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31. 发明授权

US08119105B2 Aerosol container and a method for storage and administration of a pre-determined amount of a pharmaceutically active aerosol 失效
标题翻译：气溶胶容器和用于储存和施用预定量的药学活性气溶胶的方法
公开(公告)号：US08119105B2
公开(公告)日：2012-02-21
申请号：US10424633
申请日：2003-04-28
申请人： Francois Brugger , Angelika Stampf
发明人： Francois Brugger , Angelika Stampf
IPC分类号： A61K9/12 , A61M11/00
CPC分类号： A61K9/008 , B65D83/54
摘要： The invention relates to an aerosol container for pharmaceutically active aerosols that are to be administered in predetermined amounts and that are supplied in the container in the form of a suspension, the suspension also comprising, in addition to a pharmaceutically active substance, at least a propellant gas. The aerosol container has a metering valve that comprises a metering chamber and a valve stem. In a first position of the valve stem, the metering chamber is in communication with the interior of the container and has been filled with a predetermined amount of the aerosol. In a second position of the valve stem, the amount of aerosol disposed in the metering chamber is released. The propellant gas is an alternative propellant gas that is free of fluorochlorohydrocarbons, preferably a propellant gas that comprises only fluorohydrocarbons, and the inner wall of the container is coated with a plastics coating.
摘要翻译：本发明涉及一种用于药物活性气溶胶的气溶胶容器，其以预定量施用并以悬浮液的形式供应到容器中，所述悬浮液除药学活性物质外还包含至少一种推进剂加油站。气溶胶容器具有包括计量室和阀杆的计量阀。在阀杆的第一位置中，计量室与容器的内部连通，并且已经填充有预定量的气溶胶。在阀杆的第二位置，释放设置在计量室中的气溶胶的量。推进剂气体是不含氟氯代烃的替代推进剂气体，优选仅包含氟代烃的推进剂气体，并且容器的内壁涂覆有塑料涂层。

32. 发明授权

US6110493A Terazosin capsules 有权
标题翻译：特拉唑嗪胶囊
公开(公告)号：US6110493A
公开(公告)日：2000-08-29
申请号：US313613
申请日：1999-05-18
申请人： Jeffrey W. Guentensberger , Christopher L. Pelloni
发明人： Jeffrey W. Guentensberger , Christopher L. Pelloni
IPC分类号： A61K9/48 , A61K31/506 , A61K31/517
CPC分类号： A61K31/506 , A61K31/517 , A61K9/4858 , A61K9/4866
摘要： A capsule dosage form containing solid form of terazosin in a solid carrier is disclosed. The capsule dosage form is stable under accelerated stability conditions and therapeutically equivalent to known liquid-filled terazosin capsules.
摘要翻译：公开了一种在固体载体中含有固体形式的特拉唑嗪的胶囊剂型。胶囊剂型在加速稳定条件下是稳定的，治疗上相当于已知的液体填充特拉唑嗪胶囊。

33. 发明授权

US6066718A Reshaped monoclonal antibodies against an immunoglobulin isotype 失效
公开(公告)号：US6066718A
公开(公告)日：2000-05-23
申请号：US127721
申请日：1993-09-27
申请人： Norman Hardman , Frank Kolbinger , Jose Saldanha
发明人： Norman Hardman , Frank Kolbinger , Jose Saldanha
IPC分类号： A61K38/00 , A61K47/48 , A61P37/08 , C07K16/42 , C07K16/46 , C12P21/08 , C07K16/00 , C07H21/04 , C12N5/06
CPC分类号： A61K47/48653 , C07K16/4291 , C07K16/465 , A61K2039/505 , A61K38/00 , C07K2317/565 , C07K2319/00
摘要： The invention relates to reshaped human monoclonal antibodies directed against isotypic determinants of immunoglobulin E (IgE), direct equivalents and derivatives of said antibodies. The molecules of the invention are useful for diagnostics, prophylaxis and treatment of allergy.

34. 发明授权

US6066596A Herbicidal synergistic composition, and method of controlling weeds 失效
标题翻译：除草协同组合物及控制杂草的方法
公开(公告)号：US6066596A
公开(公告)日：2000-05-23
申请号：US729100
申请日：1996-10-11
申请人： Jean Louis Allard , Manfred Hudetz
发明人： Jean Louis Allard , Manfred Hudetz
IPC分类号： C07D239/60 , A01N37/18 , A01N37/22 , A01N37/34 , A01N39/04 , A01N43/46 , A01N43/54 , A01N43/56 , A01N43/66 , A01N43/78 , A01N47/12 , A01N47/20 , A01N47/36 , C07D277/68 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04
CPC分类号： A01N43/54
摘要： A herbicidal synergistic composition, comprising, besides customary inert formulation auxiliaries, a compound of formula I ##STR1## and a synergistically active amount of at least one active ingredient selected from among the compounds of formula II ##STR2## and of formula III ##STR3## and of formula V ##STR4##
摘要翻译：一种除草协同组合物，除了常规惰性制剂助剂外，还包含式I化合物和协同活性量的至少一种选自式II和式III化合物和式V化合物的活性成分

