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21. 发明申请

US20070011753A1 Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse 审中-公开
标题翻译：适用于异源细胞移植，分化和增殖的小鼠的方法，通过该方法产生的小鼠和使用小鼠
公开(公告)号：US20070011753A1
公开(公告)日：2007-01-11
申请号：US11517698
申请日：2006-09-08
申请人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
发明人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
IPC分类号： A01K67/027
CPC分类号： C07K16/18 , A01K67/027 , A01K67/0271 , A01K2267/03 , A01K2267/0331 , A01K2267/0337 , A61K39/00
摘要： The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
摘要翻译：本发明提供了适合于异源细胞的移植，分化和增殖的免疫缺陷小鼠（NOG小鼠），以及这种小鼠的制备方法。该小鼠通过用NOD / Shi小鼠回交C.B-17- scid小鼠并通过回交的小鼠进一步回交白细胞介素2受体γ链基因敲除小鼠而获得。它可用于产生人抗体并建立干细胞测定系统，肿瘤模型和病毒感染模型。

22. 发明申请

US20100158982A1 SHEET FOR GUIDING REGENERATION OF MESENCHYMAL TISSUE AND PRODUCTION METHOD THEREOF 有权
标题翻译：引导生殖组织再生及其生产方法的论文
公开(公告)号：US20100158982A1
公开(公告)日：2010-06-24
申请号：US12709748
申请日：2010-02-22
申请人： Toshitsugu KAWATA , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
发明人： Toshitsugu KAWATA , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
IPC分类号： A61K35/28 , A61K9/70 , A61P19/00 , A61P21/00
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译：为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上，并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。

23. 发明申请

US20080220521A1 SHEET FOR GUIDING REGENERATION OF MESENCHYMAL TISSUE AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：引导生殖组织再生及其生产方法的论文
公开(公告)号：US20080220521A1
公开(公告)日：2008-09-11
申请号：US12123572
申请日：2008-05-20
申请人： Toshitsugu Kawata , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
发明人： Toshitsugu Kawata , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
IPC分类号： C12N5/02
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译：为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上，并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。

24. 发明授权

US06733954B2 Semiconductor module substrate sheet, semiconductor module substrate sheet fabricating method and semiconductor module 失效
标题翻译：半导体模块基板，半导体模块基板制造方法和半导体模块
公开(公告)号：US06733954B2
公开(公告)日：2004-05-11
申请号：US10396419
申请日：2003-03-26
申请人： Kunitoshi Yamamoto , Koichiro Tsuji
发明人： Kunitoshi Yamamoto , Koichiro Tsuji
IPC分类号： G03C556
CPC分类号： H01L23/13 , H01L21/561 , H01L23/3121 , H01L23/49805 , H01L23/49838 , H01L23/50 , H01L24/48 , H01L24/49 , H01L24/97 , H01L2224/16225 , H01L2224/32225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/49175 , H01L2224/73265 , H01L2224/97 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01018 , H01L2924/01019 , H01L2924/01023 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01039 , H01L2924/01046 , H01L2924/01047 , H01L2924/01054 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/07811 , H01L2924/12041 , H01L2924/12042 , H01L2924/1301 , H01L2924/15151 , H01L2924/181 , H01L2924/3025 , H05K1/0206 , H05K1/141 , H05K3/0052 , H05K3/0082 , H05K3/064 , H05K3/108 , H05K3/184 , H05K3/3442 , H05K3/403 , H05K2201/049 , H05K2201/0959 , H05K2201/09645 , H05K2203/1407 , H01L2224/85 , H01L2224/81 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： Through holes are formed at four peripheral edges of a plurality of semiconductor chip placement regions of an insulating substrate, except for coupling portions partially arranged thereat. A substrate sheet for semiconductor module is used in which connecting portions between inner lead portions and outer lead portions arranged on both surfaces of the substrate are formed in pattern on the side wall surface of the through hole. The semiconductor chip is mounted on each region, electrode terminals thereof and the inner lead portions are electrically connected to each other, the chip is sealed, and then the coupling portions are cut.
摘要翻译：绝缘基板的多个半导体芯片配置区域的四个周缘形成通孔，除了部分地布置在其上的耦合部分之外。使用半导体模块用基板，其中，设置在基板的两面的内引线部和外引线部之间的连接部形成为贯通孔的侧壁面。半导体芯片安装在每个区域上，其电极端子和内引线部分彼此电连接，芯片被密封，然后切断连接部分。

