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31. 发明申请

WO2019173815A2 METHOD FOR ANTI-MUC1* CAR T CELL STIMULATION 审中-公开
公开(公告)号：WO2019173815A2
公开(公告)日：2019-09-12
申请号：PCT/US2019/021556
申请日：2019-03-11
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia , GLENNIE, Nelson
IPC分类号： A61K39/395
摘要： The present application discloses a composition comprising a MUC1* extra cellular domain peptide attached to a surface and an immune cell that bears a receptor that binds to the peptide.

32. 发明申请

WO2019165421A1 DIAGNOSTIC METHODS USING ANTI-MUC1* ANTIBODIES 审中-公开
公开(公告)号：WO2019165421A1
公开(公告)日：2019-08-29
申请号：PCT/US2019/019566
申请日：2019-02-26
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia
IPC分类号： C07K16/30 , C07K16/28 , A61P35/04 , A61K39/395 , A61K47/68 , G01N33/574 , G01N33/53
摘要： The present application discloses a method of determining suitability of treating a patient suffering from cancer or metastasis of cancer characterized by aberrant expression of MUCl, with a MUCl* targeting therapeutic.

33. 发明申请

WO2019126357A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS 审中-公开
公开(公告)号：WO2019126357A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066552
申请日：2018-12-19
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia , MOE, Scott
IPC分类号： G01N33/574
摘要： The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

34. 发明申请

WO2018071583A3 HUMANIZED ANTI-MUC1* ANTIBODIES AND USE OF CLEAVAGE ENZYME 审中-公开
公开(公告)号：WO2018071583A3
公开(公告)日：2018-04-19
申请号：PCT/US2017/056204
申请日：2017-10-11
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia , SMAGGHE, Benoit , DEARY, Luke
IPC分类号： A61K35/17 , A61K39/395 , C07K14/705 , C07K16/30
摘要： The present application discloses humanized antibodies and antibody like proteins and fragments thereof and use of cleavage enzyme.

35. 发明申请

WO2012126013A2 METHOD FOR MAKING PLURIPOTENT STEM CELLS 审中-公开
标题翻译：多功能干细胞的制备方法
公开(公告)号：WO2012126013A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029706
申请日：2012-03-19
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia
发明人： BAMDAD, Cynthia
IPC分类号： A61K39/00 , A61K31/7088 , A61K38/00 , A61P35/00 , C12N5/02 , C12N11/00 , C12Q1/02 , C12Q1/68 , A61P37/02
CPC分类号： C12N11/06 , A61K31/7088 , C07K16/2863 , C07K16/3092 , C07K2317/35 , C07K2317/75 , C12N5/0606 , C12N5/0696 , C12N2500/98 , C12N2501/115 , C12N2501/727 , C12N2533/50 , C12Q1/6881 , C12Q2600/158 , C12Q2600/178
摘要： The present application discloses a method for inducing cells to gain characteristics of naive stem cell state comprising culturing the cells in the presence of a MUCl* activator.
摘要翻译：本申请公开了诱导细胞获得幼稚干细胞状态特征的方法，包括在MUC1 *激活剂存在下培养细胞。

36. 发明申请

WO2010144887A1 METHODS FOR CULTURING STEM AND PROGENITOR CELLS 审中-公开
标题翻译：培养干细胞和祖细胞的方法
公开(公告)号：WO2010144887A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038438
申请日：2010-06-11
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia
发明人： BAMDAD, Cynthia
IPC分类号： C12N5/02 , C12N11/00 , C12N11/06
CPC分类号： G01N33/57492 , C12N5/0606 , C12N5/0647 , C12N5/0695 , C12N2501/998 , C12N2502/30 , C12N2533/90 , G01N33/56966
摘要： The present application describes a method of culturing, expanding or growing stem or stem-like cells or induced pluripotent stem cells on a surface, including attaching the cells to the surface through a ligand that binds to the surface and the cells.
摘要翻译：本申请描述了在表面上培养，扩增或培养茎或干样细胞或诱导的多能干细胞的方法，包括通过与表面和细胞结合的配体将细胞附着到表面。

37. 发明申请

WO2010042891A2 METHOD FOR INDUCING PLURIPOTENCY IN CELLS 审中-公开
标题翻译：在细胞中诱导细胞周期的方法
公开(公告)号：WO2010042891A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/060272
申请日：2009-10-09
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia , FESSLER, Shawn
发明人： BAMDAD, Cynthia , FESSLER, Shawn
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2501/40 , C12N2501/50 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/998
摘要： The present application describes a method for inducing or maintaining pluripotency in a cell by contacting the cell with a biological or chemical species that increases MUCl* activity.
摘要翻译：本申请描述了通过使细胞与增加MUCl *活性的生物或化学物质接触来诱导或维持细胞中多能性的方法。

