专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

WO0243506A3 CHOLESTEROL LOWERING SUPPLEMENT 审中-公开
标题翻译：胆固醇降低补充剂
公开(公告)号：WO0243506A3
公开(公告)日：2002-10-03
申请号：PCT/NL0100866
申请日：2001-11-29
申请人： NUTRICIA NV , CHEN QI , DE BONT HENDRICUS BARTHOLOMEUS , VAN DER ZEE LUUTSCHE , LANSINK MIRIAN , VAN NORREN KLASKE , VAN DER BURGT LEONTINE MARTINA
发明人： CHEN QI , DE BONT HENDRICUS BARTHOLOMEUS , VAN DER ZEE LUUTSCHE , LANSINK MIRIAN , VAN NORREN KLASKE , VAN DER BURGT LEONTINE MARTINA
IPC分类号： A23L1/30 , A23L1/308 , A61K36/236 , A61K36/254 , A61K36/282 , A61K36/287 , A61K36/481 , A61K36/505 , A61K36/537 , A61K36/704 , A61K36/734 , A61K36/88 , A61K36/884 , A61K36/8969 , A61K36/9066
CPC分类号： A61K36/734 , A23L33/105 , A23L33/11 , A23L33/21 , A23V2002/00 , A61K36/236 , A61K36/254 , A61K36/282 , A61K36/287 , A61K36/481 , A61K36/505 , A61K36/537 , A61K36/704 , A61K36/88 , A61K36/884 , A61K36/8969 , A61K36/9066 , A61K2300/00 , A23V2250/2136 , A23V2250/21 , A23V2250/187 , A23V2250/1868 , A23V2250/1842 , A23V2250/712 , A23V2250/5072 , A23V2250/506 , A23V2250/5028 , A23V2250/507 , A23V2250/5034
摘要： The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as a suitable composition comprising (a) one or more phytosterols and/or phytostanols capable of reducing cholesterol absorption in the intestine and/or one more soluble fibres capable of inhibiting ileal bile acid absorption, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions (b) and (c) is preferably derived from plants.
摘要翻译：本发明提供了用于降低血清胆固醇水平或用于预防血清胆固醇水平升高的组合物和方法，以及合适的组合物，其包含（a）能够降低肠中胆固醇吸收的一种或多种植物甾醇和/或植物甾烷醇和（b）能够抑制胆汁酸生物合成的组合物，和（c）能够增加胆固醇代谢的组合物，其中组合物（b）和（c）优选来源于植物。

32. 发明申请

WO9924076A9 SALICYLATE DERIVATIZED THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：盐酸衍生的治疗和诊断试剂
公开(公告)号：WO9924076A9
公开(公告)日：2000-06-08
申请号：PCT/US9823706
申请日：1998-11-06
申请人： CONJUCHEM INC , KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QI QI , SETTINERI TINA
发明人： KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QI QI , SETTINERI TINA
IPC分类号： A61K35/16 , A61K38/00 , A61K47/48 , A61K49/00 , A61P7/02 , A61P25/04 , A61P43/00 , C07K7/08 , C07K14/665 , C07K14/75 , C07K14/78
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/6901
摘要： The present invention relates to novel salicylate compounds which comprise a salicylate moiety and a biologically active agent of interest, where the compound binds and bonds specifically through reaction of the salicylate ester to serum albumin at Lys 199. Albumin is a long-lived moiety present in the blood. Novel salicylate compounds of the present invention provide for long-lived maintenance of the biologically active entity in the host. These compounds find broad applications in prophylactic and therapeutic applications, production of antibodies, reduction of the biologically effective concentration or activity of an endogenous or exogenous blood component, and in other situations where long term administration of a physiologically active compound is of interest.
摘要翻译：本发明涉及包含水杨酸酯部分和感兴趣的生物活性剂的新型水杨酸酯化合物，其中该化合物通过水杨酸酯在Lys 199处与血清白蛋白的反应而特异性地结合和键合。白蛋白是存在于血液。本发明的新型水杨酸酯化合物提供宿主中生物活性实体的长期维持。这些化合物在预防和治疗应用中广泛应用，产生抗体，降低内源或外源性血液成分的生物学有效浓度或活性，以及其他感兴趣的生理活性化合物的长期给药的情况。

