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    • 40. 发明授权
    • Soluble epidermal growth factor receptor isoforms
    • 可溶性表皮生长因子受体亚型
    • US08017752B1
    • 2011-09-13
    • US12731387
    • 2010-03-25
    • Nita J. MaihleJill Reiter
    • Nita J. MaihleJill Reiter
    • C12P19/34C07K14/71
    • G01N33/57449G01N33/6872G01N2333/485
    • The present invention relates to the discovery of soluble isoforms of an Epidermal Growth Factor Receptor, or sErbB1 variants, the provision of the sequences of nucleic acids encoding these isoforms, purified recombinant proteins, novel antibodies specific for these isoforms, and the use of immunoassay and other protein assay techniques to measure the concentration of these protein isoforms in a patient biological sample in the femtomolar range. The present invention also provides methods for determining the presence of an ovarian carcinoma in the patient by assaying the concentration of soluble ErbB1 variants in a biological sample from a patient.
    • 本发明涉及表皮生长因子受体或sErbB1变体的可溶性同种型的发现,编码这些同种型的核酸序列的提供,纯化的重组蛋白,对这些同种型特异的新抗体,以及使用免疫测定和 其他蛋白质测定技术来测量这些蛋白质同种型在患者生物样品中的浓度。 本发明还提供了通过测定来自患者的生物样品中可溶性ErbB1变体的浓度来确定患者中卵巢癌存在的方法。