38. 发明申请

WO2007053135A1 METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：癌症诊断和治疗方法
公开(公告)号：WO2007053135A1
公开(公告)日：2007-05-10
申请号：PCT/US2005/032821
申请日：2005-09-14
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： A01N43/54 , A61K31/517 , C07D419/00 , C07D239/72 , A61K31/495 , C07D209/00 , C07D209/48
CPC分类号： A61K31/495 , A61K31/517 , B82Y30/00
摘要： The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
摘要翻译：本申请公开了一种异常表达MUC1的癌症检测方法。

39. 发明申请

WO2005007282A2 STORAGE AND USE OF COLLOIDS 审中-公开
标题翻译：存储和使用胶体
公开(公告)号：WO2005007282A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/015088
申请日：2004-05-13
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： B01J
CPC分类号： G01N33/54346 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N2610/00
摘要： The present invention discloses compositions and methods for enabling the longterm storage and/or use of colloid particles without substantial degradation of their performance, for example, by chemical or physical degradation, by particle aggregation, changes in pH and/or relative humidity, changes in salt concentration, and/or by a decrease in the binding activity or other detrimental change in biological, chemical, or physical properties of the colloid particles. In one aspect of the invention, the colloid particles are treated with an aggregation-preventing entity, for example, by immobilizing the entity relative to the colloid particle. In one embodiment, the aggregation-preventing entity forms at least a part of, and/or is immobilized relative to, a self-assembled monolayer ("SAM") immobilized to the colloid particle. The aggregation-preventing entity may be added to non-aggregated or aggregated particles, for example to prevent aggregation and/or to reduce the degree of aggregation. In some embodiments of the invention, the colloid particles are essentially free of surfactants and/or other non immobilized aggregation-preventing entities. The colloid particles and/or solutions thereof may be stored before use without substantial degradation or aggregation over long periods of time in a dried state and/or at low temperatures. After storage, certain colloid particles provided by the invention can remain substantially non-aggregated. Various colloid particles of the invention may be used in many techniques, for example, in gels or other assay systems. In some cases, the colloid particles have a high degree of specificity and/or activity, which is due, at least in part, to their ability to remain in a substantially non-aggregated and detergent-free state during storage and/or use.
摘要翻译：本发明公开了能够长期储存和/或使用胶体颗粒的组合物和方法，而不会通过化学或物理降解，通过颗粒聚集，pH和/或相对湿度的变化，盐浓度，和/或通过胶体颗粒的生物学，化学或物理性质的结合活性或其它有害变化的降低。在本发明的一个方面，胶体颗粒用聚集防止实体进行处理，例如通过相对于胶体颗粒固定该实体。在一个实施方案中，聚集防止实体相对于固定在胶体颗粒上的自组装单层（“SAM”）形成至少一部分和/或固定。可以将聚集防止实体添加到非聚集或聚集的颗粒，例如以防止聚集和/或降低聚集度。在本发明的一些实施方案中，胶体颗粒基本上不含表面活性剂和/或其它非固定的聚集防止物质。胶体颗粒和/或其溶液可以在使用前储存，在干燥状态和/或低温下长时间不会显着降解或聚集。储存后，本发明提供的某些胶体颗粒可以保持基本上不聚集。本发明的各种胶体颗粒可用于许多技术中，例如在凝胶或其它测定系统中。在一些情况下，胶体颗粒具有高度的特异性和/或活性，其至少部分是由于其在储存和/或使用期间保持基本上非聚集和无去污剂状态的能力。

40. 发明申请

WO2004059347A3 OPTICAL DEVICES AND METHODS INVOLVING NANOPARTICLES 审中-公开
公开(公告)号：WO2004059347A3
公开(公告)日：2004-07-15
申请号：PCT/US2003/041258
申请日：2003-12-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： G01N21/00
摘要： The present invention relates generally to optical materials and applications of optical materials and, more particularly, to optical materials incorporating particles , such as nanoparticles, methods of forming such materials, and applications of such materials in various devices, for example, for filters, displays, coatings for glare reduction, and the like. The present invention can provide control over fabrication dimensions at very small scale, for example, at the molecular scale rather than at a macroscopic scale. The invention also involves, in some cases, controlling the interaction of many wavelengths of electromagnetic radiation with these materials. The optical materials and devices of the invention may be constructed and arranged for a response to, control of, and/or interaction with essentially any electromagnetic radiation, electric field, and/or magnetic field.

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