33. 发明申请

WO2020252772A1 METHOD FOR PRODUCING THIXOTROPIC CURABLE SILICONE COMPOSITION 审中-公开
公开(公告)号：WO2020252772A1
公开(公告)日：2020-12-24
申请号：PCT/CN2019/092283
申请日：2019-06-21
申请人： DOW SILICONES CORPORATION , DOW TORAY CO., LTD. , HONG, Debo , LI, Xiucuo , OKABE, Kazutoshi , ADACHI, Hiroshi , FANG, Lei , CHEN, Qi
发明人： HONG, Debo , LI, Xiucuo , OKABE, Kazutoshi , ADACHI, Hiroshi , FANG, Lei , CHEN, Qi
IPC分类号： C08L83/04 , C08K5/00 , C08K5/549 , C08K5/5419
摘要： Disclosed is a method for producing a thixotropic curable silicone composition comprising: (A) a silicone base material comprising: an organopolysiloxane having at least two alkoxysilyl-containing groups per molecule and filler other than fumed silica; (B) a hydrophobic fumed silica; (C) a carbasilatrane derivative; (D) an alkoxysilane or its partial hydrolysis and condensation product; and (E) a condensation reaction catalyst, wherein the method comprises the following steps: (I) mixing components (A) and (B); (II) mixing component (C) with a mixture obtained by said step (I); and then (III) mixing components (D) and (E) with a mixture obtained by said step (II) under free of moisture. The curable silicone composition obtained by the method has thixotropic property and can cure at room temperature by contact with moisture in air.

34. 发明申请

WO2008101036A1 DYNAMIC LEAKAGE CONTROL USING SELECTIVE BACK-BIASING 审中-公开
标题翻译：使用选择性反向偏移的动态泄漏控制
公开(公告)号：WO2008101036A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/053890
申请日：2008-02-13
申请人： ADVANCED MICRO DEVICES, INC. , SHIMIZU, Daniel , WANG, David , CHEN, Qi
发明人： SHIMIZU, Daniel , WANG, David , CHEN, Qi
IPC分类号： H03K19/00
CPC分类号： H03K19/0013 , H03K2217/0018
摘要： Embodiments of a dynamic leakage control circuit for use with graphics processor circuitry are described. The dynamic leakage control circuit selectively enables back biasing of the transistors comprising the graphics processor circuits during particular modes of operation. The back biasing levels are controlled by two separate power rails. A first power rail is coupled to an existing power supply and the second power rail is coupled to a separate adjustable voltage regulator A separate voltage regulator may also be provided for the first power rail. A hardware-based state machine or software process is programmed to detect the occurrence of one or more modes of operation and adjust the voltage regulators for the first and second power rails to either enable or disable the back biasing state of the circuit, or alter the threshold voltage of the circuit within a specified voltage range.
摘要翻译：描述了用于图形处理器电路的动态泄漏控制电路的实施例。动态泄漏控制电路在特定的操作模式期间选择性地实现包括图形处理器电路的晶体管的反向偏置。后偏置电平由两个单独的电源轨控制。第一电力轨耦合到现有电源，第二电力轨耦合到单独的可调电压调节器。也可以为第一电力轨提供单独的电压调节器。对基于硬件的状态机或软件过程进行编程以检测一个或多个操作模式的发生，并且调整用于第一和第二电力轨的电压调节器以使得或禁用电路的反向偏置状态，或者改变电路的阈值电压在规定的电压范围内。

35. 发明申请

WO2006078865A2 DIRECT RACEMIZATION OF INDOLE DERIVATIVES 审中-公开
标题翻译：直接表达吲哚衍生物
公开(公告)号：WO2006078865A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001974
申请日：2006-01-20
申请人： CEPHALON, INC. , CHEN, Jian , CHEN, Qi
发明人： CHEN, Jian , CHEN, Qi
IPC分类号： C07D498/02 , C07D491/02 , C07D491/052 , C07D471/02
CPC分类号： C07D495/04 , C07D471/04 , C07D491/04
摘要： The present invention discloses processes for the racemization of enantiomers of etodolac and other tetra-hydropyrano indole derivatives.
摘要翻译：本发明公开了依托度酸和其他四氢吡喃吲哚衍生物的对映异构体外消旋化的方法。

