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31. 发明申请

US20110136136A1 Methods For Detection Of Hydrophobic Drugs 有权
标题翻译：疏水药物检测方法
公开(公告)号：US20110136136A1
公开(公告)日：2011-06-09
申请号：US13026756
申请日：2011-02-14
申请人： Tie Q. Wei , Alan Craig , Amy Posey
发明人： Tie Q. Wei , Alan Craig , Amy Posey
IPC分类号： G01N33/53
CPC分类号： G01N33/9493 , Y10S435/962 , Y10S436/815 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/25625
摘要： Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided in a medium. The combination comprises (i) the sample, (ii) a releasing agent for releasing the hydrophobic drug and the metabolites from endogenous binding moieties, and (iii) a selective solubility agent that provides for substantially equal solubility of the hydrophobic drug and the metabolites in the medium. The selective solubility agent comprises a water miscible, non-volatile organic solvent and is present in the medium in a concentration sufficient to provide for substantially equal solubility of the hydrophobic drug and the metabolites in the medium. The medium, which may further comprise a hemolytic agent, is incubated under conditions for releasing the hydrophobic drug and the metabolites from endogenous binding moieties. For conducting an assay for the hydrophobic drug, the above pretreatment is performed and to the medium is added reagents for determining the presence and/or amount of the hydrophobic drug in the sample wherein the reagents comprise at least one antibody for the hydrophobic drug. The medium is examined for the presence of a complex comprising the hydrophobic drug and the antibody for the hydrophobic drug, the presence and/or amount of the complex indicating the presence and/or amount of the hydrophobic drug in the sample.
摘要翻译：公开了用于预处理疑似含有疏水性药物的样品以进行用于检测疏水性药物的测定方法的方法和试剂。在介质中提供组合。组合包括（i）样品，（ii）用于释放疏水性药物的释放剂和来自内源结合部分的代谢物，和（iii）选择性溶解剂，其提供疏水性药物和代谢物在介质。选择性溶解剂包括水混溶性，非挥发性有机溶剂，并且以足以提供疏水性药物和介质中代谢物基本上相等的溶解度的浓度存在于培养基中。可以进一步包含溶血剂的培养基在用于从内源结合部分释放疏水性药物和代谢物的条件下孵育。为了进行疏水性药物的测定，进行上述预处理，向培养基中加入用于测定样品中的疏水性药物的存在和/或量的试剂，其中试剂包含至少一种用于疏水性药物的抗体。检查介质是否存在包含疏水性药物和疏水性药物抗体的复合物，表明该样品中疏水性药物的存在和/或量的存在和/或数量。

32. 发明申请

US20060105472A1 Reduction of non-specific binding in assays 有权
公开(公告)号：US20060105472A1
公开(公告)日：2006-05-18
申请号：US10989677
申请日：2004-11-16
申请人： Zhu Teng , Jeffrey Moore , Alan Craig , Gary Hickey , Carsten Schelp , Tie Wei
发明人： Zhu Teng , Jeffrey Moore , Alan Craig , Gary Hickey , Carsten Schelp , Tie Wei
IPC分类号： G01N33/543 , C07K14/765
CPC分类号： G01N33/548 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.

