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21. 发明授权

US4252796A Stable water-in-oil emulsions 失效
标题翻译：稳定的油包水乳液
公开(公告)号：US4252796A
公开(公告)日：1981-02-24
申请号：US67714
申请日：1979-08-17
申请人： Ruey J. Yu , Eugene J. Van Scott
发明人： Ruey J. Yu , Eugene J. Van Scott
IPC分类号： A61K8/06 , A61K8/26 , A61K9/00 , A61K9/107 , A61K47/02 , A61Q19/00 , A61K37/40
CPC分类号： A61K8/064 , A61K47/02 , A61K8/06 , A61K8/26 , A61K9/0014 , A61K9/107 , A61Q19/00
摘要： Stabilized water-in-oil emulsions useful as vehicles for cosmetics and for therapeutic compositions to be topically applied is disclosed. The emulsions utilize a concentration of from 0.001 to 0.9% by weight of at least one of the aluminum containing compound as a primary emulsion stabilizer. A stable water-in-oil emulsion may also be formulated by utilizing from 0.001 to 0.2% of magnesium hydroxide or magnesium oxide as a primary emulsion stabilizer. This emulsion may be acidified to a desired pH with secondary emulsion stabilizer such as phosphoric acid, metallic chloride or metallic chlorohydroxide.
摘要翻译：公开了可用作化妆品载体的稳定的油包水乳液和用于局部施用的治疗组合物。乳液使用0.001至0.9重量％的至少一种含铝化合物作为主要乳液稳定剂。还可以通过使用0.001至0.2％的氢氧化镁或氧化镁作为主要乳液稳定剂来配制稳定的油包水乳液。该乳液可以用二级乳液稳定剂如磷酸，金属氯化物或金属氯代氢氧化物酸化至所需的pH。

22. 发明授权

US4018754A Novel polypeptides having ACTH-like action 失效
标题翻译：具有ACTH样作用的新型多肽
公开(公告)号：US4018754A
公开(公告)日：1977-04-19
申请号：US596246
申请日：1975-07-16
申请人： Ken Inouye , Masaru Shin , Kunio Watanabe
发明人： Ken Inouye , Masaru Shin , Kunio Watanabe
IPC分类号： C07K14/575 , A61K38/00 , A61K38/22 , C07K1/113 , C07K14/695 , C07C103/52 , A61K37/40
CPC分类号： C07K14/695 , C07K14/6955 , A61K38/00 , Y02P20/55 , Y10S930/29
摘要： A polypeptide of the formula:X.sub.1 --Tyr--Ser--X.sub.2 --X.sub.3 --His--Phe--Arg--Trp--Gly--Lys--Pro--Val--Gly--(Lys).sub.n --Ywherein X.sub.1 is .alpha.-aminoisobutyric acid, .beta.-alanine, L-serine, D-serine, glycine, D-alanine, .gamma.-aminobutyric acid or sarcosine residue; X.sub.2 is L-methionine, L-norleucine, L-isoleucine or L-norvaline residue; X.sub.3 is L-glutamic acid or L-glutamine residue; n is an integer of 5-10; and Y is --R.sub.1, ##STR1## wherein R.sub.1 is hydroxy or lower alkoxy having 1-5 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen or lower alkyl having 1-5 carbon atoms; m is an integer of 1-10 and Y is a group bound to the carbonyl group of the C-terminal lysine residue; non-toxic acid addition salts thereof; and complexes thereof; being useful as a medicament owing to their strong adrenal-stimulating activity with protracted action and little side effects. They can be prepared by condensing the amino acids together one by one or by condensing the small peptide fragments together in a per se conventional manner.
摘要翻译：一种下式的多肽：

23. 发明授权

US3915949A Solid phase synthesis of ACTH 失效
标题翻译：固相合成ACTH
公开(公告)号：US3915949A
公开(公告)日：1975-10-28
申请号：US44177074
申请日：1974-02-12
申请人： ARMOUR PHARMA
发明人： COLESCOTT ROBERT L , KAISER EMIL , BOSSINGER CHARLES D , COOK PAUL I
IPC分类号： C08F8/00 , A61K38/00 , A61P5/38 , C07K1/04 , C07K14/575 , C07K14/695 , C07K17/08 , C08F8/24 , C08F8/30 , C08H1/00 , C07C103/52 , A61K37/40
CPC分类号： C08H1/00 , A61K38/00 , C07K1/042 , C07K14/695 , C08F8/30 , Y02P20/55 , Y10S514/805 , Y10S930/28 , C08F12/08
摘要： Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R -CH2-Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.
摘要翻译：可用于制备具有生物活性的肽的树脂肽，特别是在氨基酸链的一端含有R -CH2-Phe-Glu的树脂肽，R为树脂，Phe和Glu为氨基酸苯丙氨酸的残基和谷氨酸; 以及制备这种树脂肽的方法。公开了含有与具有生物活性的天然肽的氨基酸链相同的氨基酸链的树脂肽。公开了其中含有氨基酸残基的氨基酸残基的其它树脂肽，其中氨基酸残基的种类和序列与天然生物活性肽的氨基酸序列不同，但可以衍生出具有生物活性的肽。

