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31. 发明申请

WO2012087616A2 POLYMER SUBSTRATES HAVING IMPROVED BIOLOGICAL RESPONSE FROM HKDCS 审中-公开
标题翻译：聚合物基质具有来自HKDCS的改进生物反应
公开(公告)号：WO2012087616A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/064207
申请日：2011-12-09
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , COOPER, Kevin, L. , MARTIN, Alisha , NATARAJAN, Sriram , VETRECIN, Robert , LIU, Changdeng
发明人： COOPER, Kevin, L. , MARTIN, Alisha , NATARAJAN, Sriram , VETRECIN, Robert , LIU, Changdeng
IPC分类号： C08J3/28
CPC分类号： C08J3/28 , B29C59/14 , C08J7/12 , Y10T428/24355
摘要： A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as medical devices.
摘要翻译：公开了使用RF等离子体处理对生物相容性生物可降解聚合物基材进行表面改性的方法。这种方法和所产生的表面提供了增强的细胞如hKDC的粘附和增殖，并且可以与用于组织再生的支架以及与其他递送载体如医疗装置一起使用。

32. 发明申请

WO2012044538A1 MEDICAL DEVICES WITH GALVANIC PARTICULATES 审中-公开
标题翻译：具有气雾颗粒的医疗装置
公开(公告)号：WO2012044538A1
公开(公告)日：2012-04-05
申请号：PCT/US2011/052985
申请日：2011-09-23
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , CHOI, Jennifer, Hagyoung, Kang , YANG, Chunlin , SUN, Ying , MING, Xintian , HAUSCHILD, James, E. , BAR, Saumen, N. , CICHOCKI, Frank, R., Jr , CHANTALAT, Jeannetee , FANG, Carrie, H.
发明人： CHOI, Jennifer, Hagyoung, Kang , YANG, Chunlin , SUN, Ying , MING, Xintian , HAUSCHILD, James, E. , BAR, Saumen, N. , CICHOCKI, Frank, R., Jr , CHANTALAT, Jeannetee , FANG, Carrie, H.
IPC分类号： A61N1/20 , A61F2/28 , A61L27/24
CPC分类号： A61N1/205 , A61F2/28 , A61F2002/30051 , A61F2310/00359 , A61F2310/0097 , A61L27/24 , A61L27/446 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/102 , A61L2300/104 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/45 , A61L2300/622 , A61L2430/02 , A61N1/306
摘要： Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting. The medical devices may be used as bone implants.
摘要翻译：公开了具有电偶颗粒的可植入医疗装置。颗粒可以涂覆在医疗装置的表面的至少一部分上。此外，电化学颗粒可以包含在用于制造抗微生物医疗装置的材料中，或者可以嵌入医疗装置的表面中。本发明还提供了新的涂布方法和加工方法。该装置可具有促进抗微生物，消炎和组织再生的有利特征和作用。医疗装置可以用作骨植入物。

33. 发明申请

WO2012030570A1 ADHESIVE STRUCTURE WITH STIFF PROTRUSIONS ON ADHESIVE SURFACE 审中-公开
标题翻译：粘合表面粘结结构
公开(公告)号：WO2012030570A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/048584
申请日：2011-08-22
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATARAJAN, Sriram , COOPER, Kevin , ELMOUELHI, Noha , VYAKARNAM, Murty, N. , YEE, Low, Hong , RODRIGUEZ, Isabel , TIONG, Lim, Chee , YEE, Audrey, Ho Yoke
发明人： NATARAJAN, Sriram , COOPER, Kevin , ELMOUELHI, Noha , VYAKARNAM, Murty, N. , YEE, Low, Hong , RODRIGUEZ, Isabel , TIONG, Lim, Chee , YEE, Audrey, Ho Yoke
IPC分类号： C09J7/00 , A61B17/08 , A61L31/04 , A61L31/06 , A61F2/00 , B29C33/52
CPC分类号： C09J7/00 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L24/106 , B29C33/424 , B29C33/52 , C09J2201/626 , C09J2423/106 , C09J2467/006 , Y10T428/24008 , C08L67/04 , C08L23/12
摘要： An adhesive structure is provided comprising a surface from which extend substantially cylindrical protrusions comprising a stiff resin having a Young's modulus of greater than 17 MPa. The protrusions are of sufficiently low diameter to promote adhesion by physical attractive forces, e.g., Van der Waals attractive forces, as measured by shear adhesion between the adhesive structure and a target surface. A method for preparing the structure is provided as well as a combination of the adhesive structure and target surface.
摘要翻译：提供了一种粘合剂结构，其包括表面，从该表面延伸出基本上圆柱形的突起，其包括具有大于17MPa的杨氏模量的刚性树脂。突起具有足够低的直径，以通过物理吸引力（例如，通过粘合剂结构和目标表面之间的剪切粘合力测量的范德华力吸引力）来促进粘附。提供了制备该结构的方法以及粘合剂结构和目标表面的组合。

