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31. 发明申请

WO2008109991A1 INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER 审中-公开
标题翻译： CARNITINE PALMITOYLTRANSFERASE和治疗癌症的抑制剂
公开(公告)号：WO2008109991A1
公开(公告)日：2008-09-18
申请号：PCT/CA2008/000440
申请日：2008-03-06
申请人： UNIVERSITY HEALTH NETWORK , PAULS, Heinz, W. , SAMPSON, Peter, Brent , FORREST, Bryan, T. , LAUFER, Radoslaw , LIU, Yong , FEHER, Miklos , YAO, YI , PAN, Guohua
发明人： PAULS, Heinz, W. , SAMPSON, Peter, Brent , FORREST, Bryan, T. , LAUFER, Radoslaw , LIU, Yong , FEHER, Miklos , YAO, YI , PAN, Guohua
IPC分类号： C07C275/28 , A61K31/195 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/44 , A61K31/495 , A61P35/00 , C07C233/83 , C07C233/52 , C07C237/42 , C07C275/06 , C07C307/06 , C07C307/10 , C07C311/19 , C07C311/29 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/44 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04
CPC分类号： C07D409/06 , C07C1/26 , C07C17/10 , C07C2529/40 , C07D207/325 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D263/34 , C07D277/48 , C07D295/215 , C07D307/24 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07C9/00 , C07C19/075
摘要： A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： CPT抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。

32. 发明申请

WO2008095275A1 METHODS FOR THE TREATMENT OF SENILE DEMENTIA OF THE ALZHEIMER'S TYPE 审中-公开
标题翻译：治疗阿尔茨海默病类型的敏感性方法
公开(公告)号：WO2008095275A1
公开(公告)日：2008-08-14
申请号：PCT/CA2007/001472
申请日：2007-08-27
申请人： PHENOMENOME DISCOVERIES INC. , GOODENOWE, Dayan
发明人： GOODENOWE, Dayan
IPC分类号： A61K31/232 , A61P25/28 , A61P3/06
CPC分类号： A61K31/232 , A61K31/661 , A61K31/6615
摘要： The present invention relates to the diagnosis, risk assessment, prevention, and treatment of Senile Dementia of the Alzheimer's Type (SDAT). More specifically the present invention relates to the measurement of ethanolamine phospholipids in human serum. Subsets of these molecules are significantly altered in subjects with pathologically confirmed deposits of β-amyloid versus subjects without β-amyloid deposits and in subjects with a clinical manifestation of dementia consistent with a diagnosis of SDAT versus non-demented controls. Further, the invention relates to the diagnosis of various stages of SDAT, the early detection and prevention of SDAT symptoms, the treatment of SDAT, the differential diagnosis of non-SDAT dementia, and the identification of molecular targets for which chemical or biological treatments can be designed for the therapeutic intervention of SDAT. The present invention also relates to methods of using a molecular diagnostic assay to direct and select the appropriate therapeutic intervention for subjects suffering from dementia. The present invention also relates to small molecules or metabolites that are found to have significantly different abundances between persons with a clinical manifestation of SDAT and normal, non-demented patients.
摘要翻译：本发明涉及老年痴呆型老年痴呆症（SDAT）的诊断，风险评估，预防和治疗。更具体地说，本发明涉及人血清中乙醇胺磷脂的测定。这些分子的亚群在病理证实的β-淀粉样蛋白沉积物与没有β-淀粉样蛋白沉积物的受试者和具有与SDAT与非痴呆对照的诊断一致的痴呆临床表现的受试者中显着改变。此外，本发明涉及SDAT的各个阶段的诊断，SDAT症状的早期检测和预防，SDAT的治疗，非SDAT痴呆的鉴别诊断以及化学或生物治疗可以分析的分子靶标的鉴定设计用于SDAT的治疗干预。本发明还涉及使用分子诊断测定法来指导和选择患有痴呆症的受试者的适当治疗干预的方法。本发明还涉及发现具有SDAT和正常非痴呆患者的临床表现的人之间具有显着不同丰度的小分子或代谢物。

