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31. 发明公开

EP0688202A1 CALCIUM PHOSPHATE HYDROXYAPATITE PRECURSOR AND METHODS FOR MAKING AND USING THE SAME 失效
标题翻译：磷酸钙为生产商品，它们的用途羟基磷灰石PRE和方法
公开(公告)号：EP0688202A1
公开(公告)日：1995-12-27
申请号：EP93921602.0
申请日：1993-09-15
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61L24 , A61F2 , A61K6 , A61K8 , A61L27 , A61Q11 , C01B25 , C09K3
CPC分类号： A61Q11/00 , A61F2310/00293 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0675 , A61K8/19 , A61K8/24 , A61L24/02 , A61L27/12
摘要： Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.

32. 发明公开

EP0151612A1 IMPROVING THE ADHESION OF COMPOSITES TO DENTIN, ENAMEL AND OTHER SUBSTRATES 失效
标题翻译：增牙科KOMPOSITMASSEN的腿，搪瓷等基材的附着力。
公开(公告)号：EP0151612A1
公开(公告)日：1985-08-21
申请号：EP84902974.0
申请日：1984-07-16
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： BOWEN, Rafael, L.
IPC分类号： A61K6 , C09J4 , C09J5
CPC分类号： C09J4/00 , C09J5/02 , C08F220/00 , A61K6/0023 , C08L33/068 , C08L33/14
摘要： Des matériaux et des procédés pour améliorer l'adhésion de matériaux composites et des résines sur la dentine, l'émail et sur d'autres substrats sont décrits. De préférence, la surface du substrat est traitée avec une solution aqueuse d'au moins un sel acide contenant un cation polyvalent qui de préférence est capable de changer la valence par étapes unitaires (changements univalents) et qui peut se lier sur des sites superficiels de dentine ou d'émail, et au moins un anion qui forme de préférence un ou des précipités relativement insolubles dans l'eau avec du calcium, et qui contient au moins un groupe carboxyle et de préférence deux ou plusieurs groupes carboxyles. La surface obtenue est ensuite traitée avec un solvant contenant une composition comprenant de préférence N-phénylglycine. Finalement, on applique une solution qui contient au moins un composé sélectionné dans le groupe constitué de (1) le produit de réaction d'addition de dianhydride d'acide pyromélitique et 2-hydroxyéthylméthacrylate (PMDM), (2) le produit de réaction d'addition de dianhydride (3, 3', 4, 4')-benzophénonetétracarboxylique et 2-hydroxyéthylméthacrylate (BTDA-HEMA), et (3) l'anhydride 4-méthacryloxyéthyltrimélitique (4-META). D'autres modes de réalisation sont également décrits.

33. 发明公开

EP0952851A1 ANTI-CARIOUS CHEWING GUMS, CANDIES, GELS, TOOTHPASTES AND DENTIFRICES 失效
标题翻译： ANTI-KARÖSE口香糖，糖果，糖果，凝胶剂，牙膏和牙齿护理
公开(公告)号：EP0952851A1
公开(公告)日：1999-11-03
申请号：EP97938396.0
申请日：1997-08-19
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： CHOW, Laurence, C. , TAKAGI, Shozo , VOGEL, Gerald, L.
IPC分类号： A23G3 , A23G4 , A61K8 , A61K9 , A61K33 , A61P19 , A61Q11
CPC分类号： A61Q11/00 , A23G3/362 , A23G4/064 , A61K8/19 , A61K8/24 , A61K9/0058
摘要： The invention relates to anticarious delivery vehicles, specifically chewing-gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.

34. 发明授权

EP0688202B1 CALCIUM PHOSPHATE HYDROXYAPATITE PRECURSOR AND METHODS FOR MAKING AND USING THE SAME 失效
标题翻译：磷酸钙为生产商品，它们的用途羟基磷灰石PRE和方法
公开(公告)号：EP0688202B1
公开(公告)日：1999-08-18
申请号：EP93921602.4
申请日：1993-09-15
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61K6/033 , A61L27/00 , A61L25/00
CPC分类号： A61Q11/00 , A61F2310/00293 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0675 , A61K8/19 , A61K8/24 , A61L24/02 , A61L27/12

35. 发明公开

EP0806936A1 CONTROL OF CALCIUM FLUORIDE FORMATION IN MOUTH RINSES, DENTIFRICES AND GELS 失效
标题翻译：氟化钙形成控制在漱口水，牙膏和凝胶
公开(公告)号：EP0806936A1
公开(公告)日：1997-11-19
申请号：EP96902105.0
申请日：1996-01-05
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61K8 , A61K9 , A61Q11
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K8/365 , A61K8/44 , A61K8/55 , A61K2800/88
摘要： Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.

