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31. 发明申请

WO1996010843A1 PHOTOSENSITIVE SEMICONDUCTOR ARRAY 审中-公开
标题翻译：光敏半导体阵列
公开(公告)号：WO1996010843A1
公开(公告)日：1996-04-11
申请号：PCT/AU1995000644
申请日：1995-09-29
申请人： THE UNIVERSITY OF WESTERN AUSTRALIA , SILIQUINI, John, Frank , FARAONE, Lorenzo
发明人： THE UNIVERSITY OF WESTERN AUSTRALIA
IPC分类号： H01L27/146
CPC分类号： H01L27/1467 , H01L31/1013
摘要： An array of photo sensing elements and a pixel therefor comprising a photoconductor semiconductor material (31, 33) fixed to a conducting (or in some applications non-conducting) substrate (29) which can conduct photons to be detected by the pixel. On top of the photoconductor semiconductor material (31, 33) is a metal terminal (41), which provides an electrode connection to the pixel. In the case of a conducting substrate, mounted on the light receiving face on the side of the substrate (29) opposite the pixel, are metal terminals (45), to provide the other terminal connections. The light receiving face of the substrate is on the opposing side of the substrate to the pixels, which allows a higher packing density of the pixels, and other advantages. Indium bumps (43) provide a connection for signal processing. The semiconductor surfaces have a passivation layer (39).
摘要翻译：一种感光元件阵列及其像素，其包括固定到导电（或一些应用中不导电）衬底（29）的光电导体半导体材料（31,33），其可以传导要由像素检测的光子。在光电导体半导体材料（31,33）的顶部是金属端子（41），其提供与像素的电极连接。在与像素相对的基板（29）一侧的光接收面上安装导电基板的情况下，为金属端子（45），以提供其它端子连接。基板的光接收面位于基板的与像素相对的一侧，这允许像素的更高的堆积密度等优点。铟凸块（43）提供用于信号处理的连接。半导体表面具有钝化层（39）。

32. 发明申请

WO2023081967A1 COMPOUNDS AND USES THEREFOR 审中-公开
公开(公告)号：WO2023081967A1
公开(公告)日：2023-05-19
申请号：PCT/AU2022/051340
申请日：2022-11-10
申请人： THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： VRIELINK, Alice , STUBBS, Keith , KAHLER, Charlene
IPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P29/00 , A61P31/04 , C07D233/84 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/04 , C07D409/04
摘要： Provided herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising said compounds. Also provided are uses of the compounds for sensitising bacterial cells expressing EptA to cationic antimicrobial peptides, for inhibiting the growth of bacterial cells expressing EptA, and for treating or inhibiting bacterial infections or for treating or preventing diseases caused by or associated with said bacterial infections.

33. 发明申请

WO2022011434A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2022011434A1
公开(公告)日：2022-01-20
申请号：PCT/AU2021/050770
申请日：2021-07-16
申请人： THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： BLANCAFORT, Pilar , DUFFY, Ciara
IPC分类号： C07K14/435 , C07K16/18 , A61K31/282 , A61K31/337 , A61K38/00 , A61K38/17 , A61P35/00 , C07K14/43572 , C07K2319/035
摘要： The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins αvβ6 and αvβ3. Preferably the RGD-motif containing fusion peptide can reduce viability of cancer cells, including in particular, TNBC and HER2-enriched breast cancer cells, and ovarian cancer cells.

34. 发明申请

WO2020093088A1 A METHOD OF DETECTING A FLOW IN A SEQUENCE OF IMAGES 审中-公开
公开(公告)号：WO2020093088A1
公开(公告)日：2020-05-14
申请号：PCT/AU2019/051211
申请日：2019-11-04
申请人： THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： GONG, Peijun , WANG, Qiang , SAMPSON, David D
IPC分类号： G06T7/20 , A61B8/00 , G16H30/00 , A61B6/03 , G16H50/50
摘要： A method of detecting a flow in sequence of images of a material. Providing a sequence of at least three images of an area of the material. Each image includes a plurality of voxels or regions of interest such that the at least three images of the area of the material provide for each voxel or region of interest an intensity for at least three points in time, Fourier transforming for each voxel or region of interest to obtain a frequency distribution including the intensities for the at least three points in time, analysing for each voxel or region of interest and generating a processed image of area of the material including the voxels or regions of interest, associating voxels or regions of interest that have a larger amplitude at a higher frequency range with a first visual property and voxels or regions of interest that have smaller amplitude in the higher frequency range with a second visual property.

