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21. 发明授权

US5256675A Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same 失效
标题翻译：噻唑衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US5256675A
公开(公告)日：1993-10-26
申请号：US867085
申请日：1992-04-14
申请人： Masaaki Matsuo , Takashi Ogino , Norihiro Igari , Hachiro Seno , Kyoichi Shimomura
发明人： Masaaki Matsuo , Takashi Ogino , Norihiro Igari , Hachiro Seno , Kyoichi Shimomura
IPC分类号： C07D277/40 , C07D277/46 , C07D277/54 , C07D277/56 , C07D417/12 , A61K31/44 , A01N43/40 , C07D409/00 , C07D411/00
CPC分类号： C07D417/12 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/56
摘要： Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.
摘要翻译：其中A是S，SO或SO 2，R 1是H或酰基，R 2是H，烷基，羟基烷基，卤素或羧基，R 3是吡啶基。这些化合物可用作治疗药物的治疗剂。风湿病，肾炎和血小板减少症。

22. 发明授权

US4242510A Cephalosporin compounds and processes for the preparation thereof 失效
标题翻译：头孢菌素化合物及其制备方法
公开(公告)号：US4242510A
公开(公告)日：1980-12-30
申请号：US916858
申请日：1978-06-19
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
IPC分类号： C07D501/34 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D279/10 , C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08 , C07D501/20 , C07D501/36 , C07D501/56
CPC分类号： C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08
摘要： Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino,M is sulfur or oxygen,R.sup.2 is hydrogen, or a saturated or unsaturated aliphatic hydrocarbon residue,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, acyloxymethyl or heterocyclic-thiomethyl which may be substituted with lower alkyl, andR.sup.5 is carboxy or its derivative, and nontoxic, pharmaceutically salt thereof.
摘要翻译：式（I）的头孢菌素化合物：其中R1是下式的基团：其中X是硫，氧或取代或未取代的亚氨基，M是硫或氧，R 2是氢，或饱和或不饱和的脂族烃残基，R 3为氢或低级烷基，R 4为氢，卤素，低级烷基，酰氧基甲基或可被低级烷基取代的杂环硫甲基，R5为羧基或其衍生物，且为无毒的的盐。

23. 发明授权

US08859041B2 Thermal spraying preprocessing method and a cylinder block of an engine so preprocessed 有权
标题翻译：热喷涂预处理方法和发动机的气缸体如此预处理
公开(公告)号：US08859041B2
公开(公告)日：2014-10-14
申请号：US10572137
申请日：2005-10-14
申请人： Takashi Sekikawa , Masahiko Iizumi , Takashi Ogino , Kimio Nishimura , Eiji Shiotani , Hideo Takahashi
发明人： Takashi Sekikawa , Masahiko Iizumi , Takashi Ogino , Kimio Nishimura , Eiji Shiotani , Hideo Takahashi
IPC分类号： B05D7/22 , B23P9/02 , C23C28/02 , C23C24/02 , B24B33/02 , C23C26/00 , C23C4/02
CPC分类号： B23P9/02 , B24B33/02 , C23C4/02 , C23C24/02 , C23C26/00 , C23C28/02 , C23C28/021 , C23C28/023 , Y10T29/49272
摘要： The adhesiveness of a thermal spray coating and a cylinder internal surface is improved by forming a sufficient roughened surface on an internal surface. A processing roller is installed on the main shaft of a processing device via a pressurizing mechanism. An uneven surface is provided on the external periphery of the processing roller. By pressing the processing roller against the internal surface while the roller rotates and moves, a fine unevenness that corresponds to the unevenness of the roller is formed on the cylinder internal surface. A thermal spray coating is formed on the internal surface where the inner surface has been roughened by forming the above-mentioned unevenness.
摘要翻译：通过在内表面上形成足够的粗糙表面来改善热喷涂层和气缸内表面的粘合性。处理辊经由加压机构安装在处理装置的主轴上。在处理辊的外周设有不平坦的表面。通过在辊旋转移动的同时将处理辊压靠在内表面上，在气缸内表面上形成与辊不均匀相对应的微细凹凸。通过形成上述凹凸，在内表面被粗糙化的内表面上形成热喷涂。

24. 发明申请

US20140201955A1 BOOT BAND 有权
标题翻译：引导带
公开(公告)号：US20140201955A1
公开(公告)日：2014-07-24
申请号：US14129371
申请日：2012-05-31
申请人： Takashi Ogino , Hiroshi Ikeda
发明人： Takashi Ogino , Hiroshi Ikeda
IPC分类号： F16B2/08
CPC分类号： F16B2/08 , F16D2003/22316 , F16J3/042 , Y10T24/14
摘要： Provided is a boot band that is configured for preventing the occurrence of buckling in the inner-layer portion of a band body. In the boot band, by applying a diameter-reducing tightening force on the band body when an engagement pawl of an inner-layer portion of the band body has entered a top-end engagement hole of an outer-layer portion of the band body, the top-end engagement hole rides over the engagement pawl. Buckling is prevented by providing, at the area of the top-end engagement hole opposite where the engagement pawl enters therein, a guide that faces the engagement pawl.
摘要翻译：提供了一种引导带，其构造成用于防止在带体的内层部分中发生屈曲。在引导带中，当带体的内层部分的接合爪进入带体的外层部分的顶端接合孔时，通过在带体上施加减小直径的紧固力，顶端接合孔骑在接合爪上。通过在接合爪进入其中的顶端接合孔的区域处设置面向接合爪的引导件来防止弯曲。

