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31. 发明申请

WO2006113440A2 MULTI-TRANSDUCTION MECHANISM BASED MICROFLUIDIC ANALYTE SENSORS 审中-公开
标题翻译：基于多传感器机理的微流感分析仪
公开(公告)号：WO2006113440A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014079
申请日：2006-04-14
申请人： WORCESTER POLYTECHNIC INSTITUTE , MCGIMPSEY, Grant, W. , LAMBERT, Christopher, R. , BENCO, John, S. , THALLADI, Venkat, R.
发明人： MCGIMPSEY, Grant, W. , LAMBERT, Christopher, R. , BENCO, John, S. , THALLADI, Venkat, R.
IPC分类号： G01N21/64 , G01N27/333 , G01N33/487
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N21/6428 , G01N33/54373 , G01N33/5438
摘要： In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of analyte detection, utilize two transduction mechanisms from the same molecule to determine analyte presence, analyte concentration, or both. An analyte sensing molecule is used that can provide both an optical signal and electrochemical signal when an analyte is recognized by an analyte binding portion of the sensing molecule.
摘要翻译：在各个方面提供了一种微流体和/或纳流感传感器，其可以提供其测量被研究样品中分析物的存在的可靠性的指示，所研究的样品中的分析物浓度或两者。所提供的传感器，微流体装置和分析物检测方法利用来自相同分子的两个转导机制来确定分析物存在，分析物浓度或两者。使用分析物感测分子，当分析物被感测分子的分析物结合部分识别时，可以提供光学信号和电化学信号。

32. 发明申请

WO2005114700A2 EXPRESSION QUANTIFICATION USING MASS SPECTROMETRY 审中-公开
标题翻译：使用质谱分析的表达量
公开(公告)号：WO2005114700A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017799
申请日：2005-05-19
申请人： APPLERA CORPORATION , HUNTER, Christie, L. , WEBB, Sally , HUNT, Antony, J. , KITTERINGHAM, Neil , PENNINGTON, Stephen
发明人： HUNTER, Christie, L. , WEBB, Sally , HUNT, Antony, J. , KITTERINGHAM, Neil , PENNINGTON, Stephen
IPC分类号： H01J49/00
CPC分类号： G01N33/68 , G01N33/6803 , G01N33/6848 , G01N33/6851 , G01N2333/90209 , H01J49/0031
摘要： In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present teachings provide methods of determining the absolute concentration of one or more isoforms of a protein using standard samples of signature protein fragments and parent-daughter ion transition monitoring (PDITM). In various embodiments, the absolute concentration of multiple isoforms of a biomolecule in a sample, multiple proteins in a biological process, a combination of multiple samples, or combinations thereof, can be determined in a multiplex fashion using the present teachings. In various aspects, provided are methods of assessing the response of a biological system to a chemical agent.
摘要翻译：在各个方面，本教导提供用于蛋白质表达的绝对定量的系统，方法，测定和试剂盒。在各个方面，本教导提供了确定感兴趣的一种或多种感兴趣的一种或多种感兴趣的蛋白质的浓度的方法。在各个方面，本教导提供使用标记蛋白片段和父 - 子离子转移监测（PDITM）的标准样品测定蛋白质的一种或多种同种型的绝对浓度的方法。在各种实施方案中，可以使用本教导以多种方式确定样品中生物分子的多种同种型，生物过程中的多种蛋白，多种样品的组合或其组合的绝对浓度。在各个方面，提供了评估生物系统对化学试剂的响应的方法。

