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21. 发明申请

US20130137880A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-SUBSTITUTED-3-FORMYL-2-HYDROXYPROPANOIC ACID COMPOUND 有权
标题翻译：用于制备光学活性3-取代-3-甲基-2-羟基丙酸化合物的方法
公开(公告)号：US20130137880A1
公开(公告)日：2013-05-30
申请号：US13701314
申请日：2011-05-30
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07C67/343 , C07C67/31 , C07D209/48 , C07D321/00 , C07C69/66
CPC分类号： C07C67/343 , C07B53/00 , C07C67/31 , C07C69/708 , C07C69/716 , C07C69/732 , C07D209/48
摘要： The present invention provides a production method of optically active 3-substituted-3-formyl-2-hydroxypropanoic acid compound (4), which includes a step of reacting glyoxylic acid compound (1-1) or (1-2) with aldehyde (2) in the presence of optically active pyrrolidine compound (3); wherein each symbol is as defined in the specification.
摘要翻译：本发明提供光学活性3-取代-3-甲酰基-2-羟基丙酸化合物（4）的制备方法，该方法包括使乙醛酸化合物（1-1）或（1-2）与醛反应 2）在光学活性吡咯烷化合物（3）的存在下; 其中每个符号如说明书中所定义。

22. 发明申请

US20100143310A1 SPINAL NERVE REPAIR PROMOTING THERAPEUTICS CONTAINING GHRELIN OR ITS DERIVATIVES OR SUBSTANCES THAT ACT ON GHS-R1a AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：含有GHRELIN或其衍生物或作为活性成分的GHS-R1a作用的物质的脊髓神经修复促进治疗
公开(公告)号：US20100143310A1
公开(公告)日：2010-06-10
申请号：US12377056
申请日：2007-08-10
申请人： Noboru Murakami , Keiko Nakahara , Miho Hashimoto , Yujiro Hayashi , Kenji Kangawa
发明人： Noboru Murakami , Keiko Nakahara , Miho Hashimoto , Yujiro Hayashi , Kenji Kangawa
IPC分类号： A61K45/00 , C07K7/08 , C07K14/00 , C12N5/079 , A61P25/00
CPC分类号： C07K14/60 , A61K38/00
摘要： The invention provides a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like.The invention provides an agent that contains a substance (e.g., ghrelin) that acts on the growth hormone secretagogue-receptor as an active ingredient, the agent being a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of cultured spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like.
摘要翻译：本发明提供了用于治疗脊髓神经元损伤的脊髓神经元损伤治疗剂或用于促进脊髓神经元前体细胞培养中脊髓神经元前体细胞增殖的药剂，或用于促进脊髓神经再生的药剂移植后培养的脊髓神经元前体细胞等。本发明提供一种包含作用于生长激素促分泌素受体作为活性成分的物质（例如生长激素释放肽）的药剂，所述药剂是用于治疗脊髓神经元损伤的脊髓神经元损伤治疗剂或药剂用于促进脊髓神经元前体细胞培养中培养的脊髓神经元前体细胞的增殖，或用于促进培养的脊髓神经元前体细胞移植后脊髓神经再生的试剂等。

23. 发明申请

US20090305969A1 Skin Repair Accelerating Therapeutic Agent Containing Desacyl Ghrelin and Derivatives Thereof as Active Ingredient 审中-公开
标题翻译：含有脱酰基Ghrelin及其衍生物的皮肤修复加速治疗剂作为活性成分
公开(公告)号：US20090305969A1
公开(公告)日：2009-12-10
申请号：US12085220
申请日：2006-11-21
申请人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
发明人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
IPC分类号： A61K38/22 , C12N5/00 , A61P17/00
CPC分类号： C07K14/60 , A61K38/25
摘要： The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing desacyl ghrelin or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了一种新型的皮肤损伤治疗剂和皮肤再生促进剂。皮肤损伤治疗剂和含有脱酰基生长素释放肽或其药学上可接受的盐的皮肤再生促进剂作为活性成分。