25. 发明授权

US06573028B1 Base sheet for semiconductor module, method for manufacturing base sheet for semiconductor module, and semiconductor module 有权
标题翻译：半导体模块用基板，半导体模块用基板的制造方法以及半导体模块
公开(公告)号：US06573028B1
公开(公告)日：2003-06-03
申请号：US09601766
申请日：2000-08-08
申请人： Kunitoshi Yamamoto , Koichiro Tsuji
发明人： Kunitoshi Yamamoto , Koichiro Tsuji
IPC分类号： G03C556
CPC分类号： H01L23/13 , H01L21/561 , H01L23/3121 , H01L23/49805 , H01L23/49838 , H01L23/50 , H01L24/48 , H01L24/49 , H01L24/97 , H01L2224/16225 , H01L2224/32225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/49175 , H01L2224/73265 , H01L2224/97 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01018 , H01L2924/01019 , H01L2924/01023 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01039 , H01L2924/01046 , H01L2924/01047 , H01L2924/01054 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/07811 , H01L2924/12041 , H01L2924/12042 , H01L2924/1301 , H01L2924/15151 , H01L2924/181 , H01L2924/3025 , H05K1/0206 , H05K1/141 , H05K3/0052 , H05K3/0082 , H05K3/064 , H05K3/108 , H05K3/184 , H05K3/3442 , H05K3/403 , H05K2201/049 , H05K2201/0959 , H05K2201/09645 , H05K2203/1407 , H01L2224/85 , H01L2224/81 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： Through holes are formed at four peripheral edges of a plurality of semiconductor chip placement regions of an insulating substrate, except for coupling portions partially arranged thereat. A substrate sheet for semiconductor module is used in which connecting portions between inner lead portions and outer lead portions arranged on both surfaces of the substrate are formed in pattern on the side wall surface of the through hole. The semiconductor chip is mounted on each region, electrode terminals thereof and the inner lead portions are electrically connected to each other, the chip is sealed, and then the coupling portions are cut.
摘要翻译：绝缘基板的多个半导体芯片配置区域的四个周缘形成通孔，除了部分地布置在其上的耦合部分之外。使用半导体模块用基板，其中，设置在基板的两面的内引线部和外引线部之间的连接部形成为贯通孔的侧壁面。半导体芯片安装在每个区域上，其电极端子和内引线部分彼此电连接，芯片被密封，然后切断连接部分。

26. 发明授权

US5427514A Magnetic plastic rotor disk manufacturing apparatus 失效
标题翻译：磁性塑料转子盘制造装置
公开(公告)号：US5427514A
公开(公告)日：1995-06-27
申请号：US201155
申请日：1994-02-24
申请人： Kinya Horibe , Masazumi Kawai , Yasukazu Hoshino , Koichiro Tsuji , Kiyofumi Uchida
发明人： Kinya Horibe , Masazumi Kawai , Yasukazu Hoshino , Koichiro Tsuji , Kiyofumi Uchida
IPC分类号： B29C45/00 , B29C45/27 , B29C45/32
CPC分类号： B29C45/0013 , B29C45/2701
摘要： A magnetic plastic rotor disk manufacturing apparatus, includes an injection device for injecting a magnetic plastic material containing a synthetic resin matrix and a magnetic powder; a mold for molding the magnetic plastic material injected thereinto from the injection device, and a device for generating a magnetic field and magnetizing the magnetic powder in a direction along a diameter of the magnetic plastic rotor disks. The mold includes a three-plate type mold constructed of two retainer plates and a single runner stripper plate. One of the retainer plates is formed with a plurality of pin gates corresponding to the cavities so as to supply the magnetic plastic material through the pin gates into the cavities.
摘要翻译：一种磁性塑料转子盘制造装置，包括：注入含有合成树脂基体和磁性粉末的磁性塑料的注射装置; 用于模制从注射装置注入的磁性塑料材料的模具，以及用于产生磁场并沿着磁性塑料转子盘的直径的方向磁化磁粉的装置。模具包括由两个保持板和单个脱模板构成的三板式模具。保持板中的一个形成有与空腔对应的多个销浇口，以便通过销浇口将磁性塑料材料供应到空腔中。

