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    • 22. 发明申请
    • Topical composition comprising a functional aromatic derivative cosmetic bonding agent
    • 包含功能性芳族衍生物化妆品粘合剂的局部组合物
    • US20020176829A1
    • 2002-11-28
    • US10091731
    • 2002-03-06
    • Haimanot Bekele
    • A61K007/42A61K007/44A61K007/00
    • A61Q19/08A61K8/4906A61K2800/522A61K2800/94A61Q1/02A61Q1/10A61Q15/00A61Q17/00A61Q17/04A61Q19/00A61Q19/001A61Q19/04A61Q19/06
    • The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functional aromatic derivative bonding agent having a structure selected from the group consisting of 1 wherein X is one or more cosmetic benefit agents that may or may not be attached to a chemical linker; Y, Z, and W are selected from the group consisting of H, NO2, CN, CF3, SO2R, COR, and V is selected from the group consisting of F, I, Br, Cl, NO2, SOPh, N3, Oar, OSO2R, OR, X; SR, and NH2; Vnull and Ynull are selected from the group consisting of C, N, and combinations thereof; Znull and Wnull are selected from the group consisting of F, I, Br, Cl, H, SR, X, or combinations thereof; wherein R is an alkyl or phenyl; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.
    • 本发明涉及化妆品组合物,其包含:a)安全有效量的具有选自以下的结构的官能芳族衍生物粘合剂,其中X是一种或多种可能附着或不附着于 化学接头; Y,Z和W选自H,NO 2,CN,CF 3,SO 2 R,COR,V选自F,I,Br,Cl,NO 2,SOPh,N 3,Oar, OSO2R,OR,X; SR和NH2; V“和Y”选自C,N及其组合; Z“和W”选自F,I,Br,Cl,H,SR,X或它们的组合; 其中R是烷基或苯基; 和b)用于粘合剂的美容上可接受的载体,其中所述组合物局部施用于哺乳动物蛋白质底物,并且其中所述粘合剂与所述基质中包含的蛋白质反应,使得所述粘合剂,从而所述化妆品有益剂共价连接 到基底。 本发明还涉及使用上述组合物以及包括所要求保护的组合物的各种产品的方法。