25. 发明授权

US08653285B2 Aminopropylidene derivative 有权
标题翻译：氨基亚丙基衍生物
公开(公告)号：US08653285B2
公开(公告)日：2014-02-18
申请号：US13055780
申请日：2009-07-31
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
IPC分类号： C07D313/08 , C07D333/50 , A61K31/38 , A61K31/335
CPC分类号： C07D495/04 , C07D333/78
摘要： An aminopropylidene derivative having excellent histamine receptor antagonistic action, a compound which is useful as a pharmaceutical composition, especially as an active ingredient, having alleviated side effects in the central nervous system is described. In the aminopropylidene derivative, R1 and R2, which may be identical or different, stand for a hydrogen, a substituted carbonyl, a substituted carbonylalkyl, and acrylic acid, excluding a case where both are hydrogen; R3 and R4, which may be identical or different, stand for hydrogen, an alkyl which may be substituted with phenyl, or the like; A stands for unsubstituted or an oxo; B stands for a carbon or an oxygen; one of X and Y stands for a carbon and the other stands for a sulfur, a broken line part stands for a single bond or a double bond, and a wavy line stands for cis-form and/or trans-form.
摘要翻译：描述了具有优异的组胺受体拮抗作用的氨基亚丙基衍生物，可用作药物组合物的化合物，特别是作为活性成分，在中枢神经系统中具有缓解的副作用。在氨基亚丙基衍生物中，R 1和R 2可以相同或不同，代表氢，取代的羰基，取代的羰基烷基和丙烯酸，不包括两者均为氢的情况; R3和R4可以相同或不同，代表氢，可被苯基取代的烷基等; A代表未取代或氧代; B代表碳或氧; X和Y中的一个代表碳，另一个代表硫，虚线部分代表单键或双键，波浪线代表顺式和/或反式。

26. 发明授权

US08222419B2 Oxepin derivative 有权
标题翻译：奥克辛衍生物
公开(公告)号：US08222419B2
公开(公告)日：2012-07-17
申请号：US12311215
申请日：2007-09-27
申请人： Kunihiko Higashiura , Takashi Ogino , Kazuhito Furukawa , Yuriko Yamazaki
发明人： Kunihiko Higashiura , Takashi Ogino , Kazuhito Furukawa , Yuriko Yamazaki
IPC分类号： C07D401/00
CPC分类号： C07D405/04
摘要： The present invention provides a compound, an oxepin derivative having excellent histamine receptor antagonistic action, which is useful as an antihistamine. The oxepin derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low intracerebral migration even when a mouse that is orally administered with the compound is subjected to an intracerebral receptor binding test, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The oxepin derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供一种化合物，具有优异的组胺受体拮抗作用的氧杂环丁衍生物，其可用作抗组胺药。本发明的oxepin衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使经口给予该化合物的小鼠进行脑内受体结合试验，也显示低脑内迁移，使得该化合物具有优选的减轻中枢神经系统副作用的性质，例如作为嗜睡本发明的oxepin衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药如睡意觉是非常有用的。

27. 发明授权

US08199428B2 Clamp of disk rotation driver 有权
标题翻译：磁盘旋转驱动器夹
公开(公告)号：US08199428B2
公开(公告)日：2012-06-12
申请号：US12596909
申请日：2008-03-24
申请人： Toshimitsu Araki , Takashi Ogino , Atsushi Shitama
发明人： Toshimitsu Araki , Takashi Ogino , Atsushi Shitama
IPC分类号： G11B17/02
CPC分类号： G11B17/0284
摘要： A clamp for a disk rotation driver stably and surely supports a disk in the disk rotation driver.The clamp 7 for a disk rotation driver 1 having a central portion and a periphery being circumferentially provided with a contact portion 13, the central portion fastened to a hub 5 to be rotated, and the contact portion 13 pressed against a recordable disk 3 attached to the hub 5 to apply a pressing force Fv to the disk 3 in a rotation axis direction and fixedly support the magnetic disk 3 on the hub 5, the clamp 7 comprising: a wall portion 25 extending from the periphery and being oriented in the rotation axis direction to form the contact portion 13 so that a frictional force μFy produced between the contact portion 13 and the magnetic disk 3 and resisting a locomotion Fx that acts on the contact portion 13 and radially outwardly biases the contact portion 13 when the contact portion 13 is in contact with the magnetic disk 3 is equal to or larger than the locomotion Fx.
摘要翻译：用于盘旋转驱动器的夹具稳定且可靠地支撑盘旋转驱动器中的盘。用于具有中心部分和周边的盘旋转驱动器1的夹具7周向地设置有接触部分13，中心部分紧固到要旋转的轮毂5，并且接触部分13压靠在可记录盘3上，附接到轮毂5沿旋转轴线方向将压力Fv施加到盘3，并将磁盘3固定地支撑在轮毂5上，夹具7包括：壁部25，其从周边延伸并且沿旋转轴定向方向形成接触部分13，使得在接触部分13和磁盘3之间产生的摩擦力μFy抵抗作用在接触部分13上的运动Fx并且当接触部分13为径向向外偏压接触部分13时与磁盘3接触等于或大于运动Fx。