24. 发明授权

US5841279A Body coil, gradient coil and NMR apparatus 失效
标题翻译：体线圈，梯度线圈和NMR装置
公开(公告)号：US5841279A
公开(公告)日：1998-11-24
申请号：US771996
申请日：1996-12-23
申请人： Yujiro Hayashi , Kazuhiko Hayakawa , Kazuhiko Sato , Zenchi Hiyama
发明人： Yujiro Hayashi , Kazuhiko Hayakawa , Kazuhiko Sato , Zenchi Hiyama
IPC分类号： G01R33/34 , A61B5/055 , G01R33/385 , G01V3/00
CPC分类号： G01R33/3854
摘要： An RF coil is surrounded externally with dampers. Arresting plates are attached securely to the exterior of the dampers to arrest vibrations of the latter. The thickness of the arresting plates is made substantially the same as that of a body coil bobbin.
摘要翻译：射频线圈外部带阻尼器。止动板牢固地连接到阻尼器的外部，以阻止后者的振动。止动板的厚度与身体线圈骨架的厚度基本相同。

25. 发明授权

US08716500B2 Method for producing five-membered ring-containing compound 有权
标题翻译：生产五元环化合物的方法
公开(公告)号：US08716500B2
公开(公告)日：2014-05-06
申请号：US14113611
申请日：2012-04-27
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07D307/02
CPC分类号： C07D307/45 , C07B53/00 , C07C67/30 , C07C69/732 , C07C69/738 , C07C201/12 , C07C205/05 , C07C2601/08 , C07C2601/14 , C07D307/42 , C07C205/18 , C07C205/44 , C07C205/41 , C07C205/55
摘要： The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an α,β-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active α-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II).
摘要翻译：本发明提供了一种制备用于形成前列腺素等五元环的合成中间体的立体有择和不对称的五元环化合物的方法，其在非对映选择性和对映选择性方面具有高产率和优异的立体选择性一个简单的过程，而不需要麻烦的程序，如光学分辨率。含有五元环的化合物的制造方法包括在下述化学式（I）表示的α，β-不饱和硝基化合物与1,4-丁二酮化合物的存在下，由具有吡咯烷环和光学活性α-碳的化合物相对于环上的氮形成的催化剂在水不溶性有机溶剂和/或非含氧原子的水溶性有机溶剂中形成的催化剂，以便以制备由以下化学式（II）表示的含五元环的化合物。

26. 发明申请

US20140051874A1 METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND 有权
标题翻译：生产含五元环的化合物的方法
公开(公告)号：US20140051874A1
公开(公告)日：2014-02-20
申请号：US14113611
申请日：2012-04-27
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07D307/45 , C07C205/05 , C07C69/738 , C07C201/12 , C07C67/30 , C07C69/732
CPC分类号： C07D307/45 , C07B53/00 , C07C67/30 , C07C69/732 , C07C69/738 , C07C201/12 , C07C205/05 , C07C2601/08 , C07C2601/14 , C07D307/42 , C07C205/18 , C07C205/44 , C07C205/41 , C07C205/55
摘要： The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an α,β-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active α-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II).
摘要翻译：本发明提供了一种制备用于形成前列腺素等五元环的合成中间体的立体有择和不对称的五元环化合物的方法，其在非对映选择性和对映选择性方面具有高产率和优异的立体选择性一个简单的过程，而不需要麻烦的程序，如光学分辨率。制备含五元环的化合物的方法包括在下列化学式（I）表示的α，β-不饱和硝基化合物与1,4-丁二酮化合物的存在下缩合和环化的环化步骤：由具有吡咯烷环和光学活性α-碳的化合物相对于环上的氮，在水不溶性有机溶剂和/或非含氧原子的水溶性有机溶剂中形成的催化剂，以便产生由以下化学式（II）表示的含五元环的化合物。

