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31. 发明申请

WO1995026158A1 METHOD AND APPARATUS FOR DIAGNOSING ERECTILE DYSFUNCTION 审中-公开
标题翻译：用于诊断溃疡性功能障碍的方法和装置
公开(公告)号：WO1995026158A1
公开(公告)日：1995-10-05
申请号：PCT/US1995003514
申请日：1995-03-20
申请人： VIVUS, INC.
发明人： VIVUS, INC. , PLACE, Virgil, A.
IPC分类号： A61B05/00
CPC分类号： A61B5/4393 , A61F5/41 , A61K9/0034 , A61M31/00
摘要： A method for diagnosing vasculogenic erectile dysfunction, including vasculogenic impotence and Peyronie's syndrome, is provided. The method involves transurethral administration of a vasodilating agent to induce an erection, followed by hemodynamic evaluation using duplex ultrasonography, NMR, angiography, or the like. Kits for conducting the diagnostic method are provided as well, as are methods of treatment based on the diagnostic conclusion. The kits for diagnosing erectile dysfunction comprise a vasodilating agent (4) effective to induce erection of the penis, a drug delivery means (1, 11, or 49) for administering the vasodilating agent transurethrally, a container (15 or 55) for housing the agent and drug delivery means, and written instructions for using the agent and the drug delivery means.
摘要翻译：提供了一种诊断血管性勃起功能障碍，包括血管性勃起功能障碍和佩罗尼氏综合征的方法。该方法包括经尿道给药血管舒张剂诱导勃起，然后使用双相超声检查，NMR，血管造影术等进行血液动力学评估。还提供了用于进行诊断方法的试剂盒，以及基于诊断结论的治疗方法。用于诊断勃起功能障碍的试剂盒包括有效诱导勃起阴茎的血管扩张剂（4），用于经尿道施用血管舒张剂的药物递送装置（1,11或49），用于容纳阴茎的容器（15或55）药剂和药物递送手段，以及使用该药剂和药物递送装置的书面说明。

32. 发明申请

WO2015176008A1 ORALLY DISINTEGRATING DOSAGE FORM FOR ADMINISTRATION OF AVANAFIL, AND ASSOCIATED METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译： ORA用于治疗AVANAFIL的剂型及相关制造和使用方法
公开(公告)号：WO2015176008A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/031198
申请日：2015-05-15
申请人： VIVUS, INC.
发明人： BROMAN, Calvin Theodore , SHEU, Eric
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/2031 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K31/506
摘要： Formulations are provided for the oral administration of avanafil, a Type V phosphodiesterase inhibitor ("PDE V inhibitor"), and analogs thereof. The formulations are orally disintegrating tablets (ODTs) that rapidly dissolve or disintegrate in the oral cavity. The tablets contain an absorption enhancing composition that increases the duodenal absorption of the active agent, following transfer from the low pH environment of the stomach to the more basic pH of the duodenum. Methods for administering the active agent using the dosage forms are provided. The invention also encompasses a method of selecting components and compositions to incorporate in the formulations which will facilitate increased absorption of the active agent in the duodenum and thus serve as "absorption enhancing compositions" herein. Also provided are methods for manufacturing orally disintegrating tablets to optimize the physical properties of the dosage forms, particularly hardness and disintegration time.
摘要翻译：提供了用于口服给予阿伐他非，V型磷酸二酯酶抑制剂（“PDE V抑制剂”）及其类似物的制剂。制剂是在口腔中快速溶解或分解的口腔崩解片（ODT）。在从胃的低pH环境转移到十二指肠的更基本的pH之后，片剂含有增加活性剂的十二指肠吸收的吸收促进组合物。提供了使用剂型给药活性剂的方法。本发明还包括选择组合物和组合物以掺入制剂中的方法，其将促进活性剂在十二指肠中的增加的吸收，因此用作本文的“吸收增强组合物”。还提供了制备口腔崩解片以优化剂型的物理性质，特别是硬度和崩解时间的方法。

33. 发明申请

WO2009152190A1 ESCALATING DOSING REGIMEN FOR EFFECTING WEIGHT LOSS AND TREATING OBESITY 审中-公开
标题翻译：用于治疗体重减轻和治疗肥胖的排毒计划
公开(公告)号：WO2009152190A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/046805
申请日：2009-06-09
申请人： VIVUS, INC. , NAJARIAN, Thomas , TAM, Peter, Y. , WILSON, Leland, F.
发明人： NAJARIAN, Thomas , TAM, Peter, Y. , WILSON, Leland, F.
IPC分类号： A61K31/35 , A61K31/137 , A61P3/04
CPC分类号： A61K31/357 , A61K9/1623 , A61K9/1629 , A61K9/167 , A61K9/1676 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/35 , A61K31/7048 , A61K47/38 , A61K2300/00
摘要： The present invention is drawn to novel topiramate compositions as well as methods for effecting weight loss, e.g., in the treatment of obesity and related conditions, including conditions associated with and/or caused by obesity per se. The present invention features an escalating dosing regimen adapted for the administration of topiramate and optionally a sympathomimetic agent such as phentermine or bupropion, in the treatment of obesity and related conditions.
摘要翻译：本发明涉及新的托吡酯组合物以及用于减轻体重的方法，例如用于治疗肥胖症和相关病症，包括与肥胖本身相关的和/或由肥胖本身引起的疾病。本发明的特征在于适于在治疗肥胖症和相关病症中施用托吡酯和任选的拟交感神经药物如苯丁胺或安非他酮的升级给药方案。