33. 发明授权

US06930999B1 Scalable voice over IP system providing independent call bridging for outbound calls initiated by user interface applications 有权
标题翻译：可扩展的IP语音系统，为用户界面应用程序发起的出站呼叫提供独立的呼叫桥接
公开(公告)号：US06930999B1
公开(公告)日：2005-08-16
申请号：US09606692
申请日：2000-06-30
申请人： James Alan Craig , Kelly Wycall Phillips , Narasimha K. Nayak
发明人： James Alan Craig , Kelly Wycall Phillips , Narasimha K. Nayak
IPC分类号： H04J3/16 , H04J3/22 , H04L12/16 , H04L12/66 , H04L29/06 , H04M1/64 , H04M3/533 , H04M3/58 , H04M7/00 , H04Q11/00
CPC分类号： H04L29/06027 , H04L65/1009 , H04L65/1026 , H04L65/103 , H04L65/1036 , H04L65/104 , H04L65/608 , H04L65/80 , H04M3/533 , H04M3/53333 , H04M3/58
摘要： An IP telephony gateway and a user interface resource enable a subscriber to place an outgoing call according to the voice over IP (H.323) protocol to a destination party from a user interface session of an intelligent dial tone service such as voice activated dialing, and resume the user interface session upon completion of the outgoing call with the destination party. The IP telephony gateway establishes a user interface session for the subscriber with the user interface resource across a first Real Time Protocol (RTP) data stream. The user interface resource initiates a second RTP data stream to a destination party in response to reception of a prescribed command from the subscriber. Although an RTP bridge connecting the first and second RTP data streams can be maintained by the user interface resource, the user interface resource may also use the Empty Capability Set feature in the H.323 standard to cause the IP telephony gateway to close the first and second RTP data streams to the user interface resource. The user interface resource then issues Non-Empty Capability Set messages to the IP telephony gateway for the first and second RTP data streams, causing the IP telephony gateway to internally bridge the first and second RTP data streams. The user interface resource monitors connections between the subscriber and the destination party, and upon detecting a disconnect by the destination party causes the IP telephony gateway to resume the user interface session, by repeating the sequence of sending Empty Capability Set and Non-Empty Capability Set messages to the IP telephony gateway to break down the bridge and re-establish the connection between the subscriber and the user interface resource.
摘要翻译： IP电话网关和用户接口资源使订户能够根据IP语音（H.323）协议将出呼叫从智能拨号音服务的用户接口会话（例如语音激活拨号）发送到目的地，并且在与目标方进行呼出完成时恢复用户界面会话。 IP电话网关通过第一实时协议（RTP）数据流为用户建立与用户接口资源的用户接口会话。响应于从订户接收到规定的命令，用户接口资源向目的地发起第二RTP数据流。虽然连接第一和第二RTP数据流的RTP桥可以由用户界面资源来维护，但是用户接口资源也可以使用H.323标准中的空能力集特征来使得IP电话网关关闭第一和第第二RTP数据流到用户界面资源。然后，用户接口资源向第一和第二RTP数据流的IP电话网关发出非空能力设置消息，导致IP电话网关内部桥接第一和第二RTP数据流。用户接口资源监视用户和目的方之间的连接，并且在检测到目的方之间的断开连接时，通过重复发送空能力集和非空能力集的顺序使得IP电话网关恢复用户界面会话消息到IP电话网关，以分解网桥并重新建立用户和用户界面资源之间的连接。

34. 发明授权

US5836837A Apparatus for circular court ball game 失效
公开(公告)号：US5836837A
公开(公告)日：1998-11-17
申请号：US792547
申请日：1996-11-06
申请人： Gregory Alan Craig
发明人： Gregory Alan Craig
IPC分类号： A63B63/00 , A63B63/08 , A63B67/00
CPC分类号： A63B67/002 , A63B2063/001 , A63B63/083
摘要： An apparatus for use in a round ball rebounding game played on a circular court consisting of a spherical structure supported by a single pole and having a plurality of goals placed at equidistant intervals about the maximum horizontal diameter of the sphere and parallel to the playing surface. The apparatus further comprising a plurality of discharge tubes inserted into the bottom of the sphere, said number of tubes corresponding to the number of goals. Openings are further cut into the sphere relative to the position of each goal such that a net attached to the bottom of each goal can direct a round ball into the interior of the sphere with the ball eventually departing the bottom of the sphere through one of the discharge tubes which then deposit the ball at the base of the structure along the playing surface.

35. 发明授权

US08478828B2 Methods, systems, and computer readable media for inter-diameter-message processor routing 有权
标题翻译：用于直径间消息处理器路由的方法，系统和计算机可读介质
公开(公告)号：US08478828B2
公开(公告)日：2013-07-02
申请号：US13025968
申请日：2011-02-11
申请人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
发明人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
IPC分类号： G06F15/16
CPC分类号： H04L45/028 , H04L43/0805 , H04L45/28 , H04L45/304 , H04L45/34 , H04L45/60 , H04L63/0892 , H04L69/08
摘要： According to one aspect, the subject matter described herein includes a method for routing Diameter messages. The method includes steps occurring at a Diameter signaling router (DSR) comprising a plurality of Diameter message processors. The method also includes receiving, by a first of the plurality of Diameter message processors and from a first Diameter node, a Diameter message, wherein the Diameter message is received via a first Diameter connection. The method further includes determining, by the first Diameter message processor, a next-hop Diameter node for the Diameter message. The method further includes communicating, by the first of the plurality of Diameter message processors and to a second of the plurality of Diameter message processors, the Diameter message. The method further includes communicating, by the second Diameter message processor and to the next-hop Diameter node, the Diameter message, wherein the Diameter message is communicated via a second Diameter connection.
摘要翻译：根据一个方面，本文描述的主题包括用于路由Diameter消息的方法。该方法包括在包括多个Diameter消息处理器的Diameter信令路由器（DSR）处发生的步骤。该方法还包括由多个Diameter消息处理器中的第一个和第一Diameter节点接收Diameter消息，其中Diameter消息经由第一Diameter连接被接收。该方法还包括由第一Diameter消息处理器确定Diameter消息的下一跳Diameter节点。该方法还包括由多个Diameter消息处理器中的第一个和多个Diameter消息处理器中的第二个Diameter消息进行通信。该方法还包括由第二Diameter消息处理器和下一跳Diameter节点通信Diameter消息，其中Diameter消息经由第二Diameter连接来传送。

