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31. 发明申请

WO2014018554A1 PTPRS AND PROTEOGLYCANS IN AUTOIMMUNE DISEASE 审中-公开
标题翻译：自杀性疾病中的PTPRS和保护剂
公开(公告)号：WO2014018554A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051723
申请日：2013-07-23
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
发明人： BOTTINI, Nunzio , STANFORD, Stephanie
IPC分类号： C07K16/40 , G01N33/573 , A61K39/395 , A61P37/00
CPC分类号： C12N9/16 , A61K39/395 , C07K14/705 , C07K16/18 , C07K16/40 , C12Y301/03048 , G01N33/68 , G01N2500/02
摘要： Provided herein, inter alia, are PTPRS de-clustering agents and compositions and kits comprising the agents. Provided are methods of modulating extracellular matrix or decreasing fibroblast activity in a subject. Also provided are methods of treating subjects with or at risk of developing extracellular matrix diseases, fibroblast-mediated diseases, or autoimmune diseases.
摘要翻译：特别地，本文提供了PTPRS去聚类剂和包含该试剂的组合物和试剂盒。提供调节受试者的细胞外基质或降低成纤维细胞活性的方法。还提供了治疗患有或具有发展细胞外基质疾病，成纤维细胞介导的疾病或自身免疫疾病的风险的受试者的方法。

32. 发明申请

WO2013119863A1 TIMOTHY GRASS ALLERGENS AND METHODS AND USES FOR IMMUNE RESPONSE MODULATION 审中-公开
标题翻译： TIMOTHY GRASS ALLERGENS及其免疫调节方法及用途
公开(公告)号：WO2013119863A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025213
申请日：2013-02-07
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , SETTE, Alessandro , SCHULTEN, Veronique , GREY, Howard , PETERS, Bjoern , GREENBAUM, Jason
发明人： SETTE, Alessandro , SCHULTEN, Veronique , GREY, Howard , PETERS, Bjoern , GREENBAUM, Jason
IPC分类号： A61K39/35 , A61K38/16
CPC分类号： C07K14/415 , A61K38/00 , A61K39/36 , A61K2039/543 , A61K2039/55505
摘要： The invention relates to Timothy Grass proteins and peptides, subsequences, portions, homologues, variants and derivatives thereof, and methods and uses of Timothy Grass proteins and peptides. Methods include, for example, modulating an immune response; protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease; and inducing immunological tolerance to the allergen in a subject.
摘要翻译：本发明涉及Timothy Grass蛋白质和肽，亚序列，部分，同系物，变体和衍生物，以及Timothy Grass蛋白质和肽的方法和用途。方法包括例如调节免疫应答; 保护受试者免受或治疗受试者的过敏反应，过敏性疾病或过敏性疾病; 并且在受试者中诱导对变应原的免疫耐受性。

33. 发明申请

WO2012177788A1 MODULATORS OF 4-1BB AND IMMUNE RESPONSES 审中-公开
标题翻译： 4-1BB和免疫应答的调节器
公开(公告)号：WO2012177788A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043383
申请日：2012-06-20
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , CROFT, Michael , MADIREDDI, Shravan
发明人： CROFT, Michael , MADIREDDI, Shravan
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/241 , A61K38/02 , A61K2039/505 , C07K16/2851 , C07K16/2878 , C07K2317/76 , C07K2319/30 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/3513
摘要： The invention provides peptides and fragments, methods and uses based upon modulating the binding or interaction between 4-lBB and galectins such as Galectin-9. Modulating such binding or interaction between 4- IBB and a galectin, such as Galectin 9. modulates an immune response.
摘要翻译：本发明提供了基于调节4-1BB和半乳凝素如Galectin-9之间的结合或相互作用的肽和片段，方法和用途。调节4-IBB和半乳凝素如Galectin9之间的这种结合或相互作用调节免疫应答。

34. 发明申请

WO2011123697A3 HISTAMINE-RELEASING FACTOR (HRF), HRF-RECEPTOR AND METHODS OF MODULATING INFLAMMATION 审中-公开
公开(公告)号：WO2011123697A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/030809
申请日：2011-03-31
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KAWAKAMI, Toshiaki , KAWAKAMI, Yuko
发明人： KAWAKAMI, Toshiaki , KAWAKAMI, Yuko
IPC分类号： A61K38/10 , A61K38/16
摘要： Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally controlled tumor protein (TCTP) is contacted with a compound that inhibits or reduces binding of HRF/TCTP to an immunoglobulin in order to treat the food allergy, allergic reaction, hypersensitivity, inflammatory response, or inflammation. Methods of reducing or decreasing the probability, severity, frequency, duration or preventing a subject from having an acute or chronic food allergy, allergic reaction, hypersensitivity, an inflammatory response or inflammation, are also provided. In one method, histamine releasing factor (HRF)/translationally controlled tumor protein (TCTP) is contacted with a compound that inhibits or reduces binding of HRF/TCTP to an immunoglobulin in order to reduce or decrease the probability, severity, frequency, duration or prevent a subject from having an acute or chronic food allergy, allergic reaction, hypersensitivity, an inflammatory response or inflammation.

