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31. 发明授权

US10134132B2 Signal processing for intravascular imaging 有权
公开(公告)号：US10134132B2
公开(公告)日：2018-11-20
申请号：US15615130
申请日：2017-06-06
申请人： ACIST Medical Systems, Inc.
发明人： Duc Lam , J Steve Reynolds
IPC分类号： A61B5/00 , G06T7/00 , A61B8/12 , A61B8/08 , A61B5/02 , G01S15/89 , G01S7/52
摘要： An intravascular imaging system includes a transducer capable of generating raw data representative of the structure of a patient's vasculature. The system includes an imaging engine for receiving the raw data and generating enhanced data for presentation to a user. The imaging engine includes a coherence filter, an envelope detection module having one or more envelope detectors, and a spatial filter for processing data in various stages. Such stages of processing in the imaging engine act to reduce high frequency noise, generate low frequency data, reduce low frequency noise, and display low frequency data with an improved signal-to-noise ratio. The system can include an image generator for generating an image based on enhanced data and a display for displaying the generated image.

32. 发明授权

US09610425B2 Endoventricular injection catheter system with integrated echocardiographic capabilities 有权
公开(公告)号：US09610425B2
公开(公告)日：2017-04-04
申请号：US14507438
申请日：2014-10-06
申请人： ACIST Medical Systems, Inc.
发明人： Kendall R. Waters , Thomas C. Moore , Robert Zelenka , Paul Zalesky
IPC分类号： A61B8/14 , A61B8/12 , A61B8/00 , A61M25/00 , A61M25/01 , A61B8/08 , A61M25/06
CPC分类号： A61M25/0133 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/5223 , A61M25/0084 , A61M25/0662 , A61M2025/0089 , A61M2025/0166 , A61M2025/0175 , A61M2025/0681 , A61M2210/125
摘要： Methods of providing image-guided transendocardial injection of a therapeutic agent into a left ventricular wall of a heart. Some methods enable injections into heart tissue under visualization. The methods may include providing an endoventricular injection catheter having integrated echocardiographic capability. The endoventricular injection catheter may have an imaging core and an injection system carried on the elongated body with the imaging core. The method may include positioning the endoventricular injection catheter into the left ventricle of the heart, which inserts the imaging core into the heart. The method may also include transmitting ultrasonic energy via the imaging core, receiving reflected ultrasonic energy at the distal end, visualizing the left ventricular wall of the heart using the imaging core, identifying infarct regions of the left ventricle, and injecting a therapeutic agent into the visualized infarcted regions of the left ventricle using the injection system.

33. 发明授权

US09530955B2 Ultrasound transducer and processing methods thereof 有权
标题翻译：超声换能器及其加工方法
公开(公告)号：US09530955B2
公开(公告)日：2016-12-27
申请号：US13679847
申请日：2012-11-16
申请人： ACIST MEDICAL SYSTEMS, INC.
发明人： Richard Bautista , Robert Zelenka
IPC分类号： H04R31/00 , H01L41/08 , B06B1/06 , H04R1/02 , H04R1/10
CPC分类号： H01L41/0825 , B06B1/067 , H01L41/0805 , H01L41/081 , H01L41/277 , H04R1/023 , H04R1/1016 , H04R1/1091 , H04R31/00 , Y10T29/42
摘要： An ultrasonic transducer includes a backing element, an active element overlying the backing layer, and a matching element overlying the active element, the matching element having an inner surface that contacts the active element and an outer surface with a non-homogeneous texture and/or material composition. The matching element may be formed by subtractive or deposition techniques.
摘要翻译：超声波换能器包括背衬元件，覆盖背衬层的有源元件和覆盖有源元件的匹配元件，匹配元件具有接触有源元件的内表面和具有不均匀纹理的外表面和/或材料组成。匹配元件可以由减法或沉积技术形成。

