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21. 发明授权

US08216826B2 Fluid analyzing apparatus 有权
标题翻译：流体分析仪
公开(公告)号：US08216826B2
公开(公告)日：2012-07-10
申请号：US12251274
申请日：2008-10-14
申请人： Kun Feng Lee , Pei-Shin Jiang , Yuh-Jiuan Lin
发明人： Kun Feng Lee , Pei-Shin Jiang , Yuh-Jiuan Lin
IPC分类号： C12M1/34
CPC分类号： G01N35/08 , G01N2035/00326
摘要： A fluid analyzing apparatus. The fluid analyzing apparatus sequentially or simultaneously detects and analyzes a multiplex fluid sample with suitable analyzing elements. Meanwhile, the fluid analyzing apparatus may be disassembled to a first unit, a second unit and a third unit, such that the analyzing elements therein are easily disposed and replaced. The fluid analyzing apparatus analyzes and detects the multiplex fluid sample by allowing the multiplex fluid sample to sequentially or simultaneously flow through a plurality of target chambers. The fluid analyzing apparatus sequentially or simultaneously transports the multiplex fluid sample to the target chambers, thereby enhancing the speed and analysis thereof.
摘要翻译：流体分析装置。流体分析装置顺序或同时地检测并分析具有合适的分析元件的多重流体样品。同时，流体分析装置可以分解成第一单元，第二单元和第三单元，使得其中的分析元件容易地设置和更换。流体分析装置通过使多重流体样品依次或同时流过多个目标室来分析和检测多重流体样品。流体分析装置顺序或同时地将多重流体样品输送到目标室，从而提高其速度和分析。

22. 发明申请

US20100304399A1 METHOD FOR CONTINUOUSLY DETECTING GLUCOSE CONCENTRATION IN SAMPLE, KIT THEREOF AND METHOD FOR USING BIOSENSOR 有权
标题翻译：用于连续检测样品中葡萄糖浓度的方法，套件及其使用生物传感器的方法
公开(公告)号：US20100304399A1
公开(公告)日：2010-12-02
申请号：US12717542
申请日：2010-03-04
申请人： Kun-Feng Lee , Chien-An Chen , Hong-Wen Chang , Yuh-Jiuan Lin
发明人： Kun-Feng Lee , Chien-An Chen , Hong-Wen Chang , Yuh-Jiuan Lin
IPC分类号： G01N33/53
CPC分类号： G01N33/66
摘要： The invention provides a method for continuously detecting glucose concentration in a sample, including: (a) providing a biosensor comprising a transducer and a polysaccharide covered on the surface of the transducer; (b) providing a carbohydrate binding protein solution, wherein the carbohydrate binding protein has at least one receptor, and the receptor is capable of binding to the polysaccharide and glucose; (c) mixing a sample and the carbohydrate binding protein solution to form a mixture; (d) contacting the mixture with the biosensor; (e) detecting the amount of carbohydrate binding proteins bound to the polysaccharide by the biosensor, wherein glucose concentration of the sample is inversely proportional to the amount of carbohydrate binding proteins bound to the polysaccharide; and (f) refreshing the surface of the biosensor with a high concentration glucose solution.
摘要翻译：本发明提供了一种用于连续检测样品中葡萄糖浓度的方法，包括：（a）提供包含换能器和覆盖在换能器表面上的多糖的生物传感器; （b）提供碳水化合物结合蛋白质溶液，其中所述碳水化合物结合蛋白具有至少一种受体，并且所述受体能够结合所述多糖和葡萄糖; （c）将样品和碳水化合物结合蛋白溶液混合以形成混合物; （d）使混合物与生物传感器接触; （e）通过生物传感器检测与多糖结合的碳水化合物结合蛋白的量，其中样品的葡萄糖浓度与结合多糖的碳水化合物结合蛋白的量成反比; 和（f）用高浓度葡萄糖溶液刷新生物传感器的表面。

23. 发明申请

US20090041623A1 FLUID ANALYZING APPARATUS 有权
标题翻译：流体分析装置
公开(公告)号：US20090041623A1
公开(公告)日：2009-02-12
申请号：US12251274
申请日：2008-10-14
申请人： Kun Feng LEE , Pei-Shin Jiang , Yuh-Jiuan Lin
发明人： Kun Feng LEE , Pei-Shin Jiang , Yuh-Jiuan Lin
IPC分类号： G01N35/10 , B01J19/00 , G01N21/01 , C12Q1/02 , G01N25/00 , G01N27/00
CPC分类号： G01N35/08 , G01N2035/00326
摘要： A fluid analyzing apparatus. The fluid analyzing apparatus sequentially or simultaneously detects and analyzes a multiplex fluid sample with suitable analyzing elements. Meanwhile, the fluid analyzing apparatus may be disassembled to a first unit, a second unit and a third unit, such that the analyzing elements therein are easily disposed and replaced. The fluid analyzing apparatus analyzes and detects the multiplex fluid sample by allowing the multiplex fluid sample to sequentially or simultaneously flow through a plurality of target chambers. The fluid analyzing apparatus sequentially or simultaneously transports the multiplex fluid sample to the target chambers, thereby enhancing the speed and analysis thereof.
摘要翻译：流体分析装置。流体分析装置顺序或同时地检测并分析具有合适的分析元件的多重流体样品。同时，流体分析装置可以分解成第一单元，第二单元和第三单元，使得其中的分析元件容易地设置和更换。流体分析装置通过使多重流体样品依次或同时流过多个目标室来分析和检测多重流体样品。流体分析装置顺序或同时地将多重流体样品输送到目标室，从而提高其速度和分析。

