
申请日：2014-03-04
申请人： CureVac GmbH
发明人： Patrick BAUMHOF , Thomas SCHLAKE
IPC分类号： A61K47/48
CPC分类号： A61K48/0041 , A61K47/60 , A61K47/6455
摘要： The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.
摘要翻译：本发明涉及根据通式（I）的本发明的聚合物载体分子及其变体，其允许核酸在体内和体外有效转染细胞，由核酸形成的聚合载体载体复合物和本发明的聚合物载体分子，而且还涉及本发明的聚合物载体分子和本发明的聚合物载体载体复合物的制备方法。本发明还提供了本发明的聚合物载体分子和本发明的聚合物载体载体复合物作为药物，用于治疗各种疾病和制备用于治疗这些疾病的药物组合物的应用和应用的方法。

40. 发明申请

US20130273001A1 IMMUNOSTIMULATION BY CHEMICALLY MODIFIED RNA 审中-公开
标题翻译：通过化学修饰的RNA免疫
公开(公告)号：US20130273001A1
公开(公告)日：2013-10-17
申请号：US13850024
申请日：2013-03-25
申请人： Curevac GMBH
发明人： Ingmar HOERR , Florlan Von Der Mulbe , Steve Pascolo
IPC分类号： A61K39/39
CPC分类号： C12N15/117 , A61K31/7115 , A61K31/7125 , A61K39/0011 , A61K39/39 , A61K47/42 , A61K2039/55561 , A61K2039/572 , C12N2310/17 , C12N2310/315 , C12N2320/31 , C12N2320/32 , Y02A50/412
摘要： The present invention relates to an immunostimulating agent comprising at least one chemically modified RNA. The invention furthermore relates to a vaccine which comprises at least one antigen in combination with the immunostimulating agent. The immunostimulating agent according to the invention and the vaccine according to the invention are employed in particular against infectious disease or cancer diseases.
摘要翻译：本发明涉及包含至少一种化学修饰的RNA的免疫刺激剂。本发明还涉及包含与免疫刺激剂组合的至少一种抗原的疫苗。根据本发明的免疫刺激剂和根据本发明的疫苗特别用于感染性疾病或癌症疾病。

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