35. 发明申请

WO2010121195A2 METHODS OF INHIBITING ADVERSE CARDIAC EVENTS AND TREATING ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE USING GALECTIN-3 BINDING PROTEIN (GAL-3BP, BTBD17B, MAC-2 BINDING PROTEIN) 审中-公开
标题翻译：使用GALECTIN-3结合蛋白（GAL-3BP，BTBD17B，MAC-2结合蛋白）抑制不良心脏事件和治疗角膜内膜疾病和冠状动脉疾病的方法
公开(公告)号：WO2010121195A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031479
申请日：2010-04-16
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , LEY, Klaus , GLEISSNER, Christian
发明人： LEY, Klaus , GLEISSNER, Christian
IPC分类号： A61K38/17
CPC分类号： A61K38/1732 , A61K38/1709
摘要： The invention provides Galectin-3 binding protein (Gal-3BP, BTBD17B) polypeptide sequences and compositions that include Gal-3BP polypeptide sequences, and methods of using Gal-3BP polypeptide sequences, including modified forms and wild type (native) forms of Gal-3BP polypeptide, such as in treatment, diagnostic, detection and prognostic methods.
摘要翻译：本发明提供了Galectin-3结合蛋白（Gal-3BP，BTBD17B）多肽序列和包含Gal-3BP多肽序列的组合物，以及使用Gal-3BP多肽序列（包括修饰形式）和野生型（天然）形式的Gal- 3BP多肽，如治疗，诊断，检测和预后方法。

36. 发明申请

WO2010006071A1 HVEM/BTLA, HVEM/CD160 AND HVEM/GD CIS COMPLEXES AND METHODS OF USE 审中-公开
标题翻译： HVEM / BTLA，HVEM / CD160和HVEM / GD CIS复合物及其使用方法
公开(公告)号：WO2010006071A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/049968
申请日：2009-07-08
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , WARE, Carl, F. , CHEUNG, Timothy, C. , STEINBERG, Marcos
发明人： WARE, Carl, F. , CHEUNG, Timothy, C. , STEINBERG, Marcos
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： A61K39/0005 , C07K16/2803 , C07K16/2818 , C07K16/2878 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2319/30 , G01N2333/70578
摘要： The invention provides HVEM cis complexes which include, for example, HVEM/BTLA, HVEM/CD160 and HVEM/gD cis complexes. The invention provides ligands and agents that bind to HVEM cis complexes, such as antibodies. The invention further provides methods of use of the HVEM cis complexes, and the ligands and agents (e.g., antibodies) that bind to the HVEM cis complexes.
摘要翻译：本发明提供HVEM顺式复合物，其包括例如HVEM / BTLA，HVEM / CD160和HVEM / gD顺式复合物。本发明提供了与HVEM顺式复合物如抗体结合的配体和试剂。本发明还提供使用HVEM顺式复合物的方法，以及结合HVEM顺式复合物的配体和试剂（例如抗体）。

37. 发明申请

WO2009048839A2 VACCINIA VIRUS H3L AND B5R SPECIFIC MONOCLONAL ANTIBODIES AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： VACCINIA病毒H3L和B5R特异性单克隆抗体及其制备和使用方法
公开(公告)号：WO2009048839A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/078955
申请日：2008-10-06
申请人： KYOWA HAKKO KIRIN CO., LTD. , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KATO, Shinichiro , GRANGER, Steve , CROTTY, Shane , RICKERT, Sandra , KORIAZOVA, Lilia , TAHARA, Tomoyuki
发明人： KATO, Shinichiro , GRANGER, Steve , CROTTY, Shane , RICKERT, Sandra , KORIAZOVA, Lilia , TAHARA, Tomoyuki
IPC分类号： C07K16/08 , A61K39/42 , A61P31/20
CPC分类号： C07K16/081 , A61K2039/507 , C07K2317/565 , C07K2317/734
摘要： The invention relates to antibodies and subsequences thereof that specifically bind to poxvirus B5R envelope protein, antibodies and subsequences thereof that specifically bind to poxvirus H3L envelope protein, and combinations thereof.
摘要翻译：本发明涉及与痘病毒B5R包膜蛋白特异性结合的抗体及其子序列，与痘病毒H3L包膜蛋白特异性结合的抗体及其子序列，及其组合。

