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21. 发明申请

US20180154186A1 HISTOTRIPSY THERAPY SYSTEMS AND METHODS FOR THE TREATMENT OF BRAIN TISSUE 审中-公开
公开(公告)号：US20180154186A1
公开(公告)日：2018-06-07
申请号：US15737761
申请日：2016-06-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Zhen XU , Jonathan SUKOVICH , Aditya S. PANDEY , Charles A. CAIN , Hitinder S. GURM
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61N7/00 , A61N2007/003 , A61N2007/0039 , A61N2007/0047 , A61N2007/0065 , A61N2007/0078 , A61N2007/0086 , A61N2007/0095
摘要： A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

22. 发明授权

US09937364B2 High intensity focused ultrasound with capacitive micromachined transducers 有权
公开(公告)号：US09937364B2
公开(公告)日：2018-04-10
申请号：US14391142
申请日：2013-04-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Max Oskar Köhler
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61N7/00 , A61N7/02 , A61N2007/0004 , A61N2007/0043 , A61N2007/0078 , A61N2007/0086
摘要： A medical instrument (900, 1000) comprising a high intensity focused ultrasound system (911) comprising an ultrasound transducer (102, 104, 202, 204, 302, 407, 08) with an adjustable sonication frequency. The ultrasound transducer comprises capacitive micromachined transducers (102, 104, 202, 204, 302, 407, 508). Execution of machine executable instructions by a processor causes the processor to: receive (700, 800) a treatment plan (924) descriptive of a target zone (908) within a subject (902); determine (702, 802) a traversal distance (926) through the subject to the target zone using the treatment plan, wherein the traversal distance is descriptive of the traversal of ultrasound from the ultrasound transducer to the target zone; determine (704, 804) a sonication frequency (829) using the traversal distance for focusing the sonication volume onto the target zone; and sonicate (706, 806) the target zone using the high intensity focused ultrasound system at the sonication frequency.

23. 发明申请

US20170312002A1 Ultrasonic Lesion Feedback, Antipop Monitoring, and Force Detection 审中-公开
公开(公告)号：US20170312002A1
公开(公告)日：2017-11-02
申请号：US15637896
申请日：2017-06-29
申请人： St. Jude Medical, Inc.
发明人： John W. Sliwa , Zhenyi Ma , Stephen A. Morse
IPC分类号： A61B18/04 , A61B18/14 , A61B90/00 , A61B18/00 , A61B17/00 , A61N7/00
CPC分类号： A61B18/04 , A61B18/1492 , A61B90/06 , A61B2017/00106 , A61B2018/00577 , A61B2090/061 , A61B2090/065 , A61B2090/3784 , A61B2218/002 , A61N2007/0004 , A61N2007/0086
摘要： An ablation catheter comprises: an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; a distal member disposed adjacent the distal end, the distal member including an ablation element to ablate a biological member; one or more acoustic transducers disposed in the distal member and each configured to direct an acoustic signal toward a respective target ablation region and receive reflection echoes therefrom; and an acoustic redirection member disposed in the distal member to at least partially redirect the acoustic signal from at least one of the acoustic transducers toward a tissue target. The distal member includes a most-distal portion, a proximal portion, and a deflectable portion between the most-distal portion and proximal portion to permit deflection between the most-distal portion and proximal portion of the distal member. The transducers and redirection member are mounted on opposite sides of the deflectable portion.

24. 发明申请

US20150142034A1 HIGH INTENSITY FOCUSED ULTRASOUND TARGETING 有权
标题翻译：高强度聚焦超声波瞄准
公开(公告)号：US20150142034A1
公开(公告)日：2015-05-21
申请号：US14406550
申请日：2013-06-21
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Max Oskar Köhler
IPC分类号： A61N7/00 , A61B5/01 , A61B5/055
CPC分类号： A61N7/00 , A61B5/015 , A61B5/055 , A61B2018/00577 , A61B2018/00738 , A61B2018/00791 , A61B2018/00898 , A61B2018/00988 , A61B2090/374 , A61N7/02 , A61N2007/0086
摘要： The invention provides for a medical instrument (200) comprising a magnetic resonance imaging system (202) and a high intensity focused ultrasound system (202) with an adjustable focus (238). Execution of instructions causes a processor to control (100) medical instrument to sonicate the multiple sonication points while repeatedly acquire the thermal magnetic resonance imaging data. Multiple thermal maps are reconstructed using the thermal magnetic resonance imaging data and a heating center of mass is calculated for each. By comparing each of the heating center of masses to the sonication points a spatially dependent targeting correction (266) is determined. The spatially dependent targeting correction is then used to offset the adjustable focus.
摘要翻译：本发明提供了一种包括磁共振成像系统（202）和具有可调焦点（238）的高强度聚焦超声系统（202）的医疗器械（200）。指令的执行使得处理器控制（100）医疗仪器来重复获取热磁共振成像数据，以超声波处理多个超声处理点。使用热磁共振成像数据重建多个热图，并且计算每个热图的质量加热中心。通过将质量的加热中心与超声处理点进行比较，确定空间依赖的目标校正（266）。然后使用空间相关的瞄准校正来抵消可调焦点。