33. 发明申请

WO2005088395A3 SYSTEMS AND METHODS FOR SUB-WAVELENGTH IMAGING 审中-公开
公开(公告)号：WO2005088395A3
公开(公告)日：2005-09-22
申请号：PCT/US2005/008281
申请日：2005-03-11
申请人： WORCESTER POLYTECHNIC INSTITUTE , CYGANSKI, David , MCGIMPSEY, Grant, W.
发明人： CYGANSKI, David , MCGIMPSEY, Grant, W.
IPC分类号： G03F7/20 , G03F7/004 , G03F7/028 , G03F7/031
摘要： Preferred embodiments of the present invention provide methods of forming a photolithographic pattern by patternwise imaging each of two or more different modalities of light onto a multiphoton-specific photoinitiator material to form a photolithographic pattern on the surface where each of the patterns of the two or more different wavelengths of light overlap. In various embodiments, the invention provides a method of semiconductor fabrication capable of permitting the formation of an imaged feature having a dimension smaller than λ/(2NA), where λ is the smallest wavelength of imaging light, and NA is the numerical aperture of the imaging system.

34. 发明申请

WO2005059060A1 FILMS WITH PHOTORESPONSIVE WETTABILITY 审中-公开
标题翻译：具有光电性能的薄膜
公开(公告)号：WO2005059060A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/042259
申请日：2004-12-15
申请人： WORCESTER POLYTECHNIC INSTITUTE , MCGIMPSEY, W., Grant , MCDONALD, John, C.
发明人： MCGIMPSEY, W., Grant , MCDONALD, John, C.
IPC分类号： C09K9/02
CPC分类号： B82Y30/00 , B01L3/5027 , B01L2400/0688 , B05D1/185 , B05D5/00 , B82Y40/00 , C07B2200/11 , C07F1/005 , C09K9/02 , C09K2211/1029 , C09K2211/1092 , C09K2211/188 , G03C1/733 , Y10S430/163 , Y10T428/268
摘要： In various aspects, the present invention provides substantially monolayer thick molecular films with photoresponsive wettability, the molecules of said films comprising a photochromic molecule coordinated to a metal atom, which is coordinated to an organic tethering molecule, surface coupling group, or both, having a group for attachment to a surface of a substrate. In various aspects, the present inventions also provide photochromic articles comprising said films, methods of forming said films, and methods of manufacturing photochromic articles using said films. In various embodiments, provided are molecular films where the photoconversion between configurations of the photochromic molecule is substantially reversible by irradiation with light. In various embodiments, provided are films where the photoconversion is substantially irreversible by irradiation with light.
摘要翻译：在各个方面，本发明提供了基本上具有光响应润湿性的单层厚分子膜，所述膜的分子包含与金属原子配位的光致变色分子，其与有机系链分子，表面偶联基团或两者配位，具有组，用于附着到基底的表面。在各个方面，本发明还提供了包含所述薄膜的光致变色制品，形成所述薄膜的方法，以及使用所述薄膜制造光致变色制品的方法。在各种实施方案中，提供了分子膜，其中光致变色分子的配置之间的光转换通过光照射基本上是可逆的。在各种实施方案中，提供了通过光照射基本上不可逆转换的膜。