27. 发明授权

US08501980B2 Process for producing oseltamivir phosphate and intermediate compound 有权
公开(公告)号：US08501980B2
公开(公告)日：2013-08-06
申请号：US12995059
申请日：2009-05-28
申请人： Yujiro Hayashi , Hayato Ishikawa
发明人： Yujiro Hayashi , Hayato Ishikawa
IPC分类号： C07C323/30 , C07C323/17
CPC分类号： C07C231/14 , C07C47/198 , C07C201/12 , C07C205/55 , C07C209/48 , C07C227/04 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/52 , C07C233/91 , C07C239/18 , C07C239/20 , C07C247/22 , C07C319/18 , C07C319/20 , C07C323/53 , C07C323/58 , C07C323/59 , C07C323/60 , C07C2601/14 , C07C2601/16 , C07D209/48 , Y02P20/55 , C07C205/51 , C07C229/48 , C07C323/61
摘要： Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.

28. 发明申请

US20110082302A1 Process for Producing Oseltamivir Phosphate and Intermediate Compound 有权
标题翻译：生产磷酸奥司他韦和中间体化合物的方法
公开(公告)号：US20110082302A1
公开(公告)日：2011-04-07
申请号：US12995059
申请日：2009-05-28
申请人： Yujiro Hayashi , Hayato Ishikawa
发明人： Yujiro Hayashi , Hayato Ishikawa
IPC分类号： C07D209/48 , C07C205/51 , C07C205/55 , C07C247/12 , C07C265/10
CPC分类号： C07C231/14 , C07C47/198 , C07C201/12 , C07C205/55 , C07C209/48 , C07C227/04 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/52 , C07C233/91 , C07C239/18 , C07C239/20 , C07C247/22 , C07C319/18 , C07C319/20 , C07C323/53 , C07C323/58 , C07C323/59 , C07C323/60 , C07C2601/14 , C07C2601/16 , C07D209/48 , Y02P20/55 , C07C205/51 , C07C229/48 , C07C323/61
摘要： Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.
摘要翻译：公开了适用于高产量的大规模合成以生产奥司他韦磷酸盐的方法，其中可以制备作为药物产品高度安全的磷酸奥司他韦的制剂和用于生产磷酸奥司他韦的中间体化合物。在该制造方法中，通过使用迈克尔反应/迈克尔反应/霍纳沃兹沃斯 - 埃蒙斯反应合成由通式（V）表示的中间体化合物，通过转化该中间体化合物中的取代基来制备磷酸奥司他韦。

29. 发明申请

US20090181888A1 Skin Repair Accelerating Therapeutic Agent Containing Ghrelin and Derivatives Thereof or Substance Acting On GHS-R1a as Active Ingredient 审中-公开
标题翻译：含Ghrelin及其衍生物或GHS-R1a作为活性成分的皮肤修复加速治疗剂
公开(公告)号：US20090181888A1
公开(公告)日：2009-07-16
申请号：US12085221
申请日：2006-11-21
申请人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
发明人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
IPC分类号： A61K38/17 , C07K14/47 , C12N5/06 , A61P17/00
CPC分类号： C07K14/60 , A61K38/25 , C07K14/72
摘要： The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing a substance acting on a growth hormone secretagogue receptor or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了一种新型的皮肤损伤治疗剂和皮肤再生促进剂。皮肤损伤治疗剂和含有作用于生长激素促分泌素受体的物质或其药学上可接受的盐作为活性成分的皮肤再生促进剂。

30. 发明授权

US5250697A Cyclobutane derivatives 失效
标题翻译：环丁烷衍生物
公开(公告)号：US5250697A
公开(公告)日：1993-10-05
申请号：US657463
申请日：1991-02-19
申请人： Koichi Narasaka , Yujiro Hayashi
发明人： Koichi Narasaka , Yujiro Hayashi
IPC分类号： C07D263/26 , C07D263/04
CPC分类号： C07D263/26
摘要： Cyclobutane derivatives represented by the following general formula (I): ##STR1## wherein X represents a group represented by the formula ##STR2## or the formula ##STR3## which is expected to be useful as reagents, drugs, agricultural chemicals and perfumes as well as an intermediate for the preparation thereof.

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