36. 发明申请

WO2005069427A1 MIKROWELLENLEITENDE ANORDNUNG 审中-公开
标题翻译：微波引导装置
公开(公告)号：WO2005069427A1
公开(公告)日：2005-07-28
申请号：PCT/EP2005/050211
申请日：2005-01-19
申请人： ENDRESS+HAUSER GMBH+CO. KG , CHEN, Qi , FEISST, Klaus , BERGMANN, Eric , HAMMER, Manfred
发明人： CHEN, Qi , FEISST, Klaus , BERGMANN, Eric , HAMMER, Manfred
IPC分类号： H01P3/14
CPC分类号： H01P1/16 , Y10T29/49016
摘要： Um eine relativ einfach und damit kostengünstig zu fertigende mikrowellenleitende Anordnung zu schaffen, die sich auch für komplexe Strukturen und Geometrien eignet, schlägt die Erfindung vor, auf einem nichtleitenden Körper (12) mit einer beliebig geformten Oberfläche eine oder mehrere elektrisch leitende Schichten (14) aufzubringen. Eine dazu vorgesehene Metallisierung der Oberfläche des Körpers wird beispielsweise durch ein Aufdampfverfahen, mittels eines Flammspritzverfahrens mittels einer chemischer Metallisierung hergestellt.
摘要翻译：为了提供相对简单，因此制造成本低微波传导装置，其适于复杂的结构和几何形状，本发明提出，在非导电的本体（12）具有一个或多个导电层的任意形状的表面（14）应用。提供了一种用于所述主体的所述表面的该目的金属化A由Aufdampfverfahen产生例如，由火焰通过化学金属化的手段喷涂工艺的装置。

37. 发明申请

WO0067746A8 CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS 审中-公开
标题翻译：阻止整合素与其受体结合的羧酸衍生物
公开(公告)号：WO0067746A8
公开(公告)日：2002-02-28
申请号：PCT/US0012303
申请日：2000-05-05
申请人： TEXAS BIOTECHNOLOGY CORP , BIEDIGER RONALD J , CHEN QI , HOLLAND GEORGE W , KASSIR JAMAL M , LI WEN , MARKET ROBERT V , SCOTT IAN L , WU CHENGDE
发明人： BIEDIGER RONALD J , CHEN QI , HOLLAND GEORGE W , KASSIR JAMAL M , LI WEN , MARKET ROBERT V , SCOTT IAN L , WU CHENGDE
IPC分类号： C07D239/36 , A61K31/215 , A61K31/216 , A61K31/335 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/4015 , A61K31/4025 , A61K31/44 , A61K31/4409 , A61K31/4412 , A61K31/4427 , A61K31/445 , A61K31/4523 , A61K31/47 , A61K31/506 , A61K31/55 , A61P1/00 , A61P3/10 , A61P9/10 , A61P11/06 , A61P17/00 , A61P19/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C69/66 , C07C275/32 , C07C275/34 , C07D207/04 , C07D207/18 , C07D207/416 , C07D211/68 , C07D211/72 , C07D213/02 , C07D213/64 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D215/00 , C07D215/38 , C07D221/04 , C07D233/96 , C07D239/46 , C07D239/47 , C07D317/58 , C07D333/20 , C07D401/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07D487/04
CPC分类号： C07D213/75 , C07D239/47 , C07D405/12 , C07D409/14
摘要： A method for the inhibition of the binding of alpha 4 beta 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which alpha 4 beta 1 is involved.
摘要翻译：抑制α4β1整联蛋白与其受体结合的方法，例如VCAM-1（血管细胞粘附分子-1）和纤连蛋白; 抑制这种结合的化合物; 包含这些化合物的药物活性组合物; 以及如上所述的这种化合物的使用，或用于控制或预防涉及α4β1的疾病状态的制剂中。

