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21. 发明申请

US20170205331A1 FLOW CYTOMETER SIGNAL PEAK IDENTIFICATION EMPLOYING DYNAMIC THRESHOLDING 有权
公开(公告)号：US20170205331A1
公开(公告)日：2017-07-20
申请号：US15316427
申请日：2015-06-03
申请人： ViroCyt, Inc.
发明人： Andrew W. Smolak , Jean-Luc Fraikin , Erica Dawson Tenent , Kathy L. Rowlen
IPC分类号： G01N15/14
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1461
摘要： Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.

22. 发明申请

US20160238510A1 ENHANCED DETECTION THROUGH PARSING RECORDS INTO SIGNAL COMPONENTS 审中-公开
标题翻译：通过将记录记录到信号组件中的增强检测
公开(公告)号：US20160238510A1
公开(公告)日：2016-08-18
申请号：US14622789
申请日：2015-02-13
申请人： Artium Technologies, Inc.
发明人： William D. Bachalo , Gregory A. Payne , Khalid Ibrahim , Michael J. Fidrich , Chad M. Sipperley
IPC分类号： G01N15/14 , G01N15/02
CPC分类号： G01N15/1429 , G01N15/0205 , G01N15/0211 , G01N15/1434 , G01N2015/1075 , G01N2015/145 , G01N2015/1461 , G01N2015/1493
摘要： Methods and apparatuses to detect particles in dense particle fields are described. A time varying signal is partitioned into a plurality of segments. Parameters are determined from the segments. The time varying signal is parsed into a plurality of individual particle signal components based on the plurality of parameters.
摘要翻译：描述了在致密粒子场中检测颗粒的方法和装置。时变信号被分割成多个段。参数是从段确定的。基于多个参数将时变信号解析为多个单独的粒子信号分量。

23. 发明授权

US09335246B2 Methods for detecting coincident sample events, and devices and systems related thereto 有权
标题翻译：用于检测一致的样本事件的方法，以及与之相关的装置和系统
公开(公告)号：US09335246B2
公开(公告)日：2016-05-10
申请号：US14137363
申请日：2013-12-20
申请人： Abbott Laboratories
发明人： Amish Shah
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1459 , G01N15/1429 , G01N33/4915 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1461 , G01N2015/1486
摘要： In some aspects of the present disclosure, methods of detecting coincident sample events are provided. The methods include receiving a first set of signal data representing detected signals from a flow cytometer system; detecting, with a peak detection module, one or more peaks within the signal data; and cancelling, with a successive cancellation module, one or more individual sample events from the signal data at corresponding time indexes, wherein the cancellation of more than one individual sample event is successive. Devices and system related thereto are also provided.
摘要翻译：在本公开的一些方面，提供了检测重合样本事件的方法。所述方法包括从流式细胞仪系统接收表示检测信号的第一组信号数据; 用峰值检测模块检测所述信号数据内的一个或多个峰值; 并且利用连续的取消模块，在对应的时间索引处从所述信号数据中取消一个或多个单独的采样事件，其中所述多个单独采样事件的取消是连续的。还提供了与其相关的设备和系统。

24. 发明授权

US08154273B2 Detecting and handling coincidence in particle analysis 有权
标题翻译：在粒子分析中检测和处理巧合
公开(公告)号：US08154273B2
公开(公告)日：2012-04-10
申请号：US12249473
申请日：2008-10-10
申请人： Ted W. Britton , Jiuliu Lu , Jeffrey L. Rose
发明人： Ted W. Britton , Jiuliu Lu , Jeffrey L. Rose
IPC分类号： G01N27/00
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1037 , G01N2015/1461
摘要： Methods and systems substantially eliminate data representative of coincident events from particle analyzer data. A fluid sample containing particles for analysis is prepared. Using an electrical or optical measurement device, signals are sensed. Each signal corresponds to events detected in a sub-sample of the fluid sample flowing through a measurement region in the particle analyzer. The existence of coincidence in the events is determined based on measuring a peak and first and second points of each of the signals. The first and second points have a signal value corresponding to a predetermined portion of the peak. Results data based upon the coincident events and non-coincident events is generated. The results data is then analyzed. In various examples, the method is applicable to a variety of particle types, and may be implemented on different types of particle analyzers including hematology analyzer and flow cytometers.
摘要翻译：方法和系统基本上消除了代表颗粒分析仪数据的重合事件的数据。制备含有用于分析的颗粒的流体样品。使用电气或光学测量设备，感测到信号。每个信号对应于在流过粒子分析仪中的测量区域的流体样品的子样本中检测到的事件。基于测量每个信号的峰值和第一和第二点来确定事件中的一致性的存在。第一和第二点具有对应于峰值的预定部分的信号值。生成基于一致事件和非重合事件的结果数据。然后分析结果数据。在各种实施例中，该方法适用于各种粒子类型，并且可以在包括血液分析仪和流式细胞仪在内的不同类型的粒子分析仪上实施。

