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31. 发明专利

CA2784767A1 HUMANIZED ANTIBODIES 未知
公开(公告)号：CA2784767A1
公开(公告)日：2011-07-07
申请号：CA2784767
申请日：2011-01-04
申请人： ARGEN X BV
发明人： DREIER TORSTEN , DE HAARD JOHANNES JOSEPH WILHELMUS
IPC分类号： C07K16/24 , C07K16/46
摘要： The disclosure relates to humanized antibodies derived from the conventional antibody repertoire of species in the family Camelidae. In particular, the disclosure provides an antibody comprising a camelid VH domain and a camelid VL domain of either the lambda light chain class or the kappa light chain class, characterised in that at least one humanising amino acid substitution is present in the VH domain and/or the VL domain.

32. 发明专利

CA2728076A1 ANTIGEN BINDING POLYPEPTIDES 未知
公开(公告)号：CA2728076A1
公开(公告)日：2010-01-07
申请号：CA2728076
申请日：2009-07-02
申请人： ARGEN X BV
发明人： DREIER TORSTEN , BLANCHETOT CHRISTOPHE FREDERIC JEROME , DE HAARD JOHANNES JOESPH WILHELMUS
IPC分类号： C07K16/00 , C07K16/24
摘要： The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to antigen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.

33. 发明专利

CA2728076C ANTIGEN BINDING POLYPEPTIDES 未知
公开(公告)号：CA2728076C
公开(公告)日：2020-05-19
申请号：CA2728076
申请日：2009-07-02
申请人： ARGEN X BV
发明人： DREIER TORSTEN , BLANCHETOT CHRISTOPHE FREDERIC JEROME , DE HAARD JOHANNES JOESPH WILHELMUS
IPC分类号： C07K16/00 , C07K16/24
摘要： The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to anti-gen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.

34. 发明专利

BR112013021562A2 anticorpos para cd70 未知
公开(公告)号：BR112013021562A2
公开(公告)日：2016-11-08
申请号：BR112013021562
申请日：2012-03-16
申请人： ARGEN X BV
发明人： WAJANT HARALD , HAARD JOHANNES JOSEPH WILHELMUS DE , SILENCE KAREN , MOSHIR MAHAN , SAUNDERS MICHAEL JOHN SCOTT , ULRICHTS PETER , GABRIELS SOFIE MARIA ELVIRE , DREIER TORSTEN
IPC分类号： C07K16/28
摘要： anticorpos para cd70 a presente invenção refere-se a anticorpos e fragmentos de ligação ao antígeno dos mesmos que se ligam à proteína cd70 humana com elevada afinidade e exibem inibição potente de crescimento de células de tumor.

35. 发明专利

ECSP14029713A MOLÉCULAS DE UNIÓN IL-6 未知
公开(公告)号：ECSP14029713A
公开(公告)日：2015-09-30
申请号：ECPI201429713
申请日：2014-12-03
申请人： ARGEN X BV
发明人： BLANCHETOT CHRISTOPHE , DREIER TORSTEN , DE HAARD JOHANNES , VAN DER WONING SEBASTIAN , DE JONGE NATALIE , ONGENAE NICOLAS
IPC分类号： C07K16/24 , A61K39/395
摘要： La presente invención proporciona moléculas de unión (por ejemplo, anticuerpos o fragmentos de unión a antígeno de los mismos) que se unen específicamente a e inhiben la actividad biológica de IL-6 (por ejemplo, IL-6 humana, IL-6 de ratón e IL-6 de primate no humano). En una realización preferida, los anticuerpos o fragmentos de unión a antígeno de la invención se unen a la IL-6 e inhiben su unión a un receptor de IL-6. Tales anticuerpos o fragmentos de unión a antígeno son particularmente útiles para el tratamiento de enfermedades o trastornos asociados a IL-6 (por ejemplo, enfermedades inflamatorias y cáncer).

36. 发明专利

GB201414823D0 Multispecific antibodies 未知
公开(公告)号：GB201414823D0
公开(公告)日：2014-10-01
申请号：GB201414823
申请日：2014-08-20
申请人： ARGEN X BV
摘要： The present invention relates to multispecific antibodies, for example bispecific antibodies, and methods for the isolation or purification of the same. The antibodies of the invention comprise first and second heavy chain-light chain pairings wherein each pairing comprises a distinct selective recognition site including one or more amino acid residues contributed from the heavy chain and the light chain of the pairing. The first and second selective recognition sites differ by at least one amino acid residue and can be differentially bound by first and second selective recognition agents according to the methods of the invention. Such methods facilitate the production of antibody preparations enriched for multispecific antibodies having the correct functional heavy chain-light chain pairings.

38. 发明专利

AU2011325097A1 Anti c-Met antibodies 未知
公开(公告)号：AU2011325097A1
公开(公告)日：2013-05-02
申请号：AU2011325097
申请日：2011-11-03
申请人： ARGEN X BV
发明人： HULTBERG ANNA , SAUNDERS MICHAEL , DE HAARD JOHANNES , FESTJENS ELS , DE JONGE NATALIE , MICHIELI PAULO , BASILICO CRISTINA , DREIER TORSTEN
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

40. 发明专利

CA2816745A1 ANTI C-MET ANTIBODIES 未知
公开(公告)号：CA2816745A1
公开(公告)日：2012-05-10
申请号：CA2816745
申请日：2011-11-03
申请人： ARGEN X BV
发明人： HULTBERG ANNA , SAUNDERS MICHAEL , DE HAARD JOHANNES , FESTJENS ELS , DE JONGE NATALIE , MICHIELI PAULO , BASILICO CRISTINA , DREIER TORSTEN
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.

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