25. 发明申请

US20150066014A1 Ultrasonic lesion feedback, antipop monitoring, and force detection 有权
标题翻译：超声波病变反馈，对抗监测和力检测
公开(公告)号：US20150066014A1
公开(公告)日：2015-03-05
申请号：US14394164
申请日：2013-03-15
申请人： St. Jude Medical, Inc.
发明人： John Sliwa , Zhenyi Ma , Stephen Morse
IPC分类号： A61B18/04 , A61B19/00
CPC分类号： A61B18/04 , A61B18/1492 , A61B90/06 , A61B2017/00106 , A61B2018/00577 , A61B2090/061 , A61B2090/065 , A61B2090/3784 , A61B2218/002 , A61N2007/0004 , A61N2007/0086
摘要： An ablation catheter comprises: an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; a distal member disposed adjacent the distal end, the distal member including an ablation element to ablate a biological member; one or more acoustic transducers disposed in the distal member and each configured to direct an acoustic signal toward a respective target ablation region and receive reflection echoes therefrom; and an acoustic redirection member disposed in the distal member to at least partially redirect the acoustic signal from at least one of the acoustic transducers toward a tissue target. The distal member includes a most-distal portion, a proximal portion, and a deflectable portion between the most-distal portion and proximal portion to permit deflection between the most-distal portion and proximal portion of the distal member. The transducers and redirection member are mounted on opposite sides of the deflectable portion.
摘要翻译：消融导管包括：细长的导管主体，沿纵向轴线在近端和远端之间纵向延伸; 远端构件邻近所述远端设置，所述远端构件包括消融元件以烧蚀生物构件; 一个或多个声学换能器设置在远端构件中，并且每个声学换能器被配置为将声信号引导到相应的目标消融区域并从其接收反射回波; 以及设置在所述远端构件中以至少部分地将来自所述声学换能器中的至少一个声学信号的声学信号重定向到组织靶的声学重定向构件。远侧构件包括最远侧部分，近端部分和最远侧部分和近侧部分之间的可偏转部分，以允许远侧部件的最远侧部分和近端部分之间的偏转。换能器和重定向构件安装在可偏转部分的相对侧上。

26. 发明申请

US20130289671A1 Method for Hypopigmentation Tattooing 审中-公开
标题翻译：色素沉着纹理的方法
公开(公告)号：US20130289671A1
公开(公告)日：2013-10-31
申请号：US13458117
申请日：2012-04-27
申请人： Gregg S. Homer
发明人： Gregg S. Homer
IPC分类号： A61N5/067 , A61N5/06
CPC分类号： A61B18/203 , A61B2018/0047 , A61N5/02 , A61N5/0616 , A61N7/00 , A61N2005/0659 , A61N2005/0663 , A61N2005/067 , A61N2007/0034 , A61N2007/0086
摘要： The present invention is directed to a method for creating permanent or semi-permanent images on a pre-determined treatment area of the skin wherein electromagnetic radiation (“EMR”) is applied to the treatment area. Based on the EMR energy density selected, no hypertrophic scarring occurs. The skin is nevertheless hypopigmented where the spot is directed. When the treated area is tanned, the selected image appears. When the skin is pale, the selected image does not appear.
摘要翻译：本发明涉及一种用于在皮肤的预定治疗区域上产生永久或半永久性图像的方法，其中电磁辐射（“EMR”）被施加到治疗区域。基于选择的EMR能量密度，不发生肥厚性瘢痕形成。皮肤在斑点指向的地方色素沉着。当处理区域被鞣制时，将显示所选图像。当皮肤变浅时，所选图像不会出现。

27. 发明公开

EP3334346A1 ACOUSTIC MODULE AND CONTROL SYSTEM FOR HANDHELD ULTRASOUND DEVICE 审中-公开
公开(公告)号：EP3334346A1
公开(公告)日：2018-06-20
申请号：EP16756871.6
申请日：2016-08-11
申请人： Access Business Group International LLC
发明人： STODDARD, Ronald, L. , MILES, Michael, E. , NORCONK, Matthew J. , SCHWANNECKE, Joshua, K. , VAN DEN BRINK, Joseph, C. , MOORE, Colin, J. , UMENEI, A., Esai , SCHAMPER, Ryan, D. , BARTRUM, Mark, S. , MOES, Benjamin, C. , VECZIEDINS, Karlis , WU, Ziqi , SMITH, Mark, C. , PIPPEL, Bradley, J. , VACHON, David, S.
IPC分类号： A61B8/00 , A61N7/00 , A61N7/02 , B06B3/00 , G10K11/24
CPC分类号： A61N7/00 , A61B8/4281 , A61N7/02 , A61N2007/0034 , A61N2007/006 , A61N2007/0086 , G10K11/24
摘要： An acoustic module with a transducer and a solid waveguide. The transducer and waveguide may be curved to focus the acoustic energy along a focal line. The transducer, the top surface of the waveguide and the bottom surface of the waveguide may extend along coaxial curves. The waveguide may include a recess closely receiving the transducer. The waveguide may include an integral skirt that provides a thermal mass. The acoustic module may include a space to accommodate thermal management options. For example, the acoustic module may include a heatsink, an active ventilation system and/or a phase change material. The ultrasound device may include a controller configured to perform a uniformity scan sweep during supply of operating power to the transducer. The uniformity scan sweep can extend through a frequency range that includes the operating point of the acoustic module and does not exceed an acceptable efficiency loss.

