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21. 发明申请

WO2002059379A3 METHODS FOR DETECTING, GRADING OR MONITORING AN $I(H. PYLORI) INFECTION 审中-公开
公开(公告)号：WO2002059379A3
公开(公告)日：2002-08-01
申请号：PCT/US2002/000267
申请日：2002-01-04
申请人： EXACT SCIENCES CORPORATION
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
摘要： The present invention provides methods for determining the status of an H.pylori infection by detecting a high-integrity H. pylori nucleic acid in a patient sample.

22. 发明申请

WO2019190787A1 METHOD FOR STABILIZING HEMOGLOBIN AND REAGENTS FOR PERFORMING THE SAME 审中-公开
公开(公告)号：WO2019190787A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/022598
申请日：2019-03-15
申请人： EXACT SCIENCES CORPORATION
发明人： FOURRIER, Keith D. , HENNEK, Jacquelyn T. , DOMANICO, Michael J. , WEISBURG, William G. , LIDGARD, Graham P. , HARINGS, Kathleen S. , SIMPSON, Daniel J.
IPC分类号： A61B10/02 , A61J1/05 , A61J1/14 , G01N1/28 , G01N33/48 , G01N33/68
摘要： A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin,or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.

23. 发明申请

WO2016094813A1 COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS 审中-公开
标题翻译：用于进行甲基化检测测定的组合物和方法
公开(公告)号：WO2016094813A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065272
申请日：2015-12-11
申请人： EXACT SCIENCES CORPORATION
发明人： ALLAWI, Hatim T. , LIDGARD, Graham P.
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6881 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/166
摘要： Provided herein is technology relating compositions and methods for detecting tissue cell-specific DNA, such as epithelial cell-specific DNA, in blood or blood products from a subject. The technology also relates to use of tissue cell-specific DNAs as internal controls for methylation assays. Provided herein is technology relating to characterizing samples, e.g., blood samples, stool samples, etc., for the presence or absence of, and/or the amounts of different species of nucleic acids that, for example, may be associated with a health status of a subject. For example, in some embodiments, the technology relates to detecting and measuring DNA associated with a particular tissue in a sample type that does not typically contain DNA from that tissue. In preferred embodiments, the technology is directed to detecting and/or measuring epithelial cells and/or epithelial cell-specific DNA in blood or blood product samples.
摘要翻译：本文提供了用于检测来自受试者的血液或血液制品中的组织细胞特异性DNA（例如上皮细胞特异性DNA）的组合物和方法的技术。该技术还涉及使用组织细胞特异性DNA作为甲基化测定的内部对照。本文提供的技术涉及表征样品，例如血样，粪便样品等，用于存在或不存在不同种类的核酸，例如可能与健康状况相关联的主题。例如，在一些实施方案中，该技术涉及检测和测量与通常不含有来自该组织的DNA的样品类型中的特定组织相关的DNA。在优选实施方案中，该技术涉及检测和/或测量血液或血液制品样品中的上皮细胞和/或上皮细胞特异性DNA。

24. 发明申请

WO2015031832A1 ERGONOMIC STOOL SPECIMEN CONTAINER AND ENCLOSING HOLDER SYSTEMS, METHODS, AND KITS 审中-公开
标题翻译：有机体样本容器和包装夹系统，方法和工具
公开(公告)号：WO2015031832A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/053542
申请日：2014-08-29
申请人： EXACT SCIENCES CORPORATION
发明人： SCHIESTLE, Joseph E. , BURGER, Krystal A. , PALMER, Timothy A. , LUNDE, Jad A. , JANG, Sam M. , SCHUELKE, David A. , WOLGEMUTH, David B. , LU, Jing Yang
IPC分类号： G01N33/48
CPC分类号： A61B10/0038 , A61B10/0096 , B01L3/508 , B01L3/50825 , B01L9/00 , B01L2200/0689 , B01L2200/087 , B01L2200/185 , B01L2300/042 , B01L2300/043 , B01L2300/0832 , B01L2300/0858 , B01L2300/12 , G01N1/38 , G01N2001/386
摘要： Provided herein is technology relating to collecting and containing samples and particularly, but not exclusively, to technology for collecting and containing a stool specimen. The technology provides a device for collecting and containing a stool specimen, the device comprising ergonomic features optimized for a geriatric user. The technology also provides an enclosing holder for securing the ergonomic stool specimen container in a leak-proof manner e.g., during mechanical shaking.
摘要翻译：本文提供了涉及收集和容纳样品的技术，特别地但不排他地涉及用于收集和容纳粪便样品的技术。该技术提供了用于收集和容纳粪便样本的装置，该装置包括针对老人用户而优化的符合人体工学特征的装置。该技术还提供了一种封闭保持器，用于以机械振动的方式以防漏的方式固定符合人体工程学的粪便样本容器。

