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21. 发明公开

CN102792145A 计算流式细胞仪的液滴延迟时间的系统和方法有权
公开(公告)号：CN102792145A
公开(公告)日：2012-11-21
申请号：CN201180012767.0
申请日：2011-03-09
申请人：贝克曼考尔特公司
发明人：大卫·C·尼克尔斯 , 凯文·C·卡尔特
IPC分类号： G01N15/14
CPC分类号： G01N15/1427 , G01N2015/1406 , G01N2015/149 , Y10T436/115831
摘要：一种计算流式细胞仪的液流中的液滴延迟时间的方法。在一个实施例中，该方法包括通过基于液流的图像测量液流的宽度来确定宽度标绘图，和基于宽度标绘图设置液滴延迟时间的步骤。在另一个方面中，本发明涉及用于自动地计算液滴延迟时间的流式细胞仪系统。在一个实施例中，流式细胞仪系统包括用于基于液流的图像确定宽度标绘图的单元；和用于基于宽度标绘图计算液滴延迟时间的单元。

22. 发明公开

CN101675334A 补偿用于流式细胞仪的静电分选器中的颗粒轨迹的变化的方法和设备有权
公开(公告)号：CN101675334A
公开(公告)日：2010-03-17
申请号：CN200880014963.X
申请日：2008-05-15
申请人：贝克曼考尔特公司
发明人：埃里克·H·弗雷泽
IPC分类号： G01N21/78 , B01J19/00
CPC分类号： G01N15/1427 , G01N15/1404 , G01N15/1459 , G01N2015/1406 , G01N2015/149
摘要：一种流式细胞仪子系统监控流体传输腔内部的颗粒感应区域中的穿过的颗粒(例如，血细胞)的存在，并产生输出脉冲，输出脉冲的宽度表示轨迹并表示当颗粒穿过流体传输腔时颗粒在颗粒感应区域内的时间长度。然后根据颗粒所经过的颗粒流体传输腔的连续的时间延迟区域的几何参数对输出脉冲进行处理，以得到从颗粒的感应到包含颗粒的流体液滴将与载流流体断开的时间之间的组合时间延迟。采用组合时间延迟以精确地确定当颗粒从载运流体断开时颗粒被可控充电的时间。

23. 发明授权

CN100439899C 探测可流动样品的单个微粒的方法和设备失效
公开(公告)号：CN100439899C
公开(公告)日：2008-12-03
申请号：CN03820415.0
申请日：2003-07-01
申请人：拉什德·马弗里弗
发明人：拉什德·马弗里弗
IPC分类号： G01N15/02 , G01N33/36
CPC分类号： G01N15/1404 , G01N15/1459 , G01N2015/1406 , G01N2015/1409 , G01N2015/1413 , G01N2015/1497
摘要：本发明揭示了一种用于高浓缩系统(即悬浊液和悬浮液，下文称样品)中，例如固态微粒料浆和液-液(例如油-水)乳浊液中，微粒的光学表征的设备(100)和方法，该设备和方法不需要稀释样品。通过将样品形成厚度受控的片状液流来降低样品的透明度，以避免多重光散射的影响。利用消光方法测量样品的透明度，并控制光学盒(102)中样品的厚度，以将该样品的透明度保持在预定的数值范围内。通过这种方法，可改善个别微粒的探测效率，并避免了通常由于多重光散射所引起的信号质量的降低。

24. 发明公开

KR1020170116098A 자유-낙하 액적 내에 음장을 이용하여 정렬시킨 입자를 투여하기 위한 장치 및 방법 审中-实审
标题翻译：用于使用声场给予在自由落下的液滴中排列的粒子的设备和方法
公开(公告)号：KR1020170116098A
公开(公告)日：2017-10-18
申请号：KR1020177025201
申请日：2016-02-10
申请人： 사이테나 게엠베하
发明人： 쇤두베요나스 , 라이바허이보
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2015/1006 , G01N2015/1406 , G01N2015/142 , G01N2015/149
摘要： 자유-낙하액적(12) 내에입자(10)를투여하기위한장치는노즐(16)에유체적으로결합되는유체챔버(14), 상기유체챔버(14)에서음장을발생하도록구성됨으로써상기유체챔버(14)에서액체내의입자(10)들을소정의배열로정렬시킬수 있는음향변환기(18); 및하나이상의입자를함유하는단일액적을선택된순간에표적화된방식으로노즐로부터투여하도록구성된드롭-온-디맨드메커니즘(drop-ondemand mechanism)을갖는다.
摘要翻译：一种用于在自由落下的液滴（12）中分配颗粒（10）的设备包括流体地耦合到喷嘴（16）的流体室（14），该流体室被配置为在流体室中产生声场一种能够在容器（14）中以预定布置方式将液体中的颗粒（10）对准的声学换能器（18）; 并且被配置为从喷嘴滴在靶向少包含至少一个粒子的选定时刻的方式的单一液体剂型已需求机构（滴按需机构） - 酮。