28. 发明申请

US20110124856A1 AMINOPROPYLIDENE DERIVATIVE 有权
标题翻译：氨基酚衍生物
公开(公告)号：US20110124856A1
公开(公告)日：2011-05-26
申请号：US13055780
申请日：2009-07-31
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
IPC分类号： C07D279/12 , C07C211/32 , C07D209/56 , C07C57/50 , C07D265/30 , C07D211/08
CPC分类号： C07D495/04 , C07D333/78
摘要： An aminopropylidene derivative having excellent histamine receptor antagonistic action, a compound which is useful as a pharmaceutical composition, especially as an active ingredient, having alleviated side effects in the central nervous system is described. In the aminopropylidene derivative, R1 and R2, which may be identical or different, stand for a hydrogen, a substituted carbonyl, a substituted carbonylalkyl, and acrylic acid, excluding a case where both are hydrogen; R3 and R4, which may be identical or different, stand for hydrogen, an alkyl which may be substituted with phenyl, or the like; A stands for unsubstituted or an oxo; B stands for a carbon or an oxygen; one of X and Y stands for a carbon and the other stands for a sulfur, a broken line part stands for a single bond or a double bond, and a wavy line stands for cis-form and/or trans-form.
摘要翻译：描述了具有优异的组胺受体拮抗作用的氨基亚丙基衍生物，可用作药物组合物的化合物，特别是作为活性成分，在中枢神经系统中具有缓解的副作用。在氨基亚丙基衍生物中，R 1和R 2可以相同或不同，代表氢，取代的羰基，取代的羰基烷基和丙烯酸，不包括两者均为氢的情况; R3和R4可以相同或不同，代表氢，可被苯基取代的烷基等; A代表未取代或氧代; B代表碳或氧; X和Y中的一个代表碳，另一个代表硫，虚线部分代表单键或双键，波浪线代表顺式和/或反式。

29. 发明申请

US20100331365A1 PIPERIDINE DERIVATIVE 有权
标题翻译：哌啶衍生物
公开(公告)号：US20100331365A1
公开(公告)日：2010-12-30
申请号：US12864878
申请日：2008-11-20
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
IPC分类号： A61K31/4535 , C07D409/02 , A61P37/08
CPC分类号： C07D495/04 , C07D409/04 , C07D497/04
摘要： The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物，其可用作药物组合物，特别是抗组胺药的活性成分。本发明的哌啶衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移，因此该化合物具有减轻中枢神经系统中的副作用的优选性质，例如嗜睡。本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。

30. 发明授权

US07794306B2 Surface finishing apparatus and related method 有权
标题翻译：表面处理装置及相关方法
公开(公告)号：US07794306B2
公开(公告)日：2010-09-14
申请号：US10772429
申请日：2004-02-06
申请人： Tomohiro Kondo , Masahiko Iizumi , Masahiro Omata , Kiyoshi Hasegawa , Takashi Ogino , Takafumi Watanabe , Yoshiyuki Chida , Yasushi Matsushita , Kazuo Takeda
发明人： Tomohiro Kondo , Masahiko Iizumi , Masahiro Omata , Kiyoshi Hasegawa , Takashi Ogino , Takafumi Watanabe , Yoshiyuki Chida , Yasushi Matsushita , Kazuo Takeda
IPC分类号： B24B1/30
CPC分类号： B24B49/16 , B24B5/42 , B24B19/12 , B24B21/00
摘要： An apparatus and method for surface finishing a workpiece is disclosed as including a workpiece supporting mechanism supporting a workpiece having a target shaped periphery with a given width to be surface finished and a tool holder holding a surface finish tool in abutting contact with the target shaped periphery of the workpiece. A pressure applying mechanism is operative to apply a pressure force to the surface finish tool through the tool holder to cause the surface finish tool to be held in pressured contact with the target shaped periphery, with the pressure force exhibiting a given distribution pattern depending upon an axial direction of the workpiece. A drive mechanism rotates the workpiece to allow the surface finish tool to surface finish the target shaped periphery into a given geometrical profile, variably contoured along an axis of the workpiece depending on the given pressure distribution pattern.
摘要翻译：公开了一种用于表面处理工件的装置和方法，包括：工件支撑机构，其支撑具有待表面加工的给定宽度的目标形状周边的工件;以及保持表面加工工具以与目标形状周边抵接的工具架的工件。压力施加机构可操作以通过工具保持器向表面加工工具施加压力，以使表面精加工工具与目标形状的周边保持压力接触，其中压力显示给定的分布图案，这取决于工件的轴向。驱动机构使工件旋转以允许表面光洁度工具将目标形状的周边表面光洁成给定的几何轮廓，根据给定的压力分布图案沿着工件的轴线可变地轮廓。

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