34. 发明申请

WO2008153632A3 COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS 审中-公开
标题翻译：用于治疗肥胖和相关疾病的组合物和方法
公开(公告)号：WO2008153632A3
公开(公告)日：2009-07-02
申请号：PCT/US2008005549
申请日：2008-04-29
申请人： VIVUS INC , NAJARIAN THOMAS , TAM PETER Y , WILSON LELAND F
发明人： NAJARIAN THOMAS , TAM PETER Y , WILSON LELAND F
IPC分类号： A61K31/137 , A61K31/35 , A61P3/04
CPC分类号： A61K31/133 , A61K31/135 , A61K31/137 , A61K31/35 , A61K31/423 , A61K31/435 , A61K45/06 , A61K2300/00
摘要： The present invention is drawn to combinations of pharmaceutical agents having similar chemical and/or pharmacological properties, wherein the combinations maximize the therapeutic effect of the drug while minimizing their adverse effects. The methods and compositions of the invention are particularly useful in the treatment of obesity and related conditions which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) or bupropion in combination with an anti-epileptic agent (e.g., topiramate, zonisamide), CBl antagonists (e.g., rimonabant), or a 5HT2c-selective serotonin receptor agonist, (e.g., lorcaserin) for the treatment of obesity and related conditions. The invention also features kits for use in the practice of these novel therapies.
摘要翻译：本发明涉及具有相似化学和/或药理学性质的药物的组合，其中所述组合使药物的治疗效果最大化，同时最小化其不利影响。本发明的方法和组合物特别可用于治疗肥胖症和相关病症，其涉及用拟兴奋剂（例如苯丁胺或苯丁胺样药物）或安非他酮与抗癫痫剂（例如，，托吡酯，唑尼沙胺），CB1拮抗剂（例如利莫那班）或5HT2c选择性5-羟色胺受体激动剂（例如，氯卡色林）用于治疗肥胖症和相关病症。本发明还具有用于实施这些新型疗法的试剂盒。

35. 发明申请

WO2008156550A2 TREATMENT OF PULMONARY HYPERTENSION WITH CARBONIC ANHYDRASE INHIBITORS 审中-公开
标题翻译：用碳酸酐抑制剂治疗肺动脉高压
公开(公告)号：WO2008156550A2
公开(公告)日：2008-12-24
申请号：PCT/US2008006850
申请日：2008-05-30
申请人： VIVUS INC , NAJARIAN THOMAS , TAM PETER , WILSON LELAND , PETERSON CRAIG
发明人： NAJARIAN THOMAS , TAM PETER , WILSON LELAND , PETERSON CRAIG
IPC分类号： A61K31/7048 , A61K31/137 , A61K31/423 , A61K31/433 , A61K45/06 , A61P9/12 , A61P11/00
CPC分类号： A61K31/7048 , A61K31/137 , A61K31/18 , A61K31/198 , A61K31/34 , A61K31/357 , A61K31/382 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/635 , A61K45/06 , A61K2300/00
摘要： This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
摘要翻译：本公开一般涉及可用于治疗肺动脉高压的方法和药物组合物。在一个实施方案中，例如，本公开提供了治疗肺动脉高压的方法，包括向需要治疗的患者施用治疗有效剂量的碳酸酐酶抑制剂。该公开内容在药物和药理学领域中具有实用价值。

36. 发明申请

WO2003011301A1 AS-NEEDED ADMINISTRATION OF AN ANDROGENIC AGENT TO ENHANCE FEMALE SEXUAL DESIRE AND RESPONSIVENESS 审中-公开
标题翻译：自发性促进安哥拉代理增强女性性欲和反应性
公开(公告)号：WO2003011301A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023847
申请日：2002-07-26
申请人： VIVUS, INC.
发明人： WILSON, Leland, F. , TAM, Peter, Y.
IPC分类号： A61K31/56
CPC分类号： A61K9/0034 , A61K9/02 , A61K31/00 , A61K31/15 , A61K31/21 , A61K31/295 , A61K31/48 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/5585 , A61K31/56 , A61K45/06 , B82Y5/00 , A61K2300/00
摘要： A method is provided for enhancing a female individual's sexual desire and responsiveness. The method involves administration of a pharmaceutical formulation containing an effective amount of an androgenic agent, wherein administration is on an as needed basis rather than involving chronic pharmacotherapy. Local delivery may be accomplished via administration to the vagina, vulvar area or urethra of the individual, although oral administration is preferred for those androgenic agents that are orally active. Formulations and kits for carrying out the method are provided as well.
摘要翻译：提供了一种提高女性性欲和反应能力的方法。该方法包括给药含有有效量的雄激素药物的药物制剂，其中根据需要施用，而不是涉及慢性药物治疗。尽管对于那些口服有活性的那些雄激素剂，口服给药是优选的，但是可以通过给予个体的阴道，外阴区域或尿道来实现局部递送。还提供了用于实施该方法的制剂和试剂盒。

