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21. 发明授权

US07429474B2 2-O sulfatase compositions and methods of analyzing therewith 有权
标题翻译： 2-O硫酸酯酶组合物及其分析方法
公开(公告)号：US07429474B2
公开(公告)日：2008-09-30
申请号：US11433228
申请日：2006-05-11
申请人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
发明人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

22. 发明授权

US07412332B1 Method for analyzing polysaccharides 有权
标题翻译：多糖分析方法
公开(公告)号：US07412332B1
公开(公告)日：2008-08-12
申请号：US09557997
申请日：2000-04-24
申请人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
发明人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译：公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。聚合物可以是例如多糖，化学单元可以是糖。还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于查询序列和聚合物。本发明还涉及称为属性编码术语的符号系统。

23. 发明授权

US07247445B2 2-O sulfatase compositions and methods of hydrolyzing therewith 有权
标题翻译： 2-O硫酸酯酶组合物及其水解方法
公开(公告)号：US07247445B2
公开(公告)日：2007-07-24
申请号：US11432824
申请日：2006-05-11
申请人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
发明人： Ram Sasisekharan , James R. Myette , Zachary Shriver , Ganesh Venkataraman
IPC分类号： C12Q1/44 , C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

24. 发明授权

US07110889B2 Method for identifying or characterizing properties of polymeric units 有权
公开(公告)号：US07110889B2
公开(公告)日：2006-09-19
申请号：US10760133
申请日：2004-01-16
申请人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
发明人： Ganesh Venkataraman , Zachary Shriver , Rahul Raman , Ram Sasisekharan , Nishla Keiser
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.

25. 发明申请

US20060183713A1 Compositions of low molecular weight heparin produced with modified heparinase III 审中-公开
标题翻译：用改良的肝素酶III生产的低分子量肝素的组合物
公开(公告)号：US20060183713A1
公开(公告)日：2006-08-17
申请号：US11406215
申请日：2006-04-18
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
IPC分类号： A61K31/727 , C12P19/28
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译：本发明涉及肝素酶III及其突变体。根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等。本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。

26. 发明申请

US20050214276A9 Delta 4, 5 glycuronidase and uses thereof 审中-公开
标题翻译： Delta 4,5型糖醛酸糖苷酶及其用途
公开(公告)号：US20050214276A9
公开(公告)日：2005-09-29
申请号：US10429921
申请日：2003-05-05
申请人： James Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland McLean
发明人： James Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland McLean
IPC分类号： A61K38/00 , C07H21/04 , C12N9/24 , C12Q1/34 , A61K38/47
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译：本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。

27. 发明授权

US07695711B2 Δ 4,5 glycuronidase nucleic acid compositions 有权
标题翻译：＆Dgr 4,5糖醛酸糖苷酶核酸组合物
公开(公告)号：US07695711B2
公开(公告)日：2010-04-13
申请号：US11402491
申请日：2006-04-11
申请人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
发明人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
IPC分类号： A01N63/00 , C12N9/00 , C12N9/26 , C12N1/20 , A61K38/00 , C07H21/02
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译：本发明涉及＆amp; 4,5g糖醛酸糖苷酶，相关组合物及其使用方法。

28. 发明申请

US20090203550A1 METHODS OF MAKING GLYCOMOLECULES WITH ENHANCED ACTIVITIES AND USES THEREOF 审中-公开
标题翻译：制备具有增强活性的谷氨酸分子的方法及其用途
公开(公告)号：US20090203550A1
公开(公告)日：2009-08-13
申请号：US12351473
申请日：2009-01-09
申请人： Ganesh Venkataraman , Ram Sasisekharan , Zachary Shriver
发明人： Ganesh Venkataraman , Ram Sasisekharan , Zachary Shriver
IPC分类号： C40B40/10
CPC分类号： C08B37/00 , C12P21/005 , G01N2400/00
摘要： Methods to rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide.
摘要翻译：已经开发了快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。所述方法包括产生分子，例如包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二多糖部分的治疗分子。该方法包括：确定第二部分的全部或部分的化学组成和结构，修饰第二部分的结构以提供修饰的第二部分，以及评估或筛选具有修饰的第二部分的分子，例如，用于生物活性或其他化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库多糖。

29. 发明授权

US07504247B2 2-O sulfatase compositions and methods of degradation therewith 有权
标题翻译： 2-O硫酸酯酶组合物及其降解方法
公开(公告)号：US07504247B2
公开(公告)日：2009-03-17
申请号：US11433340
申请日：2006-05-11
申请人： Ram Sasisekharan , James Myette , Zachary Shriver , Ganesh Venkataraman
发明人： Ram Sasisekharan , James Myette , Zachary Shriver , Ganesh Venkataraman
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

30. 发明申请

US20060292673A1 2-O sulfatase compositions and methods of degradation therewith 有权
公开(公告)号：US20060292673A1
公开(公告)日：2006-12-28
申请号：US11433340
申请日：2006-05-11
申请人： Ram Sasisekharan , James Myette , Zachary Shriver , Ganesh Venkataraman
发明人： Ram Sasisekharan , James Myette , Zachary Shriver , Ganesh Venkataraman
IPC分类号： C12P19/26 , C08B37/00
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

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