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21. 发明申请

WO1998011228A2 GENETIC CONTROL OF FRUIT RIPENING 审中-公开
标题翻译：水果粕的遗传控制
公开(公告)号：WO1998011228A2
公开(公告)日：1998-03-19
申请号：PCT/GB1997002424
申请日：1997-09-08
申请人： ZENECA LIMITED , SEYMOUR, Graham, Barron , BIRD, Colin, Roger , MEDINA-SUAREZ, Rosybel de Jesús
发明人： ZENECA LIMITED
IPC分类号： C12N15/29
CPC分类号： C12N15/8249
摘要： A method of modulating the ripening and/or senescence characteristics in plants of the genus Musa comprises transforming plants with one or more sequences obtainable from the deposited cDNA library having the accession number 40184, regenerating said plants and selecting from the population of transformants those plants having modulated and/or tissue senescence characteristics.
摘要翻译：调节植物中成熟和/或衰老特性的方法包括用可从保藏号为40184的保藏cDNA文库获得的一个或多个序列转化植物，再生所述植物并从转化体群体中选择具有调节和/或组织衰老特征。

22. 发明申请

WO1998000561A1 REG GENE EXPRESSION IN CANCER TISSUE 审中-公开
标题翻译： REG基因表达在癌组织中
公开(公告)号：WO1998000561A1
公开(公告)日：1998-01-08
申请号：PCT/GB1997001739
申请日：1997-06-30
申请人： ZENECA LIMITED , MARKHAM, Alexander, Fred , GUILLOU, Pierre, John
发明人： ZENECA LIMITED
IPC分类号： C12Q01/68
CPC分类号： G01N33/57484 , C12Q1/6886 , G01N2500/00 , G01N2800/50 , G01N2800/56
摘要： The invention relates to a marker for determining the tendency towards a cancerous condition and/or the aggressive nature of cancer tissue with a view to determining a prognosis and suitable course of action/treatment. More specifically, the invention concerns an investigation for products of the (REG) gene, i.e. the pancreatic protein lithostathine (REG) gene.
摘要翻译：本发明涉及用于确定癌症状态趋势和/或癌组织侵袭性质的标志物，以便确定预后和合适的作用/治疗过程。更具体地说，本发明涉及（REG）基因，即胰腺蛋白物质（REG）基因的产物的研究。

23. 发明申请

WO1998000429A1 PROCESS FOR THE PREPARATION OF PENAM AND PENEM DERIVATIVES 审中-公开
标题翻译：制备PENAM和PENEM衍生物的方法
公开(公告)号：WO1998000429A1
公开(公告)日：1998-01-08
申请号：PCT/GB1997001714
申请日：1997-06-24
申请人： ZENECA LIMITED , GALLAGHER, Timothy, Charles , HALES, Neil, James , WISEDALE, Richard , PLANCHENAULT, Denis
发明人： ZENECA LIMITED
IPC分类号： C07D499/04
CPC分类号： C07D499/88 , C07D499/00 , Y02P20/55
摘要： The invention provides a process for the preparation of compounds of formula (I) wherein R , R , R , R and R are as defined in the specification; and wherein any functional groups are optionally protected; and salts thereof; which process includes the step of reacting the intermediate formed by heating a compound of formula (II), in an inert solvent, with a compound of the formula S=C(R )R wherein R , R , R , R and R are as defined in the specification and functional groups are optionally protected; and thereinafter, if necessary, removing any protecting groups. The compounds of the formula (I) are useful as intermediates in the preparation of penems and may possess antibacterial properties and/or inhibit beta -lactamase in their own right.
摘要翻译：本发明提供了制备式（I）化合物的方法，其中R 1，R 2，R 3，R 4和R 5如说明书中所定义; 并且其中任选的官能团被保护; 及其盐; 该方法包括使在惰性溶剂中加热式（II）化合物形成的中间体与式S = C（R 3）R 4的化合物反应的步骤，其中R 1， R 2，R 3，R 4和R 5如说明书中所定义，官能团任选地被保护; 并且如果需要，移除任何保护组。式（I）的化合物可用作制备青霉烯的中间体，并且可以具有本身的抗菌性和/或抑制β-内酰胺酶。

