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21. 发明专利

JPH10330327A PRODUCTION OF NITROESTER 失效
公开(公告)号：JPH10330327A
公开(公告)日：1998-12-15
申请号：JP14051497
申请日：1997-05-29
申请人： NIPPON STEEL CHEMICAL CO , NIPPON STEEL CORP
发明人： HARADA TAKEO , HAYASHI YOSHIO
IPC分类号： C07C201/02 , C07C203/02 , C07C203/04 , C07C271/22
摘要： PROBLEM TO BE SOLVED: To obtain a nitroester useful as an explosive or a medicine, etc., at a high yield without inducing a side reaction by making a specific eliminator exist in the reaction of a primary or secondary alcohol with a nitrate in a nonaqueous solvent. SOLUTION: This compound is obtained by dissolving 1 mol of an organic compound having a primary or secondary alcoholic hydroxyl group (e.g. a cyclic or a chain-like alkyl alcohol, alkenyl alcohol, alkynyl alcohol, etc.), and 1.0-2.0 equiv. times of a nitrate (preferably, silver nitrate or ammonium nitrate) in a nonaqueous solvent (preferably acetonitrile) and adding an eliminator necessary to eliminate a hydroxyl group (preferably an alkylsulfonyl halide-base, an arylsulfonyl halide-base, etc.), in an amount of 1.0-1.2 equiv. times of 1 mol of the alcoholic hydroxyl group to the reactive solution, then nitroesterifying at 10-30 deg.C for 6-24 hrs. A reaction intermediate is rapidly consumed and a side reaction is prevented by adding the eliminator to the reaction system.

22. 发明专利

JPH0723344B2 失效
公开(公告)号：JPH0723344B2
公开(公告)日：1995-03-15
申请号：JP24586588
申请日：1988-09-29
IPC分类号： C07C201/16 , C07C67/00 , C07C201/00 , C07C201/04 , C07C203/00 , C07C203/02 , C07C203/04

24. 发明专利

JPH01121251A METHOD AND REACTION CONTAINER FOR PRODUCING ALKYL NITRITE 失效
公开(公告)号：JPH01121251A
公开(公告)日：1989-05-12
申请号：JP24586688
申请日：1988-09-29
申请人： UNION CARBIDE CORP
发明人： JIEEMUSU RATSUSERU NERUSON
IPC分类号： C07C201/02 , B01D3/00 , C07C67/00 , C07C201/00 , C07C201/04 , C07C203/00 , C07C203/02 , C07C203/04

25. 发明专利

JPH01121250A REMOVAL OF IMPURITIES IN PRODUCTION OF ALKYL NITRITE 失效
公开(公告)号：JPH01121250A
公开(公告)日：1989-05-12
申请号：JP24586588
申请日：1988-09-29
申请人： UNION CARBIDE CORP
发明人： AASAA ROI DOUMOOKUSU JIYUNIA , JIEEMUSU RATSUSERU NERUSON
IPC分类号： C07C201/16 , C07C67/00 , C07C201/00 , C07C201/04 , C07C203/00 , C07C203/02 , C07C203/04

26. 发明专利

JPS6115847A Nitration process 失效
标题翻译：硝化过程
公开(公告)号：JPS6115847A
公开(公告)日：1986-01-23
申请号：JP13655784
申请日：1984-07-03
申请人： Kowa Co
发明人： KAWAMURA KIYOSHI , SHIBUYA MASAYUKI , ISHIHAMA HIROSHI
IPC分类号： C07D311/64 , C07B31/00 , C07B43/00 , C07C67/00 , C07C201/00 , C07C201/02 , C07C203/02 , C07C239/00 , C07C301/00 , C07C303/28 , C07C303/32 , C07C305/00 , C07D209/12 , C07D211/90 , C07D213/30 , C07D213/80 , C07D221/00 , C07D317/00 , C07D491/056
摘要： PURPOSE:To produce a nitric acid ester, in high yield and purity, economically in an industrial scale, easily under mild condition, using a regenerable reagent, by reacting a sulfonic acid ester with an organic quaternary ammonium nitrate. CONSTITUTION:The objective compound of formula III can be produced by reacting (A) the sulfonic acid ester of formula II (R'SO2 is sulfonic acid residue) obtained by the conventional sulfonation process of an alcohol of formula I (R is organic residue) with (B) the organic quaternary ammonium nitrate of formula IV(Q is organic quaternary ammonium residue), e.g. a quaternary alkyl (or substituted alkyl) ammonium nitrate or a nitrate of a strongly basic anion exchange resin having quaternary ammonium as an exchangeable group. The process can be applied to a compound which is difficult to be nitrated by conventional methods. When the process is applied to an optically active compound, a nitrate having inverted absolute configuration is prepared without causing racemization.
摘要翻译：目的：通过使磺酸酯与有机季硝酸铵反应，以高产率和纯度生产硝酸酯，在工业规模上经济地容易地在温和条件下使用可再生试剂。结构式：式Ⅲ的目的化合物可以通过使（A）式Ⅱ的磺酸酯（R'SO 2是磺酸残基）与通式Ⅰ的醇（R是有机残基）的常规磺化方法得到的与（B）式IV的有机季铵硝酸盐（Q +是有机季铵残基），例如具有季铵作为可交换基团的强碱性阴离子交换树脂的季烷基（或取代的烷基）硝酸铵或硝酸盐。该方法可以应用于难以用常规方法硝化的化合物。当将该方法应用于光学活性化合物时，制备具有反向绝对构型的硝酸盐而不引起外消旋化。