24. 发明申请

US20070237474A1 MEDICAL INSPECTION DEVICE 有权
标题翻译：医疗检查装置
公开(公告)号：US20070237474A1
公开(公告)日：2007-10-11
申请号：US11688771
申请日：2007-03-20
申请人： Kun-Feng Lee , Ching-Yi Wu , Yu-Shih Chen , Yuh-Jiuan Lin , Hsi Feng Kao
发明人： Kun-Feng Lee , Ching-Yi Wu , Yu-Shih Chen , Yuh-Jiuan Lin , Hsi Feng Kao
IPC分类号： G02B6/04
CPC分类号： A61B1/247 , A61B1/0607 , A61B1/07 , A61B1/227 , A61B1/233 , A61B1/267
摘要： A medical inspection device. A housing includes a transparent plate and a first opening. A reflective layer is formed in the housing and opposes the transparent plate. The first opening is between the reflective layer and the transparent plate. A grip is connected to the first opening and extends in the exterior of the housing. An optical fiber bundle is connected to the first opening and disposed in the grip. The optical fiber bundle extends to the exterior of the grip and outputs light into the housing. The light is output to the exterior of the housing by reflection of the reflective layer and through the transparent plate. An image outside the housing is received by the optical fiber bundle through the transparent plate and by reflection of the reflective layer.
摘要翻译：医疗检查装置外壳包括透明板和第一开口。反射层形成在壳体中并与透明板相对。第一开口位于反射层和透明板之间。手柄连接到第一开口并在壳体的外部延伸。光纤束连接到第一开口并设置在把手中。光纤束延伸到手柄的外部，并将光输出到壳体中。光通过反射层的反射并通过透明板输出到外壳的外部。外壳外的图像被光纤束通过透明板和反射层反射而被接收。

25. 发明申请

US20080114152A1 PEPTIDE COMPOUNDS 有权
标题翻译：肽类化合物
公开(公告)号：US20080114152A1
公开(公告)日：2008-05-15
申请号：US11681094
申请日：2007-03-01
申请人： PEI-CHING SHIH , Pei-shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
发明人： PEI-CHING SHIH , Pei-shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
IPC分类号： C07K7/00
CPC分类号： G01N29/036 , C07K7/06 , G01N33/54373 , G01N33/84 , G01N2291/0257 , Y10T436/175383 , Y10T436/18
摘要： A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
摘要翻译：用于测量硫化合物和氨的肽化合物和使用该化合物的测量方法和装置。该方法包括使分析物与涂覆有肽化合物的感觉装置接触以产生信号，处理信号以产生结果，并将结果与数据库进行比较以定义分析物中硫化合物和氨的存在。

26. 发明授权

US07579436B2 Peptide compound for measuring sulfur compound and ammonia 有权
标题翻译：用于测量硫化合物和氨的肽化合物
公开(公告)号：US07579436B2
公开(公告)日：2009-08-25
申请号：US11681094
申请日：2007-03-01
申请人： Pei-Ching Shih , Pei-Shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
发明人： Pei-Ching Shih , Pei-Shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
IPC分类号： C07K7/06
CPC分类号： G01N29/036 , C07K7/06 , G01N33/54373 , G01N33/84 , G01N2291/0257 , Y10T436/175383 , Y10T436/18
摘要： A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
摘要翻译：用于测量硫化合物和氨的肽化合物和使用该化合物的测量方法和装置。该方法包括使分析物与涂覆有肽化合物的感觉装置接触以产生信号，处理信号以产生结果，并将结果与数据库进行比较以定义分析物中硫化合物和氨的存在。