34. 发明授权

US09427515B1 Monitoring low pressures in high pressure environments 有权
标题翻译：监测高压环境中的低压
公开(公告)号：US09427515B1
公开(公告)日：2016-08-30
申请号：US13800969
申请日：2013-03-13
申请人： ACIST MEDICAL SYSTEMS, INC.
发明人： Sidney Donald Nystrom
IPC分类号： A61B5/02 , A61M5/00
CPC分类号： A61M5/007 , A61M5/16854
摘要： A relatively compact protective apparatus for a pressure sensor includes a diaphragm, a plate, and a sleeve that couples the sensor to the apparatus; the diaphragm, whose perimeter edge is attached to the sleeve between the plate and sleeve, forms a compressible cavity in fluid communication, via an opening in the plate, with another cavity formed between the plate and the coupled sensor. A diameter of the diaphragm is relatively small, so the diaphragm includes an undulating zone for enhanced sensitivity in response to pressure. A configuration of the cavities and the opening allows a contained volume of air to transmit a relatively low pressure, via the diaphragm, to the coupled pressure sensor, yet prevents transmission of relatively high pressures to the pressure sensor. A wall of a system fluid circuit line or a manifold connector may be configured to incorporate the protective apparatus therein.
摘要翻译：用于压力传感器的相对紧凑的保护装置包括将传感器耦合到装置的隔膜，板和套筒; 其周边边缘连接到板和套筒之间的套筒的隔膜通过板中的开口形成流体连通的可压缩空腔，在板和耦合的传感器之间形成另一空腔。隔膜的直径相对较小，因此隔膜包括用于响应于压力增强灵敏度的起伏区域。空腔和开口的构造允许容纳的空气通过隔膜将相对低的压力传递到耦合的压力传感器，但是防止相对高的压力传递到压力传感器。系统流体回路线或歧管连接器的壁可构造成将保护装置并入其中。

35. 发明申请

US20160243306A1 APPARATUS AND METHODS FOR FLUID PRESSURIZING UNITS OF INJECTION SYSTEMS 有权
标题翻译：注射系统流体加压装置及方法
公开(公告)号：US20160243306A1
公开(公告)日：2016-08-25
申请号：US15142367
申请日：2016-04-29
申请人： ACIST MEDICAL SYSTEMS, INC.
发明人： MARTIN G. HIEB , DAVID J. HAJICEK , SIDNEY D. NYSTROM
IPC分类号： A61M5/20 , A61M5/315 , A61L31/04 , A61M5/00
CPC分类号： A61M5/2053 , A61L31/048 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/31511 , A61M5/31513 , A61M5/31515 , A61M5/484 , A61M5/5066 , Y10T29/49815 , Y10T29/49826
摘要： An injection system includes a syringe, which preferably includes larger and smaller inner diameters, and a plunger. A wiper sidewall of the plunger defines a cavity, into which a plunger shaft of the system is inserted, for moving the plunger, within the syringe, for fluid injection. The plunger includes a feature for engaging the shaft, and the sidewall preferably includes an expandable-contractible portion, in which the feature is formed. When the plunger is initially mounted within the larger inner diameter of the syringe, the portion of the sidewall is expanded and the feature of the plunger does not operably engage the inserted shaft. When the shaft moves the plunger into the smaller inner diameter of the syringe, the portion of the sidewall contracts and the feature operably engages the shaft. A deformable end wall of the plunger may be spaced apart from a distal terminal end of the inserted shaft.
摘要翻译：注射系统包括优选地包括更大和更小内径的注射器和柱塞。柱塞的擦拭器侧壁限定了一个空腔，系统的柱塞轴插入该空腔中，用于在注射器内移动柱塞，用于流体注射。柱塞包括用于接合轴的特征，并且侧壁优选地包括其中形成特征的可膨胀 - 收缩部分。当柱塞最初安装在注射器的较大内径中时，侧壁的该部分被膨胀，并且柱塞的特征不能与插入的轴可操作地接合。当轴将柱塞移动到注射器的较小内径中时，侧壁的一部分收缩并且该特征可操作地接合轴。柱塞的可变形的端壁可以与插入的轴的远端终端间隔开。

