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21. 发明授权

US6162833A Photostable aqueous solution comprising benzyl alcohol derivatives 有权
标题翻译：包含苯甲醇衍生物的光稳定水溶液
公开(公告)号：US6162833A
公开(公告)日：2000-12-19
申请号：US292664
申请日：1999-04-16
申请人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Masahiro Yamazaki , Kazuya Matsuo
发明人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Masahiro Yamazaki , Kazuya Matsuo
IPC分类号： A61K31/137 , A61K47/10 , A61K47/26 , C07C215/60 , A61K31/135
CPC分类号： C07C215/60 , A61K31/137 , A61K47/10 , A61K47/26 , C07B2200/07 , Y10S514/935
摘要： Aqueous solution, including at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol represented by the following formula: ##STR1## and pharmacologically acceptable salt thereof. The aqueous solution also includes at least one photostabilizer selected from the group consisting of saccharide, sugar alcohol, and polyalcohol. A content of the at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof is 0.01 to 10% (w/v) based on a volume of the aqueous solution. A content of the at least one photostabilizer is 1 to 50% (w/v) based on the volume of the aqueous solution. The content of the at least one photostabilizer is at least 10% (w/w) based on a total weight of the at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof. Method of making a stabilized aqueous solution.
摘要翻译：水溶液，包括由下式表示的光学活性（ - ） - （R）-α-（（叔丁基氨基）甲基）-2-氯-4-羟基苄醇中的至少一种：及其药理学上可接受的盐。水溶液还包括至少一种选自糖，糖醇和多元醇的光稳定剂。光学活性（ - ） - （R）-α-（（叔丁基氨基）甲基）-2-氯-4-羟基苄醇及其药学上可接受的盐中的至少一种的含量为0.01〜10％（w / v）基于一定体积的水溶液。基于水溶液的体积，至少一种光稳定剂的含量为1至50％（w / v）。至少一种光稳定剂的含量基于光学活性（ - ） - （R）-α-（（叔丁基氨基）甲基） - 2-氯-4-羟基苄醇及其药理学上可接受的盐。制备稳定水溶液的方法

22. 发明授权

US3936460A 1',4'-Dihydro-1-methyl-spiro[piperidine and pyrolidine-2,3'(2'H)quinoline] c 失效
标题翻译： 1 {40,4 {40-二氢-1-甲基 - 螺（8）哌啶和吡咯烷-2,3（40（2（40H））喹啉{9 {0化合物
公开(公告)号：US3936460A
公开(公告)日：1976-02-03
申请号：US531322
申请日：1974-12-10
申请人： Hideo Kato , Eiichi Koshinaka
发明人： Hideo Kato , Eiichi Koshinaka
IPC分类号： C07D471/10 , C07D215/38
CPC分类号： C07D471/10
摘要： Spiro-compounds of the formula: ##SPC1##Are disclosed. These compounds are useful as analgetic, antihistamine and spasmolytic agents. They are indicated in the management of conditions such as headache, seasonal allergies and the like.
摘要翻译：下式的螺环化合物：

23. 发明授权

US3936459A 1',4'-Dihydro-1-methyl-spiro [piperidine and pyrrolidine-2,3'(2'H)quinoline]-2'-one compounds 失效
标题翻译： 1 {40,4 {40-二氢-1-甲基 - 螺（8）哌啶和吡咯烷-2,3（40（2（40H））喹啉{9-2 {
公开(公告)号：US3936459A
公开(公告)日：1976-02-03
申请号：US531452
申请日：1974-12-11
申请人： Hideo Kato , Eiichi Koshinaka
发明人： Hideo Kato , Eiichi Koshinaka
IPC分类号： C07D471/10 , C07D215/38 , C07D215/22
CPC分类号： C07D471/10
摘要： Spiro compounds having the structural formula ##SPC1##Where n is an integer of 1 or 2,Are disclosed. These compounds are useful as analgetic, antihistamine and spasmolytic agents. They are indicated in the management of conditions such as headache, seasonal allergies and the like.
摘要翻译：螺旋化合物具有结构式，其中N为1或2的整数，被披露。这些化合物可用作止痛药，抗组胺药和解痉药。它们在诸如头痛，季节性过敏等条件的管理中被指出。

24. 发明授权

US4093630A Diazabicycloalkane derivatives 失效
标题翻译：二氮杂双环烷烃衍生物
公开(公告)号：US4093630A
公开(公告)日：1978-06-06
申请号：US804591
申请日：1977-06-08
申请人： Hideo Kato , Tomoyasu Nishikawa , Eiichi Koshinaka
发明人： Hideo Kato , Tomoyasu Nishikawa , Eiichi Koshinaka
IPC分类号： A61K31/495 , A61K31/55 , A61P43/00 , C07D487/04 , C07D487/08
CPC分类号： C07D487/04
摘要： Novel diazabicycloalkane derivatives of the formula ##STR1## wherein R is hydrogen or a halogen including acid addition salts thereof are provided including a process for their preparation. These compounds are useful as antihistamines.
摘要翻译：提供了式（I）的新型二氮杂双环烷烃衍生物，其中R是氢或包括其酸加成盐的卤素包括其制备方法。这些化合物可用作抗组胺剂。

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