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31. 发明申请

US20050255042A1 On-demand cleavable linkers for radioconjugates for cancer imaging and therapy 审中-公开
标题翻译：用于癌症成像和治疗的放射性缀合物的按需可切割接头
公开(公告)号：US20050255042A1
公开(公告)日：2005-11-17
申请号：US10997759
申请日：2004-11-23
申请人： Kit Lam , Pappanaicken Kumaresan , Sally DeNardo , Gerald DeNardo
发明人： Kit Lam , Pappanaicken Kumaresan , Sally DeNardo , Gerald DeNardo
IPC分类号： A61K20060101 , A61K51/00 , A61K51/10
CPC分类号： A61K51/1093
摘要： The present invention provides compositions comprising a biological agent, a targeting moiety, and a peptide linker attaching the biological agent to the targeting moiety, wherein the peptide linker is selectively cleaved by a protease. Efficient methods are provided for administering the compositions of the present invention for treating cancer or imaging a tumor, organ, or tissue in a subject. Kits are also provided for administering the compositions of the present invention for radiotherapy or radioimaging.
摘要翻译：本发明提供了包含生物试剂，靶向部分和将生物试剂连接到靶向部分的肽接头的组合物，其中肽接头被蛋白酶选择性地切割。提供了有效的方法来施用本发明的治疗癌症或成像受试者的肿瘤，器官或组织的组合物。还提供了用于将本发明的组合物用于放射治疗或放射成像的试剂盒。

32. 发明授权

US6027585A Titanium-tantalum alloys 失效
标题翻译：钛 - 钽合金
公开(公告)号：US6027585A
公开(公告)日：2000-02-22
申请号：US404214
申请日：1995-03-14
申请人： R. Alan Patterson , Paul S. Dunn , John F. Bingert , James D. Cotton
发明人： R. Alan Patterson , Paul S. Dunn , John F. Bingert , James D. Cotton
IPC分类号： C22C1/02
CPC分类号： C22C1/02
摘要： A process of preparing a titanium-tantalum alloy including forming a suite mixture of essentially pure titanium powder and essentially pure tantalum powder, melting the mixture of titanium powder and tantalum powder by plasma torch melting under a pressure greater than atmospheric pressure to form a titanium-tantalum solution, and casting the molten solution of titanium-tantalum to form a solid homogeneous titanium-tantalum product is disclosed.The process can further include hot-rolling the cast solid homogeneous titanium-tantalum product to form a sheet of the titanium-tantalum product.
摘要翻译：一种制备钛 - 钽合金的方法，包括形成基本纯钛粉末和基本上纯的钽粉末的合适混合物，通过等离子体焰炬在大于大气压的压力下熔融熔化钛粉末和钽粉末的混合物，形成钛 - 钽溶液，并铸造钛 - 钽的熔融溶液以形成固体均匀的钛 - 钽产品。该方法还可以包括热轧铸造固体均匀的钛 - 钽产品以形成钛 - 钽产品的片材。

33. 发明授权

US5659667A Adaptive model predictive process control using neural networks 失效
标题翻译：自适应模型预测过程控制神经网络
公开(公告)号：US5659667A
公开(公告)日：1997-08-19
申请号：US373736
申请日：1995-01-17
申请人： Kevin L. Buescher , Christopher C. Baum , Roger D. Jones
发明人： Kevin L. Buescher , Christopher C. Baum , Roger D. Jones
IPC分类号： G05B13/02 , G06N3/04 , G06N3/063 , G06F15/18
CPC分类号： G05B13/027 , G06N3/049 , G06N3/063
摘要： A control system for controlling the output of at least one plant process output parameter is implemented by adaptive model predictive control using a neural network. An improved method and apparatus provides for sampling plant output and control input at a first sampling rate to provide control inputs at the fast rate. The MPC system is, however, provided with a network state vector that is constructed at a second, slower rate so that the input control values used by the MPC system are averaged over a gapped time period. Another improvement is a provision for on-line training that may include difference training, curvature training, and basis center adjustment to maintain the weights and basis centers of the neural in an updated state that can follow changes in the plant operation apart from initial off-line training data.
摘要翻译：用于控制至少一个工厂过程输出参数的输出的控制系统通过使用神经网络的自适应模型预测控制来实现。一种改进的方法和装置提供以第一采样率对工厂输出和控制输入进行采样以便以快速率提供控制输入。然而，MPC系统被提供有以第二较慢速率构造的网络状态向量，使得MPC系统使用的输入控制值在有间隙的时间段内被平均化。另一个改进是在线培训的规定，其中可能包括差异训练，曲率训练和基准中心调整，以维持神经元的权重和基础中心在更新的状态，可以跟随植物操作的变化，线路训练数据。