37. 发明申请

WO2003000343A2 ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF PREMATURE EJACULATION 审中-公开
标题翻译：磷酸二酯酶抑制剂治疗预防性呕吐的治疗
公开(公告)号：WO2003000343A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/009415
申请日：2002-03-25
申请人： VIVUS, INC.
发明人： WILSON, Leland, F. , DOHERTY, Paul, C., Jr. , PLACE, Virgil, A. , SMITH, William, L. , ABDEL-HAMID ABDOU ALI, Ibrahim, AbouBakr
IPC分类号： A61P15/00
CPC分类号： A61K9/0031 , A61K9/0056 , A61K9/006 , A61K31/00 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4164 , A61K31/4166 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/538 , A61K31/549 , A61K31/5513 , A61K45/06
摘要： A method is provided for treatment of premature ejaculation by administration of a phosphodiesterase inhibitor, e.g., an inhibitor of a Type III, Type IV, or Type V phosphodiesterase. In a preferred embodiment, administration is on as "as needed" basis, i.e., the drug is administered immediately or several hours prior to sexual activity. Pharmaceutical formulations and packaged kits are also provided.
摘要翻译：提供了通过施用磷酸二酯酶抑制剂例如III型，IV型或V型磷酸二酯酶的抑制剂来治疗早泄的方法。在优选的实施方案中，施用是“根据需要”的基础，即药物在性活动之前立即或几小时施用。还提供药物制剂和包装试剂盒。

38. 发明申请

WO9921558A3 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION 审中-公开
标题翻译：磷酸二酯酶抑制剂治疗溃疡性功能障碍的地方行政管理
公开(公告)号：WO9921558A3
公开(公告)日：2000-10-26
申请号：PCT/US9822928
申请日：1998-10-28
申请人： VIVUS INC
发明人： DOHERTY PAUL C JR , PLACE VIRGIL A , SMITH WILLIAM L
IPC分类号： A61K9/02 , A61K31/00 , A61K31/343 , A61K31/381 , A61K31/4015 , A61K31/4164 , A61K31/4166 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/485 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K31/549 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P15/10 , A61K31/505
CPC分类号： A61K45/06 , A61K9/0034 , A61K31/00 , A61K31/343 , A61K31/381 , A61K31/4015 , A61K31/4164 , A61K31/4166 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/538 , A61K31/549 , A61K31/5513
摘要： A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof, within the context of an effective dosing regimen. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.
摘要翻译：提供一种用于治疗哺乳动物男性个体勃起功能障碍的方法。该方法包括在有效给药方案的范围内局部施用磷酸二酯酶抑制剂或其药学上可接受的盐，酯，酰胺或其衍生物。优选的给药方式是经尿道。还提供药物制剂和试剂盒。

39. 发明申请

WO2016025671A3 TREATMENT OF SLEEP APNEA WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ALDOSTERONE ANTAGONIST 审中-公开
公开(公告)号：WO2016025671A3
公开(公告)日：2016-02-18
申请号：PCT/US2015/044978
申请日：2015-08-13
申请人： VIVUS, INC.
发明人： BOWDEN, Charles H. , PETERSON, Craig
IPC分类号： A61K31/35 , A61K31/585 , A61P11/00
摘要： This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from sleep apnea, including obstructive sleep apnea syndrome (OSAS). Treatment is effected by administering a carbonic anhydrase inhibitor to the patient in combination with an aldosterone antagonist. Formulations containing a therapeutically effective amount of a carbonic anhydrase inhibitor and a therapeutically effective amount of an aldosterone antagonist are provided as well.

40. 发明申请

WO2015054353A1 METHODS OF PREVENTING PROGRESSION TO TYPE 2 DIABETES MELLITUS 审中-公开
标题翻译：预防2型糖尿病进展的方法
公开(公告)号：WO2015054353A1
公开(公告)日：2015-04-16
申请号：PCT/US2014/059636
申请日：2014-10-08
申请人： VIVUS, INC. , TROUPIN, Barbara
发明人： TROUPIN, Barbara , DAY, Wesley
IPC分类号： A61K31/357 , A61P3/00 , A61K31/137
CPC分类号： A61K31/357 , A61K31/137
摘要： The present invention provides compositions and methods for delaying or preventing progression to type 2 diabetes mellitus in individuals with prediabetes and metabolic syndrome.
摘要翻译：本发明提供用于延迟或预防在糖尿病前期和代谢综合征患者中进展为2型糖尿病的组合物和方法。

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