27. 发明授权

US08722404B2 Sheet for guiding regeneration of mesenchymal tissue and production method thereof 有权
标题翻译：用于引导间充质组织再生的片材及其制造方法
公开(公告)号：US08722404B2
公开(公告)日：2014-05-13
申请号：US12709748
申请日：2010-02-22
申请人： Toshitsugu Kawata , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
发明人： Toshitsugu Kawata , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
IPC分类号： C12N5/077 , C12N5/0789 , C12N5/0797 , C12N5/02 , A61F2/00 , A61F2/02
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： Method for regeneration of mesenchymal tissue from mesenchymal cells on a porous sheet composed of bioabsorbable polymer material.
摘要翻译：从由生物可吸收聚合物材料组成的多孔片材上的间充质细胞的间充质组织的再生方法。

28. 发明授权

US08039256B2 Culturing method of mesenchymal stem cell 有权
标题翻译：间充质干细胞的培养方法
公开(公告)号：US08039256B2
公开(公告)日：2011-10-18
申请号：US12892223
申请日：2010-09-28
申请人： Yuhiro Sakai , Katsuyuki Yamanaka , Mika Takeda , Tomohisa Okura , Koichiro Tsuji
发明人： Yuhiro Sakai , Katsuyuki Yamanaka , Mika Takeda , Tomohisa Okura , Koichiro Tsuji
IPC分类号： C12N5/00 , C12N5/07 , C12N5/10 , C12N5/071
CPC分类号： C12N5/0663 , C12N2500/50
摘要： To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.
摘要翻译：为了有效地选择和增殖间充质干细胞而不需要专门的分离装置和复杂的分离操作，通过种植骨髓溶液，脐带血，外周血，滑膜中的至少一种来培养间充质干细胞和填充在容器中的液体培养基中的羊膜包含水作为主要成分，在37℃下的比重为1.06〜1.10，培养温度为37±2℃。在容器的顶棚侧表面上，优选使用选自由聚乙烯吡咯烷酮涂覆的二氧化硅细粉末，蔗糖和表氯醇的水溶性共聚物和包含三碘芳环的水溶性化合物中的至少一种来调节比重。

29. 发明申请

US20090262001A1 REMOTE CONTROL SYSTEM AND REMOTE CONTROL SIGNAL PROCESSING METHOD 失效
标题翻译：远程控制系统和远程控制信号处理方法
公开(公告)号：US20090262001A1
公开(公告)日：2009-10-22
申请号：US12401245
申请日：2009-03-10
申请人： Tsugihiko Haga , Hiroto Kimura , Masanori Machimura , Koichiro Tsuji , Toshiyuki Hino , Tetsujiro Kondo
发明人： Tsugihiko Haga , Hiroto Kimura , Masanori Machimura , Koichiro Tsuji , Toshiyuki Hino , Tetsujiro Kondo
IPC分类号： H04L17/02
CPC分类号： G08C17/02 , G08C2201/30
摘要： A remote control system is provided. The remote control system includes at least one first remote control apparatus and at least one second remote control apparatus. The at least one first remote control apparatus includes a command input unit, a first control unit, and a first output unit. The at least one second remote control apparatus includes a first user interface unit, a first input unit, a second control unit, and a second output unit.
摘要翻译：提供遥控系统。遥控系统包括至少一个第一遥控装置和至少一个第二遥控装置。所述至少一个第一遥控装置包括命令输入单元，第一控制单元和第一输出单元。所述至少一个第二遥控装置包括第一用户接口单元，第一输入单元，第二控制单元和第二输出单元。

30. 发明授权

US07145055B2 Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse 有权
标题翻译：适用于异源细胞的移植，分化和增殖的小鼠的方法，通过该方法产生的小鼠和使用小鼠
公开(公告)号：US07145055B2
公开(公告)日：2006-12-05
申请号：US10221549
申请日：2001-10-25
申请人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
发明人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
IPC分类号： G01N33/00 , C12N15/01 , A01K67/02 , A01K67/027
CPC分类号： C07K16/18 , A01K67/027 , A01K67/0271 , A01K2267/03 , A01K2267/0331 , A01K2267/0337 , A61K39/00
摘要： The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
摘要翻译：本发明提供了适合于异源细胞的移植，分化和增殖的免疫缺陷小鼠（NOG小鼠），以及这种小鼠的制备方法。该小鼠通过用NOD / Shi小鼠回交C.B-17- scid小鼠并通过回交的小鼠进一步回交白细胞介素2受体γ链基因敲除小鼠而获得。它可用于产生人抗体并建立干细胞测定系统，肿瘤模型和病毒感染模型。

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