34. 发明授权

US5658649A Corrosion resistant coating 失效
标题翻译：耐腐蚀涂层
公开(公告)号：US5658649A
公开(公告)日：1997-08-19
申请号：US345974
申请日：1994-11-28
申请人： Debra A. Wrobleski , Brian C. Benicewicz , Karen G. Thompson , Coleman J. Bryan
发明人： Debra A. Wrobleski , Brian C. Benicewicz , Karen G. Thompson , Coleman J. Bryan
IPC分类号： B05D7/00 , B05D7/16 , B32B7/02 , B32B15/08
CPC分类号： B05D7/54 , B05D7/16 , Y10T428/2495 , Y10T428/24967 , Y10T428/26 , Y10T428/263 , Y10T428/31511 , Y10T428/31551 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855
摘要： A method of protecting a metal substrate from corrosion including coating a metal substrate of, e.g., steel, iron or aluminum, with a conductive polymer layer of, e.g., polyaniline, coating upon said metal substrate, and coating the conductive polymer-coated metal substrate with a layer of a topcoat upon the conductive polymer coating layer, is provided, together with the resultant coated article from said method.
摘要翻译：一种保护金属基材免受腐蚀的方法，包括用例如钢，铁或铝的金属基材与例如聚苯胺的导电聚合物层涂覆在所述金属基材上，并涂覆导电聚合物涂覆的金属基材与导电聚合物涂层上的一层顶涂层一起，与所得到的涂覆制品一起提供。

35. 发明授权

US5641586A Fuel cell with interdigitated porous flow-field 失效
标题翻译：具有交叉多孔流场的燃料电池
公开(公告)号：US5641586A
公开(公告)日：1997-06-24
申请号：US568088
申请日：1995-12-06
申请人： Mahlon S. Wilson
发明人： Mahlon S. Wilson
IPC分类号： H01M8/02 , H01M8/10
CPC分类号： H01M8/023 , H01M8/0245 , H01M2300/0082 , H01M8/0234
摘要： A polymer electrolyte membrane (PEM) fuel cell is formed with an improved system for distributing gaseous reactants to the membrane surface. A PEM fuel cell has an ionic transport membrane with opposed catalytic surfaces formed thereon and separates gaseous reactants that undergo reactions at the catalytic surfaces of the membrane. The fuel cell may also include a thin gas diffusion layer having first and second sides with a first side contacting at least one of the catalytic surfaces. A macroporous flow-field with interdigitated inlet and outlet reactant channels contacts the second side of the thin gas diffusion layer for distributing one of the gaseous reactants over the thin gas diffusion layer for transport to an adjacent one of the catalytic surfaces of the membrane. The porous flow field may be formed from a hydrophilic material and provides uniform support across the backside of the electrode assembly to facilitate the use of thin backing layers.
摘要翻译：聚合物电解质膜（PEM）燃料电池形成有用于将气态反应物分配到膜表面的改进系统。 PEM燃料电池具有其上形成有相对的催化表面的离子传输膜，并分离在膜的催化表面处经历反应的气态反应物。燃料电池还可以包括具有第一侧和第二侧的薄气体扩散层，第一侧与第一侧接触至少一个催化表面。具有相互交叉的入口和出口反应物通道的大孔流场接触薄气体扩散层的第二侧，用于将气态反应物之一分配在薄气体扩散层上，以输送到膜的相邻一个催化表面。多孔流场可以由亲水材料形成，并且通过电极组件的背面提供均匀的支撑，以便于使用薄背衬层。