25. 发明公开

KR1020130027464A 유세포 분석 시스템 및 방법에 대한 액적 지연 계산 有权
标题翻译：计算流动细胞计数系统的延迟延迟和方法
公开(公告)号：KR1020130027464A
公开(公告)日：2013-03-15
申请号：KR1020127023417
申请日：2011-03-09
申请人： 베크만 컬터, 인코포레이티드
发明人： 넥켈스,데이비드씨. , 코터,케빈씨.
IPC分类号： G01N15/14
CPC分类号： G01N15/1427 , G01N2015/1406 , G01N2015/149 , Y10T436/115831
摘要： 유세포 분석기의 스트림에서 액적 지연을 계산하는 방법이 개시된다. 일 실시예에서, 이 방법은 흐름의 이미지에 기초하여 흐름의 폭을 측정함으로써 폭 플롯(widths plot)을 결정하는 단계, 및 폭 플롯에 기초하여 액적 지연을 설정하는 단계를 포함한다. 다른 양태에서, 본 발명은 액적 지연을 자동으로 계산하는 유세포 분석기 시스템에 관한 것이다. 일 실시예에서, 유세포 분석기 시스템은 스트림의 이미지에 기초하여 폭 플롯을 결정하는 수단; 및 폭 플롯에 기초하여 액적 지연을 계산하는 수단을 포함한다.

26. 发明申请

WO2015122160A1 PARTICLE SORTING APPARATUS, PARTICLE SORTING METHOD, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM STORING PROGRAM 审中-公开
标题翻译：颗粒分选装置，颗粒分选方法和非中间计算机可读存储介质存储程序
公开(公告)号：WO2015122160A1
公开(公告)日：2015-08-20
申请号：PCT/JP2015/000524
申请日：2015-02-05
申请人： SONY CORPORATION
发明人： OTSUKA, Fumitaka , KASAI, Hiroto , MIYATA, Takashi , KATO, Takayuki , HATAMOTO, Kouhei
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1404 , B01L3/0268 , B01L3/502715 , B01L3/502776 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0439 , B01L2400/049 , B07C5/3425 , G01N15/1459 , G01N2015/0019 , G01N2015/1006 , G01N2015/1406 , G01N2015/149
摘要： The present disclosure provides a particle sorting apparatus, a particle sorting method, and a non-transitory computer-readable storage medium storing program that enable sorting object particles to be sorted with high precision, even when the sorting object particles are large. In the particle sorting apparatus, a charging unit that applies charges to at least a part of liquid droplets ejected from an orifice to generate a fluid stream and a charging control unit that adjusts a charge application end time in the charging unit according to sizes of particles included in the liquid droplets are provided.
摘要翻译：本公开内容提供了一种粒子分选装置，粒子分选方法和非瞬态计算机可读存储介质存储程序，即使分选对象粒子大时，也能够高精度地分选对象粒子进行分类。在粒子分选装置中，对从喷嘴喷出的液滴的至少一部分施加电荷以产生流体流的充电单元，以及根据粒子的大小调整充电单元中的充电应用结束时间的充电控制单元包括在液滴中。

27. 发明申请

WO2011112656A1 CALCULATE DROP DELAY FOR FLOW CYTOMETRY SYSTEMS AND METHODS 审中-公开
标题翻译：计算流动细胞计数系统的延迟延迟和方法
公开(公告)号：WO2011112656A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027657
申请日：2011-03-09
申请人： BECKMAN COULTER, INC. , NECKELS, David C. , COURTER, Kevin C.
发明人： NECKELS, David C. , COURTER, Kevin C.
IPC分类号： G01N15/14
CPC分类号： G01N15/1427 , G01N2015/1406 , G01N2015/149 , Y10T436/115831
摘要： A method of calculating a drop delay in a stream of a flow cytometer. In one embodiment the method includes the steps of determining a widths plot by measuring the width of a stream based on an image of the stream and setting drop delay based on the widths plot. In another aspect the invention relates to a flow cytometer system for automatically calculating drop delay. In one embodiment the flow cytometer system includes means for determining a widths plot based on an image of the stream; and means for calculating drop delay based on the widths plot.
摘要翻译：一种计算流式细胞仪流中的滴落延迟的方法。在一个实施例中，该方法包括以下步骤：基于流的图像测量流的宽度并基于宽度图设置落下延迟来确定宽度图。在另一方面，本发明涉及一种用于自动计算下落延迟的流式细胞仪系统。在一个实施例中，流式细胞仪系统包括用于基于流的图像来确定宽度图的装置; 以及用于基于宽度图计算丢弃延迟的装置。