24. 发明专利

MD1591B2 Derivaţi ai peptidelor cu activitate terapeutică 未知
公开(公告)号：MD1591B2
公开(公告)日：2001-01-31
申请号：MD960137
申请日：1994-08-08
申请人： BIOMEASURE INC
发明人： KIM SUN HYUK , DONG ZHENGXIN , TAYLOR JOHN E , MOREAU SYLVIANE , KEYES SUSAN RILEY
IPC分类号： A61K38/00 , A61K38/22 , A61K38/26 , A61K38/31 , A61P1/04 , A61P1/12 , A61P1/18 , A61P3/10 , A61P5/00 , A61P5/02 , A61P5/04 , A61K38/04 , A61P5/06 , A61P5/08 , A61P5/14 , A61P5/18 , A61P5/38 , A61P5/48 , A61P7/00 , A61P9/10 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/04 , A61P43/00 , C07K1/107 , C07K5/04 , C07K7/06 , C07K7/08 , C07K7/18 , C07K7/23 , C07K14/575 , C07K14/585 , C07K14/595 , C07K14/60 , C07K14/605 , C07K14/635 , C07K14/655 , C07K14/68 , C07K14/69 , C07K14/70 , C07K7/10 , C07K7/34 , C07K7/36 , C07K7/44 , C07K7/26 , C07K7/38 , C07K7/12 , A61K37/24 , A61K37/28 , A61K37/40
摘要： Invenţia se referă la derivaţii peptidelor biologic active, utilizate în medicină, în special în oncologie.Problema pe care o rezolvă invenţia constă în crearea unor derivaţi ai peptidelor cu o activitate biologică înaltăşi de lungă durată, utili pentru tratamentul cancerului.Derivaţii peptidelor biologic active, conform invenţiei, conţin unul sau câţiva substituenţi ciclici sau aciclici, care includ radicali de diferită natură chimicăşi cel puţin una din peptide este unită cu fiecare din substituenţi prin legătura CO-N, CH2-N sau SO2-N între substituent şi atomul de azot N-terminal sau al lanţului lateral al uneia din peptide.Derivaţii peptidelor astfel modificaţi au o activitate biologică mai înaltăşi de lungă duratăşi pot fi utilizaţi în cantităţi terapeutice pentru tratamentul cancerului.

25. 发明专利

NZ241814A KILLING AND INHIBITING MICROORGANISMS, PARTICULARLY IN PLANTS, USING SELECTED PROTEINS AND PEPTIDES, TRANSFORMING PLANTS AND PHARMACEUTICAL COMPOSITIONS OF THESE PEPTIDES 未知
公开(公告)号：NZ241814A
公开(公告)日：1994-11-25
申请号：NZ24181492
申请日：1992-03-03
申请人： PIONEER HI BRED INT
发明人： DUVICK JONATHAN , ROOD TRACY
IPC分类号： A61K38/00 , A01N63/02 , A61K38/17 , A61K38/43 , A61P31/04 , C07K14/00 , C07K14/575 , C12N5/10 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/91 , C12N15/11 , C12N15/12 , C12N15/15 , C12N15/16 , C12N15/55 , C12N15/56 , A61K37/02 , A61K37/40 , A61K37/54 , A61K37/56 , A01N43/48 , A01N37/18 , A01N37/44 , C12N1/21 , A01N63/00 , A01H1/00
摘要： A selected group of proteins has been found to have antimicrobial properties. In a preferred embodiment, plant resistance to diseases caused by plant pathogens which are susceptible to these proteins is produced by inserting into the cells of a plant a gene whose expression causes production a selected protein in antimicrobial amounts.

