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21. 发明专利

AU2012284323B2 Apparatus for generating therapeutic shockwaves and applications of same 未知
公开(公告)号：AU2012284323B2
公开(公告)日：2015-01-29
申请号：AU2012284323
申请日：2012-07-13
申请人： THE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
发明人： CAPELLI CHRISTOPHER C
IPC分类号： A61H1/00
摘要： Apparatuses and methods to generate high frequency shock waves in a controlled manner. The generated shock waves can be delivered to certain cellular structures of a patient for use in medical and/or aesthetic therapeutic applications. The shock waves can be configured to impose sufficient mechanical stress to the targeted cells of the tissue to rupture the targeted cells. Embodiments of the apparatuses and methods of the present invention provide targeted rupturing of specific cells without damaging side effects such as cavitation or thermal degradation of surrounding non-targeted cells.

22. 发明专利

AU2008352005B2 Array of joined microtransponders for implantation 未知
公开(公告)号：AU2008352005B2
公开(公告)日：2012-04-19
申请号：AU2008352005
申请日：2008-11-26
申请人： MICRO TRANSPONDER INC , THE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
发明人： CAULLER LAWRENCE , WEINER RICHARD
IPC分类号： A61N1/06
摘要： A wireless microtransponder array constructed as a single structure of joined microtransponders. The microtransponders can be configured as a linear array strip with connective material in between. The microtransponders can also be entirely embedded within a strip of material, or joined by a single, common substrate structure.

23. 发明专利

AU2009229395A1 Method of treating degenerative diseases 未知
公开(公告)号：AU2009229395A1
公开(公告)日：2009-10-01
申请号：AU2009229395
申请日：2009-03-24
申请人： THE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
发明人： CARNEY DARRELL H , STEER RANDOLPH C
IPC分类号： A61K38/48 , A61P17/00 , A61P25/16 , A61P25/28 , A61P27/06
摘要： Agonists of a non-proteolytically activated receptor can be used in methods for treating a disease or disorder in a subject. The methods comprise administering to the subject a therapeutically effective amount of an agonist, wherein the disease or disorder is scleroderma, macular degeneration, diabetic retinopathy, Huntington's disease, Parkinson's disease, closed head trauma, glaucoma, optic neuritis or allograft vasculopathy.

24. 发明专利

AU2008329642A1 Implantable driver with charge balancing 未知
公开(公告)号：AU2008329642A1
公开(公告)日：2009-06-04
申请号：AU2008329642
申请日：2008-11-26
申请人： MICROTRANSPONDER INC , THE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
发明人： CAULLER LAWRENCE
IPC分类号： H04B1/04 , A61F2/02
摘要： A method and system for providing electrical stimulation to tissue includes implanting one or more battery-free micro-transponders having spiral antennas into tissue. Energy is provided wirelessly to the plurality of micro-transponders. Tissue is stimulated using the energy.

25. 发明专利

AU2002236768B2 Use of thrombin-derived peptides for the therapy of chronic dermal ulcers 未知
公开(公告)号：AU2002236768B2
公开(公告)日：2006-06-08
申请号：AU2002236768
申请日：2002-01-16
申请人： THE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
发明人： CARNEY DARRELL H
IPC分类号： A61K38/00 , A61K38/48 , A61P3/10 , A61P17/02
摘要： Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.

26. 发明申请

WO2017184562A1 CMV NEUTRALIZING ANTIGEN BINDING PROTEINS 审中-公开
标题翻译： CMV中和抗原结合蛋白
公开(公告)号：WO2017184562A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028062
申请日：2017-04-18
申请人： MERCK SHARP & DOHME CORP. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FU, Tong-Ming , TANG, Aimin , WANG, Dai , AN, Zhiqiang , ZHANG, Ningyan , HA, Sha
发明人： FU, Tong-Ming , TANG, Aimin , WANG, Dai , AN, Zhiqiang , ZHANG, Ningyan , HA, Sha
IPC分类号： A61K39/00 , A61K39/245 , A61K39/395 , A61K39/42 , C12N7/00 , C12P21/00
摘要： The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). The antigen binding proteins of the invention are useful as a prophylactic and/or therapeutic agent for preventing and/or treating CMV infections in a patient in need thereof. Also encompassed by the invention are pharmaceutical compositions comprising the antigen binding proteins of the invention and a pharmaceutically acceptable carrier. The invention further relates to methods of using the antigen binding proteins and pharmaceutical compositions of the invention for the prevention or treatment of CMV infection in patients in need thereof.
摘要翻译：本发明涉及抗原结合蛋白，其包括但不限于特异性结合并优选中和人巨细胞病毒（CMV）的单克隆抗体及其抗原结合片段。本发明的抗原结合蛋白可用作在有此需要的患者中预防和/或治疗CMV感染的预防和/或治疗剂。本发明还涵盖包含本发明的抗原结合蛋白和药学上可接受的载体的药物组合物。本发明进一步涉及使用本发明的抗原结合蛋白和药物组合物在有需要的患者中预防或治疗CMV感染的方法。