24. 发明申请

WO1997043286A1 BICYCLIC AMINES AS INSECTICIDES 审中-公开
标题翻译：双酚A作为杀虫剂
公开(公告)号：WO1997043286A1
公开(公告)日：1997-11-20
申请号：PCT/GB1997001259
申请日：1997-05-09
申请人： ZENECA LIMITED , SALMON, Roger , HOTSON, Matthew, Brian
发明人： ZENECA LIMITED
IPC分类号： C07D451/02
CPC分类号： C07D451/02 , A01N43/90
摘要： The invention provides novel compounds of formula (I) and formula (II) wherein R represents a group of formula (A) where each of W, X, Y and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y, and Z represent the nitrogen atom, and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R represents a group XR where X represents oxygen or a group NR where R and R are individually selected from hydrogen or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl, and carboxylic acyl groups, said groups comprising from 1 to 15 carbon atoms, said groups being optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl and alkyl groups; and acid addition salts and quaternary ammonium salts and N-oxides derived therefrom. The compounds have useful insecticidal properties.
摘要翻译：本发明提供新的式（I）和式（II）化合物，其中R 1表示式（A）中的基团，其中W，X，Y和Z各自表示基团CR或氮原子，条件是不多于两个W，X，Y和Z表示氮原子，并且其中每个R独立地选自氢和卤素原子和氰基，氨基，肼基，酰氨基，羟基，烷基，羟基烷基，烷氧基，卤代烷基，卤代烷氧基，烯基，烯氧基，烷氧基烯基，炔基，羧基酰基，烷氧基羰基，芳基和杂环基，所述基团包含至多6个碳原子，并且其中R 2表示XR 3基团，其中X表示氧或NR 其中R 3和R 4分别选自氢或选自烷基，芳基，杂芳基，芳烷基，杂芳基烷基，烯基，芳烯基，炔基，杂环基烷基，烷氧基羰基和羧酰基的基团，所述基团包含1至15个碳原子，所述基团是选择性的被一个或多个选自卤素，氰基，羧基，羧基酰基，氨基甲酰基，烷氧基羰基，烷氧基，亚烷基二氧基，羟基，硝基，卤代烷基和烷基的取代基取代。和酸加成盐和季铵盐和由其衍生的N-氧化物。该化合物具有有用的杀虫性质。

25. 发明申请

WO1997042252A1 PHOSPHATE ESTERS OF POLYOXYALKYLENE ETHER BLOCK COPOLYMERS AND THEIR DISPERSANTS 审中-公开
标题翻译：聚氧乙烯醚嵌段共聚物及其分散剂的磷酸酯
公开(公告)号：WO1997042252A1
公开(公告)日：1997-11-13
申请号：PCT/GB1997000930
申请日：1997-04-02
申请人： ZENECA LIMITED , THETFORD, Dean , CARTRIDGE, David, John
发明人： ZENECA LIMITED
IPC分类号： C08G65/32
CPC分类号： C09D11/03 , B01F17/0064 , C08G65/327 , C09D7/45
摘要： A composition comprising a particulate solid and a dispersant which is a phosphate ester of a compound of formula (1), wherein Y is methoxy or H-(EO)q, m and q are each independently from 5 to 50 and n is from 5 to 70. When Y is a methoxy, n is preferably 20 and m is preferably 10. When Y is H-(EO)q, m and q are preferably 13 and n is preferably 30.
摘要翻译：一种组合物，其包含颗粒状固体和分散剂，其为式（1）化合物的磷酸酯，其中Y为甲氧基或H-（EO）q，m和q各自为5至50，n为5 当Y为甲氧基时，n优选为20，m优选为10.当Y为H-（EO）q时，m和q优选为13，n优选为30。