36. 发明授权

EP0151612B1 IMPROVING THE ADHESION OF COMPOSITES TO DENTIN, ENAMEL AND OTHER SUBSTRATES 失效
标题翻译：改善复合材料对丁烯，ENAMEL和其他基材的粘合
公开(公告)号：EP0151612B1
公开(公告)日：1989-01-25
申请号：EP84902974.9
申请日：1984-07-16
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： BOWEN, Rafael, L.
IPC分类号： A61K6/00
CPC分类号： C09J4/00 , C09J5/02 , C08F220/00 , A61K6/0023 , C08L33/068 , C08L33/14
摘要： Materials and methods for improving the adhesion of composite materials and resins to dentin, enamel and other substrates. Preferably, the substrate surface is treated with an aqueous solution of at least one acidic salt containing a polyvalent cation which preferably is capable of changing valence by unit steps (univalent changes) and which can bind to dentin or enamel surface sites, and at least one anion which preferably forms a relatively water-insoluble precipitate or precipitates with calcium, and which contains at least one carboxyl group and preferably two or more carboxyl groups. The resultant surface is then treated with a solvent containing a composition preferably comprising N-phenylglycine. Finally, a solution is applied which contains at least one compound selected from the group consisting of (1) the addition reaction product of pyromellitic acid dianhydride and 2-hydroxyethyl methacrylate (PMDM), (2) the addition reaction product of 3,3',4,4'-benzophenonetetracarboxylic dianhydride and 2-hydroxyethyl methacrylate (BTDA-HEMA), and (3) 4-methacryloxyethyltrimellitic anhydride (4-META). Alternative embodiments are also set forth.

37. 发明授权

EP2421543B1 DUAL-PHASE CALCIUM PHOSPHATE CEMENT COMPOSITION 有权
公开(公告)号：EP2421543B1
公开(公告)日：2019-06-12
申请号：EP10767776.7
申请日：2010-04-22
申请人： American Dental Association Foundation
发明人： CHOW, Laurence C. , SHOZO, Takagi
IPC分类号： A61K33/42 , C01B25/37

38. 发明授权

EP2334254B1 APPARATUS AND METHODS FOR TESTING THE POLISHABILITY OF MATERIALS 失效转让
标题翻译：用于测试材料可抛光性的装置和方法
公开(公告)号：EP2334254B1
公开(公告)日：2018-03-28
申请号：EP09818464.1
申请日：2009-09-30
申请人： AMERICAN DENTAL ASSOCIATION
发明人： NJEGOVAN, Nikola , MEGREMIS, Spiro , SIROVSKAYA, Olga , SHEPELAK, Hank
IPC分类号： G01B5/28 , G01B21/30 , A61C17/16
CPC分类号： G01B21/30 , G01B5/28
摘要： A method and apparatus for measuring the polishability of a solid material such as a dental restorative material includes using a series of apparatus to perform the steps of forming the material into a desired specimen with a generally planar surface, conditioning the surface by abrasion, measuring the abraded surface with a profile determination device, optionally measuring the amount of material abraded from the surface and the gloss of the abraded surface, polishing a portion of the abraded surface with a polishing device at a controlled load for a pre-determined time and measuring the roughness and/or gloss of the polished surface followed by comparison thereof to the corresponding measurements of the unpolished, conditioned portion of the specimen surface. Polishing materials and devices may also be tested using the apparatus and method for polishing a standardized material.

39. 发明公开

EP0985407A1 Fluoride containing mouth rinses, dentifrices, gels, and chewable tablets 失效
标题翻译： FluoridaufweisendeMundspülungen，Zahnpasten，Gels sowie Kautabletten
公开(公告)号：EP0985407A1
公开(公告)日：2000-03-15
申请号：EP99111918.1
申请日：1990-03-09
申请人： American Dental Association Health Foundation
发明人： Chow, Lawrence C. , Takagi, Shozo
IPC分类号： A61K7/18 , A61K7/16
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21
摘要： Previous mouthwashes and dentifrices containing fluoride contributed relatively modest amounts of additional fluoride to the tooth surfaces, and scavenged calcium from the teeth. The present invention can deposit significantly more fluoride in the mouth than previously used formulations containing comparable amounts of fluoride, without scavenging calcium from the teeth. The invention includes a method of fluoridating teeth comprising (1) mixing in an aqueous environment a first component comprising a stable, non-toxic soluble calcium salt with a second component comprising a stable, non-toxic readily hydrolyzable complex fluoride compound, resulting in hydrolysis of the fluoride compound and precipitation of calcium fluoride, followed by (2) prompt application of the mixture to tooth surfaces. The invention also contemplates mouth rinses, dentifrices, gels or pastes, and chewable tablets for application of the above-described compositions.
摘要翻译：以前的含氟化漱口剂和洁牙剂对牙齿表面提供了相对适量的额外氟化物，并从牙齿清除钙。本发明可以比以前使用的含有相当量氟化物的制剂在口中沉积更多的氟化物，而不会从牙齿中清除钙。本发明包括一种氟化牙齿的方法，包括（1）在水性环境中将包含稳定的无毒可溶性钙盐的第一组分与包含稳定的，无毒的易水解的复合氟化物的第二组分混合，从而导致水解的氟化物和氟化钙的沉淀，然后（2）迅速将混合物施加到牙齿表面。本发明还考虑了用于施用上述组合物的漱口剂，洁牙剂，凝胶或糊剂和咀嚼片。

40. 发明授权

EP0741557B1 A METHOD AND COMPOSITION FOR PROMOTING IMPROVED ADHESION TO SUBSTRATES 失效
标题翻译：的方法和手段用于改善基材的附着力
公开(公告)号：EP0741557B1
公开(公告)日：1999-07-07
申请号：EP95908133.2
申请日：1995-01-31
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary of The United States Department of Commerce , AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： ANTONUCCI, Joseph, M. , BENNETT, Patricia, S. c/o Nat.Inst. of Standards
IPC分类号： A61K6/00
CPC分类号： A61K6/0029 , A61K6/0052 , A61K6/0023 , C08L33/08 , C08L33/10

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