26. 发明专利

DE3786682D1 未知
公开(公告)号：DE3786682D1
公开(公告)日：1993-09-02
申请号：DE3786682
申请日：1987-01-02
申请人： BERTOLINI ALFIO
发明人： BERTOLINI ALFIO
IPC分类号： A61K38/22 , A61K38/00 , A61K38/34 , A61K38/35 , A61P9/00 , A61P11/00 , C07K14/695 , A61K37/40 , A61K37/02
摘要： Pharmaceutical compsn. comprises a carrier and a polypeptide selected from (a) a fragment of ACTH (1-39) having the formula ACTH (x-y) (x = 1-5; and y = 10-39; provided that when x = 1, y is not 24); (b) N-acyl or N,O diacyl derivs. of ACTH (x-y); and (c) 4-norleucine, 7-D-phenylalanine -alpha-MSH.

27. 发明专利

BG49744A1 METHOD FOR PREPARING OF NEOTIGOGENINE 未知
公开(公告)号：BG49744A1
公开(公告)日：1992-02-14
申请号：BG9076189
申请日：1989-12-27
申请人： INST ORGANICHNA KHIM S TSENTAR
发明人： ISTOMINA ZOJA I , KAMERNITSKIJ ALEKSEJ V , ALEKSANDROVA NIKOLINA D , CHORBANOV BOZHIDAR P , KOSHOEV KEMELBEK K , DACHEVA VIOLETA K
IPC分类号： C07J71/00 , A61K37/40 , A61K35/78
摘要： The method is used in the pharmaceutical industry for the preparation of 5 α-H steroids. The method is simplified and results in an increased yield of pure neothigogenine. The method involves the extraction of ground and oil-free tomato seeds with water by boiling for 2 hours. This is followed by hydrolysing the water extract with hydrochloric acid or betaglucoamylase-hydrochloric acid, washing the settled precipitate with water, drying, extracting the precipitate with petroleum ether and evaporating the extract.

28. 发明专利

AU7551791A CRF ANALOGS 未知
公开(公告)号：AU7551791A
公开(公告)日：1991-10-21
申请号：AU7551791
申请日：1991-03-21
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： RIVIER JEAN EDOUARD FREDERIC , VALE WYLIE WALKER
IPC分类号： A61K38/35 , A61K38/00 , A61K38/04 , A61P9/12 , C07K14/575 , C07K14/655 , A61K37/40 , C07K7/38
摘要： Analogs of CRF, which are based upon rCRF, oCRF, sauvagine and alpha-helical CRF, are disclosed that can be administered to achieve a substantial elevation of ACTH, beta -endorphin, beta -lipotropin, other products of the pro-opiomelanocortin gene and corticosterone levels and/or an increase in blood pressure over an extended period of time. One analog which has been found to be particularly potent is: H-D-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu- Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-CM L-Nle-Glu-Ile-Ile-NH2. In the analogs of the native 41-residue polypeptides, one or more of the first six N-terminal residues may be deleted and/or the N-terminal alpha-amino group may be acylated by an acylating agent containing up to 7 carbon atoms. A number of other substitutions may also be made throughout the chain. These analogs or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceutically or veterinarily acceptable liquid or solid carrier, can be administered to mammals, including humans. These analogs may also be used as stimulants to elevate mood and improve memory and learning, as well as diagnostically.

29. 发明专利

AU580262B2 BIOCOMPATIBLE, WATER-SOLUBLE AMPHIPHILIC STEROIDS AS DRUG ADJUVANTS 未知
公开(公告)号：AU580262B2
公开(公告)日：1989-01-12
申请号：AU2902084
申请日：1984-06-04
申请人： CAREY MARTIN C
发明人： CAREY MARTIN C , MOSES ALAN C , FLIER JEFFREY S
IPC分类号： A61K38/21 , A61K9/00 , A61K38/00 , A61K38/22 , A61K38/24 , A61K38/26 , A61K38/28 , A61K39/39 , A61K45/06 , A61K47/28 , A61K31/135 , A61K31/56 , A61K37/26 , A61K37/28 , A61K37/40 , A61K47/00
摘要： Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of a human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.

30. 发明专利

AU558500B2 CONTROLLED SLOW RELEASE TABLET 未知
公开(公告)号：AU558500B2
公开(公告)日：1987-01-29
申请号：AU2717284
申请日：1984-04-19
申请人： ALZA CORP
发明人： ZAFFARONI ALEJANDRO , WONG PATRICK S L
IPC分类号： B01J4/00 , A61K9/20 , A61K9/26 , A61K9/70 , A61M31/00 , A61J3/06 , A61K9/00 , A61K31/135 , A61K31/565 , A61K31/57 , A61K37/38 , A61K37/40
摘要： The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a nonuniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.

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