35. 发明申请

WO2004072647A1 REMOVAL OF PROTEINS FROM A SAMPLE 审中-公开
标题翻译：从样品中去除蛋白质
公开(公告)号：WO2004072647A1
公开(公告)日：2004-08-26
申请号：PCT/US2004/003280
申请日：2004-02-06
申请人： BEYOND GENOMICS , NAYLOR, Stephen , ADAMEC, Jiri , MEYS, Michael
发明人： NAYLOR, Stephen , ADAMEC, Jiri , MEYS, Michael
IPC分类号： G01N33/68
CPC分类号： G01N30/461 , B01D15/1871 , B01D15/3804 , C07K1/36 , G01N30/14 , G01N2030/085 , G01N2030/143
摘要： In various aspects, provided are methods and devices for the depletion of two or more proteins from a sample, such as, for example, blood serum, blood plasma, cerebrospinal fluid and/or urine samples. In various embodiments, the methods deplete three or more proteins from a sample by contacting the sample with at least one chromatographic medium, the at least one chromatographic medium being capable of removing albumin, IgG, and a third abundant protein from the sample. In various embodiments, the devices comprises a first chromatography column functionalized to substantially remove a first abundant protein from the sample; a second chromatography column in serial fluidic communication with the first chromatography column and functionalized to substantially remove a second abundant protein from the sample; and a first chromatography disk in serial fluidic communication with the second chromatography column and functionalized to substantially remove a third protein from the sample.
摘要翻译：在各个方面，提供了用于从样品（例如血清，血浆，脑脊髓液和/或尿液样品）中消耗两种或更多种蛋白质的方法和装置。在各种实施方案中，该方法通过使样品与至少一种色谱介质接触而从样品中消耗三种或更多种蛋白质，所述至少一种色谱介质能够从样品中除去白蛋白，IgG和第三种丰富的蛋白质。在各种实施方案中，装置包括功能化以从样品中基本上除去第一丰富蛋白质的第一色谱柱; 第二色谱柱与第一色谱柱连续流体连通，并被功能化以从样品中基本上除去第二种丰富的蛋白质; 和与第二层析柱连续流体连通并被功能化以从样品中基本上除去第三种蛋白质的第一层析盘。

36. 发明申请

WO2004019035A2 METHOD FOR CHARACTERIZING BIOMOLECULES UTILIZING A RESULT DRIVEN STRATEGY 审中-公开
标题翻译：表征生物分子利用结果驱动策略的方法
公开(公告)号：WO2004019035A2
公开(公告)日：2004-03-04
申请号：PCT/US2003/026471
申请日：2003-08-22
申请人： APPLERA CORPORATION , GRABER, Armin , PATTERSON, Dale, H. , JUHASZ, Peter , MARTIN, Stephen, A.
发明人： GRABER, Armin , PATTERSON, Dale, H. , JUHASZ, Peter , MARTIN, Stephen, A.
IPC分类号： G01N33/483
CPC分类号： H01J49/004 , G01N33/6803 , G01N2030/8417 , H01J49/0027 , G01N30/7233
摘要： In various embodiments, the methods for analyzing a sample are provided utilizing a result dependent acquisition strategy. In various embodiments, methods for analyzing a sample are provided wherein the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MALDI and MS/MS or MS n to produce a second result.
摘要翻译：在各种实施例中，利用结果依赖获取策略来提供用于分析样本的方法。在各种实施方案中，提供了用于分析样品的方法，其中首先通过MALDI和MS分析样品以产生第一结果，然后将其用于确定用于通过MALDI和MS / MS再次分析样品的第二分析，或 MS 产生第二个结果。

37. 发明申请

WO2002080411A1 POLARIZATION MODE DISPERSION COMPENSATION IN OPTICAL TRANSMISSION MEDIA 审中-公开
标题翻译：光传输介质中的极化模式分散补偿
公开(公告)号：WO2002080411A1
公开(公告)日：2002-10-10
申请号：PCT/US2002/008399
申请日：2002-03-19
申请人： TERAPULSE, INC.
发明人： WEIN, Steven, J. , TARGOVE, James, D. , MENIKOFF, Arthur
IPC分类号： H04B10/18
CPC分类号： G02B6/278 , H04B10/2569
摘要： The present invention provides a method and apparatus for compensating for polarization mode dispersion (PMD) in an optical transmission system without perturbing the laser source. The present invention compensates for PMD by transferring a sufficient fraction of the light signal in an optical transmission system substantially into a single principal state of polarization (PSP) of the system. As a result, each light pulse in a data stream is not substantially mixed with temporally adjacent light pulses or bit periods.
摘要翻译：本发明提供一种用于补偿光传输系统中的偏振模色散（PMD）而不干扰激光源的方法和装置。本发明通过将光传输系统中的光信号的足够部分基本上转移到系统的单个主要偏振态（PSP）来补偿PMD。结果，数据流中的每个光脉冲基本上与时间上相邻的光脉冲或位周期混合。

