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    • 25. 发明公开
    • Preparation of a basic aluminium antiperspirant active material having enhanced activity
    • 具有增强活性的基础铝抗菌活性材料,含有这种材料的抗菌活性组合物及其制备方法和组合物
    • EP0455489A3
    • 1992-05-13
    • EP91303978.0
    • 1991-05-02
    • THE MENNEN COMPANY
    • Vincenti, Paul JosephBarr, Morton Lawrence
    • C01F7/00C01F7/66A61K7/38C01B11/14C01B11/18C01B11/22A61K7/34
    • C01F7/66A61K8/19A61K8/26A61K8/28A61K8/29A61K8/44A61K2800/58A61Q15/00C01B11/14C01B11/18C01B11/22C01F7/48
    • Disclosed is a basic aluminum material having enhanced antiperspirant activity, the material having the empirical formula Al₂(OH) 6-a X a , where 0.5 ≦ a ≦ 5.0, and X is a univalent complex oxoanion of nitrogen, chlorine and other halogens, which forms salts with Al³⁺ in aqueous solution so that these salts are essentially completely dissociated, which is readily soluble in water with metallic ions in the solution, and which forms conjugate acids that are strong acids; and wherein the material is characterized by:
      (a) size exclusion high performance liquid chromatography peaks corresponding to peak 3 and peak 4 of size exclusion chromatograms formed by HPLC technique; (b) a peak 4 relative area of at least 25%, a peak 3 relative area of less than 60%, the sum of the relative peak 3 and peak 4 areas being at least 50%; and (c) less than 10% chromatographic peaks eluting at shorter retention times than peak 3, corresponding to peaks 1 and 2. Illustratively, the univalent oxoanion can be ClO₃⁻, ClO₄⁻, IO₄⁻, and preferably NO₃⁻. The material is characterized by having et least 25% by weight thereof in the form of Al b polyhydroxyaquoaluminum species. Also disclosed are antiperspirant compositions including the basic aluminum material, a zirconium, hafnium, titanium and/or tin antiperspirant active material and a neutral amino acid, and methods of forming the basic aluminum material and the antiperspirant composition. The basic aluminum material can be formed at relatively low temperatures, without first forming a dilute solution of a basic aluminum compound, and the basic aluminum material has a stable enhanced activity in aqueous solution over a relatively long period of time.
    • 28. 发明授权
    • Process for the preparation of periodates
    • 制备高碘酸盐的过程
    • US6017506A
    • 2000-01-25
    • US181669
    • 1998-10-29
    • Antonius L. B. DijtWilhelmus R. M. MartensJohan T. TingeJan C. WisseRudolf M. Eder
    • Antonius L. B. DijtWilhelmus R. M. MartensJohan T. TingeJan C. WisseRudolf M. Eder
    • A61K33/18C01B11/22
    • C01B11/22
    • Process for the preparation of a sodium paraperiodate wherein an iodine compound is converted into the sodium paraperiodate in the presence of Na.sup.+ ions by means of an alkali metal hydroxide and an alkali metal hypochlorite. The iodine compound is applied in the form of an iodine-containing mixture in which besides the iodine compound in the form of I.sub.2, iodide or iodate compounds, one or more compounds chosen from the group of chlorides, bromides, sulphates, sulphites, carbonates, bicarbonates, nitrates and dissolved organic components are also present. The invention also relates to the preparation of sodium metaperiodate and other alkali and alkali earth metal periodates, wherein the sodium paraperiodate obtained is converted into sodium periodate or into an alkali or alkali earth metal periodate by means of an acid or an alkali and alkali earth metal salt at an elevated temperature. The acid used preferably is HNO.sub.3.
