专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20090306090A1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS 失效
标题翻译：杂环衍生物及其作为硬脂酸脱乙酰酶抑制剂的用途
公开(公告)号：US20090306090A1
公开(公告)日：2009-12-10
申请号：US12541005
申请日：2009-08-13
申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Lui , Shaoyi Sun , Duanjie Hou
发明人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Lui , Shaoyi Sun , Duanjie Hou
IPC分类号： A61K31/501 , C12N9/99 , C07D403/04
CPC分类号： A61K31/501 , C07D237/24 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，W，R 2，R 3，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a如本文所定义。还公开了包含式（I）化合物的药物组合物。

22. 发明授权

US07592343B2 Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors 失效
标题翻译：哒嗪 - 哌嗪化合物及其作为硬脂酰辅酶A去饱和酶抑制剂的用途
公开(公告)号：US07592343B2
公开(公告)日：2009-09-22
申请号：US11575641
申请日：2005-09-20
申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Liu , Shaoyi Sun , Duanjie Hou
发明人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Liu , Shaoyi Sun , Duanjie Hou
IPC分类号： A61K31/50
CPC分类号： A61K31/501 , C07D237/24 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (Ia): where x, y, G, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, are disclosed, as well as pharmaceutical compositions comprising the compounds. These compounds and pharmaceutical compositions are useful in treating SCD-mediated diseases or conditions.
摘要翻译：式（Ia）化合物：其中x，y，G，L，M，W，R 2，R 3，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a如本文所定义，包含该化合物的组合物。这些化合物和药物组合物可用于治疗SCD介导的疾病或病症。

23. 发明申请

US20090156615A1 ORGANIC COMPOUNDS 失效
标题翻译：有机化合物
公开(公告)号：US20090156615A1
公开(公告)日：2009-06-18
申请号：US12303490
申请日：2007-06-04
申请人： Natalie Dales , Julia Fonarev , Jianmin Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Natalia Pokrovskaia , Vandna Raina , Shaoyi Sun , Zaihui Zhang
发明人： Natalie Dales , Julia Fonarev , Jianmin Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Natalia Pokrovskaia , Vandna Raina , Shaoyi Sun , Zaihui Zhang
IPC分类号： A61K31/497 , C07D401/14 , A61K31/444 , C07D415/00 , A61K31/4439 , A61K31/4709
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。

24. 发明申请

US20080207587A1 Pyridazine Derivatives for Inhibiting Human Stearoyl-Coa-Desaturase 失效
标题翻译：用于抑制人类硬脂酰辅酶脱氢酶的哒嗪衍生物
公开(公告)号：US20080207587A1
公开(公告)日：2008-08-28
申请号：US11575642
申请日：2005-09-20
申请人： Rajender Kamboj , Zaihui Zhang , Jian-Min Fu , Serguei Sviridov , Sultan Chowdhury , Vishnumurthy Kodumuru
发明人： Rajender Kamboj , Zaihui Zhang , Jian-Min Fu , Serguei Sviridov , Sultan Chowdhury , Vishnumurthy Kodumuru
IPC分类号： A61K31/501 , C07D237/06 , C07D403/02 , A61P3/00 , A61P3/04 , A61P3/10 , C07D401/02
CPC分类号： C07D401/12 , A61K31/501 , C07D237/24 , C07D403/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a arc defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物，其中x，y，G，J，K， L，M，Q，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a。还公开了包含式（I）化合物的药物组合物。

25. 发明申请

US20080108629A1 Heterocyclic Derivatives for the Treatment of Diseases Mediated by Stearoyl-Coa Desaturase Enzymes 失效
标题翻译：用于治疗由硬脂酰辅酶脱氢酶酶介导的疾病的杂环衍生物
公开(公告)号：US20080108629A1
公开(公告)日：2008-05-08
申请号：US11575636
申请日：2005-09-20
申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
发明人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
IPC分类号： A61K31/496 , C07D417/04 , C07D413/04 , C07D403/04 , A61P3/00
CPC分类号： C07D277/28 , A61K31/381 , A61K31/41 , A61K31/415 , C07D231/38 , C07D271/113 , C07D285/01
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，W，V，R 2，R 3，R 5，R 5a，R R 6，R 6a，R 7，R 7a，R 8和R 8，R 8，本文定义了8a。还公开了包含式（I）化合物的药物组合物。