28. 发明专利

JPH07509484A 失效
公开(公告)号：JPH07509484A
公开(公告)日：1995-10-19
申请号：JP50515694
申请日：1993-07-26
IPC分类号： A61K9/20 , A61K9/48 , A61K9/50 , A61K9/70 , A61K31/04 , A61K31/34 , A61K31/60 , A61K31/625 , A61P9/08 , A61P9/10 , C07C203/02 , C07C203/04 , C07C203/06 , C07D493/04 , A61K31/62

29. 发明专利

JPH0246020B2 失效
公开(公告)号：JPH0246020B2
公开(公告)日：1990-10-12
申请号：JP20026882
申请日：1982-11-17
申请人： TOA EIYO LTD
发明人： NARA TAKESHI , NISHINOMYA YOZO , SATO KENTARO , KAMIKAMA KANEHITO
IPC分类号： C08B37/16 , A61K47/40 , C07C67/00 , C07C201/00 , C07C201/02 , C07C201/16 , C07C203/02 , C07C203/04

30. 发明专利

JPH02134316A MEDICINE COMPOSITION CONTAINING NITRATE ESTER AS ACTIVE MATERIAL AND HAVING RELAXATION ACTIVITY 失效
公开(公告)号：JPH02134316A
公开(公告)日：1990-05-23
申请号：JP24049789
申请日：1989-09-16
申请人： SEDONA PHARMACEUT BV
发明人： YAN BURON , GEERUTO YAN SUTERUKU , YAN FUETSUTSUE BAN DERU UERUFU , HENDORITSUKU TEIMUMERUMAN
IPC分类号： C07D209/10 , A61K31/21 , A61K31/215 , A61K31/27 , A61K31/33 , A61K31/35 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P9/08 , A61P9/10 , C07C203/02 , C07C203/04 , C07C203/08 , C07C205/42 , C07D213/28 , C07D213/30 , C07D213/36 , C07D213/62 , C07D213/72 , C07D215/20 , C07D215/36 , C07D215/38 , C07D215/48 , C07D277/28 , C07D307/42 , C07D333/16 , C07D335/12 , C07D493/04 , C07D521/00
摘要： PURPOSE: To obtain a pharmaceutical composition having relaxing activity and useful for treating cardinal and vascular diseases by compounding a nitrate ester. CONSTITUTION: This composition is obtained by compounding a nitrate ester of formula I [R0 is H, an OH group capable of being esterified with an aliphatic or aromatic carboxylic acid or formula II (R3 is H, an aromatic group, etc.; R4 is H, OH, an alkyl, etc.; R5 is H, an alkyl, etc.; X1 is a single bond, methylene, amine, etc.; X2 is a single bond, a double bond, a triple bond, carboxamide, etc.); R1 is a 1-8C alkylene, a 3-7C cycloalkylene, etc.; R2 is H, OH, an alkylated phenyl, etc.; (n)=1-3] or its salt in an amount able to release 0.001-10mg/Kg with conventional pharmaceutical supplements and formulating the resultant mixture. This may be formulated into tablets, capsules, an oral administration solution, suppositories, a sterilized solution or suspension for parenteral administration or a percutaneous administration form.

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