36. 发明申请

US20110202684A1 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR INTER-DIAMETER-MESSAGE PROCESSOR ROUTING 有权
标题翻译：用于直径信息处理器路由的方法，系统和计算机可读介质
公开(公告)号：US20110202684A1
公开(公告)日：2011-08-18
申请号：US13025968
申请日：2011-02-11
申请人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
发明人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
IPC分类号： G06F15/16
CPC分类号： H04L45/028 , H04L43/0805 , H04L45/28 , H04L45/304 , H04L45/34 , H04L45/60 , H04L63/0892 , H04L69/08
摘要： According to one aspect, the subject matter described herein includes a method for routing Diameter messages. The method includes steps occurring at a Diameter signaling router (DSR) comprising a plurality of Diameter message processors. The method also includes receiving, by a first of the plurality of Diameter message processors and from a first Diameter node, a Diameter message, wherein the Diameter message is received via a first Diameter connection. The method further includes determining, by the first Diameter message processor, a next-hop Diameter node for the Diameter message. The method further includes communicating, by the first of the plurality of Diameter message processors and to a second of the plurality of Diameter message processors, the Diameter message. The method further includes communicating, by the second Diameter message processor and to the next-hop Diameter node, the Diameter message, wherein the Diameter message is communicated via a second Diameter connection.
摘要翻译：根据一个方面，本文描述的主题包括用于路由Diameter消息的方法。该方法包括在包括多个Diameter消息处理器的Diameter信令路由器（DSR）处发生的步骤。该方法还包括由多个Diameter消息处理器中的第一个和第一Diameter节点接收Diameter消息，其中Diameter消息经由第一Diameter连接被接收。该方法还包括由第一Diameter消息处理器确定Diameter消息的下一跳Diameter节点。该方法还包括由多个Diameter消息处理器中的第一个和多个Diameter消息处理器中的第二个Diameter消息进行通信。该方法还包括由第二Diameter消息处理器和下一跳Diameter节点通信Diameter消息，其中Diameter消息经由第二Diameter连接来传送。

37. 发明申请

US20110200054A1 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PROVIDING LOCAL APPLICATION ROUTING AT A DIAMETER NODE 有权
标题翻译：方法，系统和计算机可读介质，用于在直径节点上提供本地应用路由
公开(公告)号：US20110200054A1
公开(公告)日：2011-08-18
申请号：US13026098
申请日：2011-02-11
申请人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , Thomas M. McCann , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
发明人： Jeffrey Alan Craig , Mark Edward Kanode , Kedar Kashinath Karmarkar , Thomas M. McCann , David Michael Sprague , Mahesh Tomar , Donald E. Wallace
IPC分类号： H04L12/56
CPC分类号： H04L45/028 , H04L43/0805 , H04L45/28 , H04L45/304 , H04L45/34 , H04L45/60 , H04L63/0892 , H04L69/08
摘要： Methods, systems, and computer readable media for providing local application routing at a Diameter node are disclosed. One method includes receiving, at an ingress Diameter message processor associated with a Diameter signaling router (DSR), a Diameter message from a peer Diameter element. At the ingress Diameter message processor, application routing data is accessed to determine whether processing of the Diameter message by a Diameter application is required. In response to determining that Diameter application processing is required, the Diameter message is forwarded to a Diameter message processor hosting a Diameter application identified by the application routing data for processing. In response to determining that Diameter application processing is not required, the Diameter message is forwarded to an egress Diameter message processor associated with the DSR.
摘要翻译：公开了用于在Diameter节点处提供本地应用路由的方法，系统和计算机可读介质。一种方法包括在与Diameter信令路由器（DSR）相关联的入口Diameter消息处理器处接收来自对等Diameter元素的Diameter消息。在入口Diameter消息处理器处，访问应用路由数据，以确定是否需要Diameter应用程序处理Diameter消息。响应于确定需要Diameter应用处理，Diameter消息被转发到承载由应用程序路由数据标识的Diameter应用程序进行处理的Diameter消息处理器。响应于确定不需要Diameter应用处理，Diameter消息被转发到与DSR相关联的出口Diameter消息处理器。