36. 发明申请

US20160022217A1 UNIVERSAL PRESSURE TRANSDUCER MOUNTING DEVICE 审中-公开
公开(公告)号：US20160022217A1
公开(公告)日：2016-01-28
申请号：US14873074
申请日：2015-10-01
申请人： ACIST Medical Systems, Inc.
发明人： John Russell , William J. Taylor
IPC分类号： A61B5/00 , A61B5/0215 , A61M5/00 , G01L19/14
CPC分类号： A61B5/6887 , A61B5/0215 , A61B5/036 , A61B2505/05 , A61M5/007 , G01L7/00 , G01L7/182 , G01L19/14
摘要： A pressure transducer mounting device may include a support member and a pressure transducer holder. In use, the support member may attach to a support surface, such as a housing of a power injection device, while the pressure transducer holder is moveably connected to the support member. The pressure transducer holder may expand open to receive one of a plurality of different sized pressure transducers and bias closed to hold a received one of the plurality of different sized pressure transducers. In addition, the pressure transducer holder may move relative to the support member to one of a plurality of different vertically elevated positions. The pressure transducer mounting device may accommodate different pressure transducers, providing a universal mounting device that can adapt to different medical provider preferences and different pressure transducer sourcing options.

37. 发明授权

US09241641B2 Fiber optic sensor assembly for sensor delivery device 有权
标题翻译：用于传感器传送装置的光纤传感器组件
公开(公告)号：US09241641B2
公开(公告)日：2016-01-26
申请号：US13828452
申请日：2013-03-14
申请人： ACIST Medical Systems, Inc.
发明人： Jason F. Hiltner , Simon Furnish , James Lamar Gray, II , William K. Dierking , Alan Evans
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/0084 , A61B5/02152 , A61B5/02154 , A61B5/6851 , A61B5/6852 , A61B2562/0247 , A61B2562/0266
摘要： Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.
摘要翻译：用于监测血管结构内的流体压力的方法和传感器传送装置，所述装置包括尺寸适于沿着导丝滑动的细长护套，包括光纤传感器的传感器组件，围绕传感器的壳体，远端所述传感器和所述壳体的远端孔口，填充物从所述壳体的至少远端向远侧延伸并朝向所述护套的外表面向内逐渐变细，所述填料中的第二腔在所述壳体的外表面处具有开口填充物并且邻接壳体的远端孔，以及光纤。传感器传送装置还可以包括用第二腔的开口部分地覆盖第二腔的外层。

38. 发明申请

US20150351645A1 PHYSIOLOGICAL SENSOR DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：生理传感器传送装置及方法
公开(公告)号：US20150351645A1
公开(公告)日：2015-12-10
申请号：US14300654
申请日：2014-06-10
申请人： ACIST Medical Systems, Inc.
发明人： Jason F. Hiltner
IPC分类号： A61B5/0215 , A61M25/09 , A61B5/02
CPC分类号： A61B5/02158 , A61B2560/0223 , A61B2562/0247
摘要： Methods of measuring Fractional Flow Reserve (FFR) including advancing a sensor delivery device within a guiding catheter to a location of interest, the sensor delivery device comprising a distal sleeve including a distal sensor and a proximal sensor, advancing only a distal portion of the distal sleeve outside of the guiding catheter such that the distal sensor is outside of the guiding catheter and downstream of the location of interest and the proximal sensor is inside of the guiding catheter, measuring a distal fluid pressure with the distal sensor distal to the location of interest, measuring a reference fluid pressure with the proximal sensor inside of the guiding catheter, and calculating FFR. One or both of the proximal and distal sensor may be comprised of a material having a low thermal coefficient.
摘要翻译：测量分数流量储备（FFR）的方法，包括将引导导管内的传感器输送装置推进到感兴趣的位置，所述传感器输送装置包括远端套筒，所述远端套筒包括远侧传感器和近侧传感器，仅推进远端的远端部分套管在引导导管的外部，使得远端传感器位于引导导管的外部并且在感兴趣的位置的下游，并且近侧传感器位于引导导管的内部，测量与远端传感器远离感兴趣位置的远端流体压力测量引导导管内部的近端传感器的参考流体压力，并计算FFR。近端和远端传感器中的一个或两个可以由具有低热系数的材料构成。