35. 发明申请

WO2019232588A1 PROTEINS AND THEIR USE FOR NUCLEOTIDE BINDING 审中-公开
公开(公告)号：WO2019232588A1
公开(公告)日：2019-12-12
申请号：PCT/AU2019/050586
申请日：2019-06-06
申请人： THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： FILIPOVSKA, Aleksandra , RACKHAM, Oliver
IPC分类号： C07K14/00 , C12N15/62 , A61K38/16 , A61P35/00
摘要： A method of regulating expression of a gene in a cell is described, comprising the step of introducing into the cell a recombinant polypeptide comprising a PPR ssDNA-binding domain which itself comprises at least a pair of PPR ssDNA base-binding motifs. The PPR ssDNA base-binding motifs of the PPR ssDNA-binding domain are operably capable of binding the target ssDNA. Recombinant polypeptides comprising at least one PPR sDNA-binding domain capable of binding to target ssDNA sequence are also described, together with fusion proteins comprising the recombinant PPR ssDNA-binding domains, as well as isolated nucleic acids useful in preparing the recombinant polypeptides described. Recombinant vectors; compositions comprising the recombinant polypeptides; isolated nucleic acids; recombinant vectors; host cells comprising same; use of same in the manufacture of a medicament for regulating gene expression; as well as systems and kits for regulating gene expression are also described.

36. 发明申请

WO2019036753A1 SCREENING ASSAYS, MODULATORS AND MODULATION OF ACTIVATION OF RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) 审中-公开
公开(公告)号：WO2019036753A1
公开(公告)日：2019-02-28
申请号：PCT/AU2018/050883
申请日：2018-08-21
申请人： MONASH UNIVERSITY , THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： PFLEGER, Kevin Donald George , THOMAS, Merlin Christopher , PICKERING, Raelene Jane , ROSADO, Carlos , TIKELLIS, Christos
IPC分类号： C07K14/00 , A61K38/00 , A61K31/00 , G01N33/15
摘要： A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.

37. 发明申请

WO2018136998A1 A METHOD AND SYSTEM FOR VALIDATING LOGGING DATA FOR A MINERAL SAMPLE 审中-公开
公开(公告)号：WO2018136998A1
公开(公告)日：2018-08-02
申请号：PCT/AU2018/050046
申请日：2018-01-24
申请人： TECHNOLOGICAL RESOURCES PTY. LIMITED , THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： HOLDEN, Eun-Jung , WEDGE, Daniel , PAINE, Mark , GREEN, Thomas , LEWAN, Andrew
IPC分类号： G01N33/24 , G01V9/00 , G01V11/00 , G06Q50/02 , E21B47/00 , E21B49/00 , E21C39/00
摘要： Disclosed is a method for validating logging data for a mineral sample which has been obtained from a region of interest. The method comprises obtaining logging data associated with a composition of the mineral sample, the logging data including one or more estimated material types present in the mineral sample. Compositional assay data indicative of an actual composition of the mineral sample or another mineral sample provided from the region of interest, is obtained. An estimated composition of the mineral sample is then determined based on the estimated material types. The estimated composition is then compared with the compositional assay data, and a data validation controller is used to provide adjusted logging data based on: the comparison of the estimated composition with the compositional assay data; and stored validation criteria which defines allowable modifications to the estimated material types based on physical properties associated with the material types.