27. 发明申请

WO2015077624A1 ADENOVIRUS EXPRESSING IMMUNE CELL STIMULATORY RECEPTOR AGONIST(S) 审中-公开
标题翻译： ADENOVIRUS表达免疫细胞刺激受体激动剂（S）
公开(公告)号：WO2015077624A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066920
申请日：2014-11-21
申请人： DNATRIX, INC. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： TUFARO, Frank , FUEYO-MARGARETO, Juan , GOMEZ-MANZANO, Candelaria , CONRAD, Charles , YUNG, W.K., Alfred , JIANG, Hong
IPC分类号： C12N15/63
CPC分类号： C12N7/00 , A61K31/495 , A61K35/761 , A61K38/217 , A61K45/06 , C07K14/52 , C12N2710/10021 , C12N2710/10034 , C12N2840/203
摘要： Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
摘要翻译：某些实施方案包括增强腺病毒癌疗法的有效性。

28. 发明申请

WO2010088079A2 AUTOMATIC FOCUSING APPARATUS AND METHOD FOR DIGITAL IMAGES USING AUTOMATIC FILTER SWITCHING 审中-公开
标题翻译：利用自动滤波器切换的数字图像的自动聚焦装置和方法
公开(公告)号：WO2010088079A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/021276
申请日：2010-01-15
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , GAMADIA, Mark, N. , KEHTARNAVAZ, Nasser
发明人： GAMADIA, Mark, N. , KEHTARNAVAZ, Nasser
IPC分类号： G03B13/20 , G03B13/18 , G02B7/09
CPC分类号： H04N5/23212
摘要： An apparatus and method for automatically focusing a lens of a digital imaging device, such as a digital still or video camera or camera phone, that reduces the auto focus time while not compromising image sharpness quality and simultaneously reducing device power consumption due to focus actuator movement, all without tuning or adjustment of thresholds or parameters is disclosed. The present invention automatically computes a set of digital band-pass filters matched to the imaging device specifications along with corresponding step-size magnitudes. A filter-switching search for the in-focus focus actuator position is formulated such that filters are switched and step-sizes are reduced as the search gets closer to the in-focus position by utilizing local estimates of the first and second-order differential information of the focus value surface.
摘要翻译：用于自动聚焦诸如数字静止或视频照相机或照相手机的数字成像设备的镜头的设备和方法，其减少自动对焦时间，同时不损害图像清晰度质量并同时减小公开了由于聚焦致动器移动引起的设备功耗，所有这些都没有调整或调整阈值或参数。本发明自动计算与成像设备规格匹配的一组数字带通滤波器以及相应的步长大小。对焦点聚焦致动器位置的滤波器切换搜索被制定为使得通过利用一阶和二阶差分信息的局部估计，当搜索靠近焦点对准位置时切换滤波器并且减小步长的焦点价值表面。

29. 发明申请

WO2010033862A2 METHODS FOR TREATING CANCER 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2010033862A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057571
申请日：2009-09-18
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CARNEY, Darrell, H.
发明人： CARNEY, Darrell, H.
IPC分类号： A61P35/00 , A61K38/48
CPC分类号： A61K38/4833
摘要： The present invention includes methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist.
摘要翻译：本发明包括治疗受试者的癌症的方法，包括向受试者施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂。

30. 发明申请

WO2010025423A2 MULTIMODE INTERFERENCE COUPLER FOR USE WITH SLOT PHOTONIC CRYSTAL WAVEGUIDES 审中-公开
标题翻译：多功能干涉仪与SLOT PHOTONIC CRYSTAL WAVEGUIDES一起使用
公开(公告)号：WO2010025423A2
公开(公告)日：2010-03-04
申请号：PCT/US2009/055446
申请日：2009-08-28
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CHEN, Xiaonan , CHEN, Ray, T.
发明人： CHEN, Xiaonan , CHEN, Ray, T.
IPC分类号： G02B6/12 , G02B6/26
CPC分类号： G02B6/1225 , B82Y20/00 , G02B6/29344
摘要： The present invention provides an optical apparatus having a multimode interference coupler configured to optically couple a strip waveguide to a slot photonic crystal waveguide. The multimode interference coupler has a coupling efficiency to the slot photonic crystal waveguide greater than or equal to 90%, a width that is approximately equal to a defect width of the slot photonic crystal waveguide, a length that is equal to or less than 1.5 μm, and interfaces with the slot photonic crystal waveguide at an edge of a period that gives a termination parameter of approximately zero. The optical apparatus may also include an insulation gap disposed between the multimode interference coupler and the slot photonic crystal waveguide, wherein the length of the multimode interference coupler is reduced by approximately one half of a width of the insulation gap.
摘要翻译：本发明提供了一种具有多模干涉耦合器的光学装置，其被配置为将条形波导光学耦合到时隙光子晶体波导。多模干扰耦合器对槽隙光子晶体波导具有大于或等于90％的耦合效率，大约等于槽光子晶体波导的缺陷宽度的宽度，等于或小于1.5μm的长度并且在给出约为零的终止参数的周期的边缘处与时隙光子晶体波导接口。光学装置还可以包括设置在多模干涉耦合器和狭缝光子晶体波导之间的绝缘间隙，其中多模干涉耦合器的长度减小绝缘间隙的宽度的大约一半。

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