25. 发明申请

WO2014143333A1 METHODS FOR DETECTING COINCIDENT SAMPLE EVENTS 审中-公开
标题翻译：检测合并样品事件的方法
公开(公告)号：WO2014143333A1
公开(公告)日：2014-09-18
申请号：PCT/US2013/077183
申请日：2013-12-20
申请人： ABBOTT LABORATORIES
发明人： SHAH, Amish
IPC分类号： G06F9/46 , G01N21/53
CPC分类号： G01N15/1459 , G01N15/1429 , G01N33/4915 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1461 , G01N2015/1486
摘要： In some aspects of the present disclosure, methods of detecting coincident sample events are provided. The methods include receiving a first set of signal data representing detected signals from a flow cytometer system; detecting, with a peak detection module, one or more peaks within the signal data; and cancelling, with a successive cancellation module, one or more individual sample events from the signal data at corresponding time indexes, wherein the cancellation of more than one individual sample event is successive. Devices and system related thereto are also provided.
摘要翻译：在本公开的一些方面，提供了检测重合样本事件的方法。所述方法包括从流式细胞仪系统接收表示检测信号的第一组信号数据; 用峰值检测模块检测所述信号数据内的一个或多个峰值; 并且利用连续的取消模块，在对应的时间索引处从所述信号数据中取消一个或多个单独的采样事件，其中多于一个的个体采样事件的取消是连续的。还提供了与其相关的设备和系统。

26. 发明申请

WO2012012163A3 APPARATUS, SYSTEM, AND METHOD FOR INCREASING MEASUREMENT ACCURACY IN A PARTICLE IMAGING DEVICE 审中-公开
标题翻译：提高颗粒成像装置测量精度的装置，系统和方法
公开(公告)号：WO2012012163A3
公开(公告)日：2012-04-19
申请号：PCT/US2011042317
申请日：2011-06-29
申请人： LUMINEX CORP , ROTH WAYNE DENNIS , FISHER MATTHEW S
发明人： ROTH WAYNE DENNIS , FISHER MATTHEW S
IPC分类号： G01B11/00 , G01N21/00
CPC分类号： G01N15/1475 , G01N21/6458 , G01N2015/1006 , G01N2015/1461 , G06K9/00134 , G06K9/52
摘要： An apparatus, system, and method for increasing measurement accuracy in imaging cytometry. The system may include a light detector configured to measure light emitted by a first particle and light emitted by a second particle, where the measured light from the second particle at least partially overlaps the measured light from the first particle in an overlap region. Additionally, the system may include a processor coupled to the light detector, where the processor is configured to determine a contribution of light from the first particle in the overlap region and determine a contribution of light from the second particle in the overlap region. The processor may also be configured to subtract the contribution of light from the second particle from the contribution of light from the first particle and determine the intensity of light emitted by the first particle.
摘要翻译：一种提高成像细胞计量术中测量准确度的装置，系统和方法。该系统可以包括被配置为测量由第一颗粒发射的光和由第二颗粒发射的光的光检测器，其中来自第二颗粒的测量光在重叠区域中至少部分地与来自第一颗粒的测量光重叠。另外，该系统可以包括耦合到光检测器的处理器，其中处理器被配置为确定来自重叠区域中的第一颗粒的光的贡献并且确定来自重叠区域中的第二颗粒的光的贡献。处理器还可以被配置为从来自第一颗粒的光的贡献中减去来自第二颗粒的光的贡献并且确定由第一颗粒发射的光的强度。