38. 发明申请

WO2015172196A1 HETEROCYCLIC COMPOUNDS AND USE OF SAME 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2015172196A1
公开(公告)日：2015-11-19
申请号：PCT/AU2015/050238
申请日：2015-05-13
申请人： MONASH UNIVERSITY , THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： BAELL, Jonathan , PIGGOTT, Matthew , RUSSELL, Stephanie , TOYNTON, Arthur , RAHMANI, Raphael , FERRINS, Lori , NGUYEN, Nghi
IPC分类号： C07D277/28 , C07D213/40 , C07D231/12 , C07D231/38 , C07D249/04 , C07D249/06 , C07D263/32 , C07D277/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D493/08 , A61K31/55 , A61K31/535 , A61K31/517 , A61K31/4725 , A61K31/4453 , A61K31/4418 , A61K31/427 , A61K31/426 , A61K31/497 , A61K31/422 , A61K31/4192 , A61K31/4155 , A61K31/415 , A61P33/02
CPC分类号： C07D213/40 , C07D231/12 , C07D231/16 , C07D231/38 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D257/04 , C07D263/32 , C07D277/10 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/56 , C07D417/04 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D493/08
摘要： Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).
摘要翻译：提供了新颖的杂环化合物，其在治疗由锥虫病引起的疾病中显示有用的功效。特别地，本发明的化合物可用于治疗HAT和/或恰加斯病和/或非洲动物非洲锥虫病（AAT）。

39. 发明申请

WO2014056041A1 A METHOD OF INCREASING PERMEABILITY OF A GEOLOGICAL STRUCTURE 审中-公开
标题翻译：增加地质结构渗透性的方法
公开(公告)号：WO2014056041A1
公开(公告)日：2014-04-17
申请号：PCT/AU2013/001178
申请日：2013-10-10
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： REGENAUER-LIEB, Klaus , SCHRANK, Christoph Eckart , KARRECH, Ali , POULET, Thomas
IPC分类号： E21B43/26
CPC分类号： E21B43/26
摘要： A method of increasing the permeability of a geological structure is described. The method comprises applying multiple fluid-conductivity increasing processes to a geological structure at different diffusion length scales based on geological properties of the geological structure. At least one of the processes is arranged to operate on the geological structure at a grain level diffusion length scale, and at least one further process is arranged to operate on the geological structure at a macroscopic diffusion length scale. The processes are applied to increase the permeability of the geological structure by creating fractures in the geological structure and/or increasing the size of existing fractures in the geological structure. The method further comprises applying at least one of the selected fluid conductivity increasing processes cyclically, and the fluid conductivity increasing processes are substantially applied at a level below a failure level expected to cause macroscopic failure of the geological structure.
摘要翻译：描述了增加地质结构渗透性的方法。该方法包括基于地质结构的地质特征，对不同扩散长度尺度的地质结构应用多种流体传导性增加过程。至少一个过程被布置成以粒度扩散长度尺度在地质结构上操作，并且布置至少一个另外的过程以在宏观扩散长度尺度上对地质结构进行操作。应用该过程通过在地质结构中产生裂缝和/或增加地质结构中现有裂缝的尺寸来增加地质结构的渗透性。该方法还包括周期性地应用所选择的流体电导率增加过程中的至少一个，并且流体电导率增加过程基本上以低于预期导致地质结构宏观破坏的破坏水平的水平施加。

40. 发明申请

WO2014045283A1 RESTORATION OF THE CFTR FUNCTION BY SPLICING MODULATION 审中-公开
标题翻译：通过分散调制恢复CFTR功能
公开(公告)号：WO2014045283A1
公开(公告)日：2014-03-27
申请号：PCT/IL2013/050789
申请日：2013-09-17
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , THE UNIVERSITY OF WESTERN AUSTRALIA
发明人： KEREM, Batsheva , TUR SINAI, Michal , PRICE, Loren , WILTON, Stephen Donald , FLETCHER, Sue
IPC分类号： C12N15/113 , A61K31/7088 , A61P11/00
CPC分类号： C12N15/113 , A61K31/7105 , A61K45/06 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2320/31 , C12N2320/33 , C12N2310/3521
摘要： The present provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, compositions comprising said oligonucleotides, kits comprising said compositions, and uses thereof. In particular, the present invention provides compositions of oligonucleotides useful in methods for suppressing exon 10 skipping optionally in combination with additional CFTR therapeutics.
摘要翻译：本发明提供能够结合和调节CFTR基因前mRNA的剪接的寡核苷酸，包含所述寡核苷酸的组合物，包含所述组合物的试剂盒及其用途。特别地，本发明提供了可用于抑制外显子10跳跃的方法的寡核苷酸组合物，任选地与另外的CFTR治疗剂组合。

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