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21. 发明申请

WO2014047221A9 DRUG DELIVERY SYSTEMS AND METHODS FOR TREATMENT OF BLADDER VOIDING DYSFUNCTION AND OTHER LOWER URINARY TRACT DISORDERS BY USING TROSPIUM 审中-公开
公开(公告)号：WO2014047221A9
公开(公告)日：2014-03-27
申请号：PCT/US2013/060479
申请日：2013-09-18
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING, Dennis
IPC分类号： A61K31/439 , A61K9/00 , A61L29/16 , A61L31/16 , A61M31/00 , A61L29/14 , A61P13/00 , A61P13/10
摘要： Methods, devices, and medicaments that include trospium are provided for use in the treatment of bladder dysfunction by locally administering the trospium into the bladder to achieve a sustained concentration of trospium in urine in the bladder sufficient to produce a therapeutic concentration of trospium in bladder tissue. The drug may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.

22. 发明专利

LT3113782T VAISTO TIEKIMO SISTEMOS IR BŪDAI, SKIRTI ŠLAPIMO PŪSLĖS VĖŽIO GYDYMUI GEMCITABINU 未知
公开(公告)号：LT3113782T
公开(公告)日：2022-11-25
申请号：LT15019262
申请日：2015-03-06
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , LEE HEEJIN , DANIEL KAREN
IPC分类号： A61K9/00 , A61K31/7068 , A61K45/06 , A61P13/10 , A61P35/00 , A61P43/00

23. 发明专利

AU2022241586A1 Drug delivery devices and methods 未知
公开(公告)号：AU2022241586A1
公开(公告)日：2022-10-27
申请号：AU2022241586
申请日：2022-09-30
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , DANIEL KAREN , LARRIVEE-ELKINS CHERYL , AGARWAL VIKAS , HO DUC HONG LINH
IPC分类号： A61M31/00
摘要： Abstract A drug delivery device for insertion into the body of a patient, the device comprising: a drug reservoir portion which comprises a lumen bounded by a reservoir wall having an interior portion which includes an inner surface; a drug formulation, which comprises a drug, located in the interior portion of the reservoir wall; and a core region in the lumen which does not comprise the drug, wherein the device is elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.

24. 发明专利

AU2022215156A1 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine 未知
公开(公告)号：AU2022215156A1
公开(公告)日：2022-09-01
申请号：AU2022215156
申请日：2022-08-08
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , LEE HEEJIN , DANIEL KAREN
IPC分类号： A61P35/00 , A61K31/7068
摘要： Abstract Drug delivery devices and methods are provided for administering gemcitabine to a patient in need of treatment of bladder cancer by intravesically administering gemcitabine into the bladder of the patient to achieve a sustained concentration of the gemcitabine in urine in the bladder sufficient to produce a therapeutically effective concentration of the gemcitabine in the tissues of the bladder. In embodiments, the local administration into the patient's bladder is at a mean average amount of from 1mg/day to about 300 mg/day of the gemcitabine (FBE).

25. 发明专利

AU2022204523A1 Intravesical drug delivery devices and methods including elastic polymer-drug matrix systems 未知
公开(公告)号：AU2022204523A1
公开(公告)日：2022-07-21
申请号：AU2022204523
申请日：2022-06-27
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , DANIEL KAREN
IPC分类号： A61K9/00 , A61M31/00
摘要： Abstract of the Disclosure An intravesical drug delivery device comprising: an elongated body having a first end, an opposed second end, and an intermediate portion between the first and second ends, wherein the elongate body comprises: a first lumen extending through the intermediate portion in a direction between the first and second ends and which contains a drug, and a second lumen extending through the intermediate portion in a direction between the first and second ends and which contains a first silicone cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.

26. 发明专利

AU2020277124B2 Drug delivery devices and methods 未知
公开(公告)号：AU2020277124B2
公开(公告)日：2022-07-07
申请号：AU2020277124
申请日：2020-11-24
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , DANIEL KAREN , LARRIVEE-ELKINS CHERYL , AGARWAL VIKAS , HO DUC HONG LINH
IPC分类号： A61M31/00
摘要： A drug delivery device for insertion into the body of a patient, the device comprising: a drug reservoir portion which comprises a drug reservoir lumen bounded by reservoir walls which comprise a water permeable polymeric material; and a drug formulation which comprises a drug and which substantially fills the drug reservoir lumen, wherein the drug reservoir lumen has a ribbon shape such that a substantial portion of the drug formulation is adjacent to the reservoir wall to facilitate diffusion of the drug through the reservoir walls, and wherein the device is elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.

27. 发明专利

BR112015022433B1 Dispositivo de liberação de droga intravesical 未知
公开(公告)号：BR112015022433B1
公开(公告)日：2022-06-21
申请号：BR112015022433
申请日：2014-03-17
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , DANIEL KAREN , SANSONE MATTHEW
IPC分类号： A61K9/00 , A61L27/00 , A61M31/00
摘要： dispositivos de liberação de droga com componente permeável à droga e métodos dispositivos de liberação de droga implantáveis incluem uma carcaça tendo um lúmen do reservatório de droga fechado delimitado por uma primeira estrutura de parede e uma segunda estrutura de parede hidrofílica, e uma droga contida no lúmen do reservatório de droga, em que a primeira estrutura de parede é impermeável à droga e a segunda estrutura de parede é permeável à droga. métodos para fornecer liberação controlada de droga a um paciente inclui a implantação de um dispositivo de liberação de droga no paciente liberando uma droga do lúmen do reservatório de droga via difusão através da segunda estrutura de parede.