25. 发明申请

WO2014159652A2 DETECTING NEOPLASM 审中-公开
标题翻译：检测NEOPLASM
公开(公告)号：WO2014159652A2
公开(公告)日：2014-10-02
申请号：PCT/US2014/024589
申请日：2014-03-12
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , EXACT SCIENCES CORPORATION
发明人： AHLQUIST, David A. , KISIEL, John B. , TAYLOR, William R. , YAB, Tracy C. , MAHONEY, Douglas W. , LIDGARD, Graham, P. , ALLAWI, Hatim, T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
摘要翻译：本文提供了涉及检测瘤形成的技术，特别但并非排他地涉及用于检测恶变和恶性肿瘤如胰腺癌和结肠直肠癌的方法，组合物和相关用途。

26. 发明申请

WO2013116375A1 MODIFICATION OF DNA ON MAGNETIC BEADS 审中-公开
标题翻译： DNA修饰磁珠
公开(公告)号：WO2013116375A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/023908
申请日：2013-01-30
申请人： EXACT SCIENCES CORPORATION , DOMANICO, Michael J. , ALLAWI, Hatim , LIDGARD, Graham P. , AIZENSTEIN, Brian , HUNT, Oliver , ZUTZ, Tobias Charles
发明人： DOMANICO, Michael J. , ALLAWI, Hatim , LIDGARD, Graham P. , AIZENSTEIN, Brian , HUNT, Oliver , ZUTZ, Tobias Charles
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6851 , C12Q2600/154 , C12Q2523/113 , C12Q2523/125 , C12Q2527/125 , C12Q2527/137
摘要： Provided herein is technology related to the chemical modification and purification of DNA. Specifically, the technology provides methods for performing a bisulfite conversion reaction on small amounts of single-stranded, fragmented DNA and performing the subsequent desulfonation and purification steps on magnetic beads.
摘要翻译：本文提供了与DNA的化学修饰和纯化有关的技术。具体地，该技术提供了在少量单链，片段化DNA上进行亚硫酸氢盐转化反应并在磁珠上进行随后的脱磺化和纯化步骤的方法。

27. 发明申请

WO2012106525A2 DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION 审中-公开
标题翻译： DNA甲基化数字序列分析
公开(公告)号：WO2012106525A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023646
申请日：2012-02-02
申请人： EXACT SCIENCES CORPORATION , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , AHLQUIST, David A. , TAYLOR, William R. , ZOU, Hongzhi , LIDGARD, Graham P.
发明人： AHLQUIST, David A. , TAYLOR, William R. , ZOU, Hongzhi , LIDGARD, Graham P.
IPC分类号： C40B20/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6858 , C12Q2600/154 , C12Q2521/331 , C12Q2523/125 , C12Q2563/159
摘要： The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
摘要翻译：本发明涉及用于确定和使用指示腺瘤和癌症的特异性甲基化模式的方法和组合物。特别地，本发明涉及在来自癌症和腺瘤样品的DNA中配位甲基化的定义的CpG基因座的分析，用于鉴定配位甲基化位点的方法以及在设计中的一个或多个标记区域中使用配位甲基化位点分析的方法腺瘤和癌症检测。