27. 发明申请

US20070269380A1 METHOTREXATE-MODIFIED NANOPARTICLES AND RELATED METHODS 审中-公开
标题翻译：甲基改性纳米粒子及相关方法
公开(公告)号：US20070269380A1
公开(公告)日：2007-11-22
申请号：US11548148
申请日：2006-10-10
申请人： Miqin Zhang , Shian-Jy Wang , Nathan Kohler , Yuh-Jiuan Lin , Conroy Sun
发明人： Miqin Zhang , Shian-Jy Wang , Nathan Kohler , Yuh-Jiuan Lin , Conroy Sun
IPC分类号： A61K31/4985 , A61K9/14 , A61P35/00 , C07D475/08 , G01N33/574
CPC分类号： G01N33/57492 , A61K31/4985 , A61K47/6923 , A61K47/6929 , A61K49/1833 , A61K49/1848 , A61K49/186
摘要： Methotrexate-modified nanoparticles that target tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles.
摘要翻译：靶向肿瘤的甲氨蝶呤修饰的纳米粒子，包括纳米颗粒的组合物，使用纳米颗粒成像组织的方法，以及使用纳米颗粒治疗组织的方法。

28. 发明授权

US07267989B2 Method and device for measuring sulfur compound and/or ammonia based on a sensory unit coated with at least one novel peptide 有权
标题翻译：用于测量基于涂覆有至少一种新型肽的感官单元的硫化合物和/或氨的方法和装置
公开(公告)号：US07267989B2
公开(公告)日：2007-09-11
申请号：US10321652
申请日：2002-12-18
申请人： Pei-Ching Shih , Pei-Shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
发明人： Pei-Ching Shih , Pei-Shin Jiang , Wen-Hsun Kuo , Yuh-Jiuan Lin
IPC分类号： G01N33/00
CPC分类号： G01N29/036 , C07K7/06 , G01N33/54373 , G01N33/84 , G01N2291/0257 , Y10T436/175383 , Y10T436/18
摘要： A peptide compound for measuring sulfur compound and ammonia and measurement method and device using the compound. The method comprises contacting an analyte with a sensory device coated with the peptide compound to produce a signal, processing the signal to produce a result, and comparing the result with a database to define the presence of the sulfur compound and ammonia in the analyte.
摘要翻译：用于测量硫化合物和氨的肽化合物和使用该化合物的测量方法和装置。该方法包括使分析物与涂覆有肽化合物的感觉装置接触以产生信号，处理信号以产生结果，并将结果与数据库进行比较以定义分析物中硫化合物和氨的存在。

29. 发明授权

US07538188B2 Method for fabricating an olfactory receptor-based biosensor 有权
标题翻译：用于制造基于嗅觉受体的生物传感器的方法
公开(公告)号：US07538188B2
公开(公告)日：2009-05-26
申请号：US10962722
申请日：2004-10-12
申请人： Yuh-Jiuan Lin , Yuh-Fan Liu
发明人： Yuh-Jiuan Lin , Yuh-Fan Liu
IPC分类号： A61K38/08 , C12M1/34 , G01N33/00
CPC分类号： C07K7/06 , G01N33/6893 , Y10T436/173845 , Y10T436/174614 , Y10T436/175383
摘要： A biosensor, a method of making a biosensor, and a method of using a biosensor are described. A biosensor includes a transducer and a peptide encoding the most probable binding domain of an olfactory receptor protein. In embodiments, the transducer is a piezoelectric crystal. The method of making a biosensor includes modeling the three dimensional structure of an olfactory receptor protein; identifying the most probable binding domain of an olfactory receptor protein using a protein docking program; synthesizing a peptide encoding the most probable binding domains or a part thereof; and attaching the peptide to a transducer.
摘要翻译：描述生物传感器，制造生物传感器的方法和使用生物传感器的方法。生物传感器包括换能器和编码嗅觉受体蛋白的最可能结合结构域的肽。在实施例中，换能器是压电晶体。制备生物传感器的方法包括对嗅觉受体蛋白质的三维结构进行建模; 使用蛋白质对接程序鉴定嗅觉受体蛋白质的最可能的结合结构域; 合成编码最可能结合结构域的肽或其一部分; 并将肽连接到换能器上。

30. 发明授权

US07338812B2 Biochemical labeling materials and manufacturing method thereof 有权
标题翻译：生化标签材料及其制造方法
公开(公告)号：US07338812B2
公开(公告)日：2008-03-04
申请号：US10600830
申请日：2003-06-23
申请人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , K Abraham Joseph , Chao-Kang Chang
发明人： Chin-I Lin , Kang-Ping Lin , Yuh-Jiuan Lin , Sheng-Ming Shih , K Abraham Joseph , Chao-Kang Chang
IPC分类号： G01N33/544
CPC分类号： B82Y15/00 , G01N33/532 , G01N33/543 , G01N33/553 , G01N33/588
摘要： A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of the matrix, leaving a cavity with specific area.
摘要翻译：生物化学标签材料及其制造方法。该制造方法提供多个纳米颗粒，通过分子印迹将纳米颗粒结合到模板分子上，聚合纳米颗粒以形成具有均匀分布的模板分子的基质，最后从基质中除去模板分子以显示基质的检测基团，留下具有特定面积的空腔。

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