26. 发明申请

WO1997038995A1 FUNGICIDAL OXAZOLIDINEDIONE DERIVATIVES 审中-公开
标题翻译：杀真菌毒素衍生物
公开(公告)号：WO1997038995A1
公开(公告)日：1997-10-23
申请号：PCT/GB1997000822
申请日：1997-03-24
申请人： ZENECA LIMITED , HUGGETT, Margaret, Jean , WHITTINGHAM, William, Guy , BUCHANAN, Kirsteen, Isobel
发明人： ZENECA LIMITED
IPC分类号： C07D413/12
CPC分类号： C07D413/12 , A01N43/76
摘要： A fungicidal oxazolidinedione compound having general formula (I) wherein R is a C-linked 6-membered heteroaromatic ring containing 2 or 3 nitrogen atoms and which is optionally N- or C-substituted with one or more of halo, hydroxy, oxo, C1-6 alkyl, C3-6 cycloalkyl, halo(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, aryl(C1-6)alkyl, C1-6 alkoxy, halo(C1-6)alkoxy, C2-4 alkenyloxy, C1-6 alkylthio, C1-6 alkylcarbonyl, C1-6 alkylcarbonylamino, C1-6 alkoxycarbonyl, arylcarbonyl, aryl, aryloxy, or heteroaryl, the aryl and heteroaryl substituents themselves being optionally substituted with one or more of halo, C1-6 alkyl, halo(C1-6)alkyl, C1-6 alkoxy, halo(C1-6)alkoxy, C1-4 alkoxy (C1-6) alkyl, nitro, amino, mono- or di(C1-4)alkylamino, cyano, C1-6 alkoxycarbonyl or C1-6 alkylcarbonyl, and R is phenyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, pyrrolyl, furyl, thienyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, thiadiazolyl, oxadiazolyl or tetrazolyl, any of which is optionally substituted with one or more of halo, C1-6 alkyl, halo(C1-6)alkyl, C1-6 alkoxy, halo(C1-6)alkoxy, C1-6 alkylthio, nitro, cyano, thiocyanato, C1-4 alkylsulphonyl, halo(C1-4)alkylsulphonyl, aminosulphonyl or C1-6 alkoxycarbonyl, or two adjacent substituents join to form with the carbon atoms to which they are attached a fused benzene ring optionally substituted with halo, C1-4 alkyl or C1-4 alkoxy.
摘要翻译：具有通式（I）的杀真菌恶唑烷二酮化合物，其中R 1是含有2或3个氮原子的C连接的6元杂芳族环，并且其任选被一个或多个卤素，羟基，氧代C 1-6烷基，C 3-6环烷基，卤代（C 1-6）烷基，C 1-4烷氧基（C 1-6）烷基，芳基（C 1-6）烷基，C 1-6烷氧基，卤代（C 1-6）烷氧基，C 2-4烷氧基，C 1-6烷硫基，C 1-6烷基羰基，C 1-6烷基羰基氨基，C 1-6烷氧基羰基，芳基羰基，芳基，芳氧基或杂芳基，芳基和杂芳基取代基本身任选被一个或多个卤代（C 1-6）烷基，C 1-6烷氧基，卤代（C 1-6）烷氧基，C 1-4烷氧基（C 1-6）烷基，硝基，氨基，单或二（C1- 4）烷基氨基，氰基，C 1-6烷氧基羰基或C 1-6烷基羰基，R 2是苯基，吡啶基，嘧啶基，哒嗪基，吡嗪基，三嗪基，吡咯基，呋喃基，噻吩基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，三唑基，噻二唑基，恶二唑基或四氢呋喃基卤代（C 1-6）烷基，C 1-6烷氧基，卤代（C 1-6）烷氧基，C 1-6烷硫基，硝基，氰基，硫氰酸酯，C 1-4烷基磺酰基，卤代（C 1-4）烷基磺酰基，氨基磺酰基或C 1-6烷氧基羰基，或两个相邻的取代基与它们所连接的碳原子一起形成，稠合苯环任选被卤素取代，C 1-4 烷基或C 1-4烷氧基。

27. 发明申请

WO1997036961A1 REACTIVE DYES 审中-公开
标题翻译：反应性染料
公开(公告)号：WO1997036961A1
公开(公告)日：1997-10-09
申请号：PCT/GB1997000707
申请日：1997-03-14
申请人： ZENECA LIMITED , RENFREW, Andrew, Hunter, Morris
发明人： ZENECA LIMITED
IPC分类号： C09B62/443
CPC分类号： C09B62/4403 , D06P1/38 , D06P1/6735 , D06P1/67366 , D06P1/67383
摘要： A dye having at least two groups each of which independently is of formula (1) and salts thereof, wherein: A is a halo triazinylamino reactive group; L is an arylene group; R and R are each independently H or alkyl; Q is a group of the formula -CO- or -SO2-; and B is an optionally substituted vinyl group or a group which is converted into an optionally substituted vinyl group in the presence of aqueous alkali.
摘要翻译：具有至少两个基团的染料，每个基团独立地具有式（1）及其盐，其中：A是卤素三嗪基氨基反应性基团; L 1是亚芳基; R 1和R 2各自独立地为H或烷基; Q是式-CO-或-SO 2 - 的基团; 并且B是任选取代的乙烯基或在碱水溶液存在下转化为任选取代的乙烯基的基团。

