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    • 28. 发明授权
    • Shellac film coatings providing release at selected pH and method
    • 紫胶胶片涂层,在选定的pH和方法下提供释放
    • US06620431B1
    • 2003-09-16
    • US09721692
    • 2000-11-24
    • Charles Signorino
    • Charles Signorino
    • A61K948
    • A61K9/2866A23L33/10A23V2002/00A61K9/282A61K9/5015A61K9/5047A23V2200/22A23V2250/204A23V2250/51086A23V2250/1946A23V2250/188
    • Film coatings for enteric and colonic release at selected pH are provided by selecting and/or formulating a shellac of a predetermined acid number. The method includes the selection of the acid number to provide the release at the specified pH and a method of providing a shellac of a predetermined acid number by blending of shellacs of different acid numbers. In general, films that release or dissolve at or above pH 7.4 are based on the selection of shellac with an acid number below 74. Films that release or dissolve above pH 7.0 are comprised of shellac selected with an acid number below 80. Films that release or dissolve at below pH 7.0 are comprised of shellac selected to have an acid number above 80. The film coating may be modified with a water soluble resin and/or a plasticizer. Preferably the shellac will comprise 50% or more of the resin system, and is formed out of water, not alcohol.
    • 通过选择和/或配制预定酸值的虫胶来提供在所选pH下肠溶和结肠释放的膜包衣。 该方法包括选择酸值以提供在指定pH下的释放,以及通过混合不同酸值的虫胶提供预定酸值的虫胶的方法。 通常,在pH 7.4以上释放或溶解的膜基于酸值低于74的虫胶的选择。pH 7.0以上释放或溶解的膜由选自酸值低于80的虫胶组成。 或溶解在低于7.0的范围内由选择为具有高于80的酸值的虫胶组成。膜涂层可以用水溶性树脂和/或增塑剂改性。 优选地,紫胶将包含50%或更多的树脂体系,并且由水而不是醇形成。
    • 30. 发明申请
    • Acidic compositions comprising protein and fiber and processes of their preparation
    • 包含蛋白质和纤维的酸性组合物及其制备方法
    • US20030203097A1
    • 2003-10-30
    • US10357684
    • 2003-02-04
    • The Procter & Gamble Company
    • Raul Victorino NunesRoger William KrummenLeonard Edwin SmallHaile Mehansho
    • A23J001/00
    • A61K31/205A23C9/1528A23C9/1544A23L2/66A23L2/68A23L7/126A23L33/12A23L33/19A23L33/21A23L33/40A23V2002/00A61K31/19A61K31/715A23V2250/5072A23V2250/5028A23V2250/54246A23V2250/242A23V2250/188A23V2250/264A23V2250/1578A23V2250/1944A23V2250/1946A23V2250/032A23V2250/5036A23V2250/5108A23V2250/1842A23V2250/5118A23V2250/5114A23V2250/5424
    • Acidic compositions comprising protein and fiber are described. In one embodiment, the compositions comprise: (a) a protein component comprising a protein selected from the group consisting of whey, casein, and mixtures thereof; and (b) from about 0.8% to about 5% of a fiber component, by weight of the composition; wherein the composition comprises particles having a median particle size of about 1 micron or less and wherein the pH of the composition is from about 3 to about 5. In another embodiment, the compositions comprise: (a) a protein component comprising a protein selected from the group consisting of whey, casein, and mixtures thereof; and (b) from about 0.05% to about 5% of a fiber component, by weight of the composition; wherein the composition comprises particles having a median particle size of greater than about 0.8 microns to about micron and wherein the pH of the composition i; from about 3 to about 5. In yet another embodiment, certain compositions may be prepared by the following process: (a) mixing the protein component and the fiber component to form a first mixture comprising the particles; and (b) mixing an acidic component and the first mixture at a temperature of from about 4null C. to about 43null C. to form a second mixture comprising the particles; wherein the particles have the median particle size of about 1 micron or less; and wherein the first mixture and second mixture are formed under high shear conditions.
    • 描述了包含蛋白质和纤维的酸性组合物。 在一个实施方案中,组合物包含:(a)蛋白质组分,其包含选自乳清,酪蛋白及其混合物的蛋白质; 和(b)占组合物重量的约0.8%至约5%的纤维组分; 其中所述组合物包含中值粒度为约1微米或更小的颗粒,并且其中所述组合物的pH为约3至约5.在另一个实施方案中,所述组合物包含:(a)蛋白质组分,其包含选自 由乳清,酪蛋白及其混合物组成的组; 和(b)占组合物重量的约0.05%至约5%的纤维组分; 其中所述组合物包含具有大于约0.8微米至约约微米的中值粒度的颗粒,并且其中组合物i的pH; 在另一个实施方案中,某些组合物可以通过以下方法制备:(a)将蛋白质组分和纤维组分混合以形成包含颗粒的第一混合物; 和(b)在约4℃至约43℃的温度下混合酸性组分和第一混合物以形成包含颗粒的第二混合物; 其中所述颗粒具有约1微米或更小的中值粒度; 并且其中所述第一混合物和第二混合物在高剪切条件下形成。