28. 发明专利

PL3432970T3 URZĄDZENIA DO DOSTARCZANIA LEKÓW IN VIVO 未知
公开(公告)号：PL3432970T3
公开(公告)日：2021-09-20
申请号：PL18705786
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00

29. 发明专利

CA2871136C IMPLANTABLE UROLOGICAL DEVICE WITH IMPROVED RETRIEVAL FEATURE 未知
公开(公告)号：CA2871136C
公开(公告)日：2021-09-14
申请号：CA2871136
申请日：2013-05-20
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , HO DUC HONG LINH
IPC分类号： A61M31/00 , A61F2/04 , A61M25/00 , A61M27/00
摘要： A urological medical device having a retrieval string is provided. The retrieval string has a proximal end connected the device and an opposed distal end. In a first embodiment, the retrieval string is configured in an initial confined form which, following a period of deployment in a patient's bladder, changes to an unconfined form in which the distal end of the retrieval string is extendible into the urethra to enable extraction of the device from bladder by pulling the retrieval string. The device may include a bioerodible component which permits the retrieval string to take the unconfined form following degradation of the bioerodible component in vivo. In another embodiment, the retrieval string includes a ferromagnetic material, which can be magnetically captured to facilitate removal of the device from the bladder. The ferromagnetic retrieval string may be buoyant in urine.

30. 发明专利

ES2847887T3 Dispositivo urológico implantable con característica de recuperación mejorada 未知
公开(公告)号：ES2847887T3
公开(公告)日：2021-08-04
申请号：ES13726371
申请日：2013-05-20
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , HO DUC HONG
IPC分类号： A61M25/00 , A61K9/00 , A61M27/00 , A61M31/00
摘要： Un dispositivo médico, que comprende un dispositivo urológico (54, 64, 74, 84, 94) que comprende un dispositivo de administración de fármacos intravesical que comprende una luz del depósito de fármaco que aloja una formulación de fármaco; y por lo menos un cordel de recuperación (52, 62, 72, 82, 92) unido al dispositivo urológico (54, 64, 74, 84, 94) en una posición de unión, el cordel de recuperación (52, 62, 72, 82, 92) teniendo un extremo proximal (51, 71, 81, 91) conectado al dispositivo urológico (54, 64, 74, 84, 94) y un extremo distal opuesto; en donde el dispositivo médico comprende además: por lo menos un componente bioerosionable (58, 68, 78, 88, 98) que asegura el por lo menos un cordel de recuperación (52, 62, 72, 82, 92) en una forma inicial, en la que el por lo menos un cordel de recuperación (52, 62, 72, 82, 92) se enrolla, bobina, encapsula, o se confina de otro modo en o sobre el dispositivo urológico, en donde, después de un periodo de despliegue seleccionado del dispositivo médico en una vejiga urinaria de un paciente, el por lo menos un componente bioerosionable (58, 68, 78, 88, 98) se degrada para liberar el por lo menor un cordel de recuperación (52, 62, 72, 82, 92) en una forma no confinada en la que el extremo distal del por lo menos un cordel de recuperación (52, 62, 72, 82, 92), después del arrastre en la orina que fluye a través de la uretra, se extiende a través de la uretra, proporcionando de este modo el dispositivo médico la salida controlada del extremo distal del cordel de recuperación (52, 62, 72, 82, 92) desde la uretra para permitir la extracción del dispositivo médico de la vejiga, y en donde el extremo distal del por lo menos un cordel de recuperación (52, 62, 72, 82, 92) en la forma inicial está fijo con respecto a la posición de unión. por lo menos un componente bioerosionable (58, 68, 78, 88, 98) que asegura el por lo menos un cordel de recuperación (52, 62, 72, 82, 92) en una forma inicial, en la que el por lo menos un cordel de recuperación (52, 62, 72, 82, 92) se enrolla, bobina, encapsula, o se confina de otro modo en o sobre el dispositivo urológico, en donde, después de un periodo de despliegue seleccionado del dispositivo médico en una vejiga urinaria de un paciente, el por lo menos un componente bioerosionable (58, 68, 78, 88, 98) se degrada para liberar el por lo menor un cordel de recuperación (52, 62, 72, 82, 92) en una forma no confinada en la que el extremo distal del por lo menos un cordel de recuperación (52, 62, 72, 82, 92), después del arrastre en la orina que fluye a través de la uretra, se extiende a través de la uretra, proporcionando de este modo el dispositivo médico la salida controlada del extremo distal del cordel de recuperación (52, 62, 72, 82, 92) desde la uretra para permitir la extracción del dispositivo médico de la vejiga, y en donde el extremo distal del por lo menos un cordel de recuperación (52, 62, 72, 82, 92) en la forma inicial está fijo con respecto a la posición de unión.

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