33. 发明申请

WO2008092280A1 METHODS FOR THE DIAGNOSIS OF OVARIAN CANCER HEALTH STATES AND RISK OF OVARIAN CANCER HEALTH STATES 审中-公开
标题翻译： OVARIAN癌症健康状况的诊断方法和OVARIAN癌症健康状况的风险
公开(公告)号：WO2008092280A1
公开(公告)日：2008-08-07
申请号：PCT/CA2008/000270
申请日：2008-02-01
申请人： PHENOMENOME DISCOVERIES INC. , RITCHIE, Shawn , BINGHAM, Erin
发明人： RITCHIE, Shawn , BINGHAM, Erin
IPC分类号： G01N33/49 , G01N27/00 , H01J49/26
CPC分类号： G01N33/57449 , G01N33/48792 , G01N33/49 , G01N2560/00 , G01N2800/50 , G01N2800/56 , G01N2800/7028 , H01J49/0036
摘要： The present invention describes a method for predicting a health-state indicative of the presence of ovarian cancer (OC). The method measures the intensities of specific small organic molecules, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to those observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed ovarian cancer-positive individuals. Specifically, the present invention relates to the diagnosis of OC through the measurement of vitamin E isoforms and related metabolites. The method enables a practitioner to determine the probability that a screened patient is positive or at risk for ovarian cancer.
摘要翻译：本发明描述了一种用于预测指示卵巢癌（OC）的存在的健康状态的方法。该方法测量具有未确定健康状态的患者的血液样品中特定的小有机分子（称为代谢物）的强度，并将这些强度与在健康个体群体中观察到的强度和/或先前观察到的强度进行比较确诊为卵巢癌阳性个体的人群。具体地，本发明涉及通过测量维生素E同种型和相关代谢物来诊断OC。该方法使得从业者能够确定筛选的患者是卵巢癌的阳性或有卵巢癌风险的概率。

34. 发明申请

WO2007143818A1 AN IDENTITY PRESERVATION SYSTEM FOR TRANSGENIC WHEAT AND TRITICALE 审中-公开
标题翻译：用于转基因谷物和TRITICALE的身份识别系统
公开(公告)号：WO2007143818A1
公开(公告)日：2007-12-21
申请号：PCT/CA2007/001001
申请日：2007-06-06
申请人： HER MAJESTY THE QUEEN IN RIGHT OF CANADA, as represented by THE MINISTER OF AGRICULTURE AND AGRI-FOOD , GRAF, Robert, J. , EUDES, François , LAROCHE, André , GAUDET, Denis, A. , DOSHI, Ketan, M.
发明人： GRAF, Robert, J. , EUDES, François , LAROCHE, André , GAUDET, Denis, A. , DOSHI, Ketan, M.
IPC分类号： A01H5/00 , A01H1/02 , A01H3/00 , C12N15/82
CPC分类号： C12N15/8212 , A01H1/04 , C12N15/825 , C12N15/8265
摘要： The growing controversy over GM/novel-trait crops and food products that possess novel industrial or nutritional traits has resulted in an increased need for technologies for rapid and reliable identification of GM/novel-trait crops at the various stages of production and processing. An Identity Preservation (IP) system is designed to provide assurances that the desired traits are present (or absent) in a product from the seed source through all steps of production and delivery. The present invention relates to a process of identity preservation for cereal crops and the grain they produce. We describe herein a visual seed identity system that permits the traceability of particular genetic characteristics of wheat or triticale using a dominant seed colour marker that is visually observable in admixed seed populations. In one example, the invention relates traceability of genetically modified crops or crops that express novel traits and their genetic characteristics in selfing, out-crossing and admixture situations with traditional, non-genetically modified or non-novel trait crops. In a preferred embodiment, the method includes introducing the Bperu and/or C1 regulatory genes under the control of a seed-specific promoter as seed colour markers into wheat or triticale, resulting in seeds with a distinct colour selected from red, blue, purple, grey, brown and black.
摘要翻译：对具有新型工业或营养特性的转基因/新品种作物和食品的争议越来越大，导致在生产和加工各个阶段快速可靠地鉴定转基因/新品种作物的技术需求增加。身份保护（IP）系统旨在提供在种子来源通过生产和交付的所有步骤的产品中存在（或不存在）所需性状的保证。本发明涉及谷类作物及其产生的谷物的身份保存过程。我们在这里描述了一种视觉种子识别系统，其允许使用在混合种子群体中可视化观察到的显性种子颜色标记来鉴定小麦或黑小麦的特定遗传特征。在一个实例中，本发明涉及在传统的，非转基因的或非新颖的特征作物的自交，过交和混合情况下表达新特征的遗传修饰作物或作物的可追溯性及其遗传特征。在优选的实施方案中，该方法包括将种子特异性启动子控制下的Bperu和/或C1调节基因作为种子颜色标记物引入小麦或黑小麦，得到具有选自红，蓝，紫，灰色，棕色和黑色。

