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31. 发明专利

CA3018013A1 REGULATION OF THE RAS/CAMP/PKA SIGNALING PATHWAY IN YEASTS 未知
公开(公告)号：CA3018013A1
公开(公告)日：2017-09-21
申请号：CA3018013
申请日：2017-03-17
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： OESER MICHELLE , HENNINGSEN BROOKS , FISHER JANET , RICE CHARLES F , FROEHLICH ALLAN , ARGYROS AARON , ZELLE RINTZE M
IPC分类号： C07K14/395 , C12N1/22 , C12P7/06
摘要： The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).

32. 发明专利

CA2905033A1 EXPRESSION OF BETA-GLUCOSIDASES FOR HYDROLYSIS OF LIGNOCELLULOSE AND ASSOCIATED OLIGOMERS 未知
公开(公告)号：CA2905033A1
公开(公告)日：2014-09-25
申请号：CA2905033
申请日：2014-03-13
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： MCBRIDE JOHN , WISWALL ERIN
IPC分类号： C12N1/16 , C12N9/42 , C12P7/10
摘要： The present invention provides for heterologous expression of beta-glucosidase (BGL) polypeptides encoded by Humicola grisea, Candida wickerhamii, Aspergillus aculeatus, Aspergillus oryzae, Penicillium decumbens, Chaetomium globosum, Neocallimastix frontalis, Debaryomyces hansenii, Kluyveromyces marxianus, or Phytophthora infestans in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed BGL. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.

33. 发明专利

CA2891455A1 AN ELECTRON CONSUMING ETHANOL PRODUCTION PATHWAY TO DISPLACE GLYCEROL FORMATION IN S. CEREVISIAE 未知
公开(公告)号：CA2891455A1
公开(公告)日：2014-05-30
申请号：CA2891455
申请日：2013-11-20
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： SHAW ARTHUR J IV , ARGYROS AARON , BARRETT TRISHA
IPC分类号： C12N9/04 , C12N9/02 , C12N9/10 , C12N9/88 , C12P7/06
摘要： The present invention provides for a mechanism to completely replace the electron accepting function of glycerol formation with an alternative pathway to ethanol formation, thereby reducing glycerol production and increasing ethanol production. In some embodiments, the invention provides for a recombinant microorganism comprising a down-regulation in one or more native enzymes in the glycerol-production pathway. In some embodiments, the invention provides for a recombinant microorganism comprising an up-regulation in one or more enzymes in the ethanol-production pathway.

34. 发明专利

AU2008251465B2 Gene knockout mesophilic and thermophilic organisms, and methods of use thereof 未知
公开(公告)号：AU2008251465B2
公开(公告)日：2013-01-10
申请号：AU2008251465
申请日：2008-05-09
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： HOGSETT DAVID A , RAJGARHIA VINEET B
IPC分类号： C07H21/02 , C12N1/20 , C12N15/00
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

35. 发明专利

CA2964245A1 YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERME TATION USING CELLULOSE 未知
公开(公告)号：CA2964245A1
公开(公告)日：2010-05-27
申请号：CA2964245
申请日：2009-11-23
申请人： UNIV STELLENBOSCH , LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： MCBRIDE JOHN , BREVNOVA ELENA , GHANDI CHHAYAL , MELLON MARK , FROEHLICH ALAN , DELEAULT KRISTEN , RAJGARHIA VINEET , FLATT JIM , VAN ZYL EMILE , DEN HAAN RIAAN , LAGRANGE DANIE , ROSE SHAUNITA , PENTTILA MERJA , ILMEN MARJA , SIIKA-AHO MATTI , UUSITALO JAANA , HAU HEIDI HANSON , RICE CHARLES , VILLARI JEFF , STONEHOUSE EMILY A , GILBERT ALAN , KEATING JEFFREY D , XU HAOWEN , WILLES DEIDRE , SHIKHARE INDRANEEL , THORNGREN NAOMI , WARNER ANNE K , MURPHY DAN
IPC分类号： C12N1/19 , C12N9/24 , C12N9/42 , C12N15/56 , C12P7/10 , C12P19/02 , C12P19/14
摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

36. 发明专利

BR112022010438A2 PROCESSO PARA DESLOCAMENTO DE UMA ENZIMA EXÓGENA 未知
公开(公告)号：BR112022010438A2
公开(公告)日：2022-10-11
申请号：BR112022010438
申请日：2020-11-25
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC , BASF SE
发明人： AARON ARGYROS , ALEXANDRA PANAITIU , CHARLES F RICE , KENNETH E BARRETT , MATTHEW B RICHARDS , TERA STOUGHTENGER
IPC分类号： C12P7/06 , C12P19/14
摘要： PROCESSO PARA DESLOCAMENTO DE UMA ENZIMA EXÓGENA. A presente invenção refere-se a um processo para fermentar uma biomassa com uma dose reduzida de uma enzima exógena purificada (que pode ser, por exemplo, uma glucoamilase exógena purificada). O processo compreende colocar em contato uma biomassa (que pode compreender amido) com uma célula hospedeira de levedura recombinante. A célula hospedeira de levedura recombinante tem uma modificação genética para expressar um polipeptídeo heterólogo com atividade de amido ou dextrina hidrolase (que pode ser, por exemplo, de uma glucoamilase). A molécula de ácido nucleico que codifica o polipeptídeo heterólogo com atividade de amido ou dextrina hidrolase compreende permitir a secreção do polipeptídeo heterólogo.