39. 发明授权

US09113843B2 Physiological sensor delivery device and method 有权
标题翻译：生理传感器输送装置及方法
公开(公告)号：US09113843B2
公开(公告)日：2015-08-25
申请号：US14642439
申请日：2015-03-09
申请人： ACIST Medical Systems, Inc.
发明人： Dale R. Manstrom , Amy R. Raatikka , Robert F. Wilson , Edward R. Miller , Jung Kwon Pak
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0215 , A61B5/026 , A61M25/09 , A61B5/0205
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0017 , A61B5/0022 , A61B5/01 , A61B5/02007 , A61B5/02055 , A61B5/0215 , A61B5/02154 , A61B5/02158 , A61B5/0261 , A61B5/145 , A61B5/14552 , A61B5/6851 , A61B5/6853 , A61B5/6862 , A61B5/742 , A61B6/507 , A61B2562/12 , A61M5/007 , A61M25/0029 , A61M25/0067 , A61M25/007 , A61M25/09 , A61M2025/0002 , A61M2025/0034 , A61M2025/0037 , A61M2025/0183 , A61M2025/091
摘要： An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.
摘要翻译：用于测量血管结构或通道内的患者的生理参数（例如血压）的血管内传感器递送装置。在一些实施例中，该装置可用于测量狭窄病变或心脏瓣膜上的压力梯度。例如，这种装置可用于测量跨狭窄病变的分数流量储备（FFR），以评估病变的严重程度。传感器传送装置具有配置成在标准医疗导丝上通过或滑动的远侧套管。距离传感器和远端套筒一些距离，设备与导丝分离，以允许传感器传送装置和导丝的独立控制。传感器传送装置的尺寸可以通过不同尺寸的导丝线，以使得能够在冠状动脉和外周动脉中使用。

40. 发明申请

US20150141853A1 MULTI-SENSOR LESION ASSESSMENT DEVICE AND METHOD 审中-公开
标题翻译：多传感器评估装置和方法
公开(公告)号：US20150141853A1
公开(公告)日：2015-05-21
申请号：US14541703
申请日：2014-11-14
申请人： ACIST Medical Systems, Inc.
发明人： Edward R. Miller, III , Sidney Donald Nystrom
IPC分类号： A61B5/02 , A61B5/00 , A61B5/0215
CPC分类号： A61B5/02007 , A61B5/0017 , A61B5/02158 , A61B5/6851 , A61B2560/063 , A61B2562/0247 , A61B2562/0266 , A61M5/007 , A61M5/14546 , A61M5/365
摘要： An intravascular sensor delivery device can have a sensor that is used to measure a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used in combination with a medical guidewire carrying another sensor also configured to measure a physiological parameter of the patient, such as blood pressure. Data generated from the intravascular sensor delivery device sensor and the guidewire sensor can be used to determine a characteristic of interest for the vascular structure under investigation. For example, the data can be used to calculate a pressure distal to pressure proximal ratio across a stenotic lesion in order to assess the severity of the lesion.
摘要翻译：血管内传感器传送装置可以具有用于测量血管结构或通道内的患者的生理参数（例如血压）的传感器。在一些实施例中，该装置可以与携带还构造成测量患者的生理参数（诸如血压）的另一传感器的医疗导丝组合使用。可以使用从血管内传感器传送装置传感器和导丝传感器产生的数据来确定被调查的血管结构感兴趣的特征。例如，可以使用数据来计算跨狭窄病变的近端压力远端的压力，以评估病变的严重程度。

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