26. 发明授权

US07288556B2 Antiproliferative 1,2,3-thiadiazole compounds 有权
标题翻译：抗增殖性1,2,3-噻二唑化合物
公开(公告)号：US07288556B2
公开(公告)日：2007-10-30
申请号：US11218969
申请日：2005-09-02
申请人： Zaihui Zhang , Gregory B Chopiuk , Timothy S Daynard , Shisen Wang
发明人： Zaihui Zhang , Gregory B Chopiuk , Timothy S Daynard , Shisen Wang
IPC分类号： C07D285/06 , A61K31/41
CPC分类号： A61K31/433 , C07D285/06
摘要： This invention is directed to methods of using compounds having the structure: and including stereoisomers, solvates, and pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3 and R4 is independently selected from hydrogen, R5, R6, and R7; R5 is selected from alkyl, heteroalkyl, aryl and heteroaryl; R6 is selected from (R5)n-alkylene, (R5)n-heteroalkylene, (R5)n-arylene and (R5)n-heteroarylene; R7 is selected from (R6)n-alkylene, (R6)n-heteroalkylene, (R6)n-arylene, and (R6)n-heteroarylene; and n is selected from 0, 1, 2, 3, 4 and 5, where R1 and R2 may together form a heterocyclic structure including the nitrogen to which they are both attached, and R3 and R4 may together form a heterocyclic structure including the nitrogen to which they are both attached; and each of L1 and L2 is independently selected from -A1-A2-A3- where each of A1, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene, arylene and heteroarylene. These compounds are useful in treating hyperproliferative disorders and inducing apoptosis.
摘要翻译：本发明涉及使用具有以下结构的化合物的方法：其包括立体异构体，溶剂化物和药学上可接受的盐，其中R 1，R 2，R 2， SO 3和R 4独立地选自氢，R 5，R 6和R 7， / SUP>; R 5选自烷基，杂烷基，芳基和杂芳基; R 6选自（R 5）N 1 - 亚烷基，（R 5）亚磺酰基，（R 5） - 亚芳基和（R 5）5 - 亚杂芳基。 R 7选自（R 6）N - 亚烷基，（R 6）亚磺酰基，（R 6） - 亚芳基和（R 6） - 亚 - 亚芳基 ; 并且n选自0,1,2,3,4和5，其中R 1和R 2可以一起形成杂环结构，包括它们是氮的杂环结构两个连接的R 3和R 4可以一起形成包括它们都连接的氮的杂环结构; 并且L 1和L 2各自独立地选自-A1-A2-A3-，其中A1，A2和A3各自独立地选自直接键，亚烷基，杂亚烷基，亚芳基和亚杂芳基。这些化合物可用于治疗过度增殖性疾病和诱导凋亡。

27. 发明授权

US07196083B2 Heteropolycyclic inhibitors of protein kinases 失效
标题翻译：蛋白激酶的杂多环抑制剂
公开(公告)号：US07196083B2
公开(公告)日：2007-03-27
申请号：US10310600
申请日：2002-12-04
申请人： Zaihui Zhang , Xinyao Du , Serguei Sviridov , Greg Chopiuk
发明人： Zaihui Zhang , Xinyao Du , Serguei Sviridov , Greg Chopiuk
IPC分类号： A61K31/53
CPC分类号： C07D487/04 , C07D513/04
摘要： A method of inhibiting tumor growth is provided, comprising administering an effective dose of a compound of the formula wherein, independently at each occurrence, w is C or N, v and x are N with H substitution as needed to fulfill open valence sites; y and z are selected from N and C, with H substitution as needed to fulfill open valence sites, with the proviso that each of w, v, x, y and z is not simultaneously C; the ring formed from v, w, x, y and z may be saturated or unsaturated; and R1, R2, R3 and R4 are selected from hydrogen, alkyl, aryl, alkaryl, aralkyl, heteroalkyl, and heteroaryl; wherein any adjacent two of R1, R2, R3 and R4 may join together to form a 5, 6 or 7-membered carbocyclic ring or a 5, 6 or 7-membered heterocyclic ring containing at least one atom selected from nitrogen, oxygen and sulfur.
摘要翻译：提供了一种抑制肿瘤生长的方法，包括施用有效剂量的下式的化合物