37. 发明专利

AR122061A1 CÉLULA HOSPEDADORA DE LEVADURA RECOMBINANTE QUE EXPRESA UNA HIDROLASA 未知
公开(公告)号：AR122061A1
公开(公告)日：2022-08-10
申请号：ARP210101289
申请日：2021-05-11
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
IPC分类号： C12N1/18 , C12N9/10 , C12N9/24 , C12N9/48 , C12P7/10
摘要： La presente descripción se refiere a una célula hospedadora de levadura recombinante que presenta una mayor estabilidad y, en algunas modalidades, un mayor rendimiento de fermentación. La estabilidad de la célula hospedadora de levadura recombinante tiene una capacidad limitada para expresar una hidrolasa durante su fase de propagación. En cambio, esto limita la escisión de un componente celular de levadura durante o después de la propagación, lo que puede ser perjudicial para la estabilidad y/o rendimientos de fermentación. La célula hospedadora de levadura recombinante expresa una hidrolasa heteróloga bajo el control de un promotor heterólogo (para limitar la expresión de la hidrolasa heteróloga durante la propagación y favorecer la expresión de la hidrolasa heteróloga durante la fermentación). Una célula hospedadora de levadura recombinante que puede expresar un primer polipéptido heterólogo bajo el control de un promotor heterólogo, donde: el primer polipéptido heterólogo es una hidrolasa; y el promotor heterólogo puede limitar la expresión del primer polipéptido heterólogo durante una propagación y favorecer la expresión del primer polipéptido heterólogo durante una fermentación; donde la hidrolasa puede generar un producto enzimático a partir de un sustrato y donde el sustrato es un componente celular de la levadura.

38. 发明专利

CA2891455C AN ELECTRON CONSUMING ETHANOL PRODUCTION PATHWAY TO DISPLACE GLYCEROL FORMATION IN S. CEREVISIAE 未知
公开(公告)号：CA2891455C
公开(公告)日：2022-07-05
申请号：CA2891455
申请日：2013-11-20
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： SHAW ARTHUR J , ARGYROS AARON , BARRETT TRISHA
IPC分类号： C12N9/04 , C12N9/02 , C12N9/10 , C12N9/88 , C12P7/06
摘要： The present invention provides for a mechanism to completely replace the electron accepting function of glycerol formation with an alternative pathway to ethanol formation, thereby reducing glycerol production and increasing ethanol production. In some embodiments, the invention provides for a recombinant microorganism comprising a down-regulation in one or more native enzymes in the glycerol-production pathway. In some embodiments, the invention provides for a recombinant microorganism comprising an up-regulation in one or more enzymes in the ethanol-production pathway.

39. 发明专利

BR102021013568A2 Fonte de nitrogênio derivada de bactérias para etanol 未知
公开(公告)号：BR102021013568A2
公开(公告)日：2022-01-25
申请号：BR102021013568
申请日：2021-07-09
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： HENNINGSEN BROOKS , PHROMMAO EKKARAT , FERNANDA CRISTINA FIRMINO , JAMES L STEELE , JEFFERY R BROADBENT
IPC分类号： C12N1/21 , C12P1/04 , C12P7/10 , C12R1/225
摘要： fonte de nitrogênio derivada de bactérias para etanol. a presente invenção refere-se a uma célula hospedeira bacteriana recombinante capaz de fornecer uma fonte de nitrogênio a uma levedura durante a fermentação para fazer etanol. a célula hospedeira bacteriana recombinante é capaz de converter uma biomassa em etanol. a célula hospedeira bacteriana recombinante tem, pelo menos, uma primeira modificação genética. a pelo menos uma modificação genética confere à célula hospedeira bacteriana recombinante a capacidade de aumentar, quando comparada a uma célula bacteriana de controle correspondente sem a pelo menos uma primeira modificação genética, a atividade proteolítica associada à célula hospedeira bacteriana recombinante. a pelo menos uma modificação genética também confere à célula hospedeira bacteriana recombinante a capacidade de fornecer uma fonte de nitrogênio a uma levedura capaz de converter a biomassa em etanol, em que a fonte de nitrogênio compreende um peptídeo, um aminoácido e/ou amônia.

40. 发明专利

CA3112754A1 YEAST EXPRESSING GLUCOAMYLASE WITH ENHANCED STARCH HYDROLYSIS 未知
公开(公告)号：CA3112754A1
公开(公告)日：2021-09-19
申请号：CA3112754
申请日：2021-03-19
申请人： LALLEMAND HUNGARY LIQUIDITY MAN LLC
发明人： ARGYROS AARON , PANAITIU ALEXANDRA-ELENA
IPC分类号： C12N1/19 , C12N9/34 , C12N15/56 , C12N15/81 , C12P7/06 , C12P19/02 , C12P19/14
摘要： The present disclosure concerns recombinant yeast host cell for saccharification of a biomass. The recombinant yeast host cell has a genetic modification for expressing a heterologous polypeptide having glucoamylase activity (Penicillum oxalicum glucoamylase). In some embodiments, the heterologous polypeptide can comprise a signal sequence. The present disclosure also concerns a process for saccharification of a biomass using the recombinant yeast host cell as well as a process for fermenting the saccharified biomass into a fermentation product.

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