36. 发明授权

US5597950A Surfactant monitoring by foam generation 失效
标题翻译：通过泡沫生成监测表面活性剂
公开(公告)号：US5597950A
公开(公告)日：1997-01-28
申请号：US334164
申请日：1994-11-03
申请人： Ken I. Mullen
发明人： Ken I. Mullen
IPC分类号： G01F23/24 , G01F23/292 , G01N13/02 , G01N27/06 , G01N37/00
CPC分类号： G01N27/06 , G01F23/241 , G01F23/2927 , G01N13/02 , G01N2013/0275
摘要： A device for monitoring the presence or absence of active surfactant or other surface active agents in a solution or flowing stream based on the formation of foam or bubbles is presented. The device detects the formation of foam with a light beam or conductivity measurement. The height or density of the foam can be correlated to the concentration of the active surfactant present.
摘要翻译：提出了一种用于基于形成泡沫或泡沫来监测溶液或流动流中活性表面活性剂或其它表面活性剂的存在或不存在的装置。该装置通过光束或电导率测量来检测泡沫的形成。泡沫的高度或密度可以与活性表面活性剂的浓度相关。

37. 发明授权

US5539800A Pseudolocal tomography 失效
标题翻译：伪局部断层扫描
公开(公告)号：US5539800A
公开(公告)日：1996-07-23
申请号：US410620
申请日：1995-03-24
申请人： Alexander J. Katsevich , Alexander G. Ramm
发明人： Alexander J. Katsevich , Alexander G. Ramm
IPC分类号： G01N23/04 , G06F15/00
CPC分类号： G01N23/046 , G01N2223/419 , Y10S378/901
摘要： Local tomographic data is used to determine the location and value of a discontinuity between a first internal density of an object and a second density of a region within the object. A beam of radiation is directed in a predetermined pattern through the region of the object containing the discontinuity. Relative attenuation data of the beam is determined within the predetermined pattern having a first data component that includes attenuation data through the region. The relative attenuation data is input to a pseudo-local tomography function, where the difference between the internal density and the pseudo-local tomography function is computed across the discontinuity. The pseudo-local tomography function outputs the location of the discontinuity and the difference in density between the first density and the second density.
摘要翻译：局部断层数据用于确定物体的第一内部密度和物体内区域的第二密度之间的不连续性的位置和值。辐射束以预定的图案被引导穿过包含不连续性的物体的区域。在具有包括通过该区域的衰减数据的第一数据分量的预定模式内确定光束的相对衰减数据。将相对衰减数据输入到伪局部断层摄影功能，其中在不连续性之间计算内部密度和伪局部断层摄影功能之间的差异。伪局部断层摄影功能输出第一密度和第二密度之间的不连续性的位置和密度差。

38. 发明授权

US5487880A Production of sodium-22 from proton irradiated aluminum 失效
标题翻译：从质子照射的铝生产钠-22
公开(公告)号：US5487880A
公开(公告)日：1996-01-30
申请号：US160601
申请日：1993-11-30
申请人： Wayne A. Taylor , Richard C. Heaton , David J. Jamriska
发明人： Wayne A. Taylor , Richard C. Heaton , David J. Jamriska
IPC分类号： C22B26/10 , C01G57/00
CPC分类号： C22B26/10
摘要： A process for selective separation of sodium-22 from a proton irradiated minum target including dissolving a proton irradiated aluminum target in hydrochloric acid to form a first solution including aluminum ions and sodium ions, separating a portion of the aluminum ions from the first solution by crystallization of an aluminum salt, contacting the remaining first solution with an anion exchange resin whereby ions selected from the group consisting of iron and copper are selectively absorbed by the anion exchange resin while aluminum ions and sodium ions remain in solution, contacting the solution with an cation exchange resin whereby aluminum ions and sodium ions are adsorbed by the cation exchange resin, and, contacting the cation exchange resin with an acid solution capable of selectively separating the adsorbed sodium ions from the cation exchange resin while aluminum ions remain adsorbed on the cation exchange resin is disclosed.
摘要翻译：一种用于从质子照射的铝靶上选择性分离钠-22的方法，包括将质子照射的铝靶溶解在盐酸中以形成包含铝离子和钠离子的第一溶液，通过结晶将一部分铝离子与第一溶液分离的铝盐，使剩余的第一溶液与阴离子交换树脂接触，由此选择由铁和铜组成的组的离子被阴离子交换树脂选择性吸收，同时铝离子和钠离子保留在溶液中，使溶液与阳离子接触交换树脂，由此阳离子交换树脂吸收铝离子和钠离子，并且使阳离子交换树脂与能够选择性地从阳离子交换树脂分离吸附的钠离子的酸溶液接触，同时铝离子保持吸附在阳离子交换树脂上被披露。