35. 发明申请

WO2007030948A1 METHOD AND APPARATUS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY 审中-公开
标题翻译：傅立叶变换离子共振质谱法的方法与装置
公开(公告)号：WO2007030948A1
公开(公告)日：2007-03-22
申请号：PCT/CA2006/001530
申请日：2006-09-15
申请人： PHENOMENOME DISCOVERIES INC. , GOODENOWE, Dayan
发明人： GOODENOWE, Dayan
IPC分类号： H01J49/26 , H01J49/14 , H01J49/40 , H01J49/42
CPC分类号： H01J49/38 , H01J49/0031 , H01J49/421
摘要： A novel method and apparatus for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS). The FTICR-MS apparatus has a pre-ICR mass separation and filtering device capable of receiving ionized molecules with a plurality of mass to charge (M/Z) sub-ranges. The pre-ICR mass separation and filtering device divides the ionized molecules into a plurality of smaller packets, each of the smaller packets is within one of the M/Z sub-ranges. A magnet in the FTICR-MS apparatus provides a controlled magnetic field. A plurality of ion cyclotron resonance (ICR) cells are arranged in series in the controlled magnetic field and operate independently. An ion trapping device connects the pre-ICR mass separation and filtering device, and stores one of the plurality of smaller packets, prior to sending it to one of the plurality of ICR cells.
摘要翻译：傅立叶变换离子回旋共振质谱（FTICR-MS）的新颖方法和装置。 FTICR-MS装置具有能够接收具有多个质量（M / Z）子范围的离子化分子的前ICR质量分离和过滤装置。前ICR质量分离和过滤装置将电离分子分成多个较小的分组，每个较小的分组在M / Z子范围之一内。 FTICR-MS装置中的磁体提供受控的磁场。多个离子回旋共振（ICR）单元在受控磁场中串联布置并独立运行。离子捕获装置将ICR前质量分离和过滤装置连接，并且在将其发送到多个ICR单元之一之前存储多个较小分组之一。

36. 发明申请

WO2007025366A1 USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS 审中-公开
标题翻译：作为P2X7受体功能的抑制剂和抗神经药物的组合物和组织蛋白样化合物的使用
公开(公告)号：WO2007025366A1
公开(公告)日：2007-03-08
申请号：PCT/CA2006/001382
申请日：2006-08-23
申请人： BERNATCHEZ-LEMAIRE Irma
发明人： BERNATCHEZ-LEMAIRE Irma
IPC分类号： C07K7/08 , A61K31/4184 , A61K31/05 , A61K38/05 , A61K38/06 , A61K38/08 , A61K38/10 , A61K38/12 , A61P19/02 , A61P25/28 , A61P29/00 , C07K5/00 , C07K7/06 , C12Q1/02 , G01N33/566
CPC分类号： G01N33/564 , A61K31/05 , A61K31/4184 , C07K7/08 , G01N33/6872 , G01N2500/04 , G01N2800/102
摘要： The invention relates to the use of Histogranin-like compounds to reduce P2X 7 ( also designed P2Z) receptor function. The invention also provides a method for the prevention and treatment of rheumatoid arthritis and a variety of diseases/disorders including inflammatory disorders and neurodegenerative diseases.
摘要翻译：本发明涉及组氨凝胶样化合物减少P2X 7（也设计的P2Z）受体功能的用途。本发明还提供了预防和治疗类风湿性关节炎和各种疾病/病症（包括炎症性疾病和神经变性疾病）的方法。

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