34. 发明申请

WO2011087722A1 OXIDIZED REGENERATED CELLULOSE ADHESIVE TAPE 审中-公开
标题翻译：氧化再生纤维素胶粘带
公开(公告)号：WO2011087722A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/061057
申请日：2010-12-17
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , GENSINI, Michel , GONZALEZ, Sandra
发明人： GENSINI, Michel , GONZALEZ, Sandra
IPC分类号： A61L15/28 , A61L15/58 , A61L26/00
CPC分类号： A61L15/58 , A61L15/28 , A61L24/06 , A61L26/0023 , C08L1/04 , C08L35/04
摘要： A novel ORC adhesive tape is disclosed. Specifically, the ORC adhesive tape is useful as an alternative to conventional mechanical and non- mechanical wound closure means. The ORC tape has a tape substrate made from neutralized ORC and it contains an adhesive composition such as a bioabsorbable alpha-cyanoacrylate.
摘要翻译：公开了一种新型的ORC胶粘带。具体地说，ORC胶带可用作常规机械和非机械伤口闭合装置的替代。 ORC带具有由中和的ORC制成的带基材，并且其包含粘合剂组合物，例如生物可吸收的α-氰基丙烯酸酯。

35. 发明申请

WO2011008496A2 A DEVICE FOR REPAIR OF UROLOGICAL STRUCTURES 审中-公开
标题翻译：一种修复尿路结构的装置
公开(公告)号：WO2011008496A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/040209
申请日：2010-06-28
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , SHETTY, Dhanuraj, S. , DONNERS, Jackie, J. , DHANURAJ, Sridevi , GEESIN, Jeffrey, C.
发明人： SHETTY, Dhanuraj, S. , DONNERS, Jackie, J. , DHANURAJ, Sridevi , GEESIN, Jeffrey, C.
IPC分类号： A61L27/18
CPC分类号： A61F2/0063 , A61F2/042 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L27/58 , A61L2430/22 , C08L67/04
摘要： A tissue engineering construct made from a nonwoven fabric. The fabric is made from first and second staple fibers. The first staple fibers are made from a first biocompatible, bioabsorbable material, and the second staple fibers are made from a second biocompatible, bioabsorbable material. The first material has a melting temperature lower than the second material. The fabric is formed into a three- dimensional construct suitable for the repair of urinary tract structures.
摘要翻译：由非织造织物制成的组织工程结构。织物由第一和第二短纤维制成。第一短纤维由第一生物相容性生物可吸收材料制成，第二短纤维由第二生物相容的生物可吸收材料制成。第一种材料的熔化温度低于第二种材料。织物形成适合于修复尿道结构的三维结构。

36. 发明申请

WO2013096686A1 DETECTION OF HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开
标题翻译：人类脐带组织细胞的检测
公开(公告)号：WO2013096686A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071072
申请日：2012-12-20
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC
发明人： DORAI, Haimanti , FAVIS, Reyna L. , YAO, Xiang , SUN, Yu , KIHM, Anthony , RASSNICK, Stefanie
IPC分类号： C12N5/071 , G01N33/50
CPC分类号： C12Q1/6888 , G01N33/56972 , G01N33/68 , G01N2333/70589
摘要： The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.
摘要翻译：本发明涉及用于检测血液中同种异体治疗细胞（如人脐带组织衍生细胞（hUTC））的方法。所述方法包括鉴定一种或多种一种或多种同种异体治疗细胞（例如hUTC）阳性的标志物和一种或多种对外周血单核细胞（PBMC）阳性的标志物的步骤; 提供来自已经用同种异体治疗细胞（例如hUTC）治疗的患者的血液样品，使用测定方法分析样品以检测一种或多种对PBMC阳性的标志物和一种或多种同种异体治疗细胞阳性的标志物（例如hUTC） ; 并区分PBMC和同种异体治疗细胞（例如hUTC）阳性的一种或多种标志物。在一个实施方案中，细胞是hUTC，hUTC阳性的标志物包括CD10和/或CD13，并且一个或多个对PBMC阳性的标志物包括CD45。