38. 发明申请

WO2016019037A1 FREE HORMONE AND HORMONE METABOLITE WORKUP AND ANALYSIS BY MASS SPECTROMETRY 审中-公开
标题翻译：免费的HORMONE和HORMONE代谢物工作和通过质谱分析
公开(公告)号：WO2016019037A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/042689
申请日：2015-07-29
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GEORGETOWN UNIVERSITY
发明人： SOLDIN, Steven J.
IPC分类号： G01N33/92 , G01N33/74 , G01N27/62 , G01N1/10
CPC分类号： G01N1/10 , B01D61/145 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2311/2676 , B01D2315/02 , G01N33/74 , G01N33/92 , G01N2001/4088
摘要： Method for performing ultrafiltration on an unbound non-polar analyte in a sample and analysis of same is described. The sample can be a hormone, such as cholecalciferol (Vitamin D). The method comprises preinserting a solution comprising an organic solvent and an internal standard for the unbound analyte, into the filtrate recovery chamber prior to filtration.
摘要翻译：对样品中未结合的非极性分析物进行超滤的方法及其分析描述。样品可以是激素，如胆钙化甾醇（维生素D）。该方法包括在过滤前将包含有机溶剂和未结合的分析物的内标的溶液预先插入滤液回收室中。

39. 发明申请

WO2008133752A2 NANOSCALE OXIDE COATINGS 审中-公开
标题翻译：纳米氧化铝涂料
公开(公告)号：WO2008133752A2
公开(公告)日：2008-11-06
申请号：PCT/US2007/087895
申请日：2007-12-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , RAMANATHAN, Shriram , CHANG, Chia-Lin
发明人： RAMANATHAN, Shriram , CHANG, Chia-Lin
IPC分类号： C23C8/10 , C23C14/58 , H01L21/306
CPC分类号： C23C8/10 , B82Y30/00 , C23C14/5853 , C23C18/14
摘要： In various aspects, the present inventions provide methods for forming corrosion resistant oxide coatings on metals and/or improving the corrosion resistance of existing native oxide coatings. In various aspects, provided are methods for forming corrosion resistant oxide coatings on metals surfaces that are immersed in an aqueous solution. Various embodiments of various aspects of the present inventions can provide a scalable process for the formation of corrosion resistant coatings on metals in a manner that does not require high-vacuum technology, can be adapted to large structures, such as ships or aircraft, and in various aspects and embodiments can improve quality of existing oxide films on a metal or alloy surface.
摘要翻译：在各个方面，本发明提供了在金属上形成耐腐蚀氧化物涂层和/或提高现有氧化物涂层的耐腐蚀性的方法。在各个方面，提供了在金属表面上形成浸渍在水溶液中的耐腐蚀氧化物涂层的方法。本发明的各个方面的各种实施方案可以提供用于以不需要高真空技术的方式在金属上形成耐腐蚀涂层的可伸缩工艺，可适用于诸如船舶或航空器的大型结构，以及各个方面和实施例可以提高金属或合金表面上现有氧化膜的质量。

40. 发明申请

WO2007140391A3 METHODS OF MAKING DECOMPOSABLE THIN FILMS OF POLYELECTROLYTES AND USES THEREOF 审中-公开
公开(公告)号：WO2007140391A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069937
申请日：2007-05-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WOOD, Kris C. , CHUANG, Helen F. , BATTEN, Robert D. , LYNN, David M. , CUNNINGHAM, Paula T. Hammond
发明人： WOOD, Kris C. , CHUANG, Helen F. , BATTEN, Robert D. , LYNN, David M. , CUNNINGHAM, Paula T. Hammond
IPC分类号： B32B7/02 , B32B15/02 , B32B15/10 , B32B27/10 , B32B27/18 , B32B27/30 , B32B27/34 , B32B27/36 , B32B27/40
摘要： A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.

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