28. 发明申请

WO01002836A1 APPARATUS AND METHOD FOR VERIFYING DROP DELAY IN A FLOW CYTOMETER 审中-公开
标题翻译：用于验证流量计的延迟延迟的装置和方法
公开(公告)号：WO01002836A1
公开(公告)日：2001-01-11
申请号：PCT/US2000/018035
申请日：2000-06-29
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/1481 , G01N2015/149 , Y10S209/906
摘要： An apparatus and method for verifying the drop delay in a flow cytometer (100), which is indicative of the time that elapses from a moment at which a particle of interest is detected at an interrogation point (122) in the flow of cytometer to the moment at which a sorting condition, such as a charging potential, is applied in response to the detection to a droplet forming at a droplet forming location (122) in the flow cytometer. The apparatus and method analyzes the content of the droplets at the droplet formation point (112) or at a location downstream of the droplet formation point, to detect the presence or absence of a particle of interest that was detected at the interrogation point (122) in the flow cytometer. The drop delay time at which the droplets being formed by the flow cytometer are charged can then be set based on the results of the analysis of the content of the droplets, to ensure that droplets containing particles of interest are charged and thus sorted by the flow cytometer, while droplets not including particles of interest remain uncharged and are not sorted.
摘要翻译：一种用于验证流式细胞仪（100）中的下落延迟的装置和方法，其指示从流式细胞仪流中的询问点（122）检测到感兴趣的颗粒的时刻经过的时间响应于对流式细胞仪中的液滴形成位置（122）处的液滴形成的检测而施加诸如充电电位的分选条件的时刻。该装置和方法分析液滴形成点（112）处或液滴形成点下游位置处的液滴的含量，以检测在询问点（122）处检测到的感兴趣的颗粒的存在或不存在，在流式细胞仪中。然后可以基于液滴含量的分析结果来设定由流式细胞计数器形成的液滴的滴下延迟时间，以确保含有感兴趣的颗粒的液滴被充入并因此被流动分选而不包含感兴趣的颗粒的液滴保持不带电并且不分类。

29. 发明申请

WO99030834A1 DEVICE AND METHOD FOR CREATING AEROSOLS FOR DRUG DELIVERY 审中-公开
标题翻译：用于产生用于药物递送的气溶胶的装置和方法
公开(公告)号：WO99030834A1
公开(公告)日：1999-06-24
申请号：PCT/IB1998/002055
申请日：1998-12-16
IPC分类号： A61M15/00 , B01D1/18 , B01F3/04 , B01F5/04 , B01J2/04 , B05B1/02 , B05B7/04 , B05B7/06 , B05B7/08 , B81C1/00 , C40B60/14 , F02M43/04 , F02M67/10 , F02M69/04 , F02M69/08 , F23D11/10 , G01N15/14 , G01N21/01
CPC分类号： B82Y30/00 , A61M11/001 , A61M15/0065 , A61M15/025 , A61M2202/064 , B01F3/0446 , B01F5/04 , B01J2219/00378 , B05B1/02 , B05B7/0475 , B05B7/061 , B05B7/065 , B05B7/066 , B05B7/0884 , C40B60/14 , F02M43/04 , F02M67/10 , F02M69/047 , F02M69/08 , F23D11/106 , G01N21/01 , G01N2015/1406 , G01N2015/1409
摘要： A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled form an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.
摘要翻译：公开了一种药物递送装置和方法，其产生用于通过吸入递送至患者的药学活性药物的雾化颗粒。该装置包括液体供给源，例如在一端加入制剂并通过出口排出的通道。进料通道由加压气室包围，气体被供给到加压室中，气体从气体中排出。排出气体的开口直接位于从进料通道排出的液体的流路的前方。调节各种参数，使得加压气体围绕从进料通道流出的液体，以便保持液体的稳定的毛细管微喷射直到液体离开压力室开口并雾化。具有约1至5微米范围内的均匀直径的雾化颗粒被吸入患者的肺中，然后到达患者的循环系统。

30. 发明申请

WO1990012308A1 METHOD AND APPARATUS FOR THE IDENTIFICATION OF PARTICLES 审中-公开
标题翻译：用于鉴定颗粒的方法和装置
公开(公告)号：WO1990012308A1
公开(公告)日：1990-10-18
申请号：PCT/CA1990000106
申请日：1990-03-30
申请人： MARITIME SCIENTIFIC SERVICES LTD.
发明人： MARITIME SCIENTIFIC SERVICES LTD. , BEZANSON, Donald, S.
IPC分类号： G01N15/14
CPC分类号： G01N15/1429 , G01N15/1459 , G01N21/47 , G01N2015/1037 , G01N2015/1406 , G01N2021/6423
摘要： Apparatus for analysing particles in which the particles traverse a sensing zone (14) one at a time. A first detector (18) measures variations in the conductivity of the fluid caused by the presence of a particle in the aperture (13). A laser irradiates the sensing zone (14) and a second detector (20) is provided responsive to light scattered by particles in the sensing zone. Additional detectors are provided responsive to fluorescence from the particles. The signals from each of the detector means are digitized and stored and then compared. The differences in successive waveforms from each detector indicate the presence of abnormal particles. Waveform shape is also used as an indication of the shape of the particles.

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