38. 发明授权

US07508609B2 Formatted storage media providing space for encrypted text and dedicated space for clear text 有权
标题翻译：格式化的存储介质为加密文本提供空间，并为明文提供专用空间
公开(公告)号：US07508609B2
公开(公告)日：2009-03-24
申请号：US11586259
申请日：2006-10-25
申请人： Jeff Robert Boyton , Matthew Thomas Starr , Stuart Alan Craig
发明人： Jeff Robert Boyton , Matthew Thomas Starr , Stuart Alan Craig
IPC分类号： G11B5/09
CPC分类号： G11B20/00086 , G11B20/00115 , G11B20/0021 , G11B20/00253 , G11B20/1201 , G11B2220/90
摘要： A storage library is provided for formatting a mobile data storage element, such as a tape, with a first space dedicated for clear text or text as received by a host, such as an Independent Software Vender, wherein the first space is intended to accommodate header information which includes attributes about the mobile storage element. The data storage element is also formatted with a second space for storing encrypted or conditioned user data. The storage library further generally includes an encryption engine for encrypting data received from a host computer, a plurality of data storage elements, and at least two drives for storing data on the data storage elements.
摘要翻译：提供存储库，用于格式化诸如磁带的移动数据存储元件，其具有专用于诸如独立软件供应商的主机所接收的明文或文本的第一空间，其中第一空间用于容纳标题包括关于移动存储元件的属性的信息。数据存储元件也被格式化为用于存储加密或调节的用户数据的第二空间。存储库还通常包括用于加密从主计算机接收的数据的加密引擎，多个数据存储元件以及用于在数据存储元件上存储数据的至少两个驱动器。

39. 发明申请

US20080217322A1 Printing Plate Ovens 审中-公开
标题翻译：印版烤箱
公开(公告)号：US20080217322A1
公开(公告)日：2008-09-11
申请号：US10577788
申请日：2004-10-28
申请人： Alan Craig Nicholl , John Cruse
发明人： Alan Craig Nicholl , John Cruse
IPC分类号： H05B3/06
CPC分类号： B41C1/10 , B41C1/1075 , B41C1/1083 , G03F7/40
摘要： The present invention relates to a printing plate oven 10 designed for lithographic printing plates and, in particular, for baking Kodak DITP gold printing plates. The printing plates oven comprises heating apparatus including a number of heating elements which extend at an angle relative to the direction of a printing plate passing through the oven. The printing plate oven also comprises drive means for driving the printing plates in which two rollers are urged towards each other on either side of the printing plates but the rollers are profiled such that they do not simultaneously contact a part of the printing plate at directly opposite locations. The printing oven includes cooling means which comprise deflecting means in order to flex a part of the printing plate during cooling. Furthermore, the heating elements of the printing oven are controlled in order to vary the heat applied to the printing plate depending upon the position of the printing plate.
摘要翻译：本发明涉及设计用于平版印刷版的印版烘箱10，特别是用于烘焙柯达DITP金印版。印版烘箱包括加热装置，其包括多个加热元件，这些加热元件相对于通过烘箱的印版的方向以一定角度延伸。印版烘箱还包括用于驱动印版的驱动装置，其中两个辊在印版的任一侧被朝向彼此推压，但是辊被成型，使得它们不与印刷板的一部分直接相对地接触位置。印刷烘箱包括冷却装置，其包括偏转装置，以便在冷却期间使印版的一部分弯曲。此外，控制印刷炉的加热元件，以便根据印刷版的位置改变施加到印刷版的热量。

40. 发明申请

US20070122850A1 Reduction of Non-Specific Binding in Assays 有权
标题翻译：测定中非特异性结合的降低
公开(公告)号：US20070122850A1
公开(公告)日：2007-05-31
申请号：US11619244
申请日：2007-01-03
申请人： Zhu Teng , Jeffrey Moore , Alan Craig , Gary Hickey , Carsten Schelp , Tie Wei
发明人： Zhu Teng , Jeffrey Moore , Alan Craig , Gary Hickey , Carsten Schelp , Tie Wei
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/548 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
摘要翻译：公开了用于在用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的试剂之一包含含有多糖的固体支持物。该方法包括在用于进行结合测定的测定培养基中包含可与多糖连接的蛋白质的可溶性化合物。还公开了用于确定疑似含有分析物的样品中分析物的存在和/或量的方法和组合物。所述方法包括作为试剂的固体支持物，其包含多糖和包含与多糖连接的蛋白质的可溶性化合物。

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