28. 发明授权

US07105503B2 Pyrazole compounds 有权
公开(公告)号：US07105503B2
公开(公告)日：2006-09-12
申请号：US10077238
申请日：2002-02-15
申请人： Zaihui Zhang , Timothy S. Daynard , Serguei V. Sviridov , Mikhail A. Chafeev , Shisen Wang
发明人： Zaihui Zhang , Timothy S. Daynard , Serguei V. Sviridov , Mikhail A. Chafeev , Shisen Wang
IPC分类号： A61K31/655 , A61K31/415 , C07D231/38
CPC分类号： C07D231/38 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/454 , A61K31/53 , A61K31/5377 , C07D231/46 , C07D231/52 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

29. 发明申请

US20050065143A1 Pyridazine derivatives and their use as therapeutic agents 有权
标题翻译：哒嗪衍生物及其作为治疗剂的用途
公开(公告)号：US20050065143A1
公开(公告)日：2005-03-24
申请号：US10901563
申请日：2004-07-29
申请人： Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael Winther , Zaihui Zhang , Melwyn Abreo , Mark Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz Gschwend
发明人： Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael Winther , Zaihui Zhang , Melwyn Abreo , Mark Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz Gschwend
IPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , A61P3/06 , C07D237/20 , C07D237/24
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R R 2，R 3，R 4，R 5，R 6，R 6a，R 7，R 7a，R 8，R 8a，R 本文定义<9>和R 9a。还公开了包含式（I）化合物的药物组合物。

30. 发明授权

US06514972B2 Heteropolycyclic inhibitors of protein kinases 失效
标题翻译：蛋白激酶的杂多环抑制剂
公开(公告)号：US06514972B2
公开(公告)日：2003-02-04
申请号：US09900073
申请日：2001-07-06
申请人： Zaihui Zhang , Xinyao Du , Serguei Sviridov , Greg Chopiuk
发明人： Zaihui Zhang , Xinyao Du , Serguei Sviridov , Greg Chopiuk
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07D513/04
摘要： A compound of the formula wherein, independently at each occurrence, v, w, and x are selected from C, N, O, and S, with H substitution as needed to fulfill open valence sites; y and z are selected from N and C, with H substitution as needed to fulfill open valence sites, with the proviso that each of w, v, x, y and z is not simultaneously C; the ring formed from v, w, x, y and z may be saturated or unsaturated; and R1, R2, R3 and R4 are selected from hydrogen, alkyl, aryl, alkaryl, aralkyl, heteroalkyl, and heteroaryl; wherein any adjacent two of R1, R2, R3 and R4 may join together to form a 5, 6 or 7-membered carbocyclic or heterocyclic ring, with the proviso that each of R1, R2, R3 and R4 is not simultaneously hydrogen. Pharmaceutical compositions of said compounds, and methods of use in the treatment of biological conditions including cellular hyperproliferation, are disclosed.
摘要翻译：在每次出现时，v，w和x独立地选自C，N，O和S的化合物，根据需要进行H取代以实现开价值位点; y和z选自N和C，根据需要进行H取代以满足开价值位置，条件是w，v，x，y和z中的每一个不同时为C; 由v，w，x，y和z形成的环可以是饱和或不饱和的; 并且R 1，R 2，R 3和R 4选自氢，烷基，芳基，烷芳基，芳烷基，杂烷基和杂芳基; 其中R 1，R 2，R 3和R 4中的任何相邻的两个可以连接在一起以形成5,6或7-元碳环或杂环，条件是R 1，R 2，R 3和R 4中的每一个不是同时氢。公开了所述化合物的药物组合物，以及用于治疗包括细胞过度增殖的生物学条件的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式