35. 发明授权

US6047495A Pest-controlling apparatus for use in livestock barns 失效
标题翻译：害虫控制装置，用于家畜仓库
公开(公告)号：US6047495A
公开(公告)日：2000-04-11
申请号：US750625
申请日：1996-12-11
申请人： Syunji Matsumura , Isao Takada , Toshiaki Mima , Kazuo Fukui
发明人： Syunji Matsumura , Isao Takada , Toshiaki Mima , Kazuo Fukui
IPC分类号： A01K31/00 , A01K31/04 , A01M1/00 , A01M1/24 , A01M29/00 , A01M29/12 , A01M7/00
CPC分类号： A01M1/245 , A01K31/04 , A01M2200/012 , Y10S43/90
摘要： Spraying tubes (20 . . . ) through each of which a plurality of spraying holes are perforated along the longitudinal axis of each tube are placed in prescribed positions upper than feces boards (10 . . . ) of henhouses; and the spraying tubes (20 . . . ) are connected to agent-supplying means for supplying an agent such as a tank, a pump, etc. and airsupplying means for supplying compressed air such as a compressor, etc. The spraying holes make an angle not smaller than 5 degrees and not greater than 90 degrees as measured downward from the horizontal plane at the time of spraying an agent, in order to make it possible to spray the agent to feces boards (10 . . . ) and feces floor (12). The eggs of pests such as housefly and the like laid on the feces adhering to the feces boards and feces floor can efficiently and certainly be controlled. Since compressed air is supplied to the spraying tubes, no residual agent remains in the spraying tubes and the agent can be used up effectively, and at the same time the spraying tubes can be prevented from, the clogging caused by the agent.
摘要翻译： PCT No.PCT / IB95 / 00451 Sec。 371日期1996年12月11日第 102（e）日期1996年12月11日PCT提交1995年6月8日PCT公布。公开号WO95 / 34198 日期1995年12月21日沿着每个管的纵向轴线穿过多个喷孔的喷射管（20 ...）放置在高于粪便板（10 ...）上方的规定位置; 和喷射管（20 ...）连接到用于供应诸如罐，泵等的试剂的供给装置和用于供应诸如压缩机等的压缩空气的空气供应装置。喷射孔使得在喷雾剂时从水平面向下测量的角度不小于5度且不大于90度，以便可以将试剂喷洒到粪便板（10 ...）和粪便地板（ 12）。可以有效且可靠地控制放置在粪便板和粪便地板上的粪便上的诸如家禽等害虫的鸡蛋。由于向喷射管供给压缩空气，所以在喷射管中不残留残留物，能够有效地使用该物质，能够防止喷雾管堵塞而引起的堵塞。

36. 发明授权

US5981582A Compositions and methods of combatting fungi 有权
公开(公告)号：US5981582A
公开(公告)日：1999-11-09
申请号：US150435
申请日：1998-09-09
申请人： Cosima Nuninger , John Edward Nicholas Goggin , Dino Sozzi
发明人： Cosima Nuninger , John Edward Nicholas Goggin , Dino Sozzi
IPC分类号： A01N37/46 , A01N20060101 , A01N37/12 , A01N37/18 , A01N37/22 , A01N37/34 , A01N37/44 , A01N43/38 , A01N43/40 , A01N47/00 , A01N47/04 , A01N47/10 , A01N47/14 , A01N47/24 , A01N47/34 , A01N59/20 , A01P3/00 , A61K31/40 , A61K31/555
CPC分类号： A01N37/46
摘要： When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.

37. 发明授权

US5972698A Tryptase inhibitor 失效
标题翻译：胰蛋白酶抑制剂
公开(公告)号：US5972698A
公开(公告)日：1999-10-26
申请号：US586676
申请日：1996-01-25
申请人： Hans Fritz , Christian Sommerhoff
发明人： Hans Fritz , Christian Sommerhoff
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P1/02 , A61P7/02 , A61P11/00 , A61P29/00 , A61P43/00 , C07H21/04 , C07K14/81 , C07K14/815 , C12N9/99 , C12N15/81 , C12P21/02 , C12R1/865 , A61K38/58 , C12N15/11
CPC分类号： C07K14/811 , C12N15/81 , A61K38/00
摘要： The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibtor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells transformed with such vectors, to the recombinant production of the inibitors, to pharmaceutical compositions containing the novel inhibitor molecules, and to their use in diagnosis and therapy.
摘要翻译： PCT No.PCT / EP94 / 02445 Sec。 371日期：1996年1月25日 102（e）日期1996年1月25日PCT 1994年7月25日PCT公布。公开号WO95 / 03333 日期1995年2月2日本发明涉及新型的类胰蛋白酶抑制剂，其从水蛭分离到编码新型抑制剂分子或其片段的核苷酸序列，涉及含有其编码序列的载体，宿主用这些载体转化的细胞，涉及重组生产的内含子，含有新型抑制剂分子的药物组合物及其在诊断和治疗中的应用。

