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21. 发明申请

US20120319328A1 TABLET MANUFACTURING METHOD 审中-公开
公开(公告)号：US20120319328A1
公开(公告)日：2012-12-20
申请号：US13582395
申请日：2011-03-03
申请人： Shinji Ando , Kenji Yoshida , Takuji Ueda
发明人： Shinji Ando , Kenji Yoshida , Takuji Ueda
IPC分类号： B29C43/02
CPC分类号： A61J3/10 , B30B11/02 , B30B15/022
摘要： An object is to provide a tablet manufacturing method which may restrain formation of a tablet edge surface and permits less effect of intra-tablet stress developed in process of press-forming on a tablet quality in cases where an upper rod and a lower rod are fittingly inserted into a vertical hole formed in a die to press powder in the die hole with a pushing surface at the lower end of the upper rod and a pushing surface at the upper end of the lower rod in order to press-form a tablet.Disclosed is a tablet manufacturing method in which an upper rod 3 and a lower rod 4 are fittingly inserted into a vertical hole 2 formed in a die 1 to press powder 5 in the die hole 2 with a pushing surface 9a at the lower end of the upper rod 3 and a pushing surface 11a at the upper end of the lower rod 4 in order to press-form a tablet 6, characterized in that concave forming grooves 2a integrally linked to the upper and lower pushing surfaces 9a and 11a are formed annularly in the inner circumferential surface of the die hole 2, and the die may be divided into an upper separable piece 7 and a lower separable piece 8 at the bottom portions of the forming grooves 2a, wherein after a final fixed rod or one of the upper and lower rods 3 and 4 is moved to and then fixed at a press-forming position at which the pushing surface 9a or 11a is integrally linked to the corresponding forming groove 2a, a final pressing rod or the other rod 3 or 4 is moved to the press-forming position so that the tablet 6 of a circular, elliptical or oval form as viewed in cross sectional side is press-formed, and then, the press-formed tablet 6 held in the forming grooves 2a is taken out of the die by separating the upper and lower separable pieces 7 and 8, in which case, the tablet 6 after being taken out of a final fixed separable piece or the separable piece 7 or 8 adjacent to the final fixed rod and also out of the final fixed rod is taken out of a final pressing separable piece or the separable piece 7 or 8 adjacent to the final pressing rod.

22. 发明申请

US20120219996A1 METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY 有权
标题翻译：使用肠杆菌属细菌生产L-氨基酸的方法
公开(公告)号：US20120219996A1
公开(公告)日：2012-08-30
申请号：US13466266
申请日：2012-05-08
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08 , C12P13/04
CPC分类号： C12P13/04 , C12P13/08 , C12P13/10 , C12P13/24
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译：公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌已被修饰以增强D-木糖通透酶的活性。

23. 发明授权

US07915018B2 Method for producing L-amino acids using bacteria of the Enterobacteriaceae family 有权
标题翻译：使用肠杆菌科的细菌生产L-氨基酸的方法
公开(公告)号：US07915018B2
公开(公告)日：2011-03-29
申请号：US11247138
申请日：2005-10-12
申请人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Ekaterina Alekseevna Savrasova , Valeriy Zavenovich Akhverdian , Elena Vitalievna Klyachko , Sergei Vladimirovich Mashko , Vera Georgievna Doroshenko , Larisa Gotlibovna Airikh , Tatyana Viktorovna Leonova , Mikhail Markovich Gusyatiner , Elvira Borisovna Voroshilova , Yury Ivanovich Kozlov , Yoshihiko Hara , Takuji Ueda
IPC分类号： C12P13/08
CPC分类号： C12P13/04 , C12P13/08 , C12P13/10 , C12P13/24
摘要： There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
摘要翻译：公开了使用肠杆菌科的细菌生产L-氨基酸的方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸或L-谷氨酸，其中细菌已被修饰以增强D-木糖通透酶的活性。

24. 发明授权

US07833762B2 Method for producing L-amino acid 有权
标题翻译：生产L-氨基酸的方法
公开(公告)号：US07833762B2
公开(公告)日：2010-11-16
申请号：US12241233
申请日：2008-09-30
申请人： Saori Kataoka , Takuji Ueda , Yuji Joe , Chie Koseki
发明人： Saori Kataoka , Takuji Ueda , Yuji Joe , Chie Koseki
IPC分类号： C12P13/04 , C12P13/08 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P13/04 , C12N9/93
摘要： An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the acetyl-CoA synthetase activity is increased.
摘要翻译： L-氨基酸是通过培养属于肠杆菌科的L-氨基酸产生菌而进行的，其被修饰以使乙酰辅酶A合成酶活性增加。

25. 发明授权

US07629142B2 L-amino acid-producing microorganism and method for producing L-amino acid 有权
标题翻译： L-氨基酸生产微生物和L-氨基酸的生产方法
公开(公告)号：US07629142B2
公开(公告)日：2009-12-08
申请号：US11044347
申请日：2005-01-28
申请人： Takuji Ueda , Yuta Nakai , Yoshiya Gunji , Rie Takikawa , Yuji Joe
发明人： Takuji Ueda , Yuta Nakai , Yoshiya Gunji , Rie Takikawa , Yuji Joe
IPC分类号： C12P1/00 , C12P1/04 , C12P13/08 , C12P13/10
CPC分类号： C12P13/10 , C07K14/245 , C12P13/04 , C12P13/08
摘要： L-amino acids are produced by culturing a microorganism which has an ability to produce the L-amino acid, but has been modified so that expression of the ybjE gene has been enhanced. The L-amino acid is collected from the culture medium or from the microorganism.
摘要翻译： L-氨基酸是通过培养具有产生L-氨基酸的能力的微生物而产生的，但是已被修饰以使ybjE基因的表达增强。从培养基或微生物收集L-氨基酸。