28. 发明申请

WO2012067831A1 REAL TIME CLEAVAGE ASSAY 审中-公开
标题翻译：实时清除测试
公开(公告)号：WO2012067831A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/059001
申请日：2011-11-02
申请人： EXACT SCIENCES CORPORATION , OLDHAM-HALTOM, Rebecca , ZOU, Hongzhi , LIDGARD, Graham, P. , DOMANICO, Michael, J. , ALLAWI, Hatim
发明人： OLDHAM-HALTOM, Rebecca , ZOU, Hongzhi , LIDGARD, Graham, P. , DOMANICO, Michael, J. , ALLAWI, Hatim
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6827 , C12Q1/6818 , C12Q1/686 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , C12Q2525/301 , C12Q2527/101 , C12Q2561/109 , C12Q2565/1015
摘要： A cleavage-based real-time PCR assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) PCR reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on the amplified nucleic acid target to two sets of thermocycling conditions. No additional reagents are added to the reaction between said first and second sets of cycles and, in each cycle of the second set of cycles, cleavage of a flap probe is measured.
摘要翻译：提供基于切割的实时PCR测定方法。一般而言，测定方法包括对包含a）PCR试剂的反应混合物进行核酸靶扩增，和b）用于在扩增的核酸靶上进行皮瓣裂解测定的两个热循环条件的瓣裂解试剂。在所述第一组和第二组循环之间没有向所述反应中加入另外的试剂，并且在第二组循环的每个循环中，测量瓣探针的切割。

29. 发明申请

WO2006047787A3 METHOD FOR MONITORING DISEASE PROGRESSION OR RECURRENCE 审中-公开
公开(公告)号：WO2006047787A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/039670
申请日：2005-10-27
申请人： EXACT SCIENCES CORPORATION , SHUBER, Anthony, P.
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
摘要： The invention provides methods for detecting and monitoring diseases associated with genetic abnormalities in a subject.

30. 发明申请

WO2005047881A2 REPETITIVE AFFINITY SEPARATION AND USES THEREFOR 审中-公开
标题翻译：重复利益分离及其用途
公开(公告)号：WO2005047881A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/036904
申请日：2004-11-05
申请人： EXACT SCIENCES CORPORATION , SHUBER, Anthony, P.
发明人： SHUBER, Anthony, P.
IPC分类号： G01N27/447
CPC分类号： G01N27/44726 , G01N27/44713 , G01N27/44747 , G01N27/44773 , G01N33/559
摘要： Improved methods for the separation, isolation, enrichment, or detection of target molecules, such as nucleic acids and proteins, within dilute or heterogeneous samples, such as bodily fluids, excreta or tissue samples, are disclosed. The methods include repetitively and rapidly passing a sample across at least one region of a conduit in which at least one region includes a binding partner specific for the target molecule. In certain methods, at least one other region includes binding partners specific for non-target molecules. The sample may be passed over the binding partner in the same direction if the conduit is a loop or in an antiparallel direction (i.e., back and forth over the binding partner). In an embodiment, the sample is electrophoresed through or over an electrophoretic medium, in which at least one region includes a binding partner for the target molecule. The invention also provides apparatus and sample preparation systems adapted for use in the methods.
摘要翻译：公开了用于分离，分离，富集或检测稀释或异质样品（例如体液，排泄物或组织样品）内的靶分子（例如核酸和蛋白质）的改进方法。所述方法包括重复地并快速地将样品通过导管的至少一个区域，其中至少一个区域包含对靶分子特异的结合配偶体。在某些方法中，至少一个其它区域包括对非靶分子特异的结合配偶体。如果导管是回路或反向平行的方向（即，在结合伙伴上前后），样品可以以相同的方向通过结合配偶体。在一个实施方案中，将样品电泳穿过电泳介质或其上至少一个区域包含靶分子的结合配偶体。本发明还提供适用于该方法的装置和样品制备系统。

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