38. 发明授权

US5965592A Acyl compounds 失效
标题翻译：酰基化合物
公开(公告)号：US5965592A
公开(公告)日：1999-10-12
申请号：US124520
申请日：1998-07-29
申请人： Peter Buhlmayer , Franz Ostermayer , Tibur Schmidlin
发明人： Peter Buhlmayer , Franz Ostermayer , Tibur Schmidlin
IPC分类号： A61K31/195 , A61K31/41 , A61K31/44 , A61K31/47 , A61K31/535 , A61K31/675 , A61P9/12 , C07C229/38 , C07C231/00 , C07C233/47 , C07C233/51 , C07C233/54 , C07C235/04 , C07C271/10 , C07C311/48 , C07D233/54 , C07D233/58 , C07D233/64 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/00 , C07D405/00 , C07D409/00 , C07F9/6524 , A61K31/235
CPC分类号： C07D233/64 , C07C229/38 , C07C233/54 , C07D257/04 , C07D401/12
摘要： Compounds of the formula ##STR1## and their salts, in which R.sub.1, is a C.sub.1 -C.sub.7 aliphatic hydrocarbon radical; X.sub.1 is --CO; X.sub.2 is a divalent aliphatic hydrocarbon radical which comprises an ethyl group and an alkylene of 2 to 6 carbon atoms; R.sub.2 is hydroxy, carboxy or alkoxycarbonyl in which alkoxy is from 1 to 7 carbon atoms; X.sub.3 is a divalent aliphatic hydrocarbon; R.sub.3 is carboxyl or 5-tetrazolyl; and the rings A and B independently of one another are otherwise unsubstituted; can be prepared in a known manner and may be used as active ingredients for medicaments.
摘要翻译：式中的化合物及其盐，其中R 1为C 1 -C 7脂族烃基; X1是-CO; X 2是包含乙基和2至6个碳原子的亚烷基的二价脂族烃基; R2是羟基，羧基或烷氧基羰基，其中烷氧基是1至7个碳原子; X3是二价脂族烃; R3是羧基或5-四唑基; 环A和B彼此独立地是未取代的; 可以以已知的方式制备并且可以用作药物的活性成分。

39. 发明授权

US5965562A Aroyl-piperidine derivatives 失效
标题翻译：芳酰基 - 哌啶衍生物
公开(公告)号：US5965562A
公开(公告)日：1999-10-12
申请号：US961546
申请日：1997-10-30
申请人： Silvio Ofner , Siem Jacob Veenstra , Walter Schilling
发明人： Silvio Ofner , Siem Jacob Veenstra , Walter Schilling
IPC分类号： C07D211/58 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/45 , A61K31/47 , A61K31/505 , A61P1/04 , A61P9/12 , A61P11/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12
CPC分类号： C07D401/12
摘要： The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(azanaphthoyl-amino)-piperidines of the formula ##STR1## wherein X and Y are each independently of the other N and/or CH and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及下式的新型N-（3,5-双 - 三氟甲基 - 苯甲酰基）-2-苄基-4-（氮杂萘甲酰基 - 氨基） - 哌啶，其中X和Y各自独立地为N和/或CH 并且环A是未取代的或被选自低级烷基，低级烷氧基，卤素，硝基和三氟甲基的取代基单取代或多取代; 及其盐，其用途，其制备方法和包含本发明化合物或其药学上可接受的盐的药物组合物。

40. 发明授权

US5952003A Terazosin capsules 失效
公开(公告)号：US5952003A
公开(公告)日：1999-09-14
申请号：US691907
申请日：1996-08-01
申请人： Jeffrey W. Guentensberger , Christopher L. Pelloni
发明人： Jeffrey W. Guentensberger , Christopher L. Pelloni
IPC分类号： A61K9/48 , A61K31/506 , A61K31/517
CPC分类号： A61K31/506 , A61K31/517 , A61K9/4858 , A61K9/4866
摘要： A capsule dosage form containing solid form of terazosin in a solid carrier is disclosed. The capsule dosage form is stable under accelerated stability conditions and therapeutically equivalent to known liquid-filled terazosin capsules.

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