26. 发明申请

US20090098621A1 METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA 有权
标题翻译：使用肠杆菌属细菌的细菌生产L-氨基酸的方法，其具有用于小RNA的基因编码的衰减表达
公开(公告)号：US20090098621A1
公开(公告)日：2009-04-16
申请号：US12212743
申请日：2008-09-18
申请人： Konstantin Vyacheslavovich Rybak , Aleksandra Yurievna Skorokhodova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Tatyana Viktorovna Leonova , Yury Ivanovich Kozlov , Takuji Ueda , Vitaly Grigorievich Paraskevov
发明人： Konstantin Vyacheslavovich Rybak , Aleksandra Yurievna Skorokhodova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Tatyana Viktorovna Leonova , Yury Ivanovich Kozlov , Takuji Ueda , Vitaly Grigorievich Paraskevov
IPC分类号： C12P13/04 , C12N1/21 , C12P13/22 , C12P13/08 , C12P13/12 , C12P13/06 , C12P13/24 , C12P13/10 , C12P13/14 , C12P13/20
CPC分类号： C12P13/04
摘要： The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
摘要翻译：本发明提供一种利用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以减弱编码sRNA的基因的表达。

27. 发明授权

US08383363B1 L-amino acid-producing microorganism and method for producing L-amino acid 有权
公开(公告)号：US08383363B1
公开(公告)日：2013-02-26
申请号：US11759419
申请日：2007-06-07
申请人： Takuji Ueda , Yuta Nakai , Yoshiya Gunji , Rie Takikawa , Yuji Joe
发明人： Takuji Ueda , Yuta Nakai , Yoshiya Gunji , Rie Takikawa , Yuji Joe
IPC分类号： C12P1/00 , C12P1/04 , C12P13/08 , C12P13/10
CPC分类号： C12P13/10 , C07K14/245 , C12P13/04 , C12P13/08
摘要： L-amino acids are produced by culturing a microorganism which has an ability to produce the L-amino acid, but has been modified so that expression of the ybjE gene has been enhanced. The L-amino acid is collected from the culture medium or from the microorganism.

28. 发明授权

US08354255B2 L-amino acid-producing bacterium and a method for producing L-amino acids 失效
标题翻译： L-氨基酸生产菌和L-氨基酸的生产方法
公开(公告)号：US08354255B2
公开(公告)日：2013-01-15
申请号：US12056390
申请日：2008-03-27
申请人： Takuji Ueda , Yuji Joe
发明人： Takuji Ueda , Yuji Joe
IPC分类号： C12P13/14 , C12P13/04 , C12P13/08
CPC分类号： C12P13/04 , C12P13/08 , C12P13/14
摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the medium or cells.
摘要翻译：提供了一种L-氨基酸的制造方法，其包括在培养基中培养具有产生L-氨基酸的能力的肠杆菌科的微生物，并且其被修饰以增强葡萄糖苷的PTS活性并从培养基或细胞中收集L-氨基酸。

29. 发明申请

US20120070865A1 METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA 有权
标题翻译：使用肠杆菌属细菌的细菌生产L-氨基酸的方法，其具有用于小RNA的基因编码的衰减表达
公开(公告)号：US20120070865A1
公开(公告)日：2012-03-22
申请号：US13307627
申请日：2011-11-30
申请人： Konstantin Vyacheslavovich Rybak , Aleksandra Yurievna Skorokhodova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Tatyana Viktorovna Leonova , Yury Ivanovich Kozlov , Vitaly Grigorievich Paraskevov , Takuji Ueda
发明人： Konstantin Vyacheslavovich Rybak , Aleksandra Yurievna Skorokhodova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Tatyana Viktorovna Leonova , Yury Ivanovich Kozlov , Vitaly Grigorievich Paraskevov , Takuji Ueda
IPC分类号： C12P13/08
CPC分类号： C12P13/04
摘要： The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
摘要翻译：本发明提供一种利用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌来生产L-氨基酸的方法，其已被修饰以减弱编码sRNA的基因的表达。

30. 发明申请

US20090275091A1 L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-AMINO ACIDS 有权
标题翻译： L-氨基酸生产细菌和一种生产L-氨基酸的方法
公开(公告)号：US20090275091A1
公开(公告)日：2009-11-05
申请号：US12056414
申请日：2008-03-27
申请人： Takuji Ueda , Yuji Joe
发明人： Takuji Ueda , Yuji Joe
IPC分类号： C12P13/04 , C12P13/08 , C12P13/14
CPC分类号： C12P13/14 , C12P13/04 , C12P13/08
摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium or in cells, and collecting the L-amino acid from the medium or cells.
摘要翻译：提供L-氨基酸的制造方法，其包括在培养基中培养具有生产L-氨基酸的能力的肠杆菌科的微生物，并且已经被改性以提高甘露糖PTS活性，培养基或细胞中的L-氨基酸，并从培养基或细胞中收集L-氨基酸。

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