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21. 发明专利

AU2018243023B2 Applicator for water-soluble sheet-shaped preparation 未知
公开(公告)号：AU2018243023B2
公开(公告)日：2022-06-02
申请号：AU2018243023
申请日：2018-03-28
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , LI YING-ZHE , HIGUCHI KIYOTSUNE , TANAKA HIROSHI , KAMIYAMA FUMIO
IPC分类号： A61M35/00 , A61M37/00
摘要： The present invention provides a means with which the administration of a water-soluble sheet-shaped preparation to skin at various areas can be ensured, and moisture can be supplied from a rear surface of the water-soluble sheet-shaped preparation. Provided are: a nozzle having at least one hole provided in a tip portion which has a plane of a size capable of holding the water-soluble sheet-shaped preparation, and having recess-and-protrusion portions on the plane excluding the hole; and an applicator for a water-soluble sheet-shaped preparation, the applicator comprising a liquid container and said nozzle.

22. 发明专利

AU2017215012B2 Coating liquid for microneedles, microneedle-coating substance, and microneedle array 未知
公开(公告)号：AU2017215012B2
公开(公告)日：2022-04-21
申请号：AU2017215012
申请日：2017-02-01
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , SAITO MIO , KITAOKA SHOUTA , KAMIYAMA FUMIO
IPC分类号： A61K47/26 , A61K9/08 , A61K9/70 , A61K47/10 , A61K47/34 , A61K47/36 , A61M37/00
摘要： Provided is a composition for a coating liquid for microneedles which is optimal for when coating microneedles with a drug. This coating liquid for microneedles is an aqueous solution which has, as essential components of a base thereof, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide, and a surfactant, and is characterized in that: the proportion of the water-soluble polysaccharide in the base is 2-60 mass%; and the hardness of a coating substance after drying is at least 10 N. A water-soluble polyhydric alcohol may also be included. It is preferable that, in the base, the proportion of the monosaccharide and/or the disaccharide be 30-95 mass%, the proportion of the surfactant be 0.05-5 mass%, and the proportion of the water-soluble polyhydric alcohol be not more than 10 mass%. Hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable as the water-soluble polysaccharide.

23. 发明专利

AU2018360546B2 Dental local anesthetic microneedle array 未知
公开(公告)号：AU2018360546B2
公开(公告)日：2021-03-25
申请号：AU2018360546
申请日：2018-11-01
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M37/00
摘要： Provided is a microneedle array that is easily applied to the oral cavity and can exhibit an anesthetic effect suited to the application site. Provided are: a fast-acting dental local anesthetic preparation which comprises a microneedle array containing a local anesthetic and has needle parts that dissolve within the mucosa when adhered to the oral mucosa or the gingiva; a microneedle array; and a microneedle patch comprising the microneedle array and a support body provided on the back face of the microneedle array. The microneedle array has microneedles, each having a height of 50 to 300 µm and a tip that is a circle with a diameter of 1 to 50 µm or a plane with the same area as the circle, and a backing with a thickness of 5 to 100 µm.

24. 发明专利

CA3089513A1 TIGHT-BINDING DEVICE FOR MICRO-NEEDLE 未知
公开(公告)号：CA3089513A1
公开(公告)日：2019-08-01
申请号：CA3089513
申请日：2019-01-23
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M5/42 , A61B5/15 , A61M37/00
摘要： Through progress in micro-machining technologies, the present invention provides an auxiliary tool with which a micro-needle array, on which a plurality of micro-needles are mounted, is more reliably injected into the skin. This skin tight-binding device is provided with a tight-binding band, and a hole formed in the tight-binding band, wherein the hole forms a micro-needle patch injecting part when the tight-binding band is fixed to the skin, and the skin tight-binding device is further provided with a fixing tool for fixing the tight-binding band to the skin.

25. 发明专利

CA3067694A1 MICRONEEDLE ARRAY FOR LIPS 未知
公开(公告)号：CA3067694A1
公开(公告)日：2019-02-21
申请号：CA3067694
申请日：2018-08-17
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO , TANAKA HIROSHI , KONDO NAOKO
IPC分类号： A61M37/00
摘要： [Problem] To provide a composition that lightens and plumps lips more effectively and in a simpler manner. [Solution] This microneedle array is applied locally to lips in order to lighten and/or plump the lips. The microneedle array includes a water-soluble polymer, and has a height of 50300 µm. The tips of the microneedles are round with a diameter of 5150 µm, or are flat surfaces with an equivalent area.