28. 发明公开

EP3157632A1 A THERMAL ABLATION SYSTEM 审中-公开
标题翻译：热敏吸收系统
公开(公告)号：EP3157632A1
公开(公告)日：2017-04-26
申请号：EP15728804.4
申请日：2015-06-04
申请人： Koninklijke Philips N.V.
发明人： WEI, Juan , ZHANG, Jianhua
IPC分类号： A61N7/02 , A61B5/055 , A61B5/00
CPC分类号： A61N7/022 , A61B5/055 , A61B5/4836 , A61B34/10 , A61B90/37 , A61B2034/104 , A61B2090/374 , A61N7/02 , A61N2007/0086
摘要： Embodiments of the invention provide a thermal ablation system. The thermal ablation comprises a thermal ablation apparatus configured to perform thermal ablation on a targeted tissue according to plan data of a treatment during a therapy mode of the thermal ablation system, a MR apparatus configured to perform a T2* weighted MR imaging for the targeted tissue to assess a therapeutic response of the thermal ablation during an assessment mode of the thermal ablation system, a control apparatus configured to switch the thermal ablation system between the therapy mode and the assessment mode. The thermal ablation apparatus is activated to perform the thermal ablation in the therapy mode, and the thermal ablation apparatus is deactivated to terminate the thermal ablation and the MR apparatus is activated to perform the T2* weighted MR imaging in the assessment mode.
摘要翻译：本发明的实施例提供一种热消融系统。热消融包括热消融装置，其被配置为根据在热消融系统的治疗模式期间的处理的计划数据对目标组织进行热消融; MR装置，被配置为对靶组织进行T2 *加权MR成像在热消融系统的评估模式期间评估热消融的治疗响应，配置为在治疗模式和评估模式之间切换热消融系统的控制装置。热消融装置被激活以在治疗模式中执行热消融，并且热消融装置被停用以终止热消融，并且激活MR装置以在评估模式中执行T2 *加权MR成像。

29. 发明公开

EP3108836A1 ULTRASONIC TREATMENT DEVICE 有权
标题翻译：超声处理装置
公开(公告)号：EP3108836A1
公开(公告)日：2016-12-28
申请号：EP15748810.7
申请日：2015-02-02
申请人： Olympus Corporation
发明人： TSUBUKU, Yoshihiro , KAWASAKI, Minoru
IPC分类号： A61B18/00
CPC分类号： A61B17/320092 , A61B17/282 , A61B17/320068 , A61B2017/00106 , A61B2017/2825 , A61B2017/2924 , A61N7/00 , A61N2007/0086
摘要： An ultrasonic treatment apparatus includes a movement unit moving in accordance with at least one of an acting state of a load to a treatment section from a jaw and an opening angle of the jaw relative to the treatment section, a movement detector detecting a moving state of the movement unit, and a peak detecting section detecting a target peak of an ultrasonic impedance value. The ultrasonic treatment apparatus includes a control section controlling the peak detecting section to a detection disallowed state where a detection of the target peak is not executed when the movement unit is not placed within a prescribed range based on a detection result in the movement detector.
摘要翻译：本发明提供一种超声波治疗装置，其特征在于，具备：移动部，该移动部根据从钳部件向治疗部的负载的作用状态和钳部相对于治疗部的打开角度中的至少一方而移动;移动检测部，移动单元以及检测超声波阻抗值的目标峰值的峰值检测部分。所述超声波治疗设备包括控制部，所述控制部基于所述移动检测器中的检测结果，将所述峰值检测部控制为当所述移动单元未处于规定范围内时不执行所述目标峰值的检测的检测不允许状态。

30. 发明公开

EP3030167A2 CAROTID BODY ABLATION VIA DIRECTED ENERGY 审中-公开
标题翻译： CAROTISKÖRPERABLATIONDURCH GERICHTETE ENERGIE
公开(公告)号：EP3030167A2
公开(公告)日：2016-06-15
申请号：EP14833876.7
申请日：2014-08-07
申请人： Cibiem, Inc.
发明人： SINELNIKOV, Yegor D.
IPC分类号： A61B17/32
CPC分类号： A61N7/022 , A61B8/06 , A61B8/0841 , A61B8/0891 , A61B8/12 , A61B8/488 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B18/24 , A61B2017/003 , A61B2018/00273 , A61B2018/00285 , A61B2018/2005 , A61B2090/378 , A61N2007/0021 , A61N2007/0086 , A61N2007/0091 , A61N2007/0095 , A61N2007/025
摘要： Methods and devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.
摘要翻译：用于评估和治疗患有交感神经介导的疾病的患者的方法和装置，通过减少化学传感器通过颈动脉身体消融输入神经系统，涉及增加的外周化学反射和增强的交感神经紧张。

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