27. 发明申请

WO2015187783A1 FLOW CYTOMETER SIGNAL PEAK IDENTIFICATION EMPLOYING DYNAMIC THRESHOLDING 审中-公开
标题翻译：流动测量仪信号峰值识别采用动态阈值
公开(公告)号：WO2015187783A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/033907
申请日：2015-06-03
申请人： VIROCYT, INC.
发明人： SMOLAK, Andrew W. , FRAIKIN, Jean-Luc , TENENT, Erica Dawson , ROWLEN, Kathy L.
IPC分类号： C12M3/00
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1461
摘要： Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
摘要翻译：在流式细胞仪器中进行流式细胞术检测的样品液体中的粒子属性的评价方法，流式细胞仪器输出的时间序列信号数据追踪处理方法以及流式细胞仪系统。在方法和系统中，数据点包括对应于在一个或多个波长范围内来自样品流体的光的流式细胞术检测期间的检测的指示在样品流体中存在一个或多个颗粒属性的时间序列信号数据迹线是批次使用根据批次特异性噪声特征确定的批次特定信号峰值阈值来处理，以识别指示样品流体中一个或多个颗粒属性的存在的批次中的信号峰。

28. 发明申请

WO2012012163A2 APPARATUS, SYSTEM, AND METHOD FOR INCREASING MEASUREMENT ACCURACY IN A PARTICLE IMAGING DEVICE 审中-公开
标题翻译：用于增加颗粒成像装置中的测量精度的装置，系统和方法
公开(公告)号：WO2012012163A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/042317
申请日：2011-06-29
申请人： LUMINEX CORPORATION , ROTH, Wayne, Dennis , FISHER, Matthew, S.
发明人： ROTH, Wayne, Dennis , FISHER, Matthew, S.
IPC分类号： G01B11/00 , G01N21/00
CPC分类号： G01N15/1475 , G01N21/6458 , G01N2015/1006 , G01N2015/1461 , G06K9/00134 , G06K9/52 , G06T5/003 , G06T5/20 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024
摘要： An apparatus, system, and method for increasing measurement accuracy in imaging cytometry. The system may include a light detector configured to measure light emitted by a first particle and light emitted by a second particle, where the measured light from the second particle at least partially overlaps the measured light from the first particle in an overlap region. Additionally, the system may include a processor coupled to the light detector, where the processor is configured to determine a contribution of light from the first particle in the overlap region and determine a contribution of light from the second particle in the overlap region. The processor may also be configured to subtract the contribution of light from the second particle from the contribution of light from the first particle and determine the intensity of light emitted by the first particle.
摘要翻译：用于提高成像细胞计量测量精度的装置，系统和方法。该系统可以包括配置成测量由第一颗粒发射的光和由第二颗粒发射的光的光检测器，其中来自第二颗粒的测量光在重叠区域中至少部分地与来自第一颗粒的测量光重叠。另外，系统可以包括耦合到光检测器的处理器，其中处理器被配置为确定来自重叠区域中的来自第一颗粒的光的贡献，并且确定来自重叠区域中的第二颗粒的光的贡献。处理器还可以被配置为从第一颗粒的光的贡献中减去来自第二颗粒的光的贡献，并确定由第一颗粒发射的光的强度。

29. 发明授权

US10866181B2 Particle detection methods and systems for practicing same 有权
公开(公告)号：US10866181B2
公开(公告)日：2020-12-15
申请号：US16847340
申请日：2020-04-13
申请人： Abbott Laboratories
发明人： Amish P. Shah , Frederic M. Hulett, III
IPC分类号： G01N15/14 , G01N21/64 , G01N15/10 , G01N21/05 , G01N15/00 , G01N21/15
CPC分类号： G01N15/1429 , G01N15/1012 , G01N15/1459 , G01N21/645 , G01N21/6486 , G01N21/05 , G01N2015/0073 , G01N2015/0084 , G01N2015/1006 , G01N2015/1068 , G01N2015/1402 , G01N2015/1461 , G01N2015/1488 , G01N2021/157
摘要： Aspects of the present disclosure include methods for detecting events in a flow cytometer. Also provided are methods of detecting cells in a flow cytometer. Other aspects of the present disclosure include methods for determining a level of contamination in a flow cell. Computer-readable media and systems, e.g., for practicing the methods summarized above, are also provided.

30. 发明申请

US20190094122A1 FLOW CYTOMETER SIGNAL PEAK IDENTIFICATION EMPLOYING DYNAMIC THRESHOLDING 审中-公开
公开(公告)号：US20190094122A1
公开(公告)日：2019-03-28
申请号：US16206350
申请日：2018-11-30
申请人： IntelliCyt Corporation
发明人： Andrew W. Smolak , Jean-Luc Fraikin , Erica Dawson Tenent , Kathy L. Rowlen
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1461
摘要： Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.

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