37. 发明申请

WO2013055983A1 SEGMENTED, EPSILON-CAPROLACTONE-RICH, POLY(EPSILON-CAPROLACTONE-CO-P-DIOXANONE) COPOLYMERS FOR MEDICAL APPLICATIONS AND DEVICES THEREFROM 审中-公开
标题翻译： SEGMENTED，EPSILON-CAPROLACTONE-RICH，POLY（EPSILON-CAPROLACTONE-CO-P-DIOXANONE）用于医疗应用的共聚物及其设备
公开(公告)号：WO2013055983A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059858
申请日：2012-10-12
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , JAMIOLKOWSKI, Dennis D. , ANDJELIC, Sasa , ERNETA, Modesto
发明人： JAMIOLKOWSKI, Dennis D. , ANDJELIC, Sasa , ERNETA, Modesto
IPC分类号： A61L17/10 , A61L31/06 , C08G63/08 , C08G63/664 , A61L17/00
CPC分类号： A61L27/18 , A61K31/09 , A61L17/005 , A61L17/105 , A61L17/12 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/56 , A61L31/06 , A61L31/16 , A61L2300/202 , A61L2300/404 , C08G63/08 , C08G63/664 , C08L67/04
摘要： Novel semi-crystalline, epsilon -caprolactone-rich block copolymers of epsilon -caprolactone and p -dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.
摘要翻译：公开了用于长期吸收医疗应用的ε-己内酯和对二恶烷酮的新型半结晶，ε-己内酯的嵌段共聚物。新型聚合物组合物可用于长期可吸收外科缝合线和其它医疗器械。还公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。

38. 发明申请

WO2012078815A1 SUSTAINED RELEASE IMPLANTS CONTAINING A BIODEGRADABLE POLYMER, CYCLODEXTRIN AND POORLY WATER SOLUBLE ACTIVE COMPOUNDS 审中-公开
标题翻译：含有可生物降解聚合物，环糊精和不溶于水的活性化合物的可持续释放植入物
公开(公告)号：WO2012078815A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063840
申请日：2011-12-07
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , SCHACHTER, Deborah, M. , ZHANG, Qian , VAN REMOORTERE, Peter , LI, Yufu
发明人： SCHACHTER, Deborah, M. , ZHANG, Qian , VAN REMOORTERE, Peter , LI, Yufu
IPC分类号： A61K9/16 , A61K9/00 , A61K47/48
CPC分类号： A61K9/0024 , A61K9/1647 , A61K47/6951 , B82Y5/00 , Y02A50/411
摘要： We have disclosed an implantable sustained release composition comprising, a biocompatible, biodegradable polymer, a cyclodextrin inclusion complex of a poorly water soluble pharmaceutical agent present, and a plasticizer, where the polymer is the minority phase of the formulation. Furthermore, we disclose an implantable sustained release composition that provides a detectable plasma level of an otherwise poorly soluble drug for at least 28 days.
摘要翻译：我们已经公开了一种植入式缓释组合物，其包含生物相容性生物可降解聚合物，存在的水溶性差的药物的环糊精包合物和增塑剂，其中所述聚合物是制剂的少数阶段。此外，我们公开了一种植入式持续释放组合物，其提供可检测的血浆水平的其他难溶性药物至少28天。

39. 发明申请

WO2011041186A1 MAMMARY ARTERY DERIVED CELLS AND METHODS OF USE IN TISSUE REPAIR AND REGENERATION 审中-公开
标题翻译：主动脉导管细胞和组织修复和再生中使用的方法
公开(公告)号：WO2011041186A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049850
申请日：2010-09-22
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , COLTER, David, C. , BUENSUCESO, Charito , KAZANECKI, Christian, C. , GOSIEWSKA, Anna, C.
发明人： COLTER, David, C. , BUENSUCESO, Charito , KAZANECKI, Christian, C. , GOSIEWSKA, Anna, C.
IPC分类号： C12N5/077 , C12N5/0775 , C12N5/074
CPC分类号： C12N5/069 , C12N5/0668 , C12N5/0692 , C12N2509/00
摘要： An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.
摘要翻译：公开了一种分离的哺乳动物内部乳腺动脉来源的细胞。此外，公开了分离哺乳动物内部乳腺动脉的细胞的方法。该细胞可用于组织工程技术，特别是在血管组织工程中。

40. 发明申请

WO2012162452A3 POLYMERIC STRUCTURES FOR ADSORBING BIOLOGICAL MATERIAL AND THEIR METHOD OF PREPARATION 审中-公开
公开(公告)号：WO2012162452A3
公开(公告)日：2012-11-29
申请号：PCT/US2012/039256
申请日：2012-05-24
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC. , AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , ELMOUELHI, Noha , COOPER, Kevin , NATARAJAN, Sriram , LOW, Hong, Yee , RODRIGUEZ, Isabel , LUONG-VAN, Emma, Kim
发明人： ELMOUELHI, Noha , COOPER, Kevin , NATARAJAN, Sriram , LOW, Hong, Yee , RODRIGUEZ, Isabel , LUONG-VAN, Emma, Kim
IPC分类号： B01J20/26 , B01J20/28 , B01J20/30
摘要： A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm - 50 μm and height greater than 1 μm.

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