38. 发明申请

WO2008027338A2 ANTAGONISTIC HUMAN LIGHT-SPECIFIC HUMAN MONOCLONAL ANTIBODIES 审中-公开
标题翻译：拮抗性人类光特异性人单克隆抗体
公开(公告)号：WO2008027338A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018832
申请日：2007-08-24
申请人： KIRIN PHARMA KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , GRANGER, Steven, W. , KATO, Shinichiro , WARE, Carl, F.
发明人： GRANGER, Steven, W. , KATO, Shinichiro , WARE, Carl, F.
IPC分类号： C07K16/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies, such as fully human antibodies, that immunospecifically bind to an hLIGHT polypeptide. Also provided are isolated nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Further provided are vectors and host cells comprising nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided are methods of making antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided herein is a method of treating a hLIGHT- mediated disease in a subject comprising administering to the subject an antibody, such as a fully human antibody, that immunospecifically binds to a hLIGHT polypeptide. In preferred embodiments, that anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo ( e.g. , the hLIGHT- mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。还提供了编码免疫特异性结合hLIGHT多肽的抗体例如完全人抗体的分离的核酸。进一步提供了包含免疫特异性结合hLIGHT多肽的编码抗体的核酸（如完全人抗体）的载体和宿主细胞。还提供了制备免疫特异性结合hLIGHT多肽的抗体如完全人抗体的方法。本文还提供了治疗受试者中hLIGHT介导的疾病的方法，其包括向受试者施用免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。在优选的实施方案中，本文提供的抗hLIGHT抗体将改善，中和或以其他方式抑制hLIGHT体内生物学活性（例如，hLIGHT介导的CCL20的产生或分泌， IL-8或来自表达hLIGHT受体的细胞的RANTES）。本文还提供了用于检测样品中hLIGHT的方法以及用于改善，中和或以其他方式抑制hLIGHT活性的方法，例如在患有hLIGHT活性是有害的病症的人类受试者中的方法。

39. 发明申请

WO1998022139A1 DETECTION OF GALECTIN-4 IN HUMAN TUMORS 审中-公开
标题翻译：在人肿瘤中检测GALECTIN-4
公开(公告)号：WO1998022139A1
公开(公告)日：1998-05-28
申请号：PCT/US1997021807
申请日：1997-11-19
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
发明人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , HUFLEJT, Margaret, E. , LIU, Fu-Tong
IPC分类号： A61K39/395
CPC分类号： G01N33/57415 , A01K2217/05 , A61K38/00 , C07K14/4726 , C07K16/3015
摘要： This invention is based on the discovery of the human galectin-4 gene, and the discovery that human galectin-4 is expressed in breast cancer. The invention provides an isolated polynucleotide encoding human galectin-4, and the human galectin-4 polypeptide. Antibodies which bind human galectin-4 polypeptide and formulations for administration of these antibodies are also disclosed. The present invention provides a method of diagnosing or determining the prognosis of cell proliferative disorder, such as breast cancer, associated with the human galectin-4. A method of determining the presence of metastases in a sample from a subject by determining the presence or absence of galectin-4 is also disclosed. A method of treating a subject having, or at risk of having, a human galectin-4 associated disorder, such as breast cancer, is also provided. A kit useful for detecting the presence of human galectin-4 polypeptide or polynucleotide in a sample from a subject having a human galectin-4-associated disorder is disclosed. A method of identifiying compounds which affect human galectin-4 expression is also provided. Transgenic nonhuman animals having a transgene encoding human galectin-4 are also described.
摘要翻译：本发明是基于人半乳凝素-4基因的发现，以及人类半乳凝素-4在乳腺癌中表达的发现。本发明提供了编码人半乳凝素-4和人半乳凝素-4多肽的分离的多核苷酸。还公开了结合人半乳凝素-4多肽的抗体和用于施用这些抗体的制剂。本发明提供了诊断或确定与人半乳凝素-4相关的细胞增殖性疾病如乳腺癌的预后的方法。还公开了通过确定半乳凝素-4的存在或不存在来确定来自受试者的样品中转移物的存在的方法。还提供了治疗患有人Galectin-4相关病症（例如乳腺癌）的风险或患有风险的受试者的方法。公开了一种用于检测来自具有人半乳凝素-4相关病症的受试者的样品中人半乳凝素-4多肽或多核苷酸的存在的试剂盒。还提供了鉴定影响人半乳凝素-4表达的化合物的方法。还描述了具有编码人galectin-4的转基因的转基因非人动物。

40. 发明申请

WO2019183610A9 TISSUE RESIDENT MEMORY CELL PROFILES, AND USES THEREOF 审中-公开
公开(公告)号：WO2019183610A9
公开(公告)日：2019-09-26
申请号：PCT/US2019/023767
申请日：2019-03-22
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , UNIVERSITY OF SOUTHAMPTON , VIJAYANAND, Pandurangan , OTTENSMEIER, Christian , CLARKE, James , SANCHEZ-ELSNER, Tilman , ESCHWEILER, Simon , AY, Ferhat
发明人： VIJAYANAND, Pandurangan , OTTENSMEIER, Christian , CLARKE, James , SANCHEZ-ELSNER, Tilman , ESCHWEILER, Simon , AY, Ferhat
IPC分类号： C12N5/0783 , A61K35/17 , C12Q1/6886 , A61K39/395 , A61P35/00 , C07K16/30
摘要： This disclosure provides methods of treating cancer or eliciting an anti-tumor response in a subject by administering an effective amount of a population of T-cells that exhibits higher or lower than baseline expression of one or more genes. In other aspects, methods are provided to diagnose cancer and determine prognosis of cancer patients. Also provided are methods to identify the antigens or antigen receptors associated with the isolated and/or purified cell populations that elicit a more positive prognosis.

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