26. 发明专利

CA3060043A1 WATER-SOLUBLE COSMETIC SHEET RETAINING FILM 未知
公开(公告)号：CA3060043A1
公开(公告)日：2018-11-29
申请号：CA3060043
申请日：2018-05-21
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , TANAKA HIROSHI , KONDOU NAOKO , KAMIYAMA FUMIO
IPC分类号： A61M37/00 , A61K8/02 , A61K8/65 , A61K8/73 , A61K8/85 , A61Q19/00
摘要： Provided is a means for enabling application of a water-soluble cosmetic sheet such as a microneedle array even without an adhesive sheet. A water-soluble sheet-like cosmetic product comprises: a re-peelable microneedle patch supporting body film which has a pattern coated adhesive surface on one surface thereof and which is in contact with a rear surface of a microneedle array substrate, with the adhesive surface interposed therebetween; a re-peelable water-soluble cosmetic sheet supporting body film which has a pattern coated adhesive surface on one surface thereof and which is in contact with a rear surface of a cosmetic sheet containing a water-soluble polymer, with the adhesive surface interposed therebetween; and a microneedle array and a supporting body film having a water-soluble polymer or a water-swelling resin as a base. The supporting body film comprises a microneedle patch which has a pattern coated adhesive surface on one surface thereof, and which is bonded to a rear surface of the microneedle array substrate, with the adhesive surface interposed therebetween, a water-soluble cosmetic sheet containing a water-soluble polymer, and a supporting body film. The supporting body film has a pattern coated adhesive surface on one surface thereof, and is bonded to a rear surface of the water-soluble cosmetic sheet with the adhesive surface interposed therebetween.

27. 发明专利

AU2017257932A1 Alcogel sheet for cosmetic use, and method for producing same 未知
公开(公告)号：AU2017257932A1
公开(公告)日：2018-11-15
申请号：AU2017257932
申请日：2017-04-28
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KONDOU NAOKO , KAMIYAMA FUMIO
IPC分类号： A61K8/73 , A61K8/20 , A61K8/34 , A61K8/365 , A61Q19/00
摘要： Provided is a gel sheet for cosmetic use, which is suitable for use in the fields of cosmetic and medicine. An alcogel sheet for cosmetic use according to the present invention is characterized by comprising a water-soluble non-woven fabric or a water-soluble film and an alcogel that is laminated on the water-soluble non-woven fabric or the water-soluble film and contains a carboxy-group-containing water-soluble polymer, a polyhydric alcohol and an acid as the essential components, wherein the gel has a water content of 30% by mass or less. It is more preferred that the carboxy-group-containing water-soluble polymer is a carboxy-group-containing polysaccharide and the polyhydric alcohol is glycerin. The alcogel sheet for cosmetic use according to the present invention can be produced by drying an aqueous solution containing a carboxy-group-containing water-soluble polymer, a polyhydric alcohol and an acid as the essential components on a mold-release sheet to produce a gel and then laminating the gel on a water-soluble non-woven fabric or a water-soluble film.

28. 发明专利

AU2017232609A1 Microneedle patch case 未知
公开(公告)号：AU2017232609A1
公开(公告)日：2018-10-04
申请号：AU2017232609
申请日：2017-03-16
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , HIGUCHI KIYOTSUNE , KAMIYAMA FUMIO
IPC分类号： A61M37/00 , A61J1/00
摘要： Provided is a patch case that can easily be attached to a microneedle applicator, enables easy separation of microneedle patches during needling, and can be used disposably. The main body of a patch case according to the present invention is characterized by having a thermoplastic polymer as a raw material and being capable of holding microneedle patches comprising a support body film that can be thermally fused with said thermoplastic polymer. It is preferable that the thermoplastic polymer of the main body and the fusible raw material of the support body film are both polyolefins or both the same thermoplastic polymer. Since the applicator does not make contact with the skin of a person receiving administration if the patch case is attached to the front surface of the applicator, hygiene can be maintained even if the applicator is used continuously.

29. 发明专利

AU2013339095A1 Retinoic acid microneedle 未知
公开(公告)号：AU2013339095A1
公开(公告)日：2015-05-21
申请号：AU2013339095
申请日：2013-11-01
申请人： PUBLIC UNIVERSITY CORP NARA MEDICAL UNIVERSITY , UNIV OSAKA , COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO , SAITO MIO , NAKAGAWA SHINSAKU , OKADA NAOKI , HIROBE SACHIKO , ASADA HIDEO
IPC分类号： A61M37/00 , A61K9/10 , A61K31/05 , A61K31/203 , A61K47/36 , A61P17/00
摘要： The present invention provides a microneedle array which is capable of effectively supplying retinoic acid to the skin and is effective for treating acne, pigmentation or wrinkles. This retinoic acid microneedle array comprises: a microneedle array which includes a microneedle substrate (5) and a microneedle (1) that is disposed on the microneedle substrate (5); and a medicine which is retained by the microneedle (1) and comprises a water-swellable polymer and retinoic acid.

30. 发明专利

AU2013219321A1 Microneedle of short-time dissolution type 未知
公开(公告)号：AU2013219321A1
公开(公告)日：2014-09-18
申请号：AU2013219321
申请日：2013-02-14
申请人： COSMED PHARMACEUTICAL CO LTD
发明人： QUAN YING-SHU , KAMIYAMA FUMIO
IPC分类号： A61M37/00 , A61L31/00
摘要： Provided is a microneedle material which dissolves in a short time and can be rapidly absorbed. Thus, the time required for microneedle application is shortened. As the microneedle material, use is made of a mixture of one or more water-soluble polymers and one or a plurality of saccharides selected from monosaccharides and disaccharides. Suitable for use as the water-soluble polymer(s) is a synthetic polymer, a protein, a polysaccharide, or a mixture of these. Suitable for use as the saccharides is any of glucose, fructose, sucrose, and lactose or a mixture of these.

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