39. 发明授权

US5468965A Circular, confined distribution for charged particle beams 失效
标题翻译：带电粒子束的圆形，有限分布
公开(公告)号：US5468965A
公开(公告)日：1995-11-21
申请号：US303963
申请日：1994-09-09
申请人： Robert W. Garnett , M. Christian Dobelbower
发明人： Robert W. Garnett , M. Christian Dobelbower
IPC分类号： G21K1/093 , H01J37/04 , H01J37/14
CPC分类号： G21K1/093 , H01J37/04 , H01J2237/04922
摘要： A charged particle beam line is formed with magnetic optics that manipulate the charged particle beam to form the beam having a generally rectangular configuration to a circular beam cross-section having a uniform particle distribution at a predetermined location. First magnetic optics form a charged particle beam to a generally uniform particle distribution over a square planar area at a known first location. Second magnetic optics receive the charged particle beam with the generally square configuration and affect the charged particle beam to output the charged particle beam with a phase-space distribution effective to fold corner portions of the beam toward the core region of the beam. The beam forms a circular configuration having a generally uniform spatial particle distribution over a target area at a predetermined second location.
摘要翻译：带电的粒子束线形成有磁光学器件，其操作带电粒子束以形成具有大致矩形构造的梁，其具有在预定位置处具有均匀粒子分布的圆形横截面。第一磁性光学器件在已知的第一位置上形成在正方形平面区域上的大致均匀的粒子分布的带电粒子束。第二磁光学接收具有大致正方形配置的带电粒子束，并且影响带电粒子束，以输出具有有效地折射束朝向光束核心区域的角部分的相位空间分布的带电粒子束。波束形成在预定的第二位置处的目标区域上具有大致均匀的空间粒子分布的圆形构造。

40. 发明授权

US5418169A Chromosome characterization using single fluorescent dye 失效
标题翻译：染色体表征使用单一荧光染料
公开(公告)号：US5418169A
公开(公告)日：1995-05-23
申请号：US218090
申请日：1994-03-25
申请人： Harry A. Crissman , Gregory T. Hirons
发明人： Harry A. Crissman , Gregory T. Hirons
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , Y10S436/80 , Y10T436/143333
摘要： Chromosomes are characterized by fluorescent emissions from a single fluorescent dye that is excited over two different wavelengths. A mixture containing chromosomes is stained with a single dye selected from the group consisting of TOTO and YOYO and the stained chromosomes are placed in a flow cytometer. The fluorescent dye is excited sequentially by a first light having a wavelength in the ultraviolet range to excite the TOTO or YOYO to fluoresce at a first intensity and by a second light having a wavelength effective to excite the TOTO or YOYO dye to fluoresce at a second intensity. Specific chromosomes may be identified and sorted by intensity relationships between the first and second fluorescence emissions.
摘要翻译：染色体的特征在于来自在两种不同波长上被激发的单一荧光染料的荧光发射。含有染色体的混合物用选自TOTO和YOYO的单一染料染色，将染色的染色体置于流式细胞仪中。荧光染料依次通过具有紫外线范围波长的第一光激发以激发TOTO或YOYO以第一强度发荧光，并通过具有有效激发TOTO或YOYO染料的波长的第二光在一秒钟发荧光强度。可以通过第一和第二荧光发射之间的强度关系来鉴定和分类特定染色体。

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