28. 发明申请

WO1997035983A2 CYSTEINE PROTEASE PROMOTER FROM OIL SEED RAPE AND A METHOD FOR THE CONTAINMENT OF PLANT GERMPLASM 审中-公开
标题翻译：来自油种子的CYSTEINE PROTEASE PROMOTER和一种植物GERMPLASM容纳方法
公开(公告)号：WO1997035983A2
公开(公告)日：1997-10-02
申请号：PCT/GB1997000729
申请日：1997-03-18
申请人： ZENECA LIMITED , JEPSON, Ian , GREENLAND, Andrew, James , THOMAS, Didier, Rene, Philippe
发明人： ZENECA LIMITED
IPC分类号： C12N15/29
CPC分类号： C12N15/8237 , C12N9/50 , C12N15/8234 , C12N15/8238 , C12N15/8261 , Y02A40/146
摘要： A promoter comprising the DNA sequence of an oil seed rape cysteine protease gene promoter of class 1, 2 or 6 is described. The promoter may be used in an expression system for at least the tissue or tissues of a germinating seedling or developing grain or plant (e.g. in the root, cotyledons, leaves and stem). In a preferred embodiment, the expression system comprises a disrupter gene fused to a promoter according to the present invention.
摘要翻译：描述了包含1,2或6类油菜半胱氨酸蛋白酶基因启动子的DNA序列的启动子。启动子可以用于表达系统中至少用于发芽幼苗或发育中的谷物或植物（例如在根，子叶，叶和茎中）的组织或组织。在优选的实施方案中，表达系统包含与根据本发明的启动子融合的破坏子基因。

29. 发明申请

WO1997033893A1 PROCESS FOR THE PREPARATION OF TETRAETHYL METHYLENEBISPHOSPHONATE 审中-公开
标题翻译：制备四乙基亚甲基二磷酸酯的方法
公开(公告)号：WO1997033893A1
公开(公告)日：1997-09-18
申请号：PCT/US1997003726
申请日：1997-03-10
申请人： ZENECA LIMITED , LEADBETTER, Michael, R. , BROWN, Richard, W. , MCKENNA, Maureen, M.
发明人： ZENECA LIMITED
IPC分类号： C07F09/40
CPC分类号： C07F9/4028
摘要： This invention relates to a process for the preparation of tetraethyl methylenebisphosphonate by the reaction of dichloromethane with diethyl phosphite, wherein the reaction is performed in a polar aprotic solvent or mixtures thereof.
摘要翻译：本发明涉及通过二氯甲烷与亚磷酸二乙酯的反应制备亚甲基双膦酸四乙酯的方法，其中反应在极性非质子溶剂或其混合物中进行。

30. 发明申请

WO1997032883A1 AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译： AZOLOBENZAZEPINE衍生物作为神经生物活性剂
公开(公告)号：WO1997032883A1
公开(公告)日：1997-09-12
申请号：PCT/GB1997000592
申请日：1997-03-04
申请人： ZENECA LIMITED , BRUSH, Kelly, Anne , CHAPDELAINE, Marc, Jerome , FRAZEE, William, Jackson , GARCIA-DAVENPORT, Laura, Enid , LEWIS, Joseph, James
发明人： ZENECA LIMITED
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/55
摘要： The invention relates to azolobenzazepine derivatives of formula (I), wherein: X is O or S; R , R , R and R are independently hydrogen, perfluorolower-alkyl, halogen, nitro or cyano; and C together with the carbon atoms to which it is attached forms a 5-membered aromatic heterocycle, to pharmaceutical compositions containing them and to methods for the treatment of neurological disorders utilizing them.
摘要翻译：本发明涉及式（I）的偶氮苯并氮杂衍生物，其中：X为O或S; R 1，R 2，R 3和R 4独立地是氢，全氟低级烷基，卤素，硝基或氰基; 和C连同其所连接的碳原子一起形成5元芳族杂环，含有它们的药物组合物和利用它们治疗神经障碍的方法。

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