38. 发明申请

WO2013025286A1 RECOMBINANT BACTERIA HAVING IMPROVED SUCROSE UTILIZATION 审中-公开
标题翻译：具有改良SUCROSE利用的重组细菌
公开(公告)号：WO2013025286A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/044088
申请日：2012-06-25
申请人： E. I. du Pont de Nemours and Company , CHEN, Qi , CHENG, Qiong , LAI, Jian Ping , RUEBLING-JASS, Kristin
发明人： CHEN, Qi , CHENG, Qiong , LAI, Jian Ping , RUEBLING-JASS, Kristin
IPC分类号： C12N1/21 , C12N15/55 , C12N15/54 , C12P7/64 , C12P7/18 , C12P7/52
CPC分类号： C12P7/18 , C07K14/245 , C12N9/1051 , C12N9/1205 , C12N9/2431 , C12P7/20 , C12P7/42
摘要： Recombinant bacteria having an improved ability to utilize sucrose are provided. These recombinant bacteria have nucleotide sequences encoding sucrose utilization polypeptides integrated into their genome between the yihP gene or its homolog and the yihO gene or its homolog. Additionally, methods of utilizing the recombinant bacteria to produce products such as glycerol and glycerol-derived products are provided.
摘要翻译：提供了具有改善的利用蔗糖能力的重组细菌。这些重组细菌具有编码在yihP基因或其同源物和yihO基因或其同源物之间整合到其基因组中的蔗糖利用多肽的核苷酸序列。此外，提供了利用重组细菌产生产物如甘油和甘油衍生产物的方法。

39. 发明申请

WO2012067933A3 RECOMBINANT ESCHERICHIA COLI HAVING ENHANCED ACETYL-COENZYME A SYNTHETASE ACTIVITY FOR PRODUCING GLYEROL AND GLYCEROL-DERIVED PRODUCTS 审中-公开
标题翻译：重组大肠杆菌具有增强的乙酰辅酶A合成酶活性用于生产甘油和甘油衍生产物
公开(公告)号：WO2012067933A3
公开(公告)日：2012-07-12
申请号：PCT/US2011060137
申请日：2011-11-10
申请人： DU PONT , CHEN QI , CHENG QIONG , ELIOT ANDREW C , RUEBLING-JASS KRISTIN
发明人： CHEN QI , CHENG QIONG , ELIOT ANDREW C , RUEBLING-JASS KRISTIN
IPC分类号： C12N1/21 , C12N15/52 , C12N15/70 , C12P7/18 , C12P7/20 , C12P7/52
CPC分类号： C12P7/20 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/52 , C12Y602/01001
摘要： Recombinant E. coli having enhanced acetyl-CoA synthetase activity and the ability to produce glycerol and glycerol-derived products, such as 3-hydroxypropionic acid, methylglyoxal, 1,2-propanediol, and 1,3-propanediol, are described. The recombinant E. coli comprise a promoter operably linked to a nucleotide sequence encoding a polypeptide having acetyl-CoA synthetase enzyme activity, wherein the promoter and nucleotide sequence are each independently either native or non-native.
摘要翻译：描述了具有增强的乙酰-CoA合成酶活性和产生甘油和甘油衍生产物如3-羟基丙酸，甲基乙二醛，1,2-丙二醇和1,3-丙二醇的能力的重组大肠杆菌。重组大肠杆菌包含与编码具有乙酰-CoA合成酶活性的多肽的核苷酸序列可操作连接的启动子，其中启动子和核苷酸序列各自独立地为天然或非天然。

40. 发明申请

WO2012021591A1 HEPATITIS C VIRUS INHIBITORS 审中-公开
公开(公告)号：WO2012021591A1
公开(公告)日：2012-02-16
申请号：PCT/US2011/047211
申请日：2011-08-10
申请人： BRISTOL-MYERS SQUIBB COMPANY , BELEMA, Makonen , SRINIVASU, Pothukanuri , BENDER, John A. , LOPEZ, Omar D. , CHEN, Qi , RAMPULLA, Richard A. , GUPTA, Samayamunthula Venkata Satya Arun Kumar , MEANWELL, Nicholas A.
发明人： BELEMA, Makonen , SRINIVASU, Pothukanuri , BENDER, John A. , LOPEZ, Omar D. , CHEN, Qi , RAMPULLA, Richard A. , GUPTA, Samayamunthula Venkata Satya Arun Kumar , MEANWELL, Nicholas A.
IPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04 , A61K31/4178 , A61K31/433 , A61P31/12
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式