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    • 22. 发明申请
    • Method for analyzing cell free notch cleavage and method for drug screening
    • 无细胞切口切割分析方法及药物筛选方法
    • US20060275856A1
    • 2006-12-07
    • US11417262
    • 2006-05-04
    • Masayasu OkochiMasatoshi Takeda
    • Masayasu OkochiMasatoshi Takeda
    • C12Q1/37
    • G01N33/6896C12Q1/37G01N2333/705G01N2500/20
    • The present invention provides a method for analyzing cell-free Notch cleavage which can be utilized for drug screening of γ-secretase inhibitors effective for the treatment of Alzheimer's disease and the drug screening method, is the method for analyzing cell-free Notch cleavage having a cell-free cleavage reaction step of contacting a crude membrane fraction of cells in which a Notch protein mutant has been expressed with a subject substance and a detection step of detecting a fragment of an amino terminal side and a fragment of a carboxyl terminal side produced by intramembrane proteolysis (dual sequential cleavage in putative transmembrane domain) of the Notch protein mutant in the above cell free cleavage reaction step, wherein the effect of the subject substance on the intramembrane proteolysis of the Notch protein mutant is analyzed, and the Notch protein mutant has at least the putative transmembrane domain of a Notch protein, deletes a part of an amino acid sequence at the amino terminal side than at least the putative transmembrane domain and has antibody recognition sites at the amino terminal side than the putative transmembrane domain and the carboxyl terminal side, respectively.
    • 本发明提供了可用于药物筛选对阿尔茨海默病有效治疗的γ-分泌酶抑制剂的药物筛选方法,用于分析无细胞的Notch切割的方法,该方法是分析无细胞的Notch切割的方法, 将其中Notch蛋白质突变体已经表达的细胞的粗膜部分与目标物质接触的无细胞裂解反应步骤和检测步骤,其检测氨基末端侧片段和羧基末端侧片段 在上述无细胞裂解反应步骤中的Notch蛋白质突变体的膜内蛋白水解(推定跨膜结构域的双连续切割),其中分析了本发明物质对Notch蛋白质突变体的膜内蛋白水解的影响,Notch蛋白质突变体具有 至少推定的Notch蛋白的跨膜结构域,删除一部分氨基酸序列 氨基末端侧比至少推定的跨膜结构域,并且在氨基末端侧分别具有比推定的跨膜结构域和羧基末端侧的抗体识别位点。
    • 25. 发明授权
    • Control system for static VAR compensator
    • 静态VAR补偿器控制系统
    • US07638986B2
    • 2009-12-29
    • US11756681
    • 2007-06-01
    • Masatoshi TakedaKoji Temma
    • Masatoshi TakedaKoji Temma
    • G05F1/70H02M7/04H02J3/24
    • G05F1/70H02J3/1864Y02E40/12
    • In a control system for a static var compensator that performs phase control of a current of a reactor for each phase by a thyristor and thus controls reactive power, a detecting unit that detects a tertiary harmonic current flowing through each phase of the static var compensator is provided, and on the basis of the tertiary harmonic current flowing through each phase detected by the detecting unit, the thyristor of each phase is controlled so that the quantity of generated tertiary harmonic current of each phase becomes equal, and therefore an outflow of the tertiary harmonic current toward a system can be restrained by an inexpensive method.
    • 在静态无功补偿器的控制系统中,通过晶闸管对每相的电抗器的电流进行相位控制,从而控制无功功率,检测流过静态无功补偿器的各相的三次谐波电流的检测单元是 基于由检测单元检测到的流过每相的三次谐波电流,控制各相的晶闸管,使得各相的三次谐波电流的量相等,因此第三次谐波的流出 可以通过廉价的方法来限制朝向系统的谐波电流。
    • 26. 发明申请
    • Power system control apparatus and power system control method
    • 电力系统控制装置及电力系统控制方法
    • US20090128100A1
    • 2009-05-21
    • US12149655
    • 2008-05-06
    • Satoshi YasudaHitoshi TeramotoMasatoshi TakedaMichihiro Tadokoro
    • Satoshi YasudaHitoshi TeramotoMasatoshi TakedaMichihiro Tadokoro
    • G05F1/70H02J3/18
    • H02J3/1821G05F1/70H02J3/1864Y02E40/12
    • A SVC control section detects a bus voltage from an instrument transformer, and adjusts reactive power generated by a SVC according to the detected bus voltage. A cooperative control section generates a control command for controlling the interconnection and parallel-off of a phase lead capacitor and a phase lag reactor on the basis of the amount of reactive power generated by the SVC and the bus voltage detected by the instrument transformer and a voltage sensor. A voltage comparator compares the bus voltage with a predetermined threshold voltage set to a voltage lower than a lower limit value of a steady state fluctuation range of the bus voltage and outputs the comparison result to a circuit breaker control section. When the bus voltage is lower than the threshold voltage, the circuit breaker control section locks the control command from the cooperative control section.
    • SVC控制部分检测仪表变压器的总线电压,根据检测到的总线电压调整SVC产生的无功功率。 合作控制部分根据由SVC产生的无功功率和由仪表变压器检测到的总线电压产生用于控制相位超前电容器和相位滞后电抗器的互连和并联的控制指令,以及 电压传感器 电压比较器将总线电压与设定为低于总线电压的稳态波动范围的下限值的电压设定的预定阈值电压进行比较,并将比较结果输出到断路器控制部。 当总线电压低于阈值电压时,断路器控制部分锁定来自协同控制部分的控制命令。
    • 27. 发明申请
    • Control System for Static VAR Compensator
    • 静态VAR补偿器控制系统
    • US20080001581A1
    • 2008-01-03
    • US11756681
    • 2007-06-01
    • Masatoshi TakedaKoji Temma
    • Masatoshi TakedaKoji Temma
    • G05F1/70
    • G05F1/70H02J3/1864Y02E40/12
    • In a control system for a static var compensator that performs phase control of a current of a reactor for each phase by a thyristor and thus controls reactive power, a detecting unit that detects a tertiary harmonic current flowing through each phase of the static var compensator is provided, and on the basis of the tertiary harmonic current flowing through each phase detected by the detecting unit, the thyristor of each phase is controlled so that the quantity of generated tertiary harmonic current of each phase becomes equal, and therefore an outflow of the tertiary harmonic current toward a system can be restrained by an inexpensive method.
    • 在静态无功补偿器的控制系统中,通过晶闸管对每相的电抗器的电流进行相位控制,从而控制无功功率,检测流过静态无功补偿器的各相的三次谐波电流的检测单元是 基于由检测单元检测到的流过每相的三次谐波电流,控制各相的晶闸管,使得各相的三次谐波电流的量相等,因此第三次谐波的流出 可以通过廉价的方法来限制朝向系统的谐波电流。