    • 制备偏高碘酸钠的方法,其中碘化合物通过碱金属氢氧化物和碱金属次氯酸盐在Na +离子存在下转化成偏高碘酸钠。 碘化合物以含碘混合物的形式施用,其中除碘,碘化物或碘酸盐化合物形式的碘化合物之外还有一种或多种选自氯化物,溴化物,硫酸盐,亚硫酸盐,碳酸盐, 也存在碳酸氢盐,硝酸盐和溶解的有机组分。 本发明还涉及偏高碘酸钠和其它碱金属和碱土金属高碘酸钠的制备,其中所得的偏高尿酸钠通过酸或碱和碱土金属转化成高碘酸钠或高碱性碱金属或碱土金属高碘酸盐 盐在升高的温度。 所使用的酸最好是HNO3。
    • 29. 发明授权
    • Basic aluminum antiperspirant active materials having enhanced activity,
antiperspirant active compositions containing such materials, and
methods for preparation of such materials and compositions
    • 具有增强活性的碱性铝止汗剂活性物质,含有这些材料的止汗活性组合物,以及制备这种材料和组合物的方法
    • US5595729A
    • 1997-01-21
    • US97620
    • 1993-07-27
    • Morton L. BarrPaul J. VincentiElaine L. Vanderhoof
    • Morton L. BarrPaul J. VincentiElaine L. Vanderhoof
    • A61K8/19A61K8/26A61K8/28A61K8/29A61K8/44A61Q15/00C01B11/14C01B11/18C01B11/22C01F7/00C01F7/48C01F7/66A61K7/38
    • C01F7/66A61K8/19A61K8/26A61K8/28A61K8/29A61K8/44A61Q15/00C01B11/14C01B11/18C01B11/22C01F7/002C01F7/48A61K2800/58C01P2002/86C01P2002/87
    • Disclosed are basic aluminum antiperspirant materials having univalent complex oxoanions (e.g., nitrate); methods of making such materials; antiperspirant compositions containing such basic aluminum materials, another antiperspirant active material (e.g., a basic zirconium halide salt), and optionally a neutral amino acid; and methods of making such compositions. Size exclusion high performance liquid chromatography chromatograms of the disclosed basic aluminum materials have a peak 4 relative area of at least 25%, a peak 3 relative area of less than 60%, the sum of the peaks 3 and 4 being at least 50%; and less than 10% of the chromatographic peaks eluting at peaks 1 and 2. The disclosed basic aluminum materials have less than 25% of the aluminum in the form of Al.sup.b polyhydroxyaquoaluminum, and have a .sup.27 Al NMR spectrum in which the area of the 71.5-73.5 ppm resonance line includes more than 50% of the combined areas of the 62.5-63.5 ppm and 71.5-73.5 ppm resonance lines, and 5%-30% of the total area under the spectrum from 140 ppm to -80 ppm is contained in the resonance line at 71.5-73.5 ppm. The basic aluminum material of the present invention can be produced by adding a stoichiometric or near-stoichiometric amount of aluminum metal to a solution of an aluminum salt having a univalent complex oxoanion; the basic aluminum material can also be made by adding to such solution of the aluminum salt, aluminum metal having, in total, a relatively small surface area (large-sized particles of aluminum).
    • 公开了具有单价复合氧代阴离子(例如硝酸盐)的碱性止汗剂材料; 制作这种材料的方法; 含有这种碱性铝材料的止汗组合物,另一种止汗剂活性物质(例如碱性卤化锆盐)和任选的中性氨基酸; 以及制备这种组合物的方法。 所公开的碱性铝材料的尺寸排阻高效液相色谱色谱图具有至少25%的峰4相对面积,峰3相对面积小于60%,峰3和4的总和至少为50%; 并且在峰1和2处洗脱的色谱峰小于10%。所公开的碱性铝材料具有少于25%的Alb聚羟基铝形式的铝,并且具有27Al NMR谱,其中71.5- 73.5ppm共振线包括62.5-63.5ppm和71.5-73.5ppm共振线的组合面积的50%以上,并且在140ppm至-80ppm的光谱范围内的总面积的5%-30%包含在 共振线为71.5-73.5ppm。 本发明的碱性铝材料可以通过将化学计量或近化学计量的铝金属加入到具有一价复合氧阴离子的铝盐溶液中来制备; 碱性铝材料也可以通过向铝盐,总共具有相对小